Greetings, and welcome to the SCYNEXIS' Third Quarter 2021 Earnings Conference Call. At this time, all participants are in a listen-only mode. A brief question-and-answer session will follow the formal presentation. [Operator Instructions] As a reminder, this conference is being recorded. It is now my pleasure to introduce your host, Debbie Etchison, Executive Director of Communications. Thank you. You may begin.

Hello everyone, and welcome to today's conference call to discuss our third quarter 2021 financial results and corporate update. Before we start, let me remind you that today's call will include forward-looking statements based on current expectations, including statements concerning our financial outlook for the future, leadership's expectations for our future financial and operational performance, as well as our business strategy. Because such statements are subject to risks and uncertainties, actual results may differ materially from those expressed or implied by such forward-looking statements. Please refer to our filings with Securities and Exchange Commission, including our most recent Annual Report on Form 10-K, and quarterly report on Form 10-Q, included in each case under the caption, Risk Factors, and in other documents subsequently filed or furnished to the Securities and Exchange Commission. All forward-looking statements speak only as of today, November 10, 2021. SCYNEXIS undertakes no obligation to update such statements to reflect events that occur or circumstances that exist after the date on which they are made. The information on today's call is not intended for promotional purposes, and not sufficient for prescribing decisions. Joining us today on the call are, SCYNEXIS President and CEO, Dr. Marco Taglietti; Chief Commercial Officer, Christine Coyne; Chief Medical Officer, Dr. David Angulo; and Chief Financial Officer, Eric Francois. Following our prepared remarks, we'll open the call to your questions. Now, I will turn the call over to Dr. Marco Taglietti.

Thank you, Debbie. Good morning, everyone, bonjourno a tutti. Thank you for joining us today for our third quarter 2021 earnings investor call. Our inaugural earnings call with investors since the FDA approval in June, and after the launch of BREXAFEMME. For all of you who have been following us in the last few years, you witness how we have been true to our word, commitments, and timelines, to turn our vision for ibrexafungerp into reality. Our vision for ibrexafungerp has always been to build a global antifungal franchise for both community and hospital infections by leveraging the versatility and potency of ibrexafungerp, and to extract the full value of this unique [systemic] [Ph] antifungal agent for the benefit of patients, and for the reward of our shareholders. And with -- and with 14 years of exclusivity, until 2035, we have the time to build a solid, long-lasting antifungal franchise, to create a stream of approvals over the years to continue to expand its use. So, today, you will hear about the significant progress we have made so far in achieving our vision for ibrexafungerp. First, you will hear from Christine, our Chief Commercial Officer, who will provide an overview of the market, our commercial activities, and the promising early trends of the launch of BREXAFEMME for the treatment of vulvovaginal candidiasis. We are very excited about bringing innovation from a new antifungal class to the millions of women suffering from this symptomatic condition, who have been underserved for so long. We are so proud to bring to patients the first new antifungal class in more than 20 years. Then, you will hear from David, our Chief Medical Officer, about our significant progress in research and development. We are finishing the Phase 3 CANDLE study for the prevention of recurrent VVC which, assuming positive data, may result in a second approval for ibrexafungerp in the second-half of next year. David will also give you an update about our liposomal intravenous formulation. We successfully completed the Phase 1 in [indiscernible], opening new avenues of development for hospital-invasive fungal infections, on top of our ongoing hospital programs. And finally, all our commercial and R&D activities are built on a solid financial foundation. Eric, our Chief Financial Officer, will give you a brief financial update. Now, I would like to turn the call over to Christine Coyne. Christine?

Thank you, Marco, and good morning. We have several exciting commercial updates to share with you today. Following the FDA approval of BREXAFEMME, in June, our team hastened the launch efforts of bringing this truly innovative product to market, and to the millions of women who suffer daily in the U.S. Vaginal yeast infections are extremely common, with about three out of four women experiencing them at least once in their lifetime. Despite the high prevalence of VVC, there have been limited advancement in this area of women's health for decades, until now. BREXAFEMME is a truly novel first-in-class antifungal with a mechanism of action designed to kill the yeast causing the infection, including azole-resistant strains. BREXAFEMME brings long-awaited innovation to the market. And physician feedback has been excellent. Healthcare providers confirm that BREXAFEMME is meaningfully different from the outdated tools they have been left to use for the last two decades. Physicians are excited about the novel mechanism of BREXAFEMME and its fungicidal properties. They are delighted that BREXAFEMME is a non-azole oral one-day dosing alternative for patients. Physicians aren't just saying great things; they are changing their long held habits, and prescribing BREXAFEMME for their patients. From the beginning of launch, we have closely monitored physicians' motivation to prescribe. These early indicators of motivation have converted to action. These indicators are quite strong and encouraging. Now, let me provide more details on the progress we've made since our launch, this summer. First, we established the foundational building blocks that set the stage for commercial success. Together with Amplity Health, our contract commercial partner, we've rapid hired, trained, and deployed high-performing sales representatives and regional sales leaders post approval. The SCYNEXIS and Amplity collaborative partnership has allowed us to efficiently leverage Amplity's deep expertise and experience to achieve our…

