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Qiagen N.V. (QGEN)

Q3 2014 Earnings Call· Wed, Oct 29, 2014

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Transcript

Operator

Operator

Ladies and gentlemen, thank you for standing by. I am Sachi, your Chorus Call operator. Welcome and thank you for joining QIAGEN’s Conference Call to discuss results for the Q3 of 2014. At this time, all participants are in a listen-only mode. Please be advised that this call is being recorded at QIAGEN’s request and will be made available on their Internet site. The presentation will be followed by a question-and-answer session. (Operator Instructions) At this time, I would like to introduce your host, John Gilardi, Vice President of Corporate Communications at QIAGEN. Please go ahead.

John Gilardi

Management

Hello and welcome to our conference call tonight. Our speakers today are Peer Schatz, the CEO of QIAGEN; and Roland Sackers, our CFO. Before we begin, I’d like to thank all of you for participating today at this unusual time for QIAGEN results call. The reason for the change was our supervisory board meeting this week at our Silicon Valley site. We will return to our traditional schedule with the fourth quarter results in January. On Slide 2, you’ll see the customary disclaimer. The discussions and responses to your questions on this call reflect management’s views as of today, October 29, 2014. We will be making statements and providing responses to your questions that state our intentions, beliefs, expectations or predictions of the future. And these constitute forward-looking statements for the purpose of the Safe Harbor provisions. These statements involve risks and uncertainties that could cause actual results to differ materially from those projected. QIAGEN disclaims any intention or obligation to revise any forward-looking statements. For more information, please refer to our filings with the U.S. Securities and Exchange Commission. I would like to now hand over to Peer.

Peer M. Schatz

Management

Thank you, John. Hello and welcome to our call today to discuss results for the third quarter and also for first nine months of the year. Our teams at QIAGEN are moving ahead to accelerate the pace of innovation and growth and we have three messages for you today. First, we achieved our target for the third quarter. As you saw in the press release, adjusted net sales rose 4% at constant exchange rates in the third quarter and this was in line with our communicated target for about 4% to 5% growth. These results include the expected decline in sales of our U.S. HPV test portfolio, which created about 5 percentage points of headwind in the third quarter. In other words, our growth excluding the HPV headwinds in the U.S. was 10% at constant exchange rates. In terms of earnings, the adjusted operating income margin remained at 25% while adjusted EPS was $0.27 per share and at the high-end of the guidance set for $0.26 to $0.27 per share. We also had strong free cash flow of $72 million in the quarter. Second, we are moving ahead on initiatives to accelerate innovation and growth, especially among our growth drivers that are creating a foundation for sustainable and long-term expansion. These products together are growing at a solid double-digit pace, now providing about 30% of our total sales. There were many recent achievements, but I’d like to quickly highlight the advances in Personalized Healthcare. First, you saw the news this week about our eighth master collaboration agreement and this was with Astellas Pharma of Japan. The Astellas collaboration involves a range of drug candidates in several therapeutic areas. Furthermore, this is another partner gaining access to our development capabilities and full workflows for both tissue and liquid biopsy processing and…

Roland Sackers

Management

Thank you, Peer. Good evening to everyone in Europe and good afternoon for those joining from the U.S. I’m now on Slide 7 and would like to review our results in more detail. In terms of adjusted net sales, we delivered 4% growth at constant and actual exchange rates for both the third quarter and for the nine months period. And this is only a small currency impact; however, we expect this currency trend to become negative in the fourth quarter and I will touch on that later with our guidance. For third quarter about one percentage point of total sales growth came from the CLC and BIOBASE bioinformatics acquisitions while about 3 percentage points came from the rest of the business including ingenuity. And for the first nine months, the 4% constant exchange rate goal has been balanced between contributions from the bioinformatic acquisitions and the rest of the portfolio. Adjusted operating income rose 7% in the third quarter at a faster pace than sales and resulting in the 50 basis points increase in the adjusted income margin compared to a year ago. In terms of margin gains, we were able to maintain the adjusted gross margin at 72% and also absorbed higher R&D investments which were about 12% of sales in the 2014 quarter compared to about 11% a year ago. Sale and marketing expenses also declined slightly compared to a year ago, while margin benefits also came from efficiency improvement in general and administration. For the first nine months of the year, we saw a similar trend in terms of adjusted operating income, generating an 8% improvement over the same period in 2013. The adjusted operating income margin showed about 80 basis points of improvement in the 2014 period and that is after observing about 20 basis…

