Good afternoon. I will be your conference operator today. [Operator Instructions]. Before we begin, I would like to remind everyone that today's call may contain forward-looking statements within the meaning of the federal securities laws, including, but not limited to, statements about BridgeBio's future operating and financial performance, business plans and prospects and strategy. These statements are based on current expectations and assumptions that are subject to risks and uncertainties, which could cause actual results to differ materially from those expressed or implied in these forward-looking statements. For a discussion of these risks and uncertainties, please refer to the disclosure in today's earnings release and BridgeBio's periodic reports and SEC filings. All statements made here are based on information available to BridgeBio as of today. And the company undertakes no obligation to update any forward-looking statements made during this call, except as required by law. With that completed, BridgeBio, you may begin your conference.

Good afternoon, everyone, and thank you for joining BridgeBio Pharma's Second Quarter 2025 Earnings Call. I'm Chinmay Shukla, Senior Vice President of Strategic Finance at BridgeBio. With me today are Neil Kumar, our CEO; Matt Outten, our Chief Commercial Officer; and Tom Trimarchi, our President and Chief Financial Officer. During today's call, we will cover our strong and accelerating launch of Attruby. We will provide updates on our late-stage pipeline, including the 3 key Phase III trials in ADH1, LGMD2I and achondroplasia. Following our prepared remarks, we will open the call for questions. For the Q&A session, we'll also be joined by Ananth Sridhar, Justin To and Christine Siu who lead our Phase III programs. Before we begin, I would like to remind you that this call will include forward-looking statements based on current expectations. These statements represent our judgment as of today and may involve risks and uncertainties that could cause actual results to differ materially. With that, I'll turn it over to Neil.

Thanks to everyone on the line for the time. Welcome to our Q2 earnings call. As always, this is a forum whereby we can communicate to you both on salient results and business strategy. A key aspect of that is ensuring we are communicating the data you feel is important and that we're doing it in a way that's clear. On our last call, we spent a lot of time talking about how we make decisions internally and focused on an NPV-led characterization of our business. Your feedback, which is important, suggested that we spend less time on that and more time on the commercial, medical and scientific performance of the business. We're excited to do that today because there's much to talk about as the business continues to deliver with the performance of Attruby and as it positions itself for 3 Phase III readouts in the coming months across ADH1, LGMD2I and achondroplasia. The continued star of the show was Attruby. The first and most important way we've monitored this launch to date is by the number of unique patient prescriptions, which now sits at an absolute number of 3,751, coupled with 1,074 unique prescribers. We're seeing growth in both the number of new prescribers as well as the depth of prescribing at their practices. For those following week-by-week status, we've seen over 30% growth in weekly scripts. That acceleration is even greater than our internal projections, given that this was the first full quarter with 3 players in the ATTR cardiomyopathy market. This prescribing ties to about 100% revenue growth that we've seen in Q2, around $78 million in global sales and $71.5 million in U.S. net sales. And of course, all of these numbers connect to the most important set of facts here. First, Attruby is now…

Thanks, Neil. I'm pleased to report that Attruby has achieved exceptional performance in the second quarter of 2025, generating $71.5 million in net product revenue, representing 100% growth over quarter 1, essentially a doubling of net product revenue. The launch of Attruby has accelerated with new patient adds now at around 120 patients per week versus 100 patients per week previously. The uptick has been driven by momentum in treatment-naive patients. This strong launch trajectory is driven by more patients starting therapy along with an increasing number of prescribers choosing Attruby for their patients. We are operating in a large and fast-growing market. The ATTR-CM category is expanding rapidly and is expected to reach $15 billion to $20 billion at peak. This strong tailwind provides a significant runway for continued growth and reinforces our conviction in Attruby becoming a category-defining therapy. In addition to the significant unmet need in ATTR-CM and the compelling value proposition of Attruby versus our competitors, our clinical data continues to demonstrate Attruby's remarkable efficacy. As Neil outlined, we are continuing to generate evidence reinforcing Attruby's position as the standard of care for ATTR-CM patients, especially in the treatment-naive setting. Let me touch on a few key highlights underlying our commercial performance in the second quarter. Attruby has a strong and expanding prescriber base. COEs and community HCPs continue to prescribe Attruby at steady rates with new prescribers initiating therapy each week. Those who have written in the past continue to do so and new adopters continue to expand. Attruby has strong momentum with new starts, capturing share from patients initiating ATTR-CM therapy for the first time and shows strong momentum against peak market share expectations of 30% to 40%. This is leading to increased demonstrated demand across segments. Sale rates remain robust, well above industry…

