Ladies and gentlemen, thank you for standing by. I'm Melinda, your PGI call operator. Welcome, and thank you for joining Qiagen's First Quarter 2024 Earnings Conference Call Webcast. [Operator Instructions] Please be advised this call is being recorded at Qiagen's request and will be made available on their Internet site. [Operator Instructions] At this time, I'd like to introduce your host, John Gilardi, Vice President of Corporate Communications and Investor Relations at QIAGEN. Please go ahead.

Thank you, operator, and welcome to all of you for joining us on this call. We appreciate your interest in QIAGEN. Our speakers today are Thierry Bernard, our Chief Executive Officer; and Roland Sackers, our Chief Financial Officer. This call is being webcast live and will be archived on the Investor Relations section of our website at www.qiagen.com. You can also find a copy of the quarterly results press release and the presentation on our website. We will begin with remarks from Thierry and Roland, followed by a Q&A session. Before we start, let me note again that we are going to host the Capital Markets Day on June 17, and the event will be held at the New York Stock Exchange. An invitation has already been sent out and information is available under our website under the Events section. You can also attend this event online, but we'd love to see you in person. Let's now go over our safe harbor statement. The views expressed during this conference call and the responses to your questions represent the views and perspectives of management as of today, April 30, 2024. We will be making statements and providing responses to your questions that convey our intentions, beliefs, expectations and predictions for the future. These forward-looking statements fall under the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. They involve risks and uncertainties, and actual results may differ materially from those suggested by these forward-looking statements. Factors that could influence results are mentioned in our filings with the U.S. Securities and Exchange Commission. These filings are available on the SEC's website and also on our website. QIAGEN disclaims any intention or obligation to update any forward-looking statements. Additionally, we will refer to certain financial measures not prepared following generally accepted accounting principles or GAAP. All references to EPS or earnings per share refer to diluted EPS. You can find a reconciliation of these non-GAAP financial measures to the most directly comparable GAAP measures in our press release and the presentation. Now I'd like to hand over the call to Thierry.

Thank you, John, and good morning, good afternoon or good evening, depending on where you are in the world, to all of you. Thanks for joining us. We are very pleased today to report another solid quarter in which our teams focused on execution and delivered results ahead of our plans. This passed [indiscernible] the cautious capital spending environment among our customers, our results show that we are on track to achieve the goals for 2024. Let me share our key messages today with you. First, our results for the first quarter of 2024, we are ahead of the outlook as we worked through the final quarter of pandemic COVID-19 headwinds. QIAGEN achieved net sales of $462 million at constant exchange rates, which was ahead of the outlook for at least $455 million CER. This represented a 5% decline from the first quarter of 2023. And sales were down 1% CER for the non-COVID product groups. Recurring consumable sales continued to account for more than 85% of total net sales, a signal of the durability of our sales base. One of the highlights of Q1 was the 5% CER growth of our Diagnostic Solutions product group. This confirmed the strength and resilience of our portfolio mix as we saw double-digit sales growth for the QuantiFERON TB test and for the QIAstat syndromic testing system amid solid placement. Adjusted earnings per share were $0.47 at CER and ahead of the outlook for at least $0.44 CER. As a second key message. Our teams executed on our balanced and focused strategy and delivering growth in many pillars. This really creates a foundation for us to build momentum during the year. QuantiFERON once again delivered a strong quarter with 11% CER sales growth, fueled by positive demand trends in every region. The first…

