Thanks Vijay. There's a few questions in there and we're excited for Bryan as well. So I'll start with COVID. As it pertains to the guide, obviously, we said at least flat year-over-year and I'd say predicting the course of COVID has not been easy, nor do we anticipate it to be easy over the next 12 months. There are certainly some variables that could make it more than this. Let me talk about it in a couple ways. One is the sequence through the year, which gets to your question about $500 million in the first quarter, and then the labs versus kind of the rest of COVID revenue piece. So in terms of the sequence, obviously, we have much better visibility, certainly to the first quarter and the first half. And our assumption in this guidance is that the vaccine kicks in and that the second half's revenue and testing come down substantially. And you can see that by evidence that almost 50% of the revenue is here in the first quarter. So we feel like that's a conservative assumption, but one that we are confident in. As it pertains to the split between core versus labs in 2020, core made up approximately 80% of the revenue. And we're predicting that that'll make up approximately 60% of the revenue. And conversely, the labs, which made up about 20% of the revenue in 2020, will step up and be a greater contributor in 2021, to be about 40%. So I think we're assuming that starting in the first quarter here, we're expecting the testing levels on the core to come back down and the level of instruments that we sell, et cetera, to kind of match what we saw probably in the third quarter. And then as it pertains to the labs, we've got a couple variables at play. First is in the UK, our contract only is valid through the end of March. So we're not yet sure whether it'll be extended beyond March, we haven't been told yet. We're obviously talking to them about that now. So this guidance assumes that the UK finishes at the end of the first quarter, and there is no revenue assumed in the end in the second quarter and beyond. And then California, as you've seen is a slow and steady ramp. So it's public information. We've ramped from almost no testing at the beginning of November. And now we're probably about 20,000 tests per week. But there's numerous sites throughout the state of California that they're trying to bring into the program. And so - but those are slow and steady. So we expect California to ramp up here, but it's not nearly as fast as we think. And so therefore, we've taken a pretty conservative assumption in the first half here as well, and then it tailors back down in the second half as well. So overall, a lot of variables in play Vijay. We're trying to set a floor here that says we think we can be at least flat. It's very much front end loaded here. And there's certainly some potential for upside here. And our supply chain can certainly deal with it as we've done in 2020. Well, non-COVID. So on the non-COVID side, the first quarter, I think the comp is a minus 3%, not a minus 7%. The rest of China was the one that was impacted the most. I think China was down over 30% in the first quarter last year, the rest of Europe and Americas was quite strong in the first quarter, which pended to down 33%. So if you look at our 1% to 3% guidance here in the first quarter that embeds the extra week, which is the equivalent of probably two percentage points, so it's more like a 3% to 5% Guide. And we've seen a slow and steady uptick here. So second quarter of last year was where we troughed, we hit I think minus 14% on the quarter book, third quarter, we hit minus 6%. This past quarter, we hit minus 3%, with a couple of difficult comps in there. So we continue to see this trend up. As it pertains to the five to seven overall for the year. Obviously, we'll probably see the largest growth from an organic growth rate perspective in the second quarter due to the comp and then it'll start to normalize in the back half of the year.