Good afternoon. I will be your conference operator today. All lines have been placed on mute to prevent any background noise. After the company’s remarks, there will be a question-and-answer session. [Operator Instructions] Thank you. Before we begin, I would like to remind everyone that today's call may contain forward-looking statements within the meaning of the federal securities laws, including, but not limited to, statements about BridgeBio's future operating and financial performance, business plans and prospects and strategy. These statements are based on current expectations and assumptions that are subject to risks and uncertainties which would cause actual results to differ materially from those expressed or implied into these forward-looking statements. For a discussion of these risks and uncertainties, please refer to the disclosure in today's earnings release and BridgeBio's periodic reports and SEC filings. All statements made here are based on information available to BridgeBio as of today, and the company undertakes no obligation to update any forward-looking statements made during this call, except as required by law. With that completed, BridgeBio, you may begin your conference.

Good afternoon and thank you for joining BridgeBio's Q1 2025 Earnings Conference Call. This is Chinmay Shukla, VP of Strategic Finance at BridgeBio. Today, we will discuss our financial results for the first quarter of 2025 and provide a review of how we measure success in our business. We'll provide insight into the early results from the launch of Attruby as well as provide an update on our pipeline, which had three Phase 3 readouts expected in the next year, including our efforts in expansion indications such as in chronic hypoparathyroidism. Today's call will feature Neil Kumar, Chief Executive Officer; Matt Outten, Chief Commercial Officer; and Tom Trimarchi, President and Chief Financial Officer. For the Q&A portion of the call, Ananth Sridhar Chief Operating Officer of BridgeBio Cardiorenal; and Justin To, Chief Executive Officer of BridgeBio Skeletal Dysplasias will also join. Following the remarks by our team, we will open up the call for Q&A. With that, I'll turn the call over to Neil.

Thanks to everyone on the line for the time, and welcome to our first earnings call. We're grateful to open up another dimension of our dialogue with our investor partners. You collectively allowed us to deliver for the patients we serve, and we look forward to your feedback on how to continually improve our discussion in this setting. Today, we know the star of the show is the Attruby launch. And the good news is that the brand is delivering for patients and the business, $36.7 million in revenue this past quarter suggest that clinicians and patients are resonating with our differentiated clinical efficacy, safety and accessibility. We continue to educate on our therapeutic impact, which comes as early as three months with a 42% relative risk reduction on cardiovascular hospitalization and mortality at 30 months, including a 50% reduction in cardiovascular hospitalization at that same time point. All these best-in-class point estimates are available at the lowest price point in the marketplace. There is much to like there and we're aware that there is much work yet to be done. You'll hear about some of that work today as it pertains both to commercial tactics and further development work. We add to Attruby good news to continued progress across our pipeline of three additional blockbuster products. Our trials in limb-girdle muscular dystrophy 2I, achondroplasia and ADH1 remain on track with low dropout rates, frequent data collection and positive site audits, all in preparation for an efficient NDA submission should the data be positive. Furthermore, key additional markets are being opened up. Our hypochondroplasia trial enrolled with incredible speed, and we now have first patient in there. Our work with encaleret in the hypoparathyroid setting positions it well for a registrational trial which if successful could pave the way for…

