Welcome, and thank you all for standing by for today's conference. At this time, your lines have been placed in listen-only mode. [Operator Instructions]. Today's conference is being recorded. If you have any objections, you may disconnect at this time. And I'd like to turn the conference over to Mr. Mike Watts. Sir, you may begin.

Thank you, Sara, and good afternoon, everyone. On behalf of our management team, I'm pleased to welcome you to this conference call to discuss our first quarter 2008 business results. The press release announcing our results was issued today just after 4 PM Eastern Time and is posted on our website at www.gen-probe.com. In our call today, Hank will first provide an overview of our top line performance in the quarter, Herm will then review our detailed results and revised 2008 guidance and then we will take your questions. As usual, the call will last about an hour. Before we begin, let me first review our Safe Harbor policy. Forward-looking guidance, financial or otherwise is only provided on conference calls or in our press releases. Any statements in this conference call about our expectations, beliefs, plans, objectives, assumptions or future events or performance are not historical facts and are forward-looking statements. These statements are often, but not always, made through the use of words and phrases such as believe, will, expect, anticipate, estimate, intend, plan, foresee, could, should and would, for example, statements concerning 2008 financial guidance, financial condition, regulatory approvals and timelines, possible or assumed future results of operations, growth opportunities, industry ranking and plans and objectives of management are all forward-looking statements. Forward-looking statements are not guarantees of performance. They involve known and unknown risks and uncertainties that may cause actual results to differ materially from those expressed or implied. Factors that might cause such differences include but are not limited to those discussed in our SEC Filings including our report on Form 10-K for the year ended December 31, 2007, and all subsequent periodic reports. Copies are available on our website, at www.sec.gov and on request from our IR department. Gen-Probe assumes no obligation and expressly disclaims any duty to update any forward-looking statements to reflect events or circumstances after the date of this call or to reflect the occurrence of unanticipated events. With that administrative detail out of the way, I'll turn the call over to Hank Nordhoff, Gen-Probe's CEO.

Thank you, Mike, and good afternoon, everyone. As described in our press release, Gen-Probe is off to a strong start in 2008. In the first quarter, the re-acceleration of our blood screening business combined with double-digit growth in clinical diagnostics helped us set a new record for quarterly product sales which exceeded $100 million for the first time. In addition, we established new all-time highs in total revenues and earnings per share, both of which were boosted by the third and the final payment from Bayer, now Siemens, in settlement of a patent infringement lawsuit. We also made important progress in our R&D pipeline during the quarter. We filed with the FDA a supplemental BLA for our PROCLEIX ULTRIO blood screening assay. We initiated our HPV clinical trial in United States and two peer review journal articles were published on our PCA3 test which we believe should help increase awareness among urologists and ultimately sales. All in all, we believe our accomplishments in the first quarter once again demonstrated Gen-Probe’s ability to execute in the short term and innovate for the long-term. I have used this metaphor before, but how do we operationalize it, by combining tight financial controls with respect for innovation and the entrepreneurial spirit, by investing heavily in R&D, but with an eye toward maintaining our historically healthy profit margins, and by working hard to keep our commitments to stockholders, both in terms of near-term EPS and longer term project targets [ph]. Said another way, we continue to believe that for Gen-Probe to be successful and for us to create lasting shareholder value, we must maintain an appropriate balance between short-term execution and long-term innovation. That's been our game plan for the last five-and-a-half years and that’s what continues to drive our strategy, resource allocation and our…