Thank you, Matt, and good afternoon, everyone. I'll now discuss our financial results for the second quarter of 2025. Please note that our commentary on today's call will focus on GAAP financials unless otherwise indicated. Total revenues were $110.6 million in Q2 2025, consisting of Attruby net product revenue, royalty revenue and license and services revenue compared to $2.2 million for the same period last year. The $10.4 million increase in total revenues was primarily due to a $71.5 million increase in net product revenue from our commercial product, Attruby, driven by strong demand across all major prescribers and patient segments. We also recorded $1.6 million in royalty revenue from ex U.S. net sales of BEYONTTRA in Europe and Japan. License and services revenue increased by $35.3 million, largely due to the $30 million regulatory milestone recognized under the license agreement with Alexion upon pricing approval of BEYONTTRA by the National Health Insurance in Japan in May 2025. Total operating costs and expenses for the second quarter of 2025 were $244.8 million compared to $177.7 million in the same period in the prior year. The $67.1 million increase in operating costs and expenses is primarily driven by $69.6 million increase in SG&A expenses, partially offset by a $3.5 million decline in R&D expenses. This reflects our continued investment in the Attruby brand awareness and ongoing investments in our late-stage clinical programs. Included in our total operating costs and expenses was $37.7 million of stock-based compensation expense compared to $21.5 million in the second quarter of 2024. We expect operating expenses to remain stable through year-end with continued revenue growth driven by Attruby. Turning to our balance sheet. We ended the second quarter with a strong cash position of $756.9 million in cash, cash equivalents and marketable securities. This includes proceeds from our strategic monetization of BEYONTTRA European royalties for $300 million, which has significantly strengthened our financial flexibility together with the proceeds from Attruby sales. Looking ahead, we expect our cash runway to extend through multiple value-creating milestones. In closing, our commercial launch of Attruby is accelerating, and our pipeline has never been stronger. We look forward to the data- rich months ahead with top line results from ADH1 and LGMD2I/R9 in the fall of 2025, achondroplasia in early 2026 and to continue our mission to serve patients and create lasting value for our stakeholders. With that, I'll turn the call back over to Chinmay.

Thank you, Neil, Matt and Tom. Operator, please open the line for questions. Thank you.

[Operator Instructions] We'll go first to Salim Syed at Mizuho.

Congrats on the quarter. I guess one from us on the 120 patient adds. So obviously -- per week. So obviously, that's faster than the 109 patient adds if we use the April and February numbers that you guys provided. I'm just curious if you can just break that down a little bit more, what you think is driving that patient add number? And specifically, if you can, how you would envision that number changing in the third and fourth quarter this year? And also, Neil, I don't know if you can comment on this, but I think it's -- or Matt, I think it's one of the more important metrics if you can provide, just what percentage of naive coming into the marketplace do you think you got in the second quarter?

Thanks for the question. I'm going to pass it on to Matt to talk about the first piece and then Neil to comment about the second piece.

Sure. And thanks for the question. I guess to respond to the first half of your question, we're seeing strength in treatment-naive starts and continued switch activity. The market itself is expanding, driven by increased screening and awareness. We're seeing that quarter- over-quarter. Unique patient starts and prescriber counts are both increasing. And this has resulted in BridgeBio becoming the partner of choice for health care professionals. In addition, the Attruby profile really resonates. Both patients and doctors are drawn to it, benefits as soon as 3 months and a 50% reduction in hospitalization rates, and that's across subgroups and across patients switching from other therapies, as Neil mentioned in his opening comments. So I think it's a combination of excellent data, an ever-expanding market and the best team in the industry. Neil, if you want to address the second part?