Thanks, Neil. To add to your comments, the launch of Attruby is off to a strong and encouraging start. Let me walk through some of the highlights in terms of what we are seeing out in the marketplace and what we think is driving the rapid momentum we’ve built in just a few short months. The first highlight is the early uptake across all major prescriber and patient segments. As shared in our press release, 2,072 unique patients have received a prescription for Attruby through April 25 and 756 unique health care providers have written at least one prescription. This early adoption spans all physician segments, including large academic centers, regional amyloid clinics, high-volume heart failure specialists and community cardiologists. Importantly, we’re seeing Attruby used across the full spectrum of patients, wild type and variant, newly diagnosed as well as switches from partial stabilizers. The fact that these different patient types are all gaining timely access and that prescribers are already writing for multiple patients gives us confidence that we’re building a strong foundation for Attruby. So let’s discuss what is driving the uptake. It comes down to strong clinical endpoints paired with our transparent patient-first support programs. Starting with the clinical data, Attruby is the only therapy for ATTR-CM that has demonstrated a separation from placebo in as early as three months. No other medicine has demonstrated that and it’s not just about efficacy. Attruby also positively impacts KCCQ scores, which directly correlate with better quality of life for patients. That’s resonating deeply with physicians who want to make a meaningful impact on their patients’ daily lives and patients who want to keep their functional activity levels. Second, let’s look at hospitalization rates. Attruby is the only ATTR-CM therapy to demonstrate 50% relative risk reduction in cardiovascular hospitalization rates.…

Thank you, Matt, and good afternoon, everyone. Q1 2025 marked BridgeBio’s first full quarter of net product revenue from the Attruby U.S. commercial launch, major milestones for the company and a significant step forward in our evolution into a fully integrated genetic medicine business. I’ll now walk through the financial highlights for the first quarter of 2025. Please note that our commentary on today’s call will focus on GAAP financial measures, unless otherwise indicated. Total revenues were $116.6 million for Q1 2025 and consists of Attruby net product revenue and license and services revenue. Attruby net product revenue was $36.7 million, driven by strong demand across all major prescribers and patient segments. License and services revenue was $79.9 million in the quarter, primarily driven by the recognition of the $75 million regulatory amount related to Beyonttra’s EU approval. Also in Q1, we received Beyonttra approval in Japan, for which we expect to recognize a $30 million milestone in the second quarter. Total operating expenses for the first quarter of 2025 were $218.4 million compared to $210.2 million in the same period last year. This increase reflects our continued investment in the Attruby brand and our advancing late-stage pipeline. Included in our total operating expenses was $29.4 million of stock-based compensation expense compared to $28.9 million in the first quarter of 2024. Looking forward, we expect only modest growth in quarterly operating expenses for the remainder of the year with an offset to total cash burn provided by Attruby sales in the U.S. and Beyonttra ex-U.S. R&D expense for the first quarter of 2025 was $111.4 million compared to $141 million in the same period last year. This decrease was largely due to the strategic carve-out of our oncology business and early-stage research programs allowing us to focus resources on the Attruby launch and late-stage pipeline. SG&A expense for the first quarter of 2025 was $106.4 million compared to $65.8 million in the same period last year. This increase was driven by the full scale commercial rollout of Attruby, including field team deployment, payer engagement and patient support infrastructure. Restructuring expense for the first quarter of 2025 was $0.6 million compared to $3.4 million in the same period last year. We ended the quarter with $540.6 million in cash and cash equivalents, which does not include $105 million in regulatory milestone payments anticipated in Q2 for ex-U.S. approvals of Beyonttra. We believe we are well financed for the continued execution of the Attruby launch and deliver on key milestones from the pipeline this year. We look forward to sharing additional commercial updates throughout the year and the top line data from our three Phase 3 programs over next year with ADH1 and LGMD2I in the second half of 2025 and achondroplasia in early 2026. With that, I’ll turn the call back to Chinmay.

Thank you, Neil, Matt and Tom. I’ll now hand it back to the moderator to open the line for questions. I would like to request our analysts to limit themselves to one question each so that more people get a chance to ask their questions.

[Operator Instructions] Your first question comes from the line of Salim Syed of Mizuho. Please go ahead.

Great. Congrats on the quarter guys, and congrats also on your first earnings call. Maybe just one for Neil or Matt here. Obviously, the quarter came in healthier than I think people had thought going into the print. And I appreciate the commentary that you provided, Matt, on some of the dynamics there. But any sort of granularity you can provide on the tailwind and which you really deem that's working well for you here? Thank you.