Thank you, Christine. After hearing these positive trends regarding BREXAFEMME commercialization activities, I will be sharing with you some updating of development programs. Please keep in mind that the programs I will be covering in this section are the evaluating indications that are not approving BREXAFEMME labeling but potential indications for BREXAFEMME curve and their clinical development. With a vision to maximize the potential for our novel agent to become a blockbuster antifungal, addressing multiple unmet needs in the market, we have been making significant progress on several development programs for BREXAFEMME. First, let me start with a quick update on our vulvovaginal candidiasis or VVC program. After securing the approval of BREXAFEMME for the treatment of VVC, with our two pivotal trials, we continue progressing our VVC development activities with our ongoing CANDLE Phase 3 trial, CANDLE is intended to support an indication of prevention of recurrence in patients with recurrent VVC. As you may recall, we have previously announced the completion of the study enrollment and I'm happy to report that we are on target for less subject less VVC by end of this year. We anticipate availability of top line results early in the second quarter of next year, followed by a supplemental NDA submission shortly after, and with a potential FDA approval of a new indication by the end of 2022, after an anticipated six months expedited review by the FDA. Moving into the hospital based indications we are quite busy, and we have some great news to share. The first exciting update relates to the intravenous formulation of ibrexafungerp. From a strategic drug development standpoint, anti infective benefit from having both an IV and an oral formulation for initial in-patient hospital IV treatment and the ability to shift to oral once the person is discharged…

Thank you, David. Let me first start my presentation by highlighting a few numbers on the revenue side. This is our first quarter ever to report product sales. We are very proud of the progress and excited about it. As you heard from Christine, the launch is proceeding well. This was a partial quarter for us, and we ended the quarter strong and already see indications of a strong positive trajectory of sales in the fourth quarter. For the third quarter of 2021, its first quarter post-launch, BREXAFEMME generated $516,000 in net sales. As a reminder, we are recording sales as soon as we sell inventory to wholesalers. At launch, we worked with wholesalers to stock more units at relevant pharmacy networks to ensure drug availability. And we expect to have approximately three weeks of inventory on hand at the wholesalers over time. The net sale number, we will be reporting, represents sales net of all discounts to insurers, and also includes any impact from patient assistance programs like our co-pay card, which is the main impact on Q3 net sales give the early commercial launch. Please refer to our press release issued today for detailed breakout of expense line items. And lastly, cash and cash equivalents totaled $100.1 million on September 3, 2021 compared to $93 million cash and cash equivalents on December 31, 2020. Based upon our existing operating plan, we believe that our existing cash and cash equivalents the sale of our New Jersey NOLs and the anticipated sales of BREXAFEMME will enable us to fund our operating requirements into 2023. We did not draw down additional debt from our remaining $30 million Hercules and SVB term loan facility in the third quarter, but we'll have access to additional capital in 2022 sending reporting positive Phase 3 data in our CANDLE for recurrent VVC and achieving [indiscernible] thresholds. As we are still early in the commercial launch, we are not providing revenue or expense guidance. I will turn the call back over to Marco.

Thank you, Eric. Before we begin the Q&A, I want to reiterate a few key points. First, our vision for ibrexafungerp is becoming a reality. Second, following approval in June, we've been aggressively executing our commercial launch plans with very positive trends, as you have heard. Third, our R&D pipeline is extremely robust, with the hospital moving into the forefront now. Stay tuned on December 6, at 10:00 AM Eastern Time, when we will provide our plans and timelines for the hospital program. Fourth, we are in a very strong financial position, with a cash runway into 2023. And lastly, just let me take a moment to thank Eric Francois, our Chief Financial Officer for his services over the last six years. As we announced, he is leaving the company to pursue a career opportunity in banking. Eric played a key role in transforming SCYNEXIS into a full integrated commercial stage company. And he leaves us well-positioned for success. We wish him the best in his next endeavor. Thank you, Eric. An interim CFO is in place, Larry Hoffman, of Danforth Advisors, for a smooth transition, and you will meet him soon. And we are actively recruiting for a new CFO. Operator, please open the floor for questions.