Thank you, Hank, and good afternoon, everyone. As described in our press release, Gen-Probe had a very strong first quarter. Product sales grew 16% compared to the same period in 2007 driven by new records in both our clinical diagnostics and blood screening businesses and exceeded $100 million for the first time. Total revenues rose 21%, helped by the third and final payment from Bayer under our patent infringement settlement. And on the bottom line, earnings per share increased by 45% to an all-time high of $0.58. Hank discussed the dynamics of product sales, so let me begin by covering collaborative research revenues, which were $2.5 million in the first quarter of 2008, up slightly from $2.4 million a year ago. This increase resulted primarily from reimbursement from Novartis of R&D expenses incurred in our blood screening collaboration and from reimbursement from 3M associated with our collaboration to develop rapid molecular tests for healthcare-associated infections. Compared to the prior-year period, these increases were largely offset by the completion of work under our prostate cancer grant from the Department of Defense and from our since cancelled food testing collaboration with 3M. Royalty and license revenues were $18.6 million in the first quarter compared to $11.5 million in the prior-year period. Royalty and license revenue in the first quarter of 2008 benefited from a one-time true-up of royalties from Chiron associated with the use of our intellectual property in the plasma screening market, where significantly our first quarter results included $16.4 million from Bayer which represents the third and final payment due in connection with the settlement of our patent infringement lawsuit. For reference, last year's first quarter results included $10.3 million from Bayer. Since the Bayer payments are now complete, we currently forecast that royalty and license revenue were normalized to…

Thanks, Herm. We are happy to take your questions now. For the Q&A, we are joined by Carl Hull, President and COO, Bill Bowen, Senior Vice President and General Counsel, Dan Kacian, Executive Vice President and Chief Scientist, Stephen Kondor, Senior Vice President, Sales and Marketing, and Kevin Herde, our Corporate Controller. In order to ensure broad participation in the Q&A session, please be courteous and limit your questions to one plus a follow-up, then please jump back into the queue. Sara, I think we are ready to take the first question. Question and Answer

Operator: Thank you. Our first question from Tycho Peterson. Your line is open and please state your company name.

Good morning, from JPMorgan. Maybe just starting up with some of the market development strategy as you know you are presuming in Europe, if you can give us a sense as to where you are spending the incremental dollars, both geographically and… you gave us... I appreciate the color around some of the clinical publications that have come out, but specifically what are some of the efforts to build physician awareness in Europe? And then you talked a little bit about distribution channels, if you can give some additional color there, that would be helpful, and this is obviously both?

We’ll ask Steve to address that.

Hello, Tycho. I am going to answer to your question assuming it’s based both on PCA3 market development efforts as well as HPA market development efforts. So, as we talked about them on previous calls, we’ve added a number of sales and marketing technical support people over in Europe to get ready for the HPV launch, I already spoke for similarly supporting PCA3 as well. So, with that going on, more resources, we are also spending money on clinical trials, clinical research trials for PCA3. Hank talked in his opening event that a couple of the paper that are out there in the last couple of months, and several of these tests also are taking place over in Europe to show if you know that the European prostrate is similar to the American prostrate. So, these studies are going on, and we are adding to that with a volume of data that I think is going to be fairly significant and we are going to use that to continue to educate the urologist over in Europe. Similarly on HPV side, we have several performance valuations studies going on. Some of these studies have already been shown in abstract part again at the end of last year. They will demonstrate the significant differentiation between messenger RNA and our competitors’ assays. Add that to the benefits and advantages that our automation platforms bring in both of these areas, we think we are doing an adequate job.

Okay, thanks. That's helpful. And then maybe just finally on, when we think about ULTRIO here in the US, you’ve been pretty clear about the timing and your expectations, when revenues will start to contribute, but can you give us a sense as to how much pent-up demand you think there might be, how we should be think about the market converting post approval, maybe as we think about it next year?

Yes, Tycho, it's Carl. I think that we see some favorable trends there. I think Hank mentioned various comments, the reaction of the America Red Cross to the current trail, post marketing trails that’s under way. So, we are continuing to see excellent performance, which we think sets the stage for a good commercial acceptance. As you know without a mandate employed, somebody doesn’t have to adopt testing right away, but it's a matter of the commercialization and the plans of each of our major blood center customers as to what they want to offer and when they want to offer it. We do think there is real advantage to adding multiple TIGRISes up and running now in blood centers, including the ARC, and we think those will give us a leg up for the ultimate adoption decision when it’s made. But key things are... is the assay, are the customers seeing good detection and good specifics [ph], and we are pleased based on their feedback of how that's going.