Yes. It's hard to tell Salim, exactly what the NBRx share is just because we don't precisely know where the knockdowns stand in terms of that. But best guess, it's somewhere in the 18% to 20% range, and it's been growing pretty healthily. And just to add to Matt's point, I mean, I think just for being out in the field, a couple of things are starting to drive, I would say, our commercial momentum. But the first is better and better access. The second and I think critically is increasing scientific share of voice. I think that serum TTR paper actually did a lot of work for us this quarter, and we can build on that. The fact that ever- increasing amounts of stabilization or in this case, with every additional mg per deciliter increase in serum TTR, you're getting a 5% decrease in mortality. And the fact that, that just got confirmed by a European group, I think 2 days ago, the Minervini paper came out as well. That's starting to become a really salient feature of both staging patients and deciding which therapy to put them on. So I think that, coupled with the variant data, coupled with the AFib data, they'll continue to drive momentum here. We just got to continue to educate.

We'll move next to Tyler Van Buren at TD Cowen.

Congratulations on the progress. So last quarter, you all noted the lower-than-expected utilization of the 28-day free trial and the patient assistant programs, while gross to net modestly boosted net revenue per patient. So could you discuss those kind of 3 components and how the trends evolved in the second quarter compared to the first quarter and how you expect them to trend moving forward as we head into the second half of the year?

Tyler, thanks for the question. We did indeed see normalization on all of those 3 fronts, the 28-day free trial, the PAT utilization and the gross to net. But let me turn it over to Neil to give more commentary on what we saw and what we expect to see going forward.

Yes, I don't have much to add. As Chinmay said, we did see normalization there. Maybe I'll talk a little bit about why this is so important to us. Obviously, with the variant data, the highest risk reduction shown in the V122I population and the broad variant population, and we'll have another publication out on that in the coming months, coupled with statistical significance, which is the first we've seen of that. It's really important for us to be able to serve the underpenetrated populations here with ATTR cardiomyopathy. And these programs are a really important feature of that. So maybe less important than the COEs, which is probably where we had initial momentum and much more important as we drive out into the community and drive out into communities that have historically been underserved. And I'm aware of kind of some of the narrative around man, you guys look at the Alnylam launch, it is at double the cost. Like why do you price, where you price? Why do you guys have a generous access program and suite, et cetera, et cetera? Look, I think long term, when you look at any category, I've honestly never seen a drug with better point estimates and a lower price, not ultimately do really well in terms of end market share. So we're in this for the long game. Honestly, these generous access programs, where we price the product, the continued education. And I think the price and these access programs will stand us in good stead long term. But yes, I think you should expect to see the GPM stay normalized over the longer course of time and not go back to what we saw initially.

We'll move next to Biren Amin at Piper Sandler.

So it seems I guess per day in the third quarter accelerated compared to the prior period while you guys face a new competitor. Can you just maybe talk about community versus academic market share for Attruby? And then maybe a question on the pipeline. What are your thoughts on infigratinib's potential market share in achon? And how are you positioning the hypochondroplasia program given the recent preclinical data?

Biren, thank you for your question. I'm going to pass it on to Matt to talk about what's driving the acceleration in the launch and specifically in the treatment-naive segment, both in the COEs and in the community setting. And then I'll pass on to Justin to talk about BNP program.

Now I mean I think it's the overall data package combined with the unmet need, patients either are not being treated effectively and are looking for something else. And so that's one patient profile. There's also patients who are newly diagnosed and are seeking something that can work very fast and hit all the endpoints that they're trying to hit. So I think regardless of the type of patients coming in, and then that can be even then split into more subgroups. We have variant populations, you have patients with AFib. Everybody is looking for something that can work quickly and for a long time. And I think that, that is what has gotten us off to such a fast start. And the question is, how do you keep that momentum going? Well, the market itself keeps growing every quarter. And that's because more and more people now are looking for the disease and finding it. So more patients sort of show up even without us doing anything in that regard. But then when they do show up and they find the information that we have, whether it's online or from their physician themselves, I think then they're impressed and want to try Attruby.

