Earnings Labs

Roivant Sciences Ltd. (ROIV)

Q3 2023 Earnings Call· Tue, Feb 13, 2024

$27.91

+0.22%

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Transcript

Operator

Operator

Hello, thank you for standing by. Welcome to Roivant Third Quarter 2023 Earnings Conference Call. At this time, all participants are in a listen-only mode. After the speaker's presentation, there will be a question-and-answer session. [Operator Instructions] I will now like to hand the conference over to Stephanie Lee. You may begin.

Stephanie Lee

Analyst

Good morning, and thanks for joining today's call to review Roivant’s financial results for the third quarter ended December 31, 2023, along with a business update. I'm Stephanie Lee with Roivant. Presenting today, we have Matt Gline, CEO of Roivant. For those dialing in via conference call you can find the slides being presented today as well as the press release announcing these updates on our IR website ww.investor.roivant.com. We'll also be providing the current side numbers as we present to help you follow along. I'd like to remind you that we'll be making certain forward-looking statements during today's presentation. We strongly encourage you to review the information that we have filed with the SEC for more information regarding these forward-looking statements and related risks and uncertainties. And with that, I'll turn it over to Matt.

Matt Gline

Analyst

Thank you, Steph, and thank you everybody for joining today. I appreciate it. It's nice to be able to talk about our third quarter results here. On Slide 4, just a brief overview of the agenda. So we'll talk a little bit about a recap of last calendar year and then we'll spend some time on the recent data coming out of Univant during the quarter, some time talking about the upcoming proof-of-concept readout at brepocitinib in NIU. We'll do a review of performance of VTAMA, highlight some upcoming catalysts and financial update and then turn it over to Q&A. It should be a relatively short presentation today. So we've talked a fair amount about last year, and this will be the last time that we take a victory lap forward. But on Slide 5, I just want to remind everybody of the year we're coming off of, during which we continue to both commercialize and maybe even more importantly, develop VTAMA with positive Phase 3 data in both of our studies, setting us up for an atopic dermatitis approval that we hope will come later this year following an NDA filing, that we hope we’ll go and sNDA filing we hope will go in very shortly. We have the sort of full round trip of our anti-TL1A antibody, which you're all quite familiar with at this point, culminating in the Sale to Roche that closed during this quarter. We generated both at this point proof-of-concept data, or not, I should say, initial human data from IMVT-1402, showing that our next-generation anti-FcRn antibody suppresses IgG. We believe as deep as any other and without any impact on albumin and LDL and in a convenient subcu format. And also, we've shown data from our Phase 2 study in Graves’ disease that…

Operator

Operator

[Operator Instructions] Our first question comes from the line of Allison Bratzel with Piper Sandler.

Allison Bratzel

Analyst

Matt, I think, I heard your characterization of the current setup as very conducive to BD, and your, and how you see pipeline expansion opportunities that are transformative. I guess could you may be set some guardrails on your current thinking on BD transformative makes it sound like you're looking at a single versus multiple opportunities, but not from interpreting that correctly. And then I think also I heard you say we should have an update on the capital allocation strategy before the next earnings report. Could you just help us understand kind of what's getting to that disclosure and how you expect to communicate that to the street?

Matt Gline

Analyst

Yes. Yes. So on the first question, I'm glad you asked it, and I'll ask Mayukh to chime in as well because I think it's important. When I -- the general sort of scope of things we're looking at, I'd say match the kinds of deals that we've done before. So partnerships or acquisitions of late stage programs generally more likely, I would say to be programs than M&A. I'd say potentially multiple over the next year, including some of the ones we've already done. And when I say transformative, what I mean by that is I think these will be programs, at least some of them going into large, late-stage studies of a kind that will change the shape of our pipeline and add meaningful heft to what we think is already a pretty great late stage effort. Mayukh, anything you you'd add to that?