Okay. Thank you very much.

Thank you, Tycho.

Bill Quirk with Piper Jaffray, your line is open.

Thanks. Good afternoon. Just a question on Tycho's TIGRIS theme here, can you guys tell me whether or not the majority of TIGRIS’ blood screening are going to US based customers or OUS based customers?

The ones in the first quarter, Bill?

Yes. That's correct.

Hang on just a second while we look to see if we’ve got that number here. I am looking around the table and I am not seeing [inaudible], give us one second. Yes, primarily ex-US.

Primarily ex-US, okay. Would it be safe to say, I guess, Hank, based on your comments as well as Herm’s and Carl’s moments ago that we should probably see that tide shift towards more US placements into the back half and obviously post approval?

That's a tough one, Bill, because it depends on adoption.

I don't think we know enough to give you a cogent answer to that one without being misleading.

Okay, understood. And then –

If you ask it again next quarter, we will have information for you.

Okay. I’ll --

[inaudible].

Fair enough. And then if I can just sneak in one kind of unrelated follow-up, and that was, was there Millipore contribution in the quarter? And if so where should we see [inaudible]?

Your question, Bill, was there a Millipore contribution?

Right. I assume it was quite small, Herm, but we should... I assume we should show that that gives a counter forum to clinical diagnostics or is that going to be kind of below that one [inaudible].

That would be to the extent there was a contribution, I'm not sure whether you are talking about ongoing revenue, or you're talking about a milestone payment.

I was referring to product revenue.

Product revenue, it would be in clinical diagnostics, and we haven't disclosed separately the amount of the Millipore revenue. Similar to PCA3, when we started talking about that one, it reaches a couple of million dollars, it will be probably be worth talking about.

Understood, thanks.

Thank you, Bill.

Imron Zafar, Deutsche Bank, your line is open.

Thank you and good afternoon. Question for you, Herm, does guidance still exclude any contribution from ULTRIO in the US?

That's true.

It does.

Okay. And then on your HPV launch strategy, now that you are about a quarter away from that in Europe, can you just give us a sense of what your strategy is with pricing relative to the Digene assay and what your inventory situation looks like?

Yeah, Imron. This is Steve. No, we are not going to talk about pricing strategies on a call, but the second part of your question was?

Inventory, how does your inventory look ahead of that launch?

Our inventory is perfectly fine in anticipation of our launching.

Okay. And then one last question for you Hank, can you just gives us an update on the timelines for Panther and Tudo [ph]. Thanks.

I don't think there’s been any change in either one, Imron.

Thanks.

Our next question from Bruce Cranna, Leerink Swann. Your line is open.

Thanks. Good afternoon, everyone.

Hi, Bruce.

Just I guess first of all on blood screening, I’m sorry, I kind of spaced out I think, Hank, on your commentary on the TIGRIS portion, the equipment piece, was it 4.4?

Yes, that's right.

Million in the quarter.

That's right.

And I know if we go back and forth on this one, it seems sometimes it's going to be slowing and then in it sort of rears its head again. Just from a modeling perspective, how should we be thinking about this on a dollar basis and then can you go through actually the gross margin impact there and how that's changing with the sharing mechanism?

Hi, Bruce, it's Herm. Modeling is tough on that because it does flip flop. But as you know in fact one of the upsides to the first quarter of 2008 was just that ordering by Novartis, Chiron pf TIGRIS instrument. So it is tough. We have got the number for the first quarter right, you know the number for the first quarter of last year, so it was roughly a couple million, I think $1.9 million or something like that higher. So, it is tough to model, and there are quarters when it's very low. So, sorry I can't help you all that much there. In terms of the effect on gross margin, up to until very recently, we sold all of those instruments, and we are only talking about the ones to Novartis, Chiron now in the US and outside the US at cost. So only recently we have been sharing in a portion of the profit of only those instruments sold in the US. So that's helped gross margin a little bit and as we've said in the prepared comments it was less than a $1 million.

I am sorry, the US portion or the margin impact.