And maybe just to build on that and addressing this specifically to your question, it's still a majority in the COE or COE capitated practices. Recall that 65% of cardiovascular practices are capitated or JVs in some way with a major provider in their space. But we are seeing a pickup in the community. And I think that has to do with a lot of the awareness stuff that we and others are doing. So it's still a majority in COE or COE capitated practices, but I expect it will continue to disperse over time. I don't know, Justin.

Yes. Infigratinib, just as a reminder, when we started this program, we have 2 key criteria, right? The first was to have a daily oral treatment option for families who are tired of injections. And the second is to have deeper levels of efficacy by not only hitting the MAPK pathway, but also STAT1. And our best-in-class HP data and proportionality data from our Phase II validate our hypothesis and most importantly, with the convenience factor of a daily oral. Now we've consistently done market research that shows an oral with similar efficacy at CMPs would take about 60% of the market in a [indiscernible] market. Why? Because clinicians and families all view an oral as better than either a daily or weekly injectable. And this market research has been done by others across indications as well back together. Now we know BioMarin showed some data yesterday on its long-acting CNP, which doesn't change our expectations here. We actually know from their existing Phase II data that efficacy on HP and cGMP [indiscernible] plateau above their go-ahead commercial dose. So a program that achieves higher levels of CNP here don't really matter. And if anything, it makes it even more important to have a therapy that impacts STAT1 since it looks like effects on MAPK or [ MAP STAT ] here. Now on hypochondroplasia, we're really excited about our recent data that we just published in the Journal of Mineral and Bone Research that shows infigratinib has low single-digit in vitro potency against the most common hypochondroplasia mutations and similar efficacy across hypochondroplasia mouse models as it did compared to achondroplasia mouse models. So given that, we expect similar best-in-class efficacy profile in our hypochondroplasia program as well. So more to come there.

We'll take our next question from Cory Kasimov at Evercore.

Question for you on encaleret. I'm curious kind of what your market research is suggesting would be considered a meaningful win in the upcoming Phase III CALIBRATE trial.

Cory, thanks for the question. I'm going to pass on to Ananth, who leads the program to talk about it.

Yes. Thanks, Cory. For this program in ADH1 in particular, we see any successful study as a win, really a home run for this community. And as we've discussed in the past and as the investor community is familiar that the available conventional therapy or standard of care to our knowledge, offers pretty meager benefit on the composite endpoint, which we are evaluating in our Phase III, which is concomitant normalization of both blood and urine calcium, which are both important biomarkers in terms of biochemistry is for the condition. So what we see as a step change for this community is really we can see a majority of patients achieving those criteria on encaleret, we see as both clinically meaningful and statistically significant, likely statistically significant benefit achieved for the study for the patient population. And as a reminder, Cory, if we looked at our Phase II cohort on the same criteria at the same time point, we saw 9 out of 13 around 69% of our study participants able to achieve that on encaleret in that same group, none or 0% were able to achieve that criteria on standard of care.

We'll take our next question from Mani Foroohar at Leerink Partners.

On the quarter. I've got a couple, and I'm going to follow here in lead by starting on the pipeline and going to commercial. For limb- girdle MD2I, can you lay out based perhaps on your KOL conversations and your interactions with the regulators, what the bar is in terms of key efficacy and biomarker thresholds for potential approval based on the upcoming interim data? And then I have a commercial question and a follow-up.

Sure. I'll pass on to Christine to talk about LGMD2I.

