Good afternoon and welcome to the Sangamo BioSciences teleconference to discuss fourth quarter and full-year 2009 financial results. Today’s call is being recorded. I would now like to pass you over to your coordinator for this event, Dr. Elizabeth Wolff, Director of Corporate Communications.

Thank you, Gwen. Good afternoon, and thank you for joining Sangamo’s management team on our conference call to discuss the Company’s fourth quarter and full year 2009 financial results. Also present during this call is several members of Sangamo’s senior management including Edward Lanphier, President, Chief Executive Officer, Ward Wolff, Executive Vice President and Chief Financial Officer, and Dale Ando, Vice President of Therapeutic Development and Chief Medical Officer. Following this introduction Edward will highlight recent activities and the significant events from the past year, Ward will then briefly review fourth quarter and full-year financial results for 2009, Dale will provide an update on our ZFP Therapeutic program and finally, Edward will update you on our goals for 2010, following that we will open up the call for questions. As we begin I’d like to remind everyone that the projections and forward-looking statements that we discuss during this conference call are based upon the information that we currently have available. This information will likely change overtime. By discussing our current perception of the market and the future performance of Sangamo with you today, we are not undertaking an obligation to provide updates in the future. Actual results may differ substantially from what we discuss today and no one should assume at a later date that our comments from today are still valid. We alert you to be aware of risks and the details in documents that the Company files with the Securities and Exchange Commission, specifically our quarterly reports on Form 10-Q and our annual report on Form 10-K. These documents include important factors that could cause the actual results of the Company’s operations to differ materially from those contained in our projections or forward-looking statements. Now I’d like to turn the call over to Edward.

Thank you, Liz, and thank you all for joining us for our conference call to discuss our fourth quarter and full year results for 2009. Past 12 months have been an important period of maturation for Sangamo as a therapeutic product development company. We expanded our pipeline by initiating two new clinical Trials, moved four programs through Phase 2 Trials and brought in over $40 million an additional capital from a variety of sources to fund these activities. In addition, this has been a period of tremendous progress in establishing our ZFP technology as a powerful platform in ground breaking applications, in plant agriculture, transgenic animals and engineered cell lines. Let me provide you with a few specific examples of our progress. A few weeks ago, we announced the initiation of a Phase 2b Clinical Trial of SB-509 in subjects with moderate severity diabetic neuropathy, or DN. As most of you already know SB-509 or lead ZFP Therapeutic is a zinc finger activator of the Vascular Endothelial Growth Factor-A gene or VEGF-A and has been shown to have significant effect on nerve and blood vessel growth in preclinical and clinical studies. Our new Phase 2b Trial, SB-509-901 is a double blind repeat dosing placebo-controlled study and is designed to build on a wealth of data that we have gathered from earlier Phase 1 and Phase 2 trial. These data have enabled us to identify a patient population, who have a level of DN severity that we believe will give the greatest response in approvable clinical end points to SB-509 treatment over 180-day time period. The 901 study is designed to finalize dose, treatment schedule and primary and secondary approvable end points for pivotal Phase III trial. I’ve asked Dale to provide more details on this important development later in the…

Thank you, Edward, and good afternoon, everyone. As you know, after the close of the market today we released our financial results for the fourth quarter and full-year ended December 31, 2009, and I am pleased to review the highlights of those results. Revenues in the fourth quarter of 2009 were $10.2 million compared to $6.8 million for the 2008 quarter. The fourth quarter 2009 revenues were primarily comprised of revenue from Sangamo’s collaboration agreements with Sigma-Aldrich and Dow AgroSciences and enabling technology agreements as well as approximately $70,000 of revenue from research grants. The increase in revenues was primarily due to the $15 million license payment that we received from Sigma as part of our expanded agreement, which we are recognizing ratably into revenue through July 2010. Total operating expenses for the fourth quarter of 2009 were $12.7 million compared to $9.0 million for the same period in 2008. R&D expenses were $8.7 million in the 2009 quarter and $6.7 million for the prior year quarter. The increase was primarily due to increased expenses related to clinical trials and manufacturing and increased personnel costs including non-cash employee stock based compensation. General and administrative expenses were $4 million in the fourth quarter of 2009, compared to $2.3 million in the 2008 quarter. The increase in general and administrative expenses was primarily due to increased personnel costs, including non-cash employee stock-based compensation and professional fees. For the fourth quarter of 2009 we reported a consolidated net loss of $2.4 million, or $0.05 per share compared to a loss of $2.6 million or $0.06 per share for the fourth quarter of 2008. For the full-year 2009 revenues were 22.2 million compared to 16.2 million in 2008. The increase in revenues for 2009 was primarily attributable to our expanded agreement with Sigma-Aldrich. Total…