Yes, maybe I'll kick it off. Thanks, Salim. It's probably too early for some of the higher cost commercial tactics that we've invested in to show ROI right now. So hearteningly, I think a lot of the demand we're seeing to date really is a product, number one, of the differentiated clinical efficacy we have, as a reminder, and you know this the earliest separation and it's a point estimate that we've seen in the field at three months, 42% relative risk reduction against ACM and CVH in 30 months. Again, the best point estimate we've seen at 30 months, coupled with that 50% reduction in hospitalization, which turns out to be a hugely meaningful measure for patients who both want to live longer, but also live healthier. So I'd say that's point number one. Point number two, as you saw as well from the Pfizer call this morning, continued market growth, right? We're one-fifth diagnosed in this space, some 50,000 or so patients diagnosed. We think there's 250,000 to 300,000 in the U.S. alone. And so physician education, coupled with there being a variety of therapeutic interventions now available, I think, is driving that growth. So that, I think, is another tailwind. And then the third is the access programs that Matt talked about. The team, I think, has done a terrific job of ensuring that patients when they are prescribed Attruby can get the medicine and stay on the medicine as long as they need to. So those would be the three salient drivers. I'd say, the final thing there's a little bit of what a physician described to us the other day is Karma. Obviously, we're the only sponsor in this space that gave free drug for life for their trial participants. Unfortunately, others decided not to. We're also the only sponsor in the space running a primary prevention study, which I think many physicians view as the ultimate in trying to catch patients in this mass action condition as early as possible to do as much as we can for their conditions. So those types of things, I think, over a long period of time, will stand us in good stead as a sponsor here in a competitive space. I don't know, Matt, if you'd add anything?

No, I think in this the people, we've spent a lot of time putting the team together both internal field to make it as easy as we can for both prescribers and for patients. And I think you're seeing the good results of that.

Great, thanks guy. Congrats again.

Thanks, Salim.

Your next question comes from the line of Tyler Van Buren of TD Cowen. Please go ahead.

Hey guys. Congrats on the stellar Attruby result as well and the ongoing progress of the pipeline. So again, the $37 million of the Attruby sales far exceeded expectations. So when you say that the paid conversion rate is well ahead, can you help quantify that? Was the time to pay quicker than a month for some patients? And how much stocking was there in the quarter?

Yes. Hey Tyler, great to hear from you and thanks for the question. I'm going to pass it on to Matt to comment more on conversion.

Yes, thanks for the question. We're really happy with how conversion is tracking, and that's for both free trial to paid and also commercial prescriptions to paid. Everything regarding conversion is consistent or better than historical launches that we've studied. I will just point out a free trial acts like a normal prescription, HCP writes it, the pharmacy processes it and the patient gets it. And we designed our network specifically with conversion in mind, and that's what makes the access so easy. Our goal remains the same, 30% to 40% peak share. It takes up three years to six years usually to hit. We're hoping we can do that a little bit faster. In regards to your channel and inventory question, I mentioned we do have a limited distribution network that allows for very frequent ordering and it allows our customers, our distributors to have just-in-time inventory. So there's no need for them to really hold large quantities. And so typically, I would say that this small group of distributors holds about one week to two weeks of inventory.

Hey Tyler, this is Tom. Let me just put a finer point on the inventory question. As I mentioned in the prepared remarks, the sales in the quarter were primarily driven by demand. So we've seen only a minor impact on inventory on total sales in the quarter. So really demand-driven here.

Yes. Thanks, Tyler. I know you had another question. So happy to answer more about this or go to your next question.

Well, that’s great. Thank you.

Your next question comes from the line of Mani Foroohar of Leerink Partners. Please go ahead.

Hey guys, congrats on the quarter. Clearly blew out expectations despite having shown pretty good scripts repeatedly. And I want to dive in on the script numbers. I'm looking at the incremental scripts on a weekly basis through that first update on January 10, or in the 60s per week? And then through the update you gave on an incremental basis on February 17, that was running north of 100 scripts a week. And again, running through from 12 and four [ph] weeks into launch and 22 weeks into launch, i.e., from February 17 to April 25, you're still running at about 100, 109 scripts per week as reported. I know it's just math and then a lot of nuance that goes into script reporting. Could you give us a sense of what the tariff on velocity of new patient scripts that you're seeing right now? And sort of what is that – so what is the kind of direction of travel out there? And I have a follow-up question.