Mani, for the top line data that we're expecting later this fall, we're going to be looking for a few different things in the data that would kind of represent a win for us, both in terms of being clinically meaningful as well as supporting a regulatory approval on an accelerated basis. So first, we're going to look for really a robust effect on the biomarkers. The primary endpoint is glycosylated alpha-dystroglycan. And what we're hoping to see there would be consistent with our Phase II results where we saw an elevation in glycosylated alpha-dystroglycan. And we think anything kind of 5% or more there would be clinically meaningful. In addition, we're going to look to see a robust reduction in CK of about 40% or more. On the functional endpoints, what would be considered a win there is a trend in one or more of those outcome measurements. It's important to note that we do not expect statistical significance at the 12-month time point. The trial was powered to show it. And the FDA has indicated that it is not a requirement for accelerated approval to see statistical significance in any of the clinical outcomes. So again, just looking for trends in one or more of the functional outcomes. And then the third thing we'd like to see is a well-tolerated safety profile consistent with our Phase II results. And I think if we saw all of those, we'd be quite encouraged. Keep in mind, there's really no available treatments today for this indication. So we're pretty excited about the FDA to have a first-to-market safe and oral therapy for this indication.

Great. And hopping over to commercial. I guess a little bit of a composite question. Alnylam talked a lot about -- on their call about adding patient volume for AMVUTTRA in both switch and new to market and new patient -- new to therapy patients. Pfizer talked on pricing, how net price had evolved and they have been doing more contracting to maintain share. So for each of these competitors, what are you seeing in terms of impact on your own contracting and pricing? And also in terms of volume, are you seeing more impact and more competitors and sort of more active competition on the switch side? Is it primarily competitive intensity for new-to-therapy patients? Like how should we interpret both of those commentaries from those separate calls? And how they inform how we think about the competitive dynamic in what is now multipayer market?

Mani, thanks for the question. As we noted in our PR, most of our growth came from the treatment-naive section and increasing share there where we've seen it grow month-over-month. But let me pass it on to Neil to talk in more detail about these things as he's been out in the field.

Yes. Thanks, Mani. I mean I guess I'd say, first and foremost, where we're seeing more pressure from the part of the knockdown is in the switch category, obviously, for us. We were 100% in the switch share prior to this. So obviously, you're going to be under pressure there. Recall, there's a couple of other modes by which they're getting patients on drug, initially. One is combination. And actually, a, we're seeing a lot of combo -- when people do reach for the combo, we are seeing people try to use the best stabilizer coupled with the knockdown agent. So we've got some combo stuff there and as does obviously, the [indiscernible] plus TAF combo. Then they had the bolus, right? They had their patients that rolled over. We didn't have that because you obviously gave away free drug for life. And then they've got what they've got in the naive population. Honestly, we're not seeing a ton of competition there from Alnylam. We're seeing much more of it from Pfizer. So then turning to what Pfizer is doing. We're also not seeing like a ton of race to the bottom GPN contracting type activity in this space. We've made it very clear that we stand on this price. We came in where we came in. We think it's the right thing and the ethical thing for the patient population, but there's not a whole lot of backdoor games that we're playing at all, and we're not seeing it from a competition either. So outside of the buy-and-bill dynamic associated with the knockdowns, we're not seeing a whole lot of competition in that vein. The competition is much more so around clinical differentiation and efficacy. Did that answer your question?

Yes, that's very helpful.

We'll move next to Greg Harrison at Scotiabank.

Congrats on another quarter of success with the launch and uptake of Attruby. I wanted to ask where you have identified areas for growth within the Attruby launch? And separately, what is BridgeBio excited about executing on for the remainder of the year?

Greg, thanks for the question. Maybe I'll first pass it on to Neil and then to Matt to talk about what we're excited about when it comes of Attruby and the company. Neil?