The margin impact and the sharing in the US portion.

Okay. Thank you for that. And then –

Just to add to what Herm said, I would just remind you, I think in our last call we did say that we expected overall instrument sales to be a bit less this year than they were last year and we would continue to be with that way.

Okay. And I think someone brought it up, but I forget who it was, it might have been Hank, it might have been Herm, but you talked about gaining some share on the screening side of EU, can you quantify where you think you are in terms of share now and what you picked up in the quarter year-over-year?

Well, I think we are higher, Bruce, but I don’t think we are in a position to quantitate any further than that.

Okay, all right. Thanks guys.

Thanks.

Peter Lawson with Thomas Weisel Partners, your line is open.

Herm, I wonder if you could give us a spread of the blood screening revenues US versus internationally and how they have changed since 1Q '07?

We usually don't of course equate that way. We give our total ex-US revenues and they have gone up from about 15% to about 20%. You also know that roughly half of our revenue is blood screening, so you can probably deduce from that that most of that ex-US is blood screening.

Okay, that's helpful. And then the revenue upside in blood screening, wonder if you could give us some kind of contribution or rank them for commercial West Nile Virus, timing of the shipments, instruments and international over the drivers there for the blood screening?

I am sorry, can you just repeat that?

Is there any way of quantifying the revenue upside on the blood screening business, where it came from as regards to West Nile Virus, the timing and the shipments, the instruments, international growth?

Well, the way I look at it, we had of course the increase in instruments, and by now you know how much that is, right. From quarter one to quarter to one, it was roughly $2 million. I think –

And most of that was overseas.

Correct. We also told you on the last call there was about $1 million also overseas of shipment of ULTRIO that couldn't be made in the fourth quarter, which was made in the first and, of course, it was about a million. West Nile Virus, I don't know when we just closed the quarter a little while ago, I don’t know that we quite cut that precise, but I am thinking there’s probably to stock up, or some of it’s stock up, and some of it's going to be recurring, but that's probably worth about other $1 million something like that.

Okay. What was the size of the… the total size of the stock-up in Chiron, do you think ?

That we don't know, because we don't have visibility into, what portion of their order is a stock up and what portion is likely to be the recurring monthly order, but we are recurring quarterly orders.

Okay thank you so much, thanks for taking my question.

Welcome.

We probably should say that the blood screening revenue recognition has been a bit lumpy in the past and we don't see that really changing in the future. I think that was one of the problems with the fourth quarter, some of the fourth quarter went into third quarter and some fell over into the first quarter this year.

Our next question from Zarak Khurshid, Caris and Company, your line is open.

Hi guys, thanks for taking my question. Could you perhaps provide, a little more color on the R&D expense specifically, maybe quantify the per quarter steady state cost of the HPV trail, may be even tell us the two year total cost, and then because of the heavy HPV expense, are you then forced to perhaps slowdown any other R&D programs, in which programs may suffer as a results?

Zarak, it's Carl. I don’t think we are going to give in some details of the total spin that we expect on the HPV trail or as calenderization. We would consider that reasonably proprietary. But instead you could understand that it is the largest clinical trail that we currently have underway. It consumes a lot of resources, and I think Herm have the guidance for what you should expect to see in the total R&D line for the next three quarters as compared to first and a lot of that really does reflect the ramp up and the sustaining efforts that we are going to put towards that HPV trail. So I think without giving you a direct answer the best I can say is it’s a significant investment, and once we get up to steady state, which would be in the end of the second quarter, end of the third quarter, it will be reasonably predictable.

Fair enough. And then just curious about the MRSA product, where do we stand with that, with the 3M collaboration and then what is the timing of the trail and has the core IP been filed? Thank you.

On the 3M collaboration for MRSA and related hospital acquired infections we are very pleased with the progress that’s being made. We hit on both milestone that we discussed in the latter quarter of last year, with respect to our ended program we are working now in what we term the feasibility phase of the project integrating our assays, on to the 3M proprietary instrument and disposable system that work is going well, we will stay in feasibility and so if we got the assays fully integrated and at that point we typically didn't come out with our program schedules in anticipated time to market.