Great. I can take that. Thank you for the question. I mean I think starting out, the thesis really – again, it remains unchanged. TTR levels go up with Attruby and it's the only year complete stabilizer on the market. When we sort of take that thesis and then dive into, okay, well, what's happening and then how do we think that's going to impact things going forward? But month-over-month growth rate in the treatment-naïve section has been very strong, and that's been across all segments. So this is in the large centers, this is in the community. That's across all types of patients, variant wild-type, there hasn't been a sort of one area or another that's done better. We've sort of seen this across the board. And so then when we look at sort of the two groups, we have the treatment-naïve patients, that's our focus. And that will continue, we believe, to grow over time as it has been. Then you have the switch patients. Of course, when we launched, we had 100% of the switch share because we were the only option you could switch to as new – now with new entrants in the market, that's going to evolve over time because they are now more choices. And so I think the data and how we report will evolve over time as well based on that. But that's kind of where we are and how we see it moving forward.

Great. That's helpful. And I have sort of a non-TTR question to everyone's surprised. When you think about limb-girdle data coming later on this year, which obviously, we've been discussing a number of calls. This is not the first time you guys have brought it up. We talked about it at my conference a couple years running, about the filability of that data set or whether a later data set in the same study will be required. Do any of the changes of FDA concern you around your ability to file on a biomarker? Do you think you have to show a distinct level of clear clinical improvement on a non-biomarker functional basis? Where are we in terms of the filability of that biomarker for limb-girdle?

Yes. I can take that. Mani, we haven't met with the agency of late on the LGMD2I program, but we have had some close to 10 meetings now over the course of the last month as it pertains to either pipeline at Gondola or a pipeline here at Bridge, probably the latest meeting was in and around the Canavan program. And I have seen nothing, but I would say, a positive inclination toward trying to get first-in-class medicines that target path a mechanism like our drug for LGMD2I onto the marketplace as quickly as possible to benefit the children that are suffering from these conditions. And so I don't think the rather clear guidance that we've gotten from the agency to date in and around filability, around glycosylation of aDG is going to change. I really don't. I have been on the record saying, I think it's going to be a problem if we go the right way and hit our primary endpoint on aDG, but we go the wrong way on all clinical measures. Obviously, I don't think that's going to be the case based on what we observed in Phase 2, which was albeit an open-label study against natural history where we saw improvements in measures of ambulation and other clinical outcomes. So I do believe these things will move toward the positive or at least a few will move toward the positive, obviously, modified North Star, North Star which is historically but the gold standard in these conditions. It's all noise over the course of the first 12 months. So what is the point estimate goes one way or the other. I think natural history has made that very clear. And that is why we're running the confirmatory trial. This is effectively a nesting trial design that goes on for another two and a half years post the readout later this year. So I mean, long story short, we continue to believe that is going to be an approvable endpoint in terms of aDG glycosylation increase.

Awesome. Thanks guys.

Thanks, Mani.

Your next question comes from the line of Tyler Van Buren of TD Cowen. Please go ahead.

Hey guys. Yes, I just had a second question that I meant to ask. But just the ADH1 and limb-girdle Phase 3 is reading out during the second half of the year, clearly level high probability success. So can you – it would be great to hear you elaborate on why investors should be excited about and more importantly, focus on those opportunities beyond the ongoing Attruby launch. What do you think the magnitude of those opportunities could be?