Thank you, Thierry. Hello, everyone. Thank you as well from me for joining our call. Our results for the first quarter were ahead of our goals and show QIAGEN is building momentum. Net sales of USD 459 million declined 5% at actual rates and also 5% at constant exchange rates despite some modest pressure on results due to the strengthening of the U.S. dollar. Consumables and related revenues had to absorb the COVID headwinds from 2023 and this led to the 4% CER decline over the year ago period. Instrument sales declined 9% CER, reflecting the challenging environment for capital purchases. At the same time, we saw good placement trends for QIAsymphony, QIAcuity and QIAstat-DX systems. Among the 4 product groups, Diagnostic Solutions led the performance. Here again, we saw double-digit gains for QuantiFERON and QIAstat-Dx, while our personal healthcare business also delivered single-digit improvements over the first quarter of 2023. In sample technologies, as mentioned earlier, we were pleased to see higher consumable sales for automated kits. The results for sample technologies take into consideration that we, along with other companies, had larger price increases at the start of 2023. This year, the price increase was more in line with our historical levels of a low single-digit increase. Additionally, we faced COVID-19 headwinds with an underlying sales decline at a modest low single-digit CER rate. We are anticipating improved growth trends during the year as we launch marketing initiatives to highlight the differentiation of our portfolio. Additionally, the decision by Congress for essentially flat federal funding for life science research in the U.S. budget was in line with our planning, and this outcome provides customers with clarity on budget. In PCR/nucleic acid amplification, the QIAcuity digital PCR system continued on a solid trajectory, delivering solid double-digit CER sales growth…

Thank you, Roland. Now let me take a moment to go over some of the progress our teams have made in advancing our portfolio. First of all, we are strengthening our dominant position in sample technologies, the first step in lab processes to gain access to DNA and RNA. Key expansion areas for QIAGEN involve new kits to support customers in fields like microbiome or liquid biopsy. Those areas are increasingly becoming critical to life sciences research and are in the early stages of clinical application. Let me start, for example, with the launch of the PAXgene Urine Liquid Biopsy Set, which offers a new noninvasive approach to collect cell-free DNA from urine. This technology holds potential for detecting minimal residual disease such as in cancer patients and improving the identification of therapeutic targets and patient monitoring for disease progression. Another example is that QIAGEN has a long-standing commitment to helping improve health for people around the world. QuantiFERON for latent TB screening continues to be a key element in the global fight against tuberculosis, which remains a leading cause of death. Recent tuberculosis outbreaks in the U.S. such as in Chicago or in San Diego, underscore the urgent need for robust screening measures. These outbreaks, particularly among immigrant population and in areas with already high tuberculosis incidence rate, highlights the importance of proactive screening initiatives. This is why we continue the conversion to modern blood-based testing from the old skin test and the majority of the market worldwide and in the U.S. is available for this conversion. In March, our global awareness event to support World Tuberculosis Day was a great success with over 3,000 participants, underpinning the significance of collaborative efforts in raising awareness. Additionally, we announced a new partnership with the International Panel Physicians Association to reinforce…

Thank you Thierry. Let me now provide more perspectives on our outlook for '24 and also for the second quarter. The start of the year shows that we are building momentum to achieve our full year outlook for at least $2 billion of sales at CER. This represents at least 2% CER growth from the $1.97 billion in '23 and also at least 3% CER growth in the non-COVID portfolio. The plan for '24 remains on track. Like others, we expect a more muted start and return to solid mid-single-digit CER growth in the second half. We continue to expect growth in the QuantiFERON TB test of at least 10% CER while also expecting double-digit CER sales improvements from QIAcuity and QIAstat-Dx. Our QIAGEN Digital Insights business is also set to deliver growth at a double-digit CER pace for the year as well. In terms of profitability, we have reaffirmed our outlook for adjusted EPS of at least $2.10 at constant exchange rates. The key profitability driver is our expectation to reach at least 28% adjusted operating income margin for '24 and up at least 1 percentage point from 27% in '23. This reflects our commitment to operational efficiency while investing in R&D and new product development and commercialization. As for currency movements and based on rates as of April '26, we expect a neutral impact on full year net sales, but for an adverse impact of about $0.01 per share on adjusted EPS results. For the second quarter, we have set an outlook for net sales of at least USD 495 million CER and adjusted earnings per share of at least $0.50 per share also at CER. I would like to now hand back to Thierry.