Our next question comes from Quintin Lai with Robert. W. Baird, your line is open.

Hi, good afternoon. Looking at your clinical diagnostics business, have you seen any changes in the selling cycle especially in respect to your customers, sources of funding and so either uptake of Type new TIGRIS instruments or decisions to switch from pace to APTIMA Combo 2?

I will shift that over to Steve Quintin.

So no changes in selling cycle. TIGRIS is certainly an important part of our continued growth in market share increase with the APTIMA product. We have targeted TIGRIS, you know at the high-volume customer labs and the mid-point customer labs. So, we are doing very well with it, we are very pleased with that growth, but not change in customer selling cycles.

And then, could you revisit the uses of cash since the last quarterly report. Your stock price has come down a little bit, any decision on stock repurchase versus M&A and any more color that you can provide Hank.

Well we prefer given a choice between the two the M&A rather than the stock repurchase. We are still involved in identifying and evaluating opportunities there. I can't report any progress since last conversation we have had like this. But we think the probability is good and it would appear to be a more prudent use of funds to do that than to buy back shares. And we would not want to initiate a buyback now, particularly in light of the probability of doing something else.

Thank you, very much.

Thank you.

Spencer Nam with Summer Street Research. Your line is open.

Thanks for taking my questions. Just a couple of quick questions. In terms of ULTRIO, the screening approval, is there some sort of a guidance like PMA, 180 days cycle as to how quickly FDA responds back to the application... the supplement application.

Yes. that's right, it's Mike. I think our guidance there hasn't changed much. We've said that we would expect approval probably in the four to six month timeframe after we filed... I think we filed in February, so the realistic expectation for third quarter on that guaranteed I think still stands.

I see. And I guess if I could just follow up on that, what makes... what could make it four months versus… I know I'm just splitting here a little bit, but what could make it four months versus six months on these kind of things?

Good question. I don’t know anybody knows the answer to that.

Certainly questions, Spencer, from the FDA could make it... take it from four months to six months or perhaps even longer.

Actually lack of [ph] questions.

Thank you. And then on this blood screening business side with the Chiron joint-venture, would the five-year agreement be extended once you get this screening approval for HPV.

The agreement will run five years after the last approval.

So, this would be… whenever the approval comes there would be another five years.

That's correct.

Now if my understanding is correct, some of the IP actually expires before that, is that correct?

I think some of the IP expires outside the U.S. on hepatitis C before that., and sometimes after that in the U.S. on hepatitis C.

And at this point do you have any plans to address the situation after it expires in the international arena.

No.

Okay. And then final question is, any updates in the industrial testing business and kind of where things are right now with different opportunities, any potential opportunities in the pipeline that you may not have discussed in the call but something that we should be aware of?

I think we're pretty well up-to-date. We talked a little bit last time about food and the new approach that the FDA is taking and the possibility that we may have a role to play on that, but nothing really has transpired since that conversation.

Right. Thanks very.

You're welcome, sir.

Sara Michelmore with Cowen. Your line is open.

Yes. Thank you. Good afternoon.

Hi, Sara.

Back to the comments on the American Red Cross trials for ULTRIO. Can you... you talk a little bit, Hank, about how many tests they've done to date. What is their rough timeline for completion of that trial? And if you could remind us what the likely process there is in terms of them committing to a contract. I know there is nothing at this point that you did allude to the fact they at least were getting some consistent results of what you would expect. If you could just kind of talk us the way of thinking there?

We expect the trial to finish in the third quarter of this year, as again as Carl was saying, they appear very pleased, they being the American Red Cross with the performance with the instruments and the assay as well. So we are optimistic about adoption rate.

Okay. And there is no time line that you would put on in evaluation process in terms of after the trial is complete?

Why don't you give that a shot?

Yes. I think in practice Sara, what's happening now does represent one of the most comprehensive evaluations you could ever structure. So I think the Red Cross will have sufficient data in front of them to engage in their decision-making process as the assay gets approved and as the deal progresses.

