Thanks, Tycho, and good morning. Look, I mean, very happy with the fact that instruments have returned to growth. And if you break it down into LC and mass spec, LC after seven quarters of decline and this is I think where your question on the replacement cycle is largely focused, after seven quarters of decline, has returned to growth. This is, of course, on the back of continued strong growth in India, of which where the generic segment is doing extremely well. But equally, with return to growth in our large pharma QA/QC customer segment where LC grew in the low single-digits, both in Europe and in the United States. And another sort of corroborating set of evidence for the replacement at the beginning of the replacement cycle is when customers and we spent a ton of time and I personally did in this last quarter with large pharma customers to understand what we were seeing from a replacement cycle perspective. Look, when the customers start their replacement cycle, they bring cross-functional teams together because this is a multiyear process. They bring in ID; they bring in the analytical labs. They bring in the procurement folks and sometimes finance folks because this is a pretty large spend item, and we have seen more and more of those meetings. Now to your question on ARC versus Alliance, I mean there is an increasing proportion of our LC fleet that is ARC HPLC and now increasing the Alliance iS, which, over the last 18 months has been trialed by each and every large pharma customers. So we feel extremely good with the feedback. And over the last few months, we've added the PDA, we've added the Alliance Bio System, and we have several other ideas to continue to improve its performance. So Alliance iS is indeed playing a part in the discussions. ARC HPLC remains a strong, strong contributor to the replacement discussions as well. We won't break it down any further than that at this point. And to your question on patent expiration, I mean, and I suspect that's referring to India. Look, India has been awesome for us for the last three to four years, gone from 5% of our sales to 8%, largely driven by a strong presence in the generic segment. I mean India supplies roughly 40% of the generics globally. And going forward, we expect at least $200 billion over the next three, four years of patent, sorry, next four to five years of around $200 billion of revenues going off pattern from originators in the next three to four years and more than half of that is small molecule. So we are very well positioned in that segment as well.