Thank you. We will now be conducting a question-and-answer session. [Operator Instructions] Our first question comes from the line of Louise Chen with Cantor Fitzgerald. Please proceed with your question.

Hi, this is [Wayne Lou Alford Louise] [Ph], and congrats on all the progress, and thank you for taking our questions. We got two, if we may. So, the first is on your partnership with Hansoh Pharma, in China, could you provide us some updates on the progress? And what is your plan on commercializing BREXAFEMME in the other regions of the world? And then our second question is VVC -- as VVC can be viewed the first step for SCYNEXIS, and now you're commercialized, what are the major catalysts we should be looking out for in the next 12 to 18 months? Thank you.

Thank you for the questions. So, let me start, first of all, with the partnership with Hansoh. It has been a great partnership. As you know, Hansoh is one of the top five largest public biotech company in China. We licensed our product at the beginning of the year. They filed the IND for vulvovaginal candidiasis in China. So, they are moving very aggressively with the development of the product in order to ensure approval in China of the product. So, we expect that just [indiscernible] of it is we expect Hansoh to continue to progress very, very rapidly in the VVC indication, but also to continue to progress with the hospital too. We are, of course, we have, as you all know, rights for the product worldwide. And of course, it is our plan to monetize this product and to have this, our product ibrexafungerp, commercialized outside of the U.S. Therefore, as you can expect, following approval, in June, of the product and following the validation of the value of the product outside of the U.S. with the partnership with Hansoh, as you can expect, our phone calls have been intensifying with potential partners outside of the U.S. But at this point, we cannot provide any other additional information, other than saying that we -- certainly, we are moving forward to make sure that ibrexafungerp becomes available to all the patients globally. And finally, yes, VVC is really the first step or the first indication of a [indiscernible] indication that we see for the product. This product has a great versatility, the ability to be used for community type of infection that are difficult to treat, like VVC, but not an [essential necessary like] [Ph] [indiscernible], but also, can be used for hospital indication where there are infections of the bloodstream, of internal organs with high mortality. And so, we are progressing all these indication in parallel. Future catalysts, next year, we expect a second approval for the prevention of recurrence of VVC for ibrexafungerp that will allow us to bring an additional indication in the bag of our sales force, and therefore to go out with a new indication to our current group of targeted doctors. But also, we expect to move forward with the hospital indication as I mentioned, stay tuned on December 6, 10:00 AM Eastern Time; we will have a teleconference to share our plans and timelines for the hospital indications. Thank you.

Thank you.

Our next question comes from the line of Michael Higgins with Ladenburg Thalmann. Please proceed with your question.

Thanks guys. Appreciate the opportunity to take some questions. And let me say, Eric, thank you. You'll be missed around here. Couple questions on the launch, if I could, with Christine. How are the commercial coverage, how is that coming along versus internal expectations? What do you see happening in the next few months? I've got a handful of them here; I'll try to keep this tight so we can talk later maybe. So, on a related Medicaid coverage, how is that tracking along? And then finally here, are you targeting nurses and pharmacists, and if so in what ways? Thanks.

Thank you for the questions, Michael. Commercial coverage, again, I spoke a little bit about this. I think the national account directors are doing [technical difficulty] -- a really great job in getting to the payer customers, and having the necessary conversations. So, they've gotten some really great traction throughout 2021. We've had a lot of meetings with important payers that are important to us. So, we are tracking over 30% commercial covered lives right now. My expectation is that trend continues going in that direction. And we'll bring in some important coverage by the end of 2021, and then we'll pick up the rest in 2022. As it relates to Medicaid, just participating in state Medicaid reviews that are ongoing, we have some states reach out to us proactively. And our, again, national account directors and our medical science liaisons take those meetings, and we'll continue watching that as it goes. As it relates to nurses and pharmacists, yes, a total -- we call it a total office call, and that includes the pharmacy as well. And we are having success there -- I should say the representatives are having great success there with not only the physicians, but their nursing staff, and then also rounding back to the pharmacies to ensure that the physician and patient have the best experience with BREXAFEMME that they can. And I -- and that's going very well. Hope that answers your question, Michael.