Mayukh Sukhatme

Analyst

Okay. If not, I'll go to the other question, but, so thanks for asking that question. It's a good question and it's important that we be clear on what we're looking at there because I think it's less likely to be either, frankly, it's less likely to be sort of M&A per se, never say never, but less likely and potentially not going to be a single program, maybe multiple. And then on the capital allocation point. So look, I think certainly by the time of our next earnings call, I expect to have made some meaningful progress here. So I say this is not just about analysis and this is a combination of frankly, advancing some of these late-stage business development conversations so that we have a sense of the exact breadth of the sort of BD piece of this. Although I think it's hard to imagine that that combination of things is going to sort of meaningfully change the total picture. And then also look, I think part of what we've talked about from a capital return perspective is the concentration of our shareholder base. And, Sumitomo, for example, has indicated, a desire to exit their position, given their own financial considerations. We -- as you can imagine, have ongoing discussions with all of our shareholders and I think we're trying to sort of progress those in the optimal way for setting us up for success. So I think all of that is what is ongoing. And once that resolves, we should be able to provide more clarity.

Operator

Operator

Our next question comes from the line of David Risinger with Leerink Partners.

David Risinger

Analyst · Leerink Partners.

So could you please discuss both the Moderna LNP litigation event path ahead and also Pfizer, LNP litigation developments to watch? I know that you're limited with respect to what you can say, but whatever you can provide on the call would be helpful. And then, Richard, could you discuss the spend 2024, specifically, SG&A and R&D.

Matt Gline

Analyst · Leerink Partners.

Thanks, Dave. Appreciate the questions as always, and appreciate that you put the caveat out there for me about my limited ability to comment here. I think on the Moderna litigation, one thing I can say, because it's obviously public information, is -- so we had our Markman, our claim construction hearing last week. I think, overall I'll say, we were pleased with our ability to make the arguments that we thought were important to us. It's an important hearing. We think that the judge is going to do a good job of considering everything everyone brought to the table. We will know more about the outcome for that. I think, the judge has said previously, sort of 60-ish days, there's no set timeline for that response. We're looking for it in about that timeframe, but it's a complicated set of issues and we want to make sure, everything gets properly evaluated. That's the next sort of significant event on the Moderna side. On the Pfizer side, that case is ongoing. There's no set date for a Markman hearing, but we would expect it to take place sometime later this year. That's all ongoing and appreciate, we know that a number of people are following along there. On the cash side, I'll turn it over to Richard, as you suggested, but I'll just say, I think there's sort of puts and takes here. Obviously TL1A is out of the spend, VTAMA continues to ramp, which is mostly helpful from a cash burn perspective. But some of it also depends on programs that we either have or we'll bring in. But Richard, any comments that you want to make on spend for the next year?

Richard Pulik

Analyst · Leerink Partners.

Yes, I would anticipate that spend would be relatively flat over the next few quarters. Obviously, one’s AD approval comes through on VTAMA towards the end of the year, we would ramp up the sales efforts there, so you'd see an uptick as we approach that towards the end of the year. And then also as the 1402, R&D spent ramps up with the additional trials that we talked about that will also start coming through, but relatively flat over the next few quarters and then see a ramp up as more trials come through. Also, we will see some data on NIU, so we'll have to make a decision there to see if we do additional spending depending on how that data reads out. And then start a dose at the end of the year as well.

Operator

Operator

Our next question comes from the line of Brian Cheng with JPMorgan.

Brian Cheng

Analyst · JPMorgan.

Matt, in the last earnings call, we didn't touch on the asset that you acquired, and it was reflected as the 14 million items in the in process R&D line and 10-Q. Can you give us more color here on the stage of the asset and indication? How much data was there behind this program, and when could we see the mixed data updates here? I have a quick follow-up.

Matt Gline

Analyst · JPMorgan.

On the unnamed asset, we've now provided a little bit more color. We've indicated that the program should be entering Phase 2, so that should give you a sense on stage. I won't say too much more. It's in a space where we feel like we have a reasonably decent handle on what's going on, but it is a development stage program. And the reason we're not talking very much about it right now, is it's broadly a competitive space and we think we have an opportunity to be ahead. So we'll talk more about it later this year as the clinical program gets up and running. I think, that was your main question there, right? And I think you had another one.

Brian Cheng

Analyst · JPMorgan.

Yes. Related Immunovant plan here. It's quite a robust development plan for the next one to two fiscal year. With the speed that you're shooting for, do you see the need for Immunovant to partner off, or do you think that they can lean on Roivant for additional financial resources?