Thank you, Roland. And we are now getting closer to the Q&A session. So let me just provide you with a quick summary. First, we are fully on track to achieve our goals for 2024. Our execution on our balanced and focused strategy anchored by our pillars of growth has been instrumental in navigating those uncertain times. The anticipated decline in sales for the first quarter was less than our initial expectations and the results demonstrate the effectiveness of our strategic initiatives. In this quarter, we are particularly pleased with the double-digit sales growth for QuantiFERON, for QIAstat Diagnostic and for QIAcuity. This is a real testament to the strength and resilience of our diversified portfolio led by 85% of sales from highly recurring consumables. Another message is that we are pleased with the very good level of profitability. Our teams are committed to delivering on the full year adjusted operating income margin target of at least 28%. Efficiency initiatives are helping to create more flexibility and enhance our effectiveness across the QIAGEN organization. All of those actions are positioning QIAGEN for solid midterm growth as we deliver higher sales and improvements in profitability. I take advantage of this call to personally invite you again to attend our Capital Markets Day event on June 17 at the New York Stock Exchange. This will be an opportunity to meet with our leadership team and learn more about our strategy to deliver our midterm ambitions for improving sales and profitability. I am personally really looking forward again to seeing all of you in person. With that, I'd like now to hand back to John and the operator for the Q&A session. Thanks a lot for your attention.

[Operator Instructions] And we'll take our first question from Matt Sykes with Goldman Sachs.

Maybe just to start out, just on QuantiFERON, it's been a pretty strong engine of growth for you previously. And looking at the first quarter results, just want to gauge sort of the phasing of growth for QuantiFERON over the course of the year to reach that greater than $450 million target that you set out, and just is the Oman collaboration that you announced in January a part of that guide? Or is that potential upside?

So thanks for the question. So directly on Oman, yes, it's part of our guidance for 2024 since we announced it. We are currently deploying the solution together with the Oman authorities, so it goes per plan, as we said before. And now on the phasing, you know that traditionally QuantiFERON accelerates starting in Q3 and Q4 for many reasons. First of all, because we have a lot of local initiatives in different countries, such as, for example, the back-to-school initiatives in the U.S. So we always expect basically a weaker Q2 and then an acceleration again in Q3 and Q4. And at this moment, we are well on track to achieve the guidance that we gave you.

Got it. And then just on cash flow, which was really strong this quarter. Maybe just talk about sort of further improvements. It looks like working capital and lower accounts receivable was the main driver of the operating cash flow. Just maybe talk about your expectations for free cash flow generation. And then Thierry, from a capital allocation standpoint, maybe just kind of -- sort of go over your priorities over the course of this year as it relates to debt, M&A, organic opportunities?

Thank you. So I will propose that Roland takes on the cash flow generation, and I will come back to you on the capital allocation. Roland?

Yes. And before I go to the cash flow, just also -- just to your first question. Have in mind, of course, but Thierry was describing was clearly the relative growth numbers, absolutely. And sequentially, we're clearly also going to grow here also from the first to the second quarter. But for us the second quarter last year, clearly was a quite strong one. Having said that, on the cash flow, we are very pleased with the full year. It's clearly important to have a good start and our operating cash flow will be probably somewhere in the mid of $500 million plus and free cash flow probably at least $350 million. I do think there is a potential for upside, a single biggest opportunity for us is clearly also inventory levels. It's quite obvious that right now, we maintain more or less an all-time high inventory level driven by -- on the one hand side, the logistical channels shows, but also some of these political reasons and variability we see around China and others. We do believe that things have an opportunity to normalize in the second half of the year as well, that would be an addition.