Peer M. Schatz

Management

Yes, thank you Roland and now on Slide 10 to the review of a few of our growth drivers that continue to deliver a strong double-digit gain and now represent about 30% of total sales and we expect this increase to about 40% in 2015. On the QIAsymphony automation platform, we are moving ahead to deliver 250 new placements in 2014, which would put us at about 250 cumulative placements at the end of the year making one of the most widely placed systems it’s not the most widely placed system for medium throughput molecular processing. A key driver is the expanding menu of the addition of seven tests so far in 2014 in the United States and Europe on the Rotor-Gene Q that’s PCR component of the workflow with growth of about 20% at constant exchange rate and on track to achieve $100 million in 2014. QuantiFERON has already surpassed the size of our U.S. HPV franchise and is now slated to top our global HPV franchise. We expect 20 constant exchange rate – growth rate into 2015 and beyond based on the strong demand for this product as a new goal standard for latent TB. The total addressable market for QuantiFERON is actually expanding. We have told you before about the U.S. Preventive Services Task Force guideline, review that in underway in the United States and that will take a few years to be completed. We also mentioned that clinical data has been showing the need for testing a people with type 2 diabetes, both would have a big impact on the total addressable market for latent TB testing. And in particular for QuantiFERON-TB Gold since it was the key test to demonstrate this. The biggest impact and – what is new just as of Tuesday is the…

Roland Sackers

Management

Thank you, Peer. I’m now on Slide 15 to review our guidance. For the full year we have tightened our adjusted net sales target to 4% at constant exchange rates, and this is in lined with our original 2014 guidance for about 4% to 5% constant exchange rate growth. To the space and about 8% constant exchange rate growth from the portfolio excluding the U.S. HPV test with headwinds of about 4 percentage points from the U.S. HPV sales. Adjusted operating income is expected to grow faster than sales and generate at least 100 basis points of margin improvement. We also tighten the range on adjusted diluted EPS through $1.08 per share at constant exchange rates, which is a mid-point of the 2014 full year range. These expectations do not take into account any further acquisition this year. Like in January we announced adjusted EPS guidance at constant exchange rates in anticipation that sometime these would move against the dollar during the year. Based on recent trends especially since September the dollar has strengthened against the euro and some other currencies especially in countries where they have rise in sales across our limited costs. So we now expect modestly negative currency impact on full year sales of up to about 50 to 100 basis points and currency related pressure on adjusted EPS that could potentially be up to $0.01 per share. For the fourth quarter adjusted net sales are expected to rise about 4% at constant exchange rates and adjusted EPS of $0.33 all to that constant exchange rates. This slide also contains adjustment assumptions. For the full year we continue to expect about $120 million for amortization of acquired intellectual property and about $15 million for business integration and acquisition items. We also tied into guidance adjusted tax rate to 20% while the number of shares outstanding remains at about 242 million. With that, I would like to hand back to Peer.

Peer M. Schatz

Management

Yes, thank you, Roland. I’m now on Slide 16 for a quick summary before we move into Q&A. We’re pleased with our performance during the first nine months of 2014 moving ahead on the initiatives to accelerate innovation and growth while working through headwinds created by the U.S HPV franchise. Let me review what we’ve announced. First, we achieved our targets for the third quarter with higher adjusted net sales and earnings per share as well as a solid increase in free cash flow. Second, we are moving ahead on initiatives to accelerate innovation and growth, especially among our growth drivers that are expanding at a solid double-digit pace and currently provide about 30% of total sales moving towards 40% in 2015. They form a foundation for sustainable growth in the coming years, especially as we work through the final year of U.S. HPV headwinds in 2015. Third, we are re-affirming our full-year 2014 guidance for adjusted net sales and earnings growth over 2013. We are committed to achieving our full-year goals and preparing our team for further innovation and growth in 2015. With that, I’d like to hand back to the operator to open up the Q&A session. Thank you.

Operator

Operator

Thank you. Ladies and gentlemen, at this time we will begin the Q&A session. (Operator Instructions) One moment please for the first question. First question is from Derik de Bruin of Bank of America. Please go ahead. Derik de Bruin – Bank of America Merrill Lynch: Hi, good afternoon.