I think as it pertains to Attruby, I'm excited about a lot of different things, but I'd start with the continued clinical and efficacy differentiation that we've been working on. I really like the way that we've started to port the story from overall, how does this work in the population to specific subpopulations. I think the AFib story or the cardiac arrhythmic story is a really powerful one and certainly opened my eyes to the power of these types of things, be it a variant story, be it a cardiac arrhythmic story, be it someone who has renal involvement story, on and on, et cetera, et cetera. So I think that's thing number one that gets me excited. Thing number two that gets me excited is the concept of early impact and efficacy. I think for the longest time, we sort of regarded this as kind of a static picture as soon as things were diagnosed. But obviously, the earlier we go, the better we do in terms of all of the clinical trials. And now we're running this prevention study. And we have drugs that I think leave patients either unprotected for long periods of time, like you see knockdown go from 60% to 82% over the course of 22 months or you have prompt resolution of destabilization like you do in the case of acoramidis where you're almost immediately stabilizing that protein and getting the serum TTR levels up by day 28. So we look forward to continuing to elaborate on that early action through publications on a go-forward basis. So I would say that's one thing. The second thing has to do with access. Obviously, given the fact that the knockdowns are already there in polyneuropathy, given the fact that TAF is already out there, our new-to-market eds are just coming off. We're working really hard with local ISPs to make sure that it's as easy to prescribe Attruby as it is anything else. We're working with new technologies that allow us to work through forms that are provider-centric, and we're working carefully with Panther and Norcini to have this sort of white glove service for patients. So again, I think if that revs up over a long period of time, this is going to be a really nice suite of programs and support for patients. I don't know, Matt, if you'd add anything.

I'd just echo maybe one of the comments that you made, making sure that anyone who wants Attruby, can get it. It's sort of our primary driver right now and how do we work through any access challenge that might appear. So the new to market edits coming off. We've been on the market, I guess, a little over 7 months now. So this is right in that sweet spot when you start to see all of those things happening, and we are seeing that now. That's going to continue. We keep talking about how we believe in HCP choice. And I think we've set ourselves up, as you can see from the many programs and different things that we're doing to try to make sure that Attruby is one of those choices and making sure that the physicians have access to the right therapy for each patient without any unnecessary barriers.

We'll go next to Anupam Rama JPM.

For Attruby, just thinking about prescribing metrics here, it looks like you grew 300-plus unique docs quarter-over-quarter. Just wondering what's resonating with both new prescribers as well as repeat prescribing dynamics and where you're seeing the most growth in terms of academic versus community centers?

Anupam, thank you for the question. I'm going to pass it on to Matt to talk about it.

Sure. And thanks for the question. First, I think when HCPs try Attruby and they see how quickly it works, it reinforces the decision that they made to prescribe Attruby. So prescription just naturally turns to 2 and so on. Patients and HCPs talk about their experience not just with a doctor-patient relationship, but also within the patient and physician communities. And their experience with the efficacy of Attruby, but also with all of our support programs that we've made available, I think, has made a tremendous impact. You mentioned community versus COEs, but I think this kind of an impact is equally important in both settings, maybe for different -- potentially different reasons. And so HCPs who haven't written, they write. They see this. We're out there with our field teams and they go ahead and make that decision. And then once they've written and those who have written, they continue to write more Attruby while we do our best to make it easy each and every time. So I would expect that you'll see these numbers continue to grow both in the academic and the community centers every quarter.

We'll take our next question from Paul Choi at Goldman Sachs.

Congratulations on all the progress. I want to turn maybe back to the pipeline for a moment and talk about encaleret and ADH1 and the potential lateral to hypoparathyroidism. Can you maybe speak to your level of conviction as to how success in ADH1 could translate to hypoparathyroidism? And maybe a little more specifically, how you're thinking about responder rates might compare to some of the existing or clinical stage therapies with regard to use of supplements or decreasing use of supplements specifically?

Paul, thank you for the question. I'll pass on to Ananth to talk about this.