That's great. Yes, [multiple speakers] --

And, Michael, as you said, Eric -- And Michael, just I wanted to say that, with Eric, don't worry, he will be around. This is a small world, so I'm sure that we will continue to interact with him, and you will continue to interact with him. Please go ahead.

I'm sure, I appreciate that. No, we look forward to that. Just one quick follow-up on that, and I'll jump back in the queue, I've got some other ones on the IV and the other studies. But just one here on the launch, any feedback on the GI, the nausea, is it being managed with food? What are you hearing from your reps? Thanks.

Yes, no, I mean they -- the reaction from the physicians is exactly what we saw on research. They're really excited to have this alternative to azole. They've just been waiting for something like this, and the reception on, Michael, on the fungicidal, the ability that it can kill the yeast infection, they can take it in one day, it's a different mechanism of action, really strong reception from our call targets.

And tolerability, as you may remember, Michael, in our clinical trails was mild -- very mild event, short-lasting. So, we don't -- this is why we see these reflected in the type of experience of our patients.

Okay, so, feedback is minimal on the GI then?

That's correct.

Okay, appreciate it. Thanks, guys. I'll jump back in the queue.

Thank you.

Thanks, Michael.

[Operator Instructions] Our next question comes from the line of Kumaraguru Raja with Brookline Capital Markets. Please proceed with your question.

Thanks for taking my questions, and congratulations on the first quarter of product sales. So, first with regard to the pent-up demand, how much of that has been satisfied? And also with regard to the physicians that are being targeted, what percentage has been targeted there, and where is this prescription that are coming from, what percentage of physicians it is coming from, and what are you seeing in terms of like, some physician prescribing more than others?

Yes, so thank you. The pent-up demand, yes, so we put stocking into the pharmacies around our call target so that our physicians once they started prescribing BREXAFEMME their patients could get the product. So, we did put that into the channel, I think my comments that you're questioning is, sometimes you see organic sales happen before the reps actually get to, in earnest round to their physicians. And that's what we were talking about. And that's right, there is an organic signal that a lot of the work that has been done previous to the sales reps getting out there with the awareness of BREXAFEMME, doctors were waiting, some doctors are waiting and ready to trial. And that's exactly what happened. As it relates to the doctors being targeted, we did a lot of research in pre launch to identify the territories that would be most advantageous and productive for us to address. And you can imagine it was high [indiscernible] prescription writers and that those are the doctors that were targeting; those doctors are in the geographies that represent around 90% of the VC prescription market. So, it's a very, as I said in the prepared remarks, very concentrated territory, which makes it easier for us to address and that's what we're seeing right now. Yes, we are seeing it's really I'm very, very delighted and extremely encouraged because part of it is what we do, part of it is organic. We are seeing prescribers, and it's increasing month-over-month. We are seeing prescribers broaden their clinical experience by using BREXAFEMME for more patients. For me, that's the effectiveness of what we're doing in a way of bringing information and education on BREXAFEMME to our prescribers, but it's also prescribers, having a good experience and wanting to expand to their patients membership. So, yes, hope that answers your question.

All right, thank you. And in terms of commercial powered life, what's happening in that front in terms of you start having impact on like, the number of prescription and how is that expected to change over time like what are you thinking in terms of time levels of getting these additional sites on board?

Yes, you're right, you expect those lines to kind of travel together. So, prescription utilization and covered lives traveling together, because obviously, when the doctor chooses BREXAFEMME for his or her patients and you generate more coverage for those patients that you start to see increases in both of those lines, they travel together.

Thanks so much.

Of course, thank you.

Thank you, Kumar.

[Operator Instructions] Our next question comes from line of Nathan Weinstein with Aegis Capital. Please proceed with your question.

Hey, good morning, Marco and Eric, thanks for taking my question, and a big thank you to Eric for being a great CFO and a great person to work with. So, maybe just anecdotally, could you speak to the role that patients themselves can play of being advocates for BREXAFEMME via word of mouth marketing, and then also there are any big communities online where the patients tend to congregate and share information?