Peer M. Schatz

Management

Hi, Derik. How are you? Derik de Bruin – Bank of America Merrill Lynch: You’ve made some really good progress in the off margin this year, 100 basis points of expansion and I guess how should we think about that for 2015, particularly since the currencies I know will potentially give you some benefit. And I guess just also from modeling purposes, how are you sort of thinking about the effects on the top line for next year?

Peer M. Schatz

Management

Roland, you want to take that?

Roland Sackers

Management

Yes, sure. Hi, Derik. Generally we still see that as a positive (indiscernible) we will create a few over the last 12 months to 18 months. And so, we want to believe that we’re able to continue that positive trend also into the quarter for 2015. Clearly it’s also to a certain extend depending to the revenue guidance which we are giving only next year. Nevertheless, if you look on the different drivers for that, a couple of them are doing quite well. If you look on our [shared] (ph) service centers all the things we were able to do in administration, integration and globalization of all procurement efforts. So we feel comfortable at least on the bill funds. And again you see it also now, finally, really pushing it’s too on the cash flow side, those things coming together quite nicely.

Operator

Operator

Next question is Daniel Wendorff with Commerzbank. Please go ahead. Daniel Wendorff – Commerzbank AG: Yes, thanks. Thanks for taking my question. And it’s actually relating the HPV franchise and Peer you mentioned that number of contracts were prolonged in the U.S. and this with broaden the first half 2015. So my question on that is and how long do these contracts normally last? If I cut it right for the past, these were around two year contract, is that still valid?

Peer M. Schatz

Management

Hello, Daniel. So it’s a well, we’re signing every year hundreds of agreements that are coming up for renewal and they can extend anywhere between even out to one year I’d say the majority are some in the range of three years. And the important thing for us clearly this year is the competition has reached at the pricing levels. That we’re actually able to secure very large portion of them, even now despite that the pricing is lower it gives us very strong market share and position also within these accounts for several years to come from which we can expand with other offerings. So it’s typically in the range of a few years, the average duration assumed is around three years.

Operator

Operator

The next question is from Tycho Peterson of JP Morgan. Please go ahead. Tycho W. Peterson – JPMorgan Chase & Co.: Thanks. I guess question on Bioinformatics, you announced where we’ve seen your higher, you announced the Genomics England project and you’ve kind of integrated Ingenuity with the Cancer Research what mentioned. So can you maybe just talk about a) the patient of Genomics England when that flows through the other still gaps you need to fill on the informatics side. And then see, just any feedback on Ingenuity with the Cancer Research Workbench solutions.

Peer M. Schatz

Management

Sure. So in terms of the portfolio to started out with that we have an incredibly strong position in secondary analysis, which we are expanding through offerings the retailer to specific type of users be the cancer researchers or others. So just for those you have never seen these types, the analysis, the secondary analysis of next-generation sequencing data is incredibly complex with many, many different ways to ultimately get to your at the definitional of what is a variant. And we’re expanding and tailoring that to the different needs we’re already today have by far the largest offering in this base. And so that position is one that we’re building from a real position strength and that will continue and very similar in the interpretation area where our knowledge bases are – were actually accelerating the efforts in this area to further broaden their capabilities and this is going at a very rapid pace. What you saw for instance at ASHG is that we’re now starting to integrate them and not only the Ingenuity Variant Analysis or the Ingenuity Clinical systems with secondary analysis from CLC bio, but now also the HCMD franchises from BIOBASE and the problem in bioinformatics today is that there are many, many different tools but there are many small individual tools that are not aggregated. We’re creating something very seamless for our customers targeted towards their applications. The response of the market is actually very, very positive. So the seamlessness takes a lot complexity in interface management out of the system, which software is just deadly and systems continue to be upgraded and enhanced over time to ensure certain seamlessness is extremely valuable for our customers. Insurance is now large contracts. We are very successful as obviously the key go to resource for interpretation secondary analysis that we have a strong – very strong and competitive position to offer. We have mentioned the 250,000 genomes that were for instance processed already or our genomic samples that were processed. This compares to a few 100 or few 1000 that you see even in very large institutions. So this number 250,000 is a one that it is just miles ahead of anything else that is out there. And I think this puts us into a very strong position for large scale genomic analysis studies that for instance you’ve referred to before.

Operator

Operator

Your next question is from Peter Lawson of Mizuho Securities. Please go ahead. Peter Lawson – Mizuho Securities: Yes, just on the HPV business. Where are you seeing the most pressures that from large competitors or small private companies? And then when do you think that business stabilizes?