Yes, good question, Tyler. As I was suggesting, we continue to be heartened by both the clinical operational positioning of LGMD2I, ADH1 and our achondroplasia trials as well as the potential to help a broad swath of patients. And I think from an investor standpoint, one asked to consider the sheer size of these marketplaces, LGMD2I as we’ve discussed, some 7,000 to 8,000 patients between the U.S. and EU. That’s a substantial market size as compared to any of the other muscular dystrophy programs that you see out there at the price points that are attendant in the space. And with ADH1, a rather much more prevalent condition, maybe 10,000 to 12,000 patients in the United States alone as suggested by statistical genetics methodology, some 4,000 or so already identified to date, that’s going to be really a program associated with the market build and finding new patients. And we’ve already shown that we can do that in some of the sequencing efforts we’ve undertaken within the nonsurgical hyperpara community where we’re reliably finding something like 20% to 25% of patients actually harbor the gain of function mutations in the calcium-sensing receptor. So I think two very exciting commercial opportunities, two very exciting opportunities for first-in-class medicines for patients there. And then I don’t think I need to belabor the achondroplasia hypothesis where we feel we have an exciting oral best-in-class – potentially best-in-class option that could provide differential safety, differential efficacy because it targets this well-described condition at its source, driving differential both changes in growth and then also importantly, impact on parameters that this community care is a great deal about like proportionality and the like. And the size of that market from the Voxzogo launch that’s ongoing. So I think all three very exciting opportunities.

Thank you.

Your next question comes from the line of Biren Amin of Equity Research Healthcare [ph]. Please go ahead.

Yes, hi. Thanks for taking my questions. Congrats on the quarter and really good launch out of the gate. I guess my question is what’s resonating with health care professionals as it relates to the Attruby launch? And what are the biggest hurdles that you’re seeing for adoption? And then maybe a second question, what was the gross to net for the quarter? And any impact that you’ve seen from the Part D redesign?

Hey Biren. Thanks for the question. I’m going to pass it on to Matt to discuss the HCP piece, and then I’ll throw it to Tom to discuss the gross to net piece.

Yes. Thanks. And I guess, there’s sort of two parts to this. The feedback from the physician segment has been positive as we’ve discussed. Our messaging around, we call it the 340, 250 [ph], but that ability to separate as early as three months and getting results around the hospitalization all-cause mortality that we’ve described. Physicians want to see a drug work really fast, and they want to be able to tie it to hard outcomes. Of course, patients do too. So this is what gives people confidence. And so those messages have been resonating extremely well and I think that’s resulted in physician trying Attruby, but then also then repeating it, right? Those are the reasons that you sort of try a medication and then when you see how well people are doing on it, then that encourages you to try it again. So we’ve seen a lot of repeat prescribers across a lot of the different segments as well. And I don’t think our expectations were otherwise are going to change anytime soon. We have very strong data package, and we also have very strong programs to help patients get on the medication once that prescription has been written. And then I’ll pass it to Neil to add on.

Yes, maybe I’ll just elaborate on that for a second before I throw it over to Tom. I think the ever increasing availability of data like most recently, Biren, I think we’ve talked about the variant data. The fact that you could achieve a hazard ratio of 0.41 with statistical significance in that relatively small subpopulation. And as someone mentioned earlier, the sickest of subpopulations continues to reinforce that differential levels of stabilization can lead to ever better outcomes. And we’re starting to find that that’s resonating. We’ve got a bevy of serum TTR associated literature coming out suggesting that ever higher levels of serum TTR correlate with ever lower levels of downstream hospitalization and mortality. The connecting of the dots between ever better stabilization and all of these downstream outcomes, I think, is what’s starting to resonate with the physician community on top of what Matt suggested the backbone, which is the 340, 250. Tom, do you want to talk about [indiscernible]

Yes, sure. On gross to net, specifically, so as we said before, the way to think about this is the floor is going to be the mandatory IRA rebate of 20%. And on top of that, you’re going to add something like you’d see in other categories for contracting is not really happening as that’s what we’re seeing here. I would say, given where we are in launch early innings, we should expect some variability here quarter-on-quarter. This quarter, gross to net trended slightly favorable versus what we were expecting. We also saw a slightly lower use of our first month free program versus what we were expecting, and we saw slightly lower use of our patient assistance program and what we’re expecting. On these three things together actually converge and cause slightly better net revenue per unit than what we were expecting, but we expect all of this to normalize throughout the course of the year.