Matt Gline

Analyst · JPMorgan.

It's a very good question. Look, I think, as we think about sort of the combination of Roivant and Immunovant, there was certainly no financial need for a partner per se, and I think the plan that we've laid out here, while it's aggressive and while it's broad, we've chosen it in part because we believe we are capable of the clinical execution. So, with a program of this breadth of opportunity, I think we are certainly able between Roivant and Immunovant and with the full use of resources that either, that are needed to do something big and important here. And I think, there are few things going on at Roivant that are more important than the successful development of 1402. So if Immunovant event would benefit from resources, either people or financial, you can bet that we'll be having those conversations. That said, it’s -- although I said the competitive intensity is comparatively low, it's obviously a competitive space and we have some well-funded and strong operationally competitors, we think we can keep pace with any of them on clinical development. But certainly, as we've said before, we're going to be ruthlessly economic in maximizing the value of the program, including thinking about partnership and other strategic opportunities for Immunovant to make sure we aren't missing a beat.

Operator

Operator

Our next question comes from the line of Yaron Werber with TD Cowen.

Joyce Zhou

Analyst · TD Cowen.

This is Joyce on for your own. Now that the lupus study is readout, what's your latest thinking on which indications to prioritize for brepocitinib and when might we hear more about that broader indication list?

Matt Gline

Analyst · TD Cowen.

Thanks for listening and thanks for the good question, and we're very excited about brepocitinib. I will potentially ask Mayukh to comment a little bit on this too. I guess this is the, maybe the first earnings call we've had since the rep brepocitinib lupus data. I don't think we read much of anything into the program at all from the lupus readout. We had always sort of indicated we thought it was going to be a high risk readout because of lupus disease dynamics. And frankly, the drug effect in the study was reasonable or in fact quite good. The problem was we saw, as we've indicated, the largest placebo response rate, I think ever observed in an SLE study. And so, I don't think that gets particularly to the opportunity for the drug. And then the safety profile remained consistent with what we've observed historically. So I think the short answer is we are full speed ahead on our original plan that centers around dermatomyositis where the study continues to enroll. Well, that includes potentially NIU and obviously as Richard said, and as I said earlier, we'll have to make a decision on what to do in NIU after observing that proof-of-concept data coming in the near future. And then other indications, we continue to evaluate a reasonable breadth of indications that sort of fit in that we call it orphan rheumatology bucket. But I'd say, one that we are sort of making a decision on in the relatively near future, potentially depending on what we see in NIU, et cetera, is HS. Where we have quite good Phase 2 data. So I think things that fit nicely with that are still on the list for us, but we're first and foremost focused on DM and then NIU.

Operator

Operator

Our next question comes from the line of Dennis Ding with Jefferies.

Dennis Ding

Analyst · Jefferies.

Two for me. So, regarding BD, can you please clarify your previous comments? You said not a single program, but multiple programs. Will this all come from a single announcement, or is this more like a string of pearls type of BD path over the next year? And then question number two around Immunovant, has the company engaged with the FDA yet on a registrational path for Graves and the level of confidence that 1402 can go directly to Phase 3 and skip a Phase 2?

Matt Gline

Analyst · Jefferies.

I think then I'll take the second question first, and then I'll briefly comment on the first. Then I'll, I'll see if Mayukh, this time around has comments on the BD question as well. On, Immunovant, I think the main answer to that question is, we're going to leave it to Immunovant to make the exact announcements of the clinical plan for 1402. But I think we're working through, with FDA and otherwise all the important regulatory questions. And I think we are, Immunovant’s guidance that they're able to go into a four to five, potentially registrational programs this year is certainly an informed view of what they're going to be able to accomplish. So I think we're feeling good there, but we'll provide specific updates on any given indication, as in when we've got them. On the BD side, again, thanks for the question. It's a great question. It's important clarification. This is not like we're working on a single large package deal of multiple things. This is just, we see quite a lot out there that we're excited about. So we've already got the one in-house and we've got a couple of other things that we're -- on our racket, I'd say. So I think it's more of a, I think you called it a string of pearls. I think it's more of a -- we see multiple programs and we'll bring potentially several things in over the next year and frankly beyond, right? It's sort of just how we've always run our business. But, Mayukh, any comments on it?