Thank you, Roland. On capital deployment, so around the 3 main axis for capital deployment, I think that QIAGEN still prioritize organic investment and R&D or growth with our investment in R&D. You know that we have a ratio which is slightly above 10% of R&D, research and development investments to sales. But we want also these investments to be profitable. So I would say priority to profitable organic investment. You know that we have also a very healthy balance sheet. So we are constantly looking at potentially accretive and synergistic acquisition, mainly bolt-on. We have several discussions ongoing. It's too early to give details, but it's clearly a priority. And third, obviously, anytime we see a good opportunity to return value to our shareholders as we have proven, for example, with the recent share buyback, we will not hesitate to do that. But that would be basically in order of priorities.

Our next question comes from Aisyah Noor with Morgan Stanley.

I have 2, please. First is, what's your view on the U.S. lab developed tests or LDT ruling released by the FDA recently. And can you give us the sense of your exposure, whether that's what portion of your test classify as an LDT or your exposure to reference labs across the business. If you could just help us quantify your exposure that could be really helpful. The second question is on NeuMoDx. I appreciate you're planning to update us on the business in June. But at this stage of the review and of the outcomes you've considered, which appear most likely? And could you remind us on the margin profile of the NeuMoDx business, please?

Thanks, Aisyah. And so first question on LDT. First of all, it's a bit premature to comment. You know that the text was issued by the FDA only yesterday. As a reminder, it's 532 pages long text. So it takes time to proceed. But a couple of points to highlight. This is not new. The FDA has been saying for many years that they believe that they have an oversight of laboratory developed test. Second, from what we have seen so far, the text issued yesterday is much softer than the first version that we saw towards the end of 2023. In that version, if you remember, no tests were grandfathered. The option for grandfathering does exist in the new proposal. Third, the exposure of QIAGEN is very limited, not to say not significant at this moment. I even believe that it will reinforce the positioning of companies like QIAGEN which are supplying quality components to laboratories or industries that are developing LDTs. And fourth, when I say it's premature, it's because everybody is expecting some litigations to start now as we know that several major actors in the U.S., especially the association of laboratories are probably not in agreement with this proposal. Too early to say. On NeuMoDx, we confirm that we will take a definitive stance by June 17. We continue to look on or to work on several scenarios. As we said previously, both of those scenarios, whether finding partners or shutting down the activities are accretive to our P&L. They are accreting from a gross margin standpoint, EBIT margin standpoint and EPS as well. This is what I would say today and more details on the decision by June 17.

Our next question comes from Michael Ryskin with Bank of America.

Congrats on the solid year. I want to ask a little bit about underlying market conditions. As you [indiscernible] quarter end, you talked a little bit about the demand patterns you're seeing from pharma and biotech and also from [indiscernible] government with your comments on flat U.S. [indiscernible] budget. Just any update on how the first 3, 4 months of the year have played out? And if there is any change relative to your expectation as you go through the rest of the year is still very uncertain time?

So Michael, I must confess that your voice was seriously muffled. I understand that you are asking about the market conditions. So if I got right, but do not hesitate to come back, market condition especially academia research. I think Roland alluded to that first point that I would say, at least in the third quarter, we get clarity or we got clarity on the level of public funding, for example, the budget for the NIH, but also in other countries. We know that it's going to be flat. This is exactly what we factored in our budget 2024. We highlighted in our call this morning that we continue to see a certain cautiousness in our customers for capital spending for capital expense, which is not a surprise because as you know, Michael, there are so many, so many countries going to election this year that elections are always creating a bit of attentisme. We see this or we plan this to improve as those elections are coming behind us, and we are progressing towards the end of the year. That's what I would clearly highlight. We expect the market to slowly ramp up sequentially. We said in the press release this morning -- yesterday and this morning that we do not expect the Chinese market to bounce back anytime soon, at least not before 2025. So at the moment, the market environment fits what we did factor for 2024.

That's helpful. And I think my [indiscernible] Hopefully, this is easier [indiscernible]. A quick follow-up. I wanted to just specifically touch on insurance portfolio. I know that is a very small part of the overall business, [indiscernible] challenge. If you could provide any color within that? You've got a couple of different product lines that fall in the instruments [indiscernible] by complexity of the instrument by ASP, just any change in that [indiscernible] as you start the year?