Thanks, Ward. As you have heard, we begin 2010 with a strong cash position. Ensuring that we have sufficient capital to expand our pipeline and prosecute our therapeutic programs is an important part of managing the drug development process. And last year, we were very successful in a number of fronts. As Ward just outlined we raised a little over $40 million in the fourth quarter of 2009. In October, we announced a major expansion of our existing license agreement with Sigma-Aldrich for which we received $20 million in upfront payments, on the heels of that transaction, we completed a $20.9 million financing. In addition, late last year, we were successful in accessing research grant funding from several sources to augment the development of several of our ZFP Therapeutic programs. The California Institute for Regenerative Medicine awarded a $14.5 million disease team research award to a multidisciplinary team of investigators led by the City of Hope to support our ZFN, CCR5 approach for HIV/AIDS in stem cells. This is in addition to a small but prestigious grant challenges explorations grant that we received from the Bill and Melinda Gates Foundation earlier in the year to support an innovative global health research project, in this case, ZFN for an In Vivo treatment of HIV infection. Our ZFN technology is also being applied to monogenic diseases, such as sickle cell disease. And our collaborator, Dr. Donald Kohn, director of UCLA Human Gene Medicine Program is a recipient of a $0.5 million Doris Duke Innovations in Clinical Research Award to support research focused on ZFN mediated gene correction in hematopoietic stem cell for sickle cell disease. Looking forward, we expect to end 2010 with at least $60 million in cash and cash equivalents. This cash projection does not include any new agreements or…

Thank you, Edward. As you’ve heard, in recent months, we have made important advances in our therapeutic pipeline with the initiation of a new Phase 2b Trial of SB-509 in diabetic neuropathy and the Phase 1 trial of our ZFN Therapeutic program for glioblastoma, a type of malignant brain cancer. A Phase 2b Clinical Trial SB-509-901 will evaluate SB-509 in subjects with moderate severity DN. It is a double blind repeat dosing placebo-controlled study designed to finalize dose treatment schedule and primary and secondary end points for pivotal Phase III trials. Importantly, the study is being carried out in a population that we have shown to be the most responsive to SB-509. Data from our earlier Phase I and Phase II trials have enabled to us identify subjects that we believe are likely to demonstrate the greatest response to SB-509 treatment over the 100-day evaluation period. The inclusion criteria for the Phase 2b trial are based upon our accumulated data and include baseline thresholds in measurement, in large sensory nerves as measured by sural nerve connection velocity or NCV in small sensory nerves by Intraepidermal Nerve Fiber Density or IENFD, IENDF and vascular disease severity of DN as measured by baseline ICAM-1 levels in the blood. NCV in the sural nerve measures the rate of transmission of an electrical signal along the major sensory nerve that runs along the top of the foot. While IENFD is a direct histologic measurement of the density of nerve fibers in the skin and is a direct enumeration of stage of the subjects neuropathy. The JDRF is particularly interested in the value of IENFD as a measure of nerve damage. The funded collection of this data in our SB-509 601 Phase III Trials are most impressed by the improvement that we have observed in…