Mayukh Sukhatme

Analyst · Jefferies.

That's right. I think you hit the, the main point right at the end there. I mean, look, this is sort of regular course for us. We're always looking for promising assets where we think we can make a difference and we're as focused on that as we've ever been. We're not resting, we're working hard towards it. The exact timing and sort of contours of that are still sort of unknown, but expect that, expect to hear more from us.

Dennis Ding

Analyst · Jefferies.

And if I can just squeeze one last question here around NIU given basic data that's coming up soon, maybe, if you can comment on what's the bar for success here, given it's a small study and there's no placebo, I know there's some numbers in your slides around expecting less than 30% treatment failure rate and you're estimating 80% to 90% stimulated placebo. But just wondering if you may actually need to see a lower failure rates since placebo if you look at Humira and filgotinib, placebo can be highly variable.

Matt Gline

Analyst · Jefferies.

Actually I'll hand it over to Mayukh, do you have sort of thoughts on that question?

Mayukh Sukhatme

Analyst · Jefferies.

No, I don't have too much, too much there. I mean, I think, look, I think you both pointed out that there is some variability there, but I think the -- look, I think we're looking at this in the same way that, that we look at all of our trials. We want to see for ourselves a pretty sort of clear signal of efficacy. I think even accounting for some potential variability in sort of notional placebo rate. And we'll be excited to move forward if it's clear.

Matt Gline

Analyst · Jefferies.

The only other thing I'd add is, remember this is a, it's a 24 patient study. It's randomized in favor of the 45 milligram. My experience -- our experience looking at Phase 2 data is you sort of expect it to be a, like you hit F9 on the computer and you get a green thumbs up or red thumbs down, and usually what you get is, like a greenish triangle or something like that, and you're like, what does that mean? And so I think you can imagine it's hard to reduce the extra data that we're going to get from the study into a single number. We did set that bar of a 70% treatment failure rate, but I also think you can be clear, we're going to be looking at every patient and trying to make sure we understand what the drug is doing. And these are quite sick patients, again, 30,000 new cases of blindness every year. It's something where we feel like we have an opportunity to make a big difference with the right clinical picture.

Mayukh Sukhatme

Analyst · Jefferies.

There are two other points to add there, I think, look, we are sort of hoping to see a bit of a dose response here and that like, while there's not a placebo, there is a relatively low dose of repo that ought to give a little bit of a, let's just call it, maybe not placebo, but something kind of closer to placebo on efficacy and the 15 milligram dose. That's thing one. And thing two is I think at least in conceptualizing the Humira, sort of comp that you cited. We've got a more aggressive steroid taper in our study than in the Humira study. And so, you'd expect to see a higher placebo failure rate as a result.

Operator

Operator

Our next question comes from the line of Louise Chen with Cantor.

Louise Chen

Analyst · Cantor.

I wanted to ask you first on how you plan to address the concentration in the shareholder base. Will that kind of all be done together with some of the announcements that you plan to make before the next earnings call? And then the second thing I wanted to ask you was on expansion of your pipeline, what therapeutic areas are you most interested in? And if you can't say what therapeutic areas you're most interested in, how competitive do you want a get with some of the most topical areas that people are investing in right now?

Matt Gline

Analyst · Cantor.

On the shareholder based side, I think the first answer is that is not a decision that we can make unilaterally. It depends on our desires, but also the desires of some of our concentrated shareholders who in many cases are happy holders and frankly, believe what we believe, which is that our stock is meaningfully undervalued given the sort of overall position of the company. So I think, that's a discussion we have to have sort of bilaterally with each of them. We'll take it in turn you, I think, what we expect to do is to be ruthlessly economic and thoughtful about how we use our cash for that purpose. Whether that means we clean them up at once, whether it means we clean some of them up, I think that depends a little bit on their needs and their appetite and on making the right economic decisions. Stay tuned is the short answer. On the BD question, and again, I'll ask Mayukh comments as well, but I think the short answer is we are sort of necessarily agnostic to therapeutic area, because so much of our opportunity comes from strategic shifts and focus at our partners and that leading them to need to rethink their portfolio. So if someone is doubling down on immunology, maybe something else is falling out as a consequence. So we're pretty flexible in general because we're in that sort of string of pearls one program from here, one program from there dynamic. What that tends to mean is, we are more excited about areas where a single program can kind of stand on its own. So, think of the immunology programs that we've developed, for example, and maybe a little bit less excited about areas where you need a concentration, either because it's like oncology where you're developing multiple drugs in combination in order to have a coherent plan or maybe because it's something like cell and gene therapy, where you have a sort of a need for manufacturing expertise that provides an economy of scale. So it's not that we would not go into either of those areas, but they're probably like modestly less likely for that reason. Mayukh, anything you'd add to that?