Absolutely. I don't know John, if you can help me, but from where I am, here in Boston, the voice is too muffled. I didn't get half of the question, at least. There's a lot of background noise.

I probably -- First of all it was not easy to understand, I agree. No, it's about instrument portfolio and growth rate. And I do think while we see as many other companies that overall, the instrumentation business is given the overall market environment clearly not the easiest one in these days. At the same time, that particular instruments like our QIAcuity and QIAstat with price points rather around $30,000, $40,000 actually are still in a quite normal environment. Once an instrument costs more than $100,000, it gets more difficult. So I would say, overall, while it's a quite difficult environment for the more expensive instruments given our exposure in particular to the QIAcuity's, QIAstat's, and QIAcube's [indiscernible] world, we feel quite comfortable going to 2024.

We go next to the line of Hugo Solvet with BNP Paribas.

I have 2, first on QIAstat. Thierry, thank you for the comments around the fact that your teams are working closely with the FDA, just -- can you maybe help us understand your level of confidence in getting an approval by the end of June to roll out the test -- the gastro test by -- in H2? And on QIAstat can you maybe give a bit more color on the placement trend? And second, on regulation, can you share your thoughts on the FDA process to [ down ] classify high-risk IVG test.

Thank you Hugo. So first of all on the level of confidence for the GI approval. Hugo, what I can say is that we have submitted all our data to the FDA and since our later submission, we didn't get any more questions and data was solid and good. They were solid in terms of analytical performance, and they were solid compared to competition. So now obviously, I cannot speak on behalf of the agency. We are in constant touch. We will continue to do so because it's important for QIAGEN to get this test approved. This is the only thing I can say. I cannot talk on behalf of the agency. Based on our data, I'm confident. On QIAstat, on your questions for the trends of placement, as we said in the press release, it's a healthy trend. We are over the 100 units for the quarter. But what is all the more satisfying for us is, one, to see the growth at more than 20% in many of our panels and not driven by COVID. So I'm referring to GI in Europe, for example, to meningitis. And two, the fact that despite having only one panel available in the U.S. that we are still able to place instruments. That's very encouraging. Third, on the FDA, I wouldn't say downgrading, but making it easier on some test or moving them from PMA to 510(k). I think it's acknowledgment from the agency that they need to keep moving in bringing added value test. I remind everybody that a 510(k) submission is not trivial either. You still need to submit a significant level of clinical data. You still need to go through a review. And so I don't say it's downgraded. It's just the FDA willing to move ahead on basically approving added value test. But both submissions take time and take clinical data.

We'll go next to the line of Patrick Donnelly with Citi.

Thierry, maybe a follow-up on the China piece. I think you guys have a few different verticals there, both life science diagnostics and then the QIAGEN brand, the private label brand. Can you just talk a little bit about going through each of those, what you're seeing? Are there different trends in China and just expectations as we work our way through the year there? Does it sound like you're overly optimistic on improvement, but I just want to talk through the outlook of the year there.

Well, I wouldn't say, Patrick, optimistic or pessimistic, I would say coherent. We keep saying the same thing since 2023, where we said that we would never expect the Chinese market to bounce back any time soon. And we always said, at least not before end of 2024 and probably more 2025, and we maintain that position. The Chinese market is in a transition phase post COVID that is impacting both life science and clinical diagnostics. QIAGEN has a relative limited exposure, it's 6% of our revenues. And we have, I think, the strategy that is needed to tackle the need of the Chinese market, which is, first, investing into local R&D and manufacturing any time this makes sense. Second, having a double brand or second brand, which is serving exclusively the Chinese customers with Chinese product. We are obviously monitoring all the initiatives taken by the Chinese authority to try to boost their market, especially the recent capital investment initiative. It's too early to say what's going to be the impact, but we are fully and closely monitoring it. So for us, China in 2024 is on track with our expectations. We don't see any bounce back. And as I said many times before, starting 2025, this market should represent a mid-single-digit growth opportunity for a company like QIAGEN.