Great. And—

We will see an avalanche effect. And as adoption starts we would expect it to increase and expect it to be very widespread.

Okay. And I guess Hank or Herm or Carl took the follow up on the earlier question in R&D. I was wondering if you could just talk kind of directionally or qualitatively even about where that line goes in 2009. I know that the HPV clinical trial cost will push this into next year, but there are other things that roll off, and I'm just wondering if directionally for looking at something flat, something up even possibly down as we head into next year? Maybe if you could just talk around what the mechanics are at least?

Yes, I guess we are talking about growth I suppose... as opposed to looking at as a percentage of revenue. So Herm why don't you address on that line?

Yes. Well, we're just updating for the first time 2008 guidance. So a little early Sara, but we've got a lot of major programs including this huge HPV clinical trial. I would expect directionally the dollars will increase. As it relates to percentage of revenue, we've set for many years we would like to see that decrease and it is decreasing a little this year. I would like to personally see that continue, but jury is still out, it's early.

Great. Thank you.

Thanks Sara.

Bruce Jackson with RBC Capital Markets. Your line is open.

Hi. I apologize if I missed this, but did you say what the West Nile virus revenue was in the quarter?

No, we didn't mention.

You didn't miss a thing.

We thought you were going to say something like nice quarter guys.

Would you be able to provide us with the West Nile virus revenue number for the quarter?

We don't parse it quite that definitively. We do give it.. of course it’s on the press release. Blood screening as compared to diagnostics but we don't give it by assay.

Okay. And then with the HPV guidelines in Europe. Can you give us a little bit more color on which countries are looking at these guidelines and are they evaluating the test as a primary screen or as a reflex test or the pap test?

Hi, Bruce. This is Steve. I'll answer your question. Yes, several countries are in the process of adopting share of guidelines for the utilization of an HPV molecular test hasn't screened or hasn't edged on surpass. Right now, it will be... France, Spain and several other countries were in that process. The Netherlands is probably closer although it’s a small market. Germany is in the process as well.

All right. Thank you.

Thank you.

Jon Wood with Banc of America Securities, your line is open.

Thanks. This is Brandon Couillard in for Jon. Would you have any problem securing favorable financing in this environment?

Well. I don’t know if we lead any, given our stock of cash and the fact that we had no debt. I don't think we would have given our stock of cash and the fact we have no debt. I am... I don't think we would. Do you... is there a reason you asked the question?

I'll just in regards to your... I guess your capital deployment philosophies, it’s kind of some of your M&A efforts along those lines.

Okay.

Secondly, your main competitor in blood screening recently was talking about more competitive landscape in that market. Could you add some context and maybe explain that data point.

Yes, I think you are referring to some comments from Roche, is that correct?

Yes.

Okay. I guess there is always two sides to every coin and when guys have used something as being highly competitive and probably difficulty in this... another side of that coin. It can be good, strong top line growth and profitability. We think we are on that side of the coin at this juncture. Having said that, it is competitive marketplace. I think that when you are faced with declining market share as of the players might be they tend to do some things that they probably wouldn’t otherwise do. Wee will deal with those pressures as time goes on and we feel very comfortable with the performance and we're seeing both domestically with account pick-ups from a very strong base and then internationally with what we see as a pretty light up and 1field with how we're doing.

Okay. Thanks.

You bet.

Thank you, sir.

Ed Antoian with Chartwell, your line is open.

Hi, I'm also not going to say good quarter, but how about just the clarification on when the rights expire. Do they not expire five years post the entry of any market with HPV and would that not be before U.S. approval?

I would be the U.S. market Ed.

Okay. Good quarter, guys.

Thank you much. I appreciate it.

Dan Leonard with First Analysis. Your line is open.

Hi. Just a quick question. On the American Red Cross trial, how many more TIGRIS instruments do you think that the American Red Cross can absorb post an HPV approval? What's the incremental opportunity there on the hardware placement side?

I'll get it a shot.