Mayukh Sukhatme

Analyst · Cantor.

I think, as we look, and this is really typical of the history of the company, I think as I kind of look at the list of things that I would say that we're excited about and prosecuting pursuing, right now it's about an eclectic a list as, as one could kind of imagine in terms of therapeutic areas. So as Matt said, we're going to continue to be therapeutic area agnostic. I think, we have tended, as for the reasons that Matt stated, we have tended to be in areas that probably at first glance tend to be a little bit off the run or a little bit of contrarian. And sometimes, I think we've shown that sometimes those areas tend to heat up as we have sort of seen with FcRn and then with TL1A in the past. And so that could well happen again, but probably again just a mix.

Matt Gline

Analyst · Cantor.

The bar for us is not, is it competitive, the bar for us is can we get something that makes sense for us given the development plan, the economic terms, et cetera. And so, there are occasionally programs in very competitive spaces where idiosyncratic factors makes them competitive from a sort of, like many people care about it perspective that are nonetheless easy for us to get. And then there are sometimes programs in less competitive areas where nonetheless they're harder to pry loose. And so I think it's not about sort of how many other people are doing it, it's about what we can get our hands on.

Operator

Operator

Our next question comes from the line of Corinne Jenkins with Goldman Sachs.

Corinne Jenkins

Analyst · Goldman Sachs.

Maybe as a follow on to Louise's question, how do you think about Roivant's ability to add value to the assets that you're considering in those deals? And what do you view as the company's core competencies in that context? And then I was also wondering, you say that the environment is sort of in really good shape, it's the best it's ever been, but what metrics are you seeing that inform that comment and as the biotech market kind of has and hopefully will continue to improve, how do you expect the environment to go from here?

Matt Gline

Analyst · Goldman Sachs.

On the first I think it is unquestionably the case, but the thing we have done most in our history and best in our history is creative, thoughtful, aggressive clinical development. We've run 10 positive Phase 3 studies. We've run many, many Phase 2 studies. We've changed indication plans for programs where we thought that made sense. We've done -- we think quite good job at late stage development for programs that we were happy with the choice of indication. So I think, first and foremost, I think value we add when we look at a new program, I think the ability to be efficient, thoughtful and creative on development strategy, selection of indication and then just strong at execution, the ability to move fast, I think is also something we are really proud of. In terms of the environment, I guess first of all -- Yeah, we're watching the sort of change in the biotech market unfold. I'd say like there are certain kinds of opportunities like, people used to ask us all the time about the number of biotech companies trading under cash. Some of those dislocations are probably changing a little bit as people feel like they've got better access to capital. Some aren't. There are still plenty of companies out there that because they don't fit the exact current moment in time are still not sort of obviously in vogue. And so we're looking broadly and I think that's all sort of positive. That's the main driving factor of our opportunity set right now isn't biotech capital markets. It's what's going on in big pharma. And I'd say that is not changing. That is the level of EPS pressure, is significant. There are patent expirations coming a across a number of different pharma companies, frankly, most of the industry. And the IRA is forcing our partners to rethink their development plans in various ways. And I think that combination of factors means that R&D portfolio prioritization has to happen at these companies. And if you are a big pharma company and if you're reprioritizing your portfolio, what we think you want in a partner is the capital to run a good program, the execution to do a good job with it, and a willingness to be creative and thoughtful on structure to provide mutual benefit. And I think there is basically nobody else, at least in sort of biotech that has the track record at those things that we do. So we think that sets us up as a partner of choice for a set of partners that have real need.