Great. Thank you.

Hey, Biren, just to add that the results are reflective of strong underlying demand for Attruby and the execution of our commercial team. And as Matt mentioned, not a lot of inventory or anything like that.

Thanks. Perfect.

Your next question comes from the line of Cory Kasimov of Evercore. Please go ahead.

Hey, good afternoon, guys. Thanks for taking the question. So it’s great to see Attruby’s off to such an impressive start, and you kind of alluded to this in a prior response, but now that you’re in the market for over a quarter. How are you thinking about new patient starts for the category going forward? I know previously, you’ve talked about numbers like 2,000 to 3,000 restarts per quarter, but that’s already looking pretty conservative. So any kind of new color there would be appreciated. Thank you.

Yes. Hey Cory, thanks for the question. I think you’re kind of thinking about it like we’re thinking about it. It does seem to keep going up every quarter. And if you look historically, that’s different. I think it is ramping a bit faster, but that also makes sense because you’re getting new products in the market. So the more companies that launch a product into a space that creates a higher share of voice. And I think that gets people educated either to go get screened or for physicians to think to themselves, I mean, if you’re a cardiologist and you have test that patients, and you’re not thinking to yourself, hey, some of these must be ATTR-CM patients. All of these companies are discussing and educating, talking about it, it gets people looking. And if you look, you find it, it’s not that uncommon. Most cardiologists have some patients that need to be treated. So I think that we don’t see that stopping anytime soon. The market could easily be a $20 billion market, and we’re not there yet. So there’s still a lot of patients who are out there who have not been diagnosed, but I think you’re going to see continued high numbers of people being diagnosed now with that interest is just continuing to grow.

Yes. And Cory, just to add one last thing. A lot of the new diagnosis is coming from the high-volume heart failure clinics that Matt mentioned in his remarks. And obviously, an oral small molecule stabilizer is a great fit for those patients.

Absolutely, very helpful. Thank you.

Your next question comes from the line of Greg Harrison of Scotiabank. Please go ahead.

Hey, good afternoon, guys. Congrats on the huge start to the launch, and thanks for taking our questions. So in our initial modeling conversations with you guys, our takeaway was that your expectation was for initial uptake to come primarily or almost exclusively from newly diagnosed patients. But to get to the revenue number you’ve reported, you have to get most of them by our math. So assuming that’s not the case, is this a function of much larger market growth than you expected? Or are you getting a large percentage or maybe even most of your patients as tafamidis switches. And if that’s the case, how do you expect this trend to evolve from here?

Hey Greg, thank you so much for the question. So I think as we have said consistently, our focus at launch has been the treatment-naive market. Very early on, we got a few more switch patients than we expected, but that started to normalize. Focus continues to be new treatment-naive patients and I think Matt mentioned in his remarks that there we are seeing consistent monthly growth gradually. In terms of what’s driving the number, I think it’s sort of all of the above, right? I think it’s a little bit of the market growth, obviously, strong demand and strong conversion. Maybe I’ll throw it on to Matt, and he can talk a little bit more about the factors driving conversion and the market size.

Yes. No, I think you hit it well, Chinmay. I don’t know that I would add that much. It’s a little tricky when you try to figure out who a switch patient is. They can – they look like a new patient most of the time. So I think it’s a little – it to be a little careful trying to determine who’s the switch and who’s new. Our focus is on the newly diagnosed. We do see switch patients come in, and sometimes we can tell that they’re a switch patient. Other times, it’s not clear. But I think as you think about the rest of 2025 moving into 2026, I think the market continues to grow. It’s been growing double digits now for quite a long time. And this past quarter, one of the best we’ve seen. I would not expect that to disappear anytime soon. There will be switch patients who want Attruby, and there will be a lot of newly diagnosed patients that want Attruby for all the reasons we've discussed, whether it's the data itself, the programs we offer. I think we're very optimistic about all of that.