I really can't answer that question. I don't have a number for you. We've got three of the national testing lines up and running right now with ULTRIO. It really depends on a lot of things including what might be happening with West Nile virus in the system and the number of sites that they move up and how fast they move. So we don't have a model for that and couldn't give you a revenue estimate for the back half of the year at this point.

Okay. Thank you

Thank you.

Operator, I think we might have time for one more question.

Thank you, sir. Victor Gizzementron [ph] with Morgan Stanley. Your line is open.

Hi Victor.

Just a follow up on Sara's question on ARC. What are the implications of ARC performance on of the study, IDT. You would express probably there is a little bit more robust and in your previous studies where you did pools and also is this kind of mix that we should be expecting once PRC implements ULTRIO, some of its IDT and some other food and what would be the implications for the price?

Hi Victor, it’s Carl. I think that as we run these large-scale trials of the assay, we and our investigative customers are looking at a range of different strategies with different pooling sizes as we evaluate the performance of the assay. As you know there is no one absolute performance levels, it’s going to depend on how may other units you put into a pool and the overall sensitivity. The customers weight that as part of their decision-making factors. I think the best thing we could say to you is it’s a very hard for any national blood system to go from a pooling strategy to IDT overnight. That doesn't happen. It takes up a lot of planning, a lot of thought in order to do it and there has to be a pretty compelling public health reason why you would want to go down that path. Work flow consideration has been able to process all the units of blood and then in the ultimate safety margin that you give from are I think the major factors that someone like the Red Cross or any other major blood center would use. So with that in mind, we wouldn't have us to get us on how that decision-making process works. We would just tell you that it's probably easier to adopt something in a pooling strategy than it is in IDT from scratch.

That's fair enough. And I think I may have missed it. Did you guys talked about optimal growth in the quarter and I think in the past you have given us sort of a ratio of PACE versus optimum in terms of volume and in terms of dollars?

Victor, our market share for APTIMA grew to about 63% according to reports that we purchased that to the United States. In terms of revenues, as well as in terms of test, we're about at the same revenue figure. In term of split between non-amplified pace and APTIMA amplified assay, we are about at 80% to 85% revenue split with APTIMA and obviously 15% test on the raising terms of split between non-amplified [inaudible] and the APTIMA, amplified assay would about 85% revenue as with APTIMA and obviously 15% on test side we're about 30% still in the taste utilization.

Maybe the last question. You talked about some changes in the R&D program. Would you appreciate the color on that. What is being done specifically within the industrial, at the industrial programs to push them along even a little bit faster?

We think they're moving along pretty quickly. We haven’t really made any great investments and additional personnel in there. We will try to give you a little more information on how they are moving in the next call.

And the very last question. Has there been any resolution as far as I think you missed the time. The deadline with DiagnoCure for submission for DMA has there been any resolution as far as that or --?

No resolution. Yet we continue to talk with a great deal of respect that each party has for the other and we expect it to reach a resolution soon. R. William Bowen - Senior Vice President, General Counsel and Secretary Hi. This is Bill Bowen. I think we should have a predicate for that. I think your question referred to first missing the deadline and we don’t deliberately miss any deadline.

There are press releases to the contrary.

Okay. I guess maybe we can discuss that offline, but thanks a lot guys.

Thank you.

Thank you.

Here now I would like to turn the conference back to Mr. Henry Nordhoff. Sir.

Thank you Sierra and thanks for all your questions. To wrap up, Gen-Probe is off to an excellent start in 2008. In the first quarter we established new records across the board and product sales on both sides of our business, in total revenues and net income and an earnings per share. As a result, we are raising our 2008 guidance for both total revenues and earnings per share. As assessed in the quarter was not limited to our financial results. In the last few months, we believe we also took important steps to generate future growth from our PROCLEIX ULTRIO, HPV and PCA3 assays and we remain very optimistic on their future potential. Thank you for your time and attention today and please contact us if you have follow-up questions.

This does conclude today's conference. You may disconnect at this time. Again, this does conclude today's conference. You may disconnect at this time.