Thanks, Dale. The ZFN glioblastoma drug, SB-313, is our third ZFP Therapeutic to enter the clinic and the second example of the ZFN-based therapeutic approach to go through the IND process. Establishing that, while the technology is novel, the FDA regards ZFN-based drugs as an important new therapeutic approach. As Dale said, we are looking forward to updating you on the progress of all of our clinical programs at appropriate medical meetings and on future calls. Outside the therapeutics area, our partners, Dow AgroSciences and Sigma-Aldrich are developing, distributing and promoting our technology in their respective fields of expertise. These relationships are not only important for their established ability to bring in near-term and longer-term revenues, but they also enable a broader distribution and recognition of the power and breadth of our technology platform. Sigma is distributing ZFPs to researchers in academia and industry all over the world and our technology is front and center in their presentation and advertising. ZFPs are being broadly applied across the life sciences, all the way from generating custom cell lines and animal models for drug discovery through improving cell lines for biologic drug production, culminating informing the basis of novel therapeutic discovery programs, which ultimately funnel back to Sangamo. Successful approaches are being rapidly adopted. Consider this. In July 2009, we published data describing the first ZFN generated Rat Knockout models. And in January 2010, the first paper was published by independent researchers who made a Knockout Rat of their own using ZFN purchase from Sigma, that’s less than six months. If you heard Sigma’s presentation from the recent JP Morgan Conference, ZFP technology is a major component of Sigma’s growth strategy and they are eager to capitalize on its “endless possibilities.” This is only one example of the growing awareness of our…

Thank you. (Operator instructions) We will take our first question from Charles Duncan with JMP Securities. Charles Duncan – JMP Securities: Hi, guys, thanks for taking the question and congratulations on a nice year of progress.

Thanks, Charles. Charles Duncan – JMP Securities: I had a couple of questions regarding the details of the diabetic neuropathy study that maybe I didn’t catch. Can you give me some color on the duration of therapy and the administration regimen?

Sure, Charles. The (inaudible regimen is the same as the 601 trial with treatment at days zero, 60 and 120 and the primary data analysis point at day 180. Is that your question? Charles Duncan – JMP Securities: Yes, that answers it, thanks. And then how is the trial blinded? Will you use an actual to the same administration with others in (inaudible)?

You mean how is it controlled? Charles Duncan – JMP Securities: Yes, yes.

Same as the 601 trial, same as the 701 trial. Charles Duncan – JMP Securities: Okay. And then finally are you allowing concomitant drugs to be used like standard of care?

For their diabetes they are allowed to be treated with their current regimen. It has to be stable. Basically, the only drugs for diabetic neuropathy are for pain symptoms, they are allowed to be treated with any pain medications. There are no drugs that are neuroregenerative that are approved for treatment. But they will be able to use their pain medicine as usual. And then final question is regarding that, you said that it was hard to detect a statistical difference in sural nerve conduction velocity change. But can you give us a sense of the magnitude of change that you would like to see?

Greater than one meter per second. Charles Duncan – JMP Securities: And that is clinically significant in your view or based on your diligence?

Yes, yes.

It’s clinically relevant, that’s right. Charles Duncan – JMP Securities: Then one last question for, Edward, perhaps, I know you are guiding to any partners, partnerships and then makes sense, I think you have the wherewithal to take this all over the goal line, but can you characterize of types of interactions you are having with potential future therapeutic partners? Are they kicking the tire? Is there some interest? And kind of what those interactions involve?

The short answer, Charles, is, yes, there’s interest, there is tire kicking and there are meaningful discussions. But as you also pointed out the premise of the question, we are in a position to take this through the Phase 2b trial on our own. It’s really now a business decision in what will create the maximum value around the program and for our shareholders. Charles Duncan – JMP Securities: Thanks for taking my questions. I’ll hop back in the queue.

Thanks, Charles.

We’ll go next to Liana Moussatos with Wedbush Securities. Liana Moussatos – Wedbush Securities: Hi, thank you.