Okay. That's helpful. And then, Roland, maybe one on the margins. You obviously had a pretty healthy ramp throughout the year, which is pretty [indiscernible] you guys. But can you just talk through the moving pieces as we work our way through that higher exit rate on the margin side and the key variables and visibility into the execution there?

Yes. Well, I think overall, as you said, a good start into the year. We also expect already that the second quarter has another ramp in terms of operating income adjusted, clearly going nicely to the 27% range. So I do think there's a good ramp. And therefore, I think also visibility for the rest of the year that we make or at least 28%. While we believe that R&D investment stays around about 10% of -- for the full year, probably a bit lower relatively in the fourth quarter, there's still leverage opportunity around SG&A, where, again, we clearly still -- utilization come from our digitalization efforts, but also scale, of course, is going to help there as well. So overall, we continue to see margin improvements options, not only for '24, but also beyond. And of course, we're going to talk about that on our Capital Markets Day. Tax rate was a bit higher in Q1. I would assume that normalized over the rest of the year as well. So as I said, so far, I would say the start was quite healthy for us.

Next, we go to Jack Meehan with Nephron Research.

Maybe just to start, I was -- I want to dive into the genomics results. Can you talk about visibility in the QDI contract timing you called out in the release and just the path to getting back to growth for that business for the rest of year, what your visibility is?

So Jack, it's very simple. The Q1 was mainly due for -- to a timing of revenue recognition. And basically, it's even for one contract, you know that in this QDI business sometime we have last contract, especially with pharma. That doesn't question at all. First of all, the investment plan that we explained to the market 6 months ago. And that doesn't question at all, our goal for double-digit growth for the rest of the year. So it's just a question of timing of recognition.

Okay. Great. And then on QIAcuity, can you talk about a little bit more on some of the key menu that you expect to roll out throughout the year? And just like what that should mean in terms of the pace of growth within the PCR line?

Well, we believe, as we said many times, Jack, that this solution has a double-digit growth potential. I'm referring to the digital PCR QIAcuity line. And when I say double digit, it's much closer to the 20% than the, let's say, low double digits, number one. Second, as you know, we have an extremely differentiated company, we offered many workflows and systematically, since the last -- or for the last 3 years, we developed a menu first for life science. And it really made a difference, started 1.5 years ago when we started to have biopharma implication. Now we are moving also to cell and gene therapy application and QC control for pharma. But remember also that we remain committed to launching this solution for the clinical market. We want QIAcuity to be FDA approved. We expect this -- the platform to be FDA approved. We expect that for -- this for 2024. And then the plan is to launch menu around hemato-oncology panels like BCR-ABL, for example. So that's the plan that we confirm. And this is where we want to go, both life science and research and clinical application.

We'll go next to Catherine Schulte with Baird.

Maybe first on the academic side. You mentioned the NIH budget came in, in line with your expectations. We have seen a slowdown in NIH outlays in the last 2 quarters. So could you just talk to what you're hearing from customers in that end market?

Well, as we said before, Catherine, if you compare, for example, 2023 with '24. In '23, we did budget for roughly a 3% increase of the NIH budget, and we were right. This year, we were more cautious for different reasons, the economic context, the political context and we said flat, and we were right as well. We continue to have extremely active collaboration with the NIH in the sense, for example, that you have heard about the recent detection, for example, of H5N1 in milk, for example, this is a field where we collaborate with the NIH. You have seen also the previous discussion, especially in February around the detection of Clade I and Clade II for monkeypox decision of the field where we collaborate with the NIH. We have an [ ample ] of fields where we can collaborate with this major research from components, oligos, enzymes to finished product, whether it is PCR or digital PCR. So it fits what we planned for the year. We believe that I cannot speak on behalf of the American authorities, obviously, but it's a kind of a transition period. And it's clear that I haven't seen the U.S. authorities saying that they don't want to invest in high-value technologies or research and development for the future. So we are still confident that this funding will bounce back at a point.