Great. Thanks again.

Your next question comes from the line of Paul Choi, Goldman Sachs. Please go ahead.

And congratulations on knocking it out of the park in your first quarter here on the launch. I want to shift gears for a minute, maybe just ask a policy question, which is to think about as Attruby growth and scale over the coming years here or this year and next year as well as we start to get sales from Europe, from a buyer and on Beyonttra and AstraZeneca in Japan. Could you maybe just help us think through where your IP is on most out at is sort of the tariff implications and just sort of the royalty streams that you'll be getting from your ex-U.S. partners and just sort of how that ultimately affects your margin and your sort of profitability profile? Any color there or directional guidance would be helpful. Thanks.

Hey Paul, thanks for the question. This is Tom. Yes, so as Neil indicated in his prepared remarks, we're fortunate to have very little impact from the – tariff discussions that are ongoing. We've done a pretty deep dive on this. As you know, the pharmaceutical has been exempt from the reciprocal tariffs, but we also looked at the IEP or IEPA and what's been said in public around the potential 232 tariffs affecting the industry. When we put all that together, based on our supply chain, we see a very, very minor impact. That's because Attruby made here in the USA. And then we're, of course, an American company, and we have all our IP domicile here in the U.S. So overall very minor impact to the business. I'm not sure, I understood the question on the royalties and how that relates, but that's off the top line revenue number. So obviously, we're getting money coming to us as before. Any implication on tariffs that would be on their end, but maybe I didn't understand the question.

No, that makes sense on the ex-U.S. business.

Your next question comes from the line of Anupam Rama of JPMorgan. Please go ahead.

Hey guys. Thanks so much for taking the question and congrats on the quarter with Attruby. I wanted to just pop in with a very quick pipeline question, so you shared some data today on the chronic hypoparathyroidism indication. So what gets you excited about this opportunity, particularly you talked about, Neil, from an NPV perspective. How does that all fit in? Thanks so much.

Hey, Anupam. Thanks for the question. We're going to drive it to Neil to talk about the NPV and then Ananth can talk more about the data and our exciting plans for the Phase 3 in HP.

Yes. I mean, from an NPV standpoint, no, I think that this isn't an exciting extension population, quite a bit larger than ADH1 itself with actually a pretty reasonable price point as well given where ascend tosend it up pricing their medicines. So there's a variety of different ways for us to take advantage of the opportunity now that many of the oral competitors have fallen by the wayside. I'm going to actually pass it over to Ananth to talk a little bit about the exciting data that we just posted.

Hey, Anupam. Great question. Thanks for your interest in this program. We – so as you mentioned, we reported data from the first nine participants with postsurgical hypoparathyroidism that were treated with Encaleret, normalized blood and urine calcium concomitantly in 78 of these participants and serves to be important oral option for these patients seeking to resolve calcium homeostasis. So we think that this could be a treatment changing or paradigm-changing treatment and we will advance development towards registration for this program. And in terms of the NPV or the market opportunity, like Neil mentioned, this is about a seven to eight times larger marketplace than the ADH1 market alone. So it could grow and expand the presence of Encaleret as we continue to investigate molecule.

Thanks so much guys.

Your next question comes from the line of Eliana Merle of UBS. Please go ahead.

Hey guys, thanks for taking the question and congrats on the quarter. Curious what you're seeing so far in terms of commercial trans since AMVUTTRA’s approval, You have a few weeks of experience now with this so far. So I mean, I guess specifically was the rate of new unique patient prescriptions consistent with what you saw in February or March? Did you see an increase say in April just associated with a broader prescriber base? Or have you maybe seen a dip in the rate of new unique patient starts just with the launch of a competitor and any sort of high level commentary on how you're thinking about positioning? Are there certain segments where you see potential greater uptake or advantages in terms of your use? Thanks.