Sure. Paul, as it relates to your question, especially thinking as ADH1 is the most common genetic subset of hypopara. So there really is a strong read-through that you're alluding to. A positive study in ADH1 would technically derisk a lot of the further evaluation that we can and will endeavor to do in chronic hypoparathyroidism broadly. I think the key aspects that I think would be important on the read-through is one importantly, a rapid and durable benefit of blood and urine calcium. I think if we see that in ADH1 population, it will certainly be encouraging as that is a critical unmet need and a clinical need for the hypopara community. And then the other is going to be on the safety aspect. So the broad exposure at the doses we're evaluating in ADH1 will also be an important derisking signal for the chronic hypoparathyroidism development program. In terms of the response rates, I think I'll point the community to our presentation of our Sentinel study of encaleret in chronic hypoparathyroidism, which we intend to present at the American Society of Bone and Mineral Research meeting, which is taking place next month. In that cohort, we resolved that within 5 days of dosing initiation with encaleret, 80% of the participants were able to normalize both blood and urine calcium concomitantly. This study did not evaluate whether patients can come off standard of care that will be evaluated in a longer-term study. But importantly, this is a key differentiating element, which Neil touched on in the earlier remarks, which encaleret could differentiate in this patient population with 3 critical elements. One is oral. Two, it may have a benefit on urine calcium on 24-hour urinary calcium excretion to the extent that other therapies have not yet shown to date. And three, it could avoid long-term bone resorptive effects that may have been seen and may continue to be seen with long-term PTH replacement therapy.

And we'll take our final question today from Andrew Tsai at Jefferies.

Congrats on the launch execution. So I think one of the thematic discussion points is that Attruby could be differentiated based on a lot of data you've generated over the past few months. So operationally speaking, how do you exactly leverage the data to convince payers and doctors to use Attruby more in the first-line setting over the coming years? And can you summarize all the additional data sets that you plan to generate over the next, let's just say, 12 to 24 months? Can we get a glimpse of the real-world data on like NT- proBNP troponin all the way to hard outcomes data? And then really quickly, can you quantify the inventory changes in Q2 relative to Q1?

Sure. Andy, thank you for your question. I'm going to pass on to Neil to talk about the Attruby data, and then Matt and I can talk a little bit about inventory at the end, but let me pass on to Neil to talk about the differentiation.

Yes. Thanks, Andy. I guess your first question was what are the tactics we're using to educate in and around the data that we have produced. Obviously, there are the obvious aspects of this at conferences, publications, et cetera. I think our medical affairs team has done a nice job of increasing our scientific share of voice. And obviously, I think we have the highest velocity of publication in this sector so far. So that's given us an opportunity to share something new with the physicians that we do see. The second piece of it, honestly, has been conversations as you say, put some fraction of your patients on the Attruby to Matt's earlier point and see what the experience is. And I think we feel very comfortable, obviously, with the 2 real-world evidence studies that have posted to date out of Dr. Masri's lab and Dr. Moore's lab, that continued outperformance in the real-world setting, and we're doing a lot more of this now on the health economic and real-world setting side, just what do hospitalizations look like with one stabilizer versus the next, what do overall expenses look like with various SPs, et cetera, et cetera. So we're doing a lot of that type of work, and I think that's another way that we can allow the data to resonate. A summary of the data, I think of the new data that we just put out has to be the variant data, the 59% relative risk reduction with the statistic, the AFib data, the 70% reduction along with the 43% reduction in CVH associated hospitalization. And then the third, and I think, honestly, the most important was the connection once again between ever higher levels of stabilization as measured by serum TTR and better outcomes as measured by…

No, I can touch on the inventory question now, if that works. I just would make a couple of comments. One, the held inventory is lower in Q2 versus Q1 as suppliers get used to our just-in-time model. And so why? Well, you can get Attruby in less than 48 hours. We talk about that for patients all the time, but it's not just patients. Our suppliers can also get a Attruby in less than 48 hours as well. So the sort of old way of doing the supply and demand model, which is, hey, I have to hold multiple weeks of inventory or more because I'm worried about running out or not being able to get some. I think we've sort of changed the game a bit in that. So now that people realize that, that's true, they don't have to hold the sort of historical larger levels. And so you're seeing that play out in the market now. And I think that's just due to the confidence that our distributors have in us. Yes.

appreciate your question.

And that concludes our Q&A for today. I will now hand it back to the company.

Thank you all for joining us on our Q2 earnings call. We look forward to updating you again in our next earnings call. Thank you. Bye.

And this concludes today's conference. Thank you for your participation. You may now disconnect.