Okay. Great. And then in sample tech, how does the non-COVID business perform outside of China? And what's your outlook for sample tech for the second quarter? Should we see a return to growth on a non-COVID basis? Or will that be more of a back half event?

I would prefer, as Roland said, to say that we still expect low to low-single-digit growth throughout the year. It's too early in the quarter. You see, as we explained, I mean, we are impacted here by weak demand in China. Obviously, the COVID impact. But on the non-COVID, we are pleased on one hand with the placement of instruments. Now we need to accelerate the consumables, both manual and automated, the market is moving probably faster into automated sample tech. But once again, I ask you to see the sequence of growth through the full year, not just on quarter 2.

We go next to Falko Friedrichs with Deutsche Bank.

So the Roche CMD is coming up now in May, everyone's looking forward to see if they do anything on the latent tuberculosis side of things. Irrespective of the decision, can you just briefly remind us why you still believe that you'd be sitting on a great business here that you can grow further even if they were to enter that market? And then related to that, if they decide to enter the market, would that change anything with regard to your further rollout strategy?

Thanks, Falko. I cannot talk on behalf of any competitors. I'm talking for QIAGEN, and I know that we have built what is the most automated -- universal automated workflow for latent TB detection. Many people have in mind the agreement with DiaSorin, which is key and has proven extremely efficient since we executed on it. But it starts also on the pre-analytical step with agreement with Tecan and Hamilton. There is no comparison on the market at the moment with that workflow. Second, as you have seen also recently, Falko, we continue to invest on the product itself. The fourth generation did replace the third generation and we continue to get publications in peer reviews on this fourth generation. Overall, since we have launched latent TB QuantiFERON. It's more than 3,000 publications. It's unprecedented. Third, there has been competition for many years for QuantiFERON. The main one is an antiquated technology called skin test. And that market is still underpenetrated, probably below 40%. So the potential to convert is still significant in the U.S., obviously, but also in other markets. And beyond skin test, the emergence or the presence of other competitors independent or not, never really changed the growth rate of QIAGEN all our market shares. So do not take this for complacency. We monitor the market very well, but we have not seen anything concrete yet. What I know is we continue to invest on our solution on the market conversion, and we believe that we are still very well positioned to lead that market.

Next, we go to the line of Dan Leonard with UBS.

I have a follow-up to an earlier question on your sample tech business. Has your level of conviction that sample tech can grow low single digits for the year. Has that level of conviction changed at all in the past 3 months?

No. As we have said, we reiterate that vision for the full year, once again, 2024. We are spending significant marketing time and analysis to understand the trends of the market worldwide. And so far, this basically confirms that assumption. So no change for the moment.

And then my follow-up, Thierry, you mentioned H5N1. How are you thinking about QIAGEN's ability to respond if there is a greater need for testing for H5N1 either in livestock or God forbid humans?

So as usual, we are extremely proactive with every relevant authorities. I spoke about the NIH before, but it's not only the NIH to discuss proactively about, one, the situation without panicking. And second, the solutions. And as I said before, what is very interesting with QIAGEN is that when I say solutions, it's not just about a kit. If the NIH decided to develop their own kit or the CDC, they will use QIAGEN components. So we can answer from component to finish kits, whether these kits is on a PCR format, on a digital PCR format or a next-generation sequencing format. You know that during the first major outbreak some years ago of H5N1, QIAGEN was 1 of the most relevant companies to step up to this challenge. And we will continue to do the same. We are very vigilant on H5N1 on the development of Monkeypox as well. And so we are ready and constantly negotiating and discussing with those agencies.

We go next to Doug Schenkel with Wolfe Research.