Operator

Operator

Our next question comes from the line of Neena Bitritto-Garg with Deutsche Bank.

Neena Bitritto-Garg

Analyst

So just a question about the non-infectious uveitis study. Can you just remind us what the definition of failure is that you're using the study? I know in some of the other studies that's a kind of multifactorial definition. And then on CIDP data for batoclimab, just wondering what you would consider to be kind of a meaningful difference, from a dose ranging perspective between 340 milligram and 680 milligram?

Matt Gline

Analyst

On NIU, Mayukh or Frank feel free to chime in. I think our definition is kind of in line with the other definitions and I don't -- sorry, I don't have the exact definition right in front of me so I can sort of make sure it gets out there after the fact. But Mayukh or Frank, do you have the exact definition handy? No worries if not. And then on CIDP, again, I think this is a little bit of a balance of factors kind of a question. But look, I think what we've seen so far in CIDP is, like IVIg like response rates if I had to characterize them. And I think what we would hope to see in the higher dose is evidence that we can clear that bar something that looks sort of better to a patient's and provider and physician's eyes that than IVIg from an efficacy perspective. I think that's kind of where our general head is at on what we could be able to deliver there. The definition -- the primary definition is discontinuation or an inter-current event at week 24.

Operator

Operator

Our next question comes from the line of Yatin Suneja with Guggenheim.

Yatin Suneja

Analyst · Guggenheim.

Question maybe on VTAMA, could you talk about what you are seeing from a competitive dynamic, your efforts on the marketing front? You continue to invest similar dollar and what -- like how should we think about inflection with atopic dermatitis? What is the timeline around it and how much of the infrastructure bill you would have to build around AD? And also, could you also comment on the net yield? How should we think about calendar 2024 from net yield perspective?

Matt Gline

Analyst · Guggenheim.

I appreciate the question and they're sort of exactly the right ones. From a competitive dynamics perspective, I think we still look narrowly versus the other novel topical agents in psoriasis. I think we still see patient -- physicians choosing us, preferentially. The truth is as we've said, we've never been that focused on novel topical agents. We've always been focused on capturing share from topical corticosteroids. We've said historically is that continues to be work. The sort of high prescribing docs write the product all the time and are really excited about it. And then there's a long tail who write it 4x a month and think that's a lot and I think haven't sort of come around to our view yet that they can write it 50x a month. So we're working through those dynamics and I'm optimistic that behavior is changing over time. Yes, there's a couple other competitive events. Obviously one of our competitors recently launched a foam that doesn't directly impact utilization of our product. We're not being used a lot on the scalp anyway. I think that should be a good indication for them, but not something we're focused on. We've obviously done some work ourselves on a foam and we'll continue to think about expansion opportunities in that direction. As far as AD is concerned, it's just -- it's a huge market. And we are excited for our product profile, which we think bluntly is even more differentiated in AD even in psoriasis. AD is also in many ways the less developed and potentially faster growing market. And it's also a market that is more primed for novel topicals than psoriasis was because there have been a few more on the market ahead of us. And so we can also look to take…

Operator

Operator

Our next question comes from the line of Douglas Tsao with HC Wainwright.

Douglas Tsao

Analyst · HC Wainwright.

Matt, you indicated that you were sort of still sort of agnostic I guess in terms of therapeutic area after you did announce the Telavant transaction with Roche. You sort of said that having a much greater cash balance potentially positioned you to sort of take on big opportunities further into development. Does that influence where, or sort of certain therapeutic areas that you might favor? Because obviously you have could the outlines of such a strong I&I portfolio right now.

Matt Gline

Analyst · HC Wainwright.

I appreciate the question and thoughtful as always. I think first of all, we continue to appreciate the pleasing coherence we have in I&I, we think, but FcRn fits nicely with brepocitinib that namilumab and sarcoidosis is sort of hewing in the same directions. So look, I think to the extent that we see things in I&I that work for us, there's something nice to that. I think in many ways what our capital base and frankly our history of development in, remember some of our first Phase 3 programs we're in endometriosis and uterine fibroids and overactive bladder, which are not necessarily indications that we're jumping up and down about literally right now for new programs. But they're big studies and big indications and I think, we have a lot of history in that kind of disease state. One of the things that I think frankly differentiates us from many biotech companies is that our capital base allows us to do larger studies for broader populations. And so I think we will potentially take advantage of that both because those can be big opportunities and because there are opportunities that will sort of necessarily get passed over by smaller folks who don't have the capital position of the development experience take them on. So I think that is a competitive opportunity for us that we will be taking advantage of.