Hi, Liana. Liana Moussatos – Wedbush Securities: Following up on Charles question, asking you what would you consider to be successful in the 701 study, what would you consider to be successful for efficacy indications in the 801 study for ALS?

For ALS, I think we are really focusing on muscle strength, which can result in an improved activity of daily living to a specific functions such as being able to use your hand. For example, ALS patients can’t use their fingers or hands, really that is relegated to (inaudible) left at home or hospice, somebody has to feed them, dress them, etc., so it’s a major change in the activities of daily living if they can’t do that. So I think what we’re really going to focus on is the ability of SB-509 to increase function of the neuromuscular junction, increase muscle strength. We’ve seen that increasing muscle strength in the 601 type DN studies so I think we have pretty good evidence in humans that we can improve muscular strength and actual muscle strength in humans. So that’s what our focus will be on. Liana Moussatos – Wedbush Securities: And what would be like a minimum quantitative unit like you gave greater than one meter per second for the 701 study for NCV?

Generally on the other of two to three units. I mean the MMT is a little complicated, but in the end I think rather than units of strength, probably the ability to maintain a specific function such as hand grip function, what will probably be much more important to the patient than any rating scale for muscle strength. Liana Moussatos – Wedbush Securities: Okay. And what duration is the minimum that matters?

Probably, I would say relatively clinically three months to four months, with the caveat being nothing of that right now period of time. Liana Moussatos – Wedbush Securities: And can we get insight going more financial, on the quarter trends, quarter by quarter trends in 2010 for operating expenses, what should we be thinking about our R&D expense versus the year end and G&A?

I will start and Ward can comment further. As you know, Liana, historically, we comment on our cash position at the end of the year, guiding to at least 60 million. Ward, beyond that, anything you want to say about OpEx?

Sure. Liana, as Edward mentioned we don’t give specific guidance on OpEx, but as you know we’ve got a fairly consistent pattern quarter-over-quarter. I will point out that in Q4 this year we had a little bit of a true-up with respect to some of the stock comp expense. And so that was a little bit higher than the trending. But I think it’s fair to look at 2010 along the lines of a slightly reduced Q4 '09 annualized.

As you know, Liana, the stock comp expenses are non-cash. Liana Moussatos – Wedbush Securities: All right. Thank you.

Thank you.

We’ll go next to Joseph Schwartz with Leerink Swann. Mike Smith – Leerink Swann: Hi, this is Mike Smith [ph] for Joseph Schwartz. Thanks for taking my call. I guess picking up on the finance, I guess, you had a pretty strong cash position at the moment. Can you give us some more color long-term on the cash burn outlook?

Mike, at this point the only cash guidance that we’re providing is through 2010 and just to reiterate that, assume no new financings, no new partnerships and continuing to prosecute all of our ongoing clinical programs, we expect to end 2010 with at least $60 million in cash and cash equivalents. We’ve not given and don’t plan to give at this time any additional guidance beyond 2010. Mike Smith – Leerink Swann: Okay, great. And regarding the Sigma partnership, I was wondering specifically, have they recorded, I guess, they started selling already the transgenic animal models, in particular, the rat models. Have they recorded any sales in the fourth quarter of '09 already?

Again, I would definitively on that question refer you to Sigma-Aldrich. Mike Smith – Leerink Swann: Okay, great. And lastly, I guess you’re going to provide an update on the HIV program later this year on a conference. Could you provide a little bit more color on the broad outlook in HIV and the indication for the company?

I give a little bit of color, maybe, Mike, I refer you to some previous presentations. But the SB-728T program employs the zinc finger nucleases that disrupt the CCR5 gene in (inaudible) T-Cells. As I mentioned on the call we’ve also along with our collaborators at City of Hope and USC received a $14.5 million grant from the CIRM, California Institute for Regenerative Medicine to apply those same reagents, the same zinc finger nucleases in hermetic system cells which if successful would create a broader population of the immune system that have a dysfunctional CCR5 receptor. And we have also received funding from the Bill and Melinda Gates Foundation to marry those nucleases with an In Vivo vaccine approach intending to create a product that can be used in a global health setting. Beyond that there are several publications, presentations, but I think that covers the scope of our development activities at this time. Mike Smith – Leerink Swann: Okay, great. Thanks a lot.