A very quick follow-up on QuantiFERON. Thierry, I think you described really well the focus in the investment community on competition is -- it's not like we unearth something that you haven't been thinking about for years. You've been competing against legacy approaches. There's an existing IGRA competitor on the market. With that in mind, is it fair to say you're going to describe in detail the CMD, not just how you stack up clinically and from a process perspective compared to alternatives, but you'll also talk in detail about efforts you've made to contractually lock in customers based on the strength of your assay and anticipating potential competition that gets broader. Is that a fair assumption?

It's a very clear assumption, Doug. It's such a key product for us that the CMD plans to give indeed details of what our expectations for the coming years. We are also very much monitoring the situation of our contract. So we will give details on the percentage of contracts that are locked into preannual contracts so that you will see really that there is no complacency. There is extreme vigilance. There is investments and there is confidence that this can continue to be a growth driver for our company.

Thank you for that. And then just a quick question on the quarter. Other companies have reported at least those that have reported thus far, a slower-than-expected start to the year when it came to lab activity and reagent demand. And then it seemed to indicate that there was a pickup in activity in March and April. I just want to be clear, did you guys see the same thing? And if so, is a continuation of that trend fully reflected in guidance assumptions? Or are you waiting for the trend to extend for a longer period of time before you would factor something like that into your guidance?

I think, Doug, Roland alluded to that during the presentation in his part. There is softness on the life science market, not just for QIAGEN. If you look at competition, I believe that we outperform competition and competition results in terms of growth. And there is more dynamism at the moment on the clinical market. The softness in life science mainly translates into cautiousness on capital expense. And as we have explained, for us, it was planned, we did even better than what we expected on Q1. We did better than the competition that have reported the results, at least those that are completely comparable to QIAGEN. And as we said and Roland as well, we reaffirm our guidance. So we see -- seeing quite solid improvement. This is where we are at the moment.

We'll take our last question from Dan Brennan with TD Cowen.

Maybe first one, just on PCR amplification. I know there was a question earlier on the digital PCR portfolio. But after the 12% decline in 1Q, I know the press release says you expect the business to improve through the year. What's assumed for the base business ex digital PCR and kind of what drives that improvement as you see it progress through the year?

Because we have such a wide portfolio in PCR, I'm not talking digital PCR, which is made of older technologies, newer applications that overall, we believe that the trend will follow the market trend in our sequential improvement expectation. So do not forget that we have a significant installed base also, which is driving this assumption. So this is confirming what we have said. But again, Dan, clearly, in PCR because we focus and because this is also a symbol of that new QIAGEN for the last years, the efforts in R&D, the efforts in presence on the ground, marketing and sales will not go overall for the PCR portfolio. It will go to the digital PCR portfolio because this is where we can really take a #1 or -- #1 position on the market. So that's the allocation of priorities. And this is what you will see also clearly on June 17.

Maybe related to that, is it reasonable to think you'll roll out kind of new multiyear growth and/or margin targets in June? And kind of can you step back? And what are the goals for the Investor Day?

I think the John and Roland can chime in as well. The goal for the Investor Day is to go on the ambitions top line and also bottom line for the coming 4 years is to show why we do believe that we have significant growth drivers in our portfolio, and we will show clear numbers here. But we also believe that QIAGEN needs to accelerate on improving profitability, and we want also to show with what kind of efficiency measures we want to achieve that. And obviously, it's also an opportunity for you guys to meet also part of the new management of QIAGEN. You know that we have brought different new manager at the Executive Committee, a new Head of Operations, a new Head for Life Science, a new Head for Clinical Diagnostics. And you will see also those last 2 ones, Head of Life Science and Clinical Diagnostics on stage and giving their also assumptions for the growth of their respective portfolio.

Thank you, Thierry, on that point. Again, we look forward to seeing you on June 17 in New York at our event. And if you have any questions or comments in the meantime. Please do not hesitate to reach out to us. And thank you again for your interest in QIAGEN. Bye-bye.

Ladies and gentlemen, this concludes the conference call. Thank you for joining, and have a pleasant day. Goodbye.