Douglas Tsao

Analyst · HC Wainwright.

And Matt, I guess as a follow-up, to the extent that you perhaps do pursue opportunities outside of I&I would you think about sort of new areas as ones in which you would want to start to build some scale? Meaning if you executed a new one single transaction as potential therapeutic area, would you be what likely looking to add to that?

Matt Gline

Analyst · HC Wainwright.

It's a discussion that we have internally as we look at our pipeline. And again, there are things that we see where we see a program and it makes more sense as a part of our portfolio, then it does sort of on a standalone basis. So I think, it's certainly possible as we build-out additional programs that they will become nexuses of scale. I think it's important to know, though, we evaluate every program on its own merits. We evaluate every program based on the data we've got, and I think we're going to pursue sort of value and risk over sort of therapeutic concentration per se. But, Mayukh, I'll hand it over to you.

Mayukh Sukhatme

Analyst · HC Wainwright.

Yeah, I think, look, I think as you've, seen from us, typically when we bring in a new program, I mean, it's sort of like by definition it's got to have enough heft to kind of stand on its own. I think that's the lens through which we look at it, that's the lens through which we sort of hire a team to sort of prosecute around it, we typically call it a new vent, but that's kind of how we think about it. And last night it's, I guess like I would say, I can't underscore the comment Matt made enough about capital being a major competitive advantage for us. Both in terms of I think like what that brings as a solution to a perspective pharma partner and that we have the sort of scale of capital that is meaningful to them. And that is unique to us. And so I think we view that as precious.

Operator

Operator

Our next question comes from the line of Robyn Karnauskas with Truist Securities.

Nishant Gandhi

Analyst · Truist Securities.

This is Nishant. I'm on for Robyn. Maybe on VTAMA GTN. You mentioned you see a steady -- slow and steady over a period of next year. You mentioned that last call, you see overall, you reach -- to reach 50% at steady state, do you still believe that to be the number for GTN long-term to this 50% steady state? And in terms of big picture for the company, how many assets would you retain over the long-term?

Matt Gline

Analyst · Truist Securities.

On the GTN question. Look, I think I have no real change for like the long-term steady-state guidance. I think it's going to take time and scale, especially because remember, a meaningful portion of the remaining yield accretion comes from volume, which is really just going to take some time to build up to. So -- but I think our guidance of 50% is sort of the same as let's say, every other biotech launch program. And I think the trends that buffet us will be largely the same as the trends that buffet other programs. So no change to sort of long-term steady-state guidance per se. And then assets that we retain for the long term, I think the short answer is we bring in programs that we are excited to invest in, that we believe will be important commercially, that we believe we will generate important clinical data on. And basically, everything we bring in, our plan is to retain it and develop it. And I think the thing that throws us off that trajectory is just the information we learn along the way, both in terms of the quality of the data that we generate and in terms of what other people think of the program and what their plans might be. But I think if you gave me a crystal ball, and it showed that we kept all of the programs in our pipeline, and they were sort of commercial opportunities for us down the line, I'd be pretty excited about that. I just -- I think we will continue to be ruthlessly economic along the way. And some of the targets we're working in a really attractive target, not just to us but to prospective partners. So I think that could -- that's the kind of thing that takes us off that path.

Operator

Operator

Ladies and gentlemen, at this time, I would like to turn the call back over to Matt for closing remarks.

Matt Gline

Analyst

Thank you, everybody. Thanks for listening. Thank you, operator, for moderating. Thanks to all our analysts and obviously, to the -- to all of our investors and to the entire team at Roivant. We appreciate another quarter with a lot for us to be proud of and a lot to look forward to in building year for 2024. So yes, looking forward to getting back on the phone. I'm sure we'll do it multiple times to come, and I will speak to you all soon.

Operator

Operator

Ladies and gentlemen, this concludes today's conference call. Thank you for your participation. You may now disconnect.