Yes, thank you for the question. Patients are very big advocates for themselves for their own health. And there's a sequence to how, we do these things, right. The most important thing and early stages of launch is to get the prescriber, the one who has the prescribing ability to understand that BREXAFEMME exists and what it is such that when the patient arrives into the physicians office and they do and ask for a product, the doctor then understands what the product is has some familiarity. They may do some research if they have yet not utilized the product. But the perfect situation is a patient walking through the doctor's office, asking for BREXAFEMME, and then the doctor knowing what BREXAFEMME is, and having clinical experience, practical experience themselves. So, that's kind of the sequence you like, that's the sequence you would like to follow. We do see patients having conversations with their physicians now. We are doing -- the marketing team is doing beautiful work to educate patients properly and in a good way, in a fruitful way in 2022, such that the connection between those patients going into the doctor's offices is a very productive one. Sometimes you can have a patient come into the physician's office, the physician doesn't know about the product, and it really is not a fruitful endeavor. Hope that helps answer the question.

Yes. Thank you. That's a very thoughtful and helpful answer, much appreciated.

Thank you.

Thank you.

Our next question is a follow up question from Michael Higgins with Ladenburg Thalmann. Please proceed with your question.

Thanks guys for taking the second round here. Quick one here for Eric, I can't let you off the hook. Are there any inventory numbers in the Q3 results? And what should we expect as the Delta on the Q4 pull through? Thanks.

Yes, no, thanks, Michael. As I mentioned in my prepared remark, we had a higher number at launch to ensure that launch -- that all relevant pharmacy networks we're had enough drug availability over time and as we mature into our commercial launch. Christine, I think we'd want to keep about three weeks of inventory on hand. And so, that's going to be basically our plan now. As we learn and as we get more historical data, we'll adjust accordingly, Michael, but for now it's just kind of the trajectory that we're taking.

I guess just a follow up to that of the 50,000 or 60,000 or so U.S. pharmacies, how many are you stocked in with at least one bottle?

I'll let Christine address.

Yes. You know what we stocked almost 50% of them early in the launch and then there is reordering happening. So, they're pulling those through now. So, we'd -- I'd have to look and see where we are at this time.

Okay. That's helpful. And then we switch to the IV, a couple questions on that. I'm sorry, if he's been asked, I'm kind of juggling calls here. Have you done any additional injection site assessments, given a history here with developing an IV ibrexafungerp? Thanks.

Sure. Thank you, Michael. This is David. Certainly, during this study, we worked addressing and assessing very carefully, what was the tolerability of the intravenous formulation. And as I mentioned during remarks initially, we did observe a substantially better tolerability of this liposomal formulation when injected in these healthy volunteers. So, we did still observe some mild infusion side reactions, typically redness, some swelling, but in no way this prevented the dosing from continuing. And that was extraordinary encouraging. So, from that point of view, this formulation, liposomal formulations is doing what we were expecting to be doing, which has really improved the tolerability of the IV administration of our product enable us to move it forward to the next stages of development.

Okay. Next question on IV is, it sounded like either in the press release comments or in your prepared remarks that there were next steps that you were considering for the IV. I'm not entirely sure what that means. I would expect that you're going into Phase 2, but are you planning to run another Phase 1 possibly? Thanks.

At this point we are -- as you mentioned, we are really doing the final analysis of our pharmacokinetic data and we are going to be in a better shape to really show you or tell you exactly what are the outline of the different stages of the next stages of the development program for this product, let's say in December, once we have all the PK data analyzed in on hand. If you ask me right now, certainly the envisioning is that probably Phase 2 is the next stage, but we would like to confirm that in December.

Okay. I'll save that follow up point here because it sounds like we'll hear this in December. A question for you on CANDLE and maybe this is a question for -- maybe for all of you, maybe for Christine. When you think about positive data hear from CANDLE, what impact do you think that will have on sales at different time points? For example once the data comes out, doctors can see that and then also following its approval is this something that you envision as kind of 10% to 25% bump on the current trajectory of sales or something more like a 50% or higher impact on sales? Thanks.

So, Michael, but there's a -- we have been actually talking about this also in the past, the real need here with the treatment of VVC with us seeing nothing coming for the last 25 years. We expect actually to have some, of course, to have the opportunity here with prevention of recurrent VVC to target another group of patients where this infection is just almost the chronic affliction. And we expect this to contribute to our bottom line, but probably we'll be a relatively small [indiscernible] additional 10%, 15% is what we have been expecting because really the innovation here is bringing a product with one day treatment can really clear the infection, thanks to its fungicidal activities and that is really where we expect there will be ibrexafungerp and BREXAFEMME really to make a significant difference.