Thank you.

We’ll go next to Alastair Mackay with GARP Research & Securities. Alastair Mackay – GARP Research & Securities: Hi, I have a follow-up question on the duration of therapeutic efficacy. The trials for diabetic neuropathy, the definitive endpoint is that 180 days, is there any thought given to looking at some of these patients beyond 180 days to gauge how persistent benefits might be?

So, Alastair, I will start and then certainly Dale can go more if need to. We do follow these patients out; in particular the primary safety analysis is done through day 360. And we continued to do neurological evaluations of patients during that time as well. And Dale, correct me if I’m wrong, but I think we did present day 360 data at the Society for Neuroscience Meeting showing some of the durability of the response as it relates to NISLL out to that point. I know we have done that for the 401 data as well. But we are continuing to evaluate the durability of this process out to at least day 360. Alastair Mackay – GARP Research & Securities: Is that a durability question, something that has come up in discussions with potential partners?

Well, every question comes up, Alastair, with regard to potential partners. I don’t mean to be glib. But, yes, certainly that question of durability, the chronic nature of the disease, the repeat dosing aspects of a plasma-based product which permits repeat dosing are all I think a significant positive product characteristics here. Alastair Mackay – GARP Research & Securities: Great. And then switching gears to ask, Dale, if you can comment on this, there has been some interesting genomics data on glioblastomas showing not surprisingly that there are several broad classes of these tumors and the suggestion being that therapeutic or the clinical courses to some extent a function of what the mutations are in the given cancer. So, if one is doing a rather small study and assigning tumors randomly that could make it harder to interpret results. Have you or Dr. Jensen given any thought to these questions?

Yes, that is more likely applies to patients who apply for primary therapy. We’re selecting a group, a very select for prognosis group, who have recurrent tumors that can be surgically resectable and that has a lot of implications as to the location and size of the tumors. So, in the experience of City of Hope, this is a pretty uniform for prognosis group. So, it basically filters out any people, who like in the VEGF-A studies for primary therapy could have a more variable duration of their tumor due to genetic factors. Alastair Mackay – GARP Research & Securities: Great. Thanks a lot.

(Operator instructions) We go next to Ted Tenthoff with Piper Jaffray. Ted Tenthoff – Piper Jaffray: Great. Thank you very much and congrats on a productive year. Two questions if I may. Firstly, with respect to looking at 4Q, I know we’ll get the details coming in the Q in a little bit, but can you give us a sense of what the Sigma-Aldrich amortization was in the quarter? Will that be straight lined ratable through July?

Yes, Ted, Ward here, yes, it will be straight line through July. Ted Tenthoff – Piper Jaffray: Great. What made up for the other kind of difference? Can you tell us what the revenues were maybe? Because didn’t the Dow Agro amortization end in September?

No, it actually carried on and initially through December and that has now been extended, but just with whatever was remaining a fairly modest amount is now being extended through 2010 because we have ongoing research activity that we have initiated in 2009, Ted, so –. Ted Tenthoff – Piper Jaffray: I got you. So there was some Dow in the quarter.

Correct. Ted Tenthoff – Piper Jaffray: Okay, cool. That’s very helpful. Good, I look forward to the clinical updates throughout 2010.

Thanks, Ted.

(Operator instructions) And that concludes our question-and-answer session. I’d like to turn the conference back over to Edward Lanphier for any closing remarks.

We’d like to thank you for joining us and we look forward to speaking with you again when we release our first quarter financial information. We will be available later today if there are any follow-up questions. Thank you.

Thank you, everyone. That does conclude today’s conference. We thank you for your participation.