Sure. This is Matt. Thank you. So the second half of your question, the audio was a little garbled. So let me answer the first one, and then if you want to repeat the second one, happy to address that as well. Your first one regarding AMVUTTRA, there's definitely a place for lots of choices in this market. And I think as a company, we're obviously happy when patients have additional choices in terms of where AMVUTTRA is going to be placed, they seem to be earmarked for mixed phenotype at the moment, that's probably 10% of the overall market. Their variant data wasn't stat sig and they're very expensive. So it's twice as expensive as Attruby right now. And they have to compete, obviously, with our 340,250 [ph], which has been pretty successful. So I don't know whether that's going to land for them. I think they have to figure out their pricing. If you're going to charge double, you need to have better results and I think you can ask them to talk about that. I'm sure that they'll have opinions on that. But right now, it's early, but we're not seeing a lot of uptake outside of the mixed phenotype.

Got it. And then just maybe this was a part of the question that broke off. I mean if you can't hear me. But just in terms of the rate of unique patient prescriptions, I guess, have you seen any change in that since the approval of AMVUTTRA. So for instance, if you saw a dip in the rate of new unique patient prescriptions in April or as saying now that you have a broader prescriber base, you've seen a similar rate in new patient prescriptions or even higher? Thanks.

Yes. So the April data, I probably wouldn't be able to comment on – I mean, they were sort of about two weeks in Q1 and now we picked up some data. We see some of the same stuff that you guys see. The trouble is even – it's buy and bill. And so they're trying to convince a community physician to put out over $100,000 per injection, the vitamin A part is cheap. So from a cost perspective, that's fine, you still have to take that every day. But that out of pocket for the doctor, they have to cash flow that. So they have to put that money out and then they have to wait to get reimbursed. Well, if you start stacking up a lot of patients, that's a lot of money, and it gets pretty expensive. So we haven't seen it yet. It doesn't necessarily mean it is or isn't happening. I think you'd have to ask them. Maybe they can do what we did and throw out some early numbers on what the first month of launch looks like.

Got it. Thanks.

No. Thank you.

Our next question comes from the line of Jason Zemansky with Bank of America. Please go ahead.

Great. Good afternoon. Congratulations on the quarter and thanks for taking our questions. I wanted to return to the question of segment growth for Attruby, if I may. It sounds like you expect the contribution from switches to slow at some point. But what does that look like over the near term? I mean do you have a sense of how quickly you may be going through a bolus of, I don't know, refractory patients versus those, as you mentioned, are looking for a stronger stabilizer because they believe in the better outcomes over time?

Hey Jason, thanks for the question. I think that high level, I can say a couple of things and then Matt going to add more details. But as we have said all along, we're not seeing any bolus or anything like that. I do think that the focus of our launch is treatment naive and where we're seeing consistent monthly share growth, and we expect that to continue. We had 100% share in the switch population and obviously, that's going to evolve now that there's a competitor. So that's sort of how we're thinking about it. Obviously, it's very early to say, and we look forward to seeing how the next quarter goes.

Yes. And I'll just add. I mean, I agree. We didn't see a bolus. I mentioned earlier, it's a little tricky to absolutely know if someone is a switch or a newly diagnosed. We don't spend a lot of time sort of thinking about it from that perspective. If patients want to get Attruby, we try to make sure they can get it for whoever they are newly diagnosed or switch. In terms of what that looks like over time, I think that's hard to predict. You can take the number of patients on Tafamidis. You can add on a progression rate of whatever you think is correct. And then kind of model that out over time. I think that's probably the best approach if any.

There are no further questions at this time, and that concludes our Q&A for today. I will now hand the call back over to the company. Please go ahead.

Thanks, everyone, for your questions today. We appreciate your interest in BridgeBio and look forward to updating you again next quarter.

This concludes our conference for today. We thank you for participating and ask that you please disconnect your lines.