That's super helpful. Thank you. One here on SCYNERGIA, you've mentioned the -- that COVID delayed enrollment in the 2022. Any plans to adjust the enrollment criteria or execution of the trial given what the CDC and that the emerging infectious disease journal posted this month about increasing prevalence of aspergillosis among COVID patients. Any positive that can come from that for you guys at least? Thanks.

Sure. Now, thank you for the question, Michael. This is David again. Yes, certainly, the COVID-19 pandemic has the impact that the ability of the institutions to really focus the resources in really enrolling or doing research and a lot of the resources were focusing COVID related -- COVID-19 related type of research if they were still available there and certainly that had an impact in the SCYNERGIA trial, the fact that COVID-19 also increases the risk of patients to really acquire invasive pulmonary aspergillosis. So, that's an opportunity there or current protocol allows for patients to be enrolled COVID-19 patients with invasive pulmonary aspergillosis to be potentially enrolled in the SCYNERGIA study. However, we need to here be careful because really it's just -- we are just learning how -- what is the actual natural progression and outcome of invasive pulmonary aspergillosis in COVID-19 afflicted subjects. And that is something that we definitely need to be careful in analyzing that information, so that we can very well assess really what is the treatment effect versus what is just the underlying condition outcome of these patients. So, we are not -- the protocol allows the inclusion of these patients. At the same time I would expect that at this point, we don't expect that it's going to be the majority of the patients enrolled because physician's side -- as you can understand, this is a new condition or a new combination of conditions, which is COVID and invasive pulmonary aspergillosis. And physicians are going to be more likely to treat them with a standard therapies rather than enroll them into clinical trials for a specifically the treatment of invasive pulmonary aspergillosis, where they may be enrolled in clinical trials for the treatment of COVID-19. That is what we have seen right now with a little bit competing priorities that they prefer to enroll the patients into studies that are being assessed in treatments for COVID-19. However, we -- I anticipate that we will have some cases.

Right, okay, that does make sense. We don't quite know the effect of standard of care here in these new patients and setting. Then one last one here on CARES and FURI, any potential for updates before Q1, when you historically provided updates given the fact that there is likely an increased pace of enrollment, maybe you can keep the 20 or so patients for FURI at least, and provide us some information by year-end, or is that -- is the plan still the wait for Q1? Thanks.

Yes, we're always very excited to take a look at the data that. And we will -- and as you know, the opportunity that these studies are open label allows us to really do that. We have not to make a decision regarding when we will be announcing the next round of results from this particular study, but certainly we are having that discussion internally here to verify when is the right time to really focus the resources of the team and in doing that analysis, we will update as we made that decision.

Okay. And, then just one final one here, finally for me, any plans to adjust FURI protocol, or the execution given the mucormycosis preclinical evidence and the synergy with Amphotericin? Thanks.

Thank you, Michael, and thank you for all those very thoughtful questions. The answer is that, we don't need to amend the FURI protocol, the FURI protocol assay as it is right now is adequately written in the way that allows enrollment of patients with different fungal infections including mucor. In the past, we were not actually advocating its use in mucormycosis patients, so Ibrexafungerp combination using mucormycosis patients in the protocol because we just didn't have enough evidence of the potential clinical benefit. Now, with this information coming from the preclinical data, we are certainly addressing it with investigators that this is a potential that they can take advantage of within the FURI protocol. So, the FURI study as it is allows the enrollment and we officially notified investigators that now this is an opportunity for them to consider patients with mucormycosis to be included in the future.

Interesting, very helpful. Thanks, guys. Appreciate the time and all the questions.

Thank you, thank you, Michael.

Thank you, Michael.

We have reached the end of the question-and-answer session. Dr. Taglietti, I would now like to turn the floor back over to you for closing comments.

Thank you very much. Now, first of all, thank you to many thanks to all of you who have been listening to our conference. I will just be saying that we share the excitement of the patients and doctor for the ability of bringing in finally a new treatment for VVC. Not to mention the progress in research and development in the area of hospital, the role of ibrexafungerp for the treatment of fungal infection will become more and more relevant as we will get new indication and at SCYNEXIS, we have the expertise, the tools, the resources to make ibrexafungerp a success. Thank you very much for listening to us.

Ladies and gentlemen, this does conclude today's teleconference. You may disconnect your lines at this time. Thank you for your participation and have a wonderful day.