Peer M. Schatz

Management

It’s very different in terms of the geography. So the HPV franchise ex-U.S. is actually doing quite well. We’re very successful. We’re winning almost every major tender where we’re moving ahead quite rapidly and develop, but also in less developed countries. In the United States – and there typically in ex-U.S., we see competition many, many players, small players, but we are – by far the majority share player there. Situation in the U.S. is very different that we clearly have a oligopoly or few players basically in this market. And what happened was that due to very poor uptick of competing tests, the pricing button was pushed and the pricing levels collapsed. And while we are still able to command a premium in many cases, it is quite clear that if customers have price of x, it is tough to charge to 2x. So, we’ve been forced to go along with those pricing levels. Competition is in the States across the three other players basically that are on the market, really only two at the moment.

Operator

Operator

The next question is from Doug Schenkel of Cowen & Company. Please go ahead.

Unidentified Analyst

Analyst

Hi, this is [Ryan Decker] (ph) filling-in for Doug. Couple on QuantiFERON. How was the launch in China tracking relative to your expectations firstly? Number two, can you talk a little bit about QuantiFERON in Japan and how successful you’ve been in winning back those accounts that you lost previously? And lastly, can you provide any additional color on commercialization timelines for TB Plus? Thank you.

Peer M. Schatz

Management

Sure. So the first question, QuantiFERON, China is moving ahead well. As you know, we were the key partner in all of the major studies that provide credits in groundbreaking, also clinical evidence for the Chinese market. Our product was a test of choice and therefore validated the benefits of our products quite impressively for the Chinese market. So, this is moving ahead quite rapidly and the uptick of these large screening programs are even subgroup testing is typically – also here is something that you don’t see a step change suddenly happen but you start seeing an acceleration overtime to open to our plan this year, but we are fully in line with our expectations for the Chinese market. The second question was on the Japanese market. In Japan, there was one disruption in 2013 that had to do with the supply chain being disrupted for certain period of time for the Japanese market which led to the loss of one account as described in Japan. And we have been very successful in regaining share in the Japanese market altogether with that one exception, but the evidence is very clear now. In the meantime also been built that, I’ll turn it to solutions. Solutions are providing significantly superior results and I think that’s strong evidence. It’s just a matter of time hopefully for this two to convert and we are doing all we can I think the rest of the world has clearly shown that the QuantiFERON solution is the way to go. In terms of the QuantiFERON post generation product we are progressing very well on that product that had some unique new features, I will be to that for now, that also open-up new opportunities and new market segment and we will talk about as that launch nears.

Operator

Operator

The next question is from Isaac Ro of Goldman Sachs. Please go ahead. Isaac Ro – Goldman Sachs Group, Inc: Good afternoon and thank you. Question on liquid biopsy this is an area where I think you have been talking little bit more about the assess that you have and the opportunity for growth, that said it is clearly a lot about the technologies out there in the marketplace that could be disruptive. So, how would you kind of put the opportunity in the liquid biopsy in context for your M&A priorities versus some of the other initiatives you had in informatics or sequencing for example?

Peer M. Schatz

Management

Sure. Well, see for us liquid biopsy is a sample technology basically the stability to enrich various scar some amounts of molecular targets from biopsy is that are more easily accessible than tissue. And they are in that market, I am not really sure what you are referring to disruptive change but in the free circulating DNA area we have extremely a strong position in that area, and also in the RNA and the fixes more RNA I think we are basically only wide available products in the market today. And so we are definitely working intensely to standardize sample technologies in these markets just like we’ve done in so many other areas of sample processing where we have shares of 56% to 70%. And this is the starting point for liquid biopsy processing. We have not been active in circulating tumor cells and that might be what you are referring to, circulating tumor, tumor cells have some benefits, they also have some disadvantages and we see with a new molecular techniques that exosomes and DNA is becoming a method of choice. Started out I think the cancer is going to bit a real opportunity to show the benefits of these technologies, currently a lot of the activities in the area of that been testing that has slightly different needs and that’s maybe on the long-term separate area not really a liquid biopsy as we would define it ultimately for diagnostic testing for instance for tumors. In terms of the M&A if you ask is there something out there that would be interesting for us to acquire and lipid biopsies had struggled to find something that with the something that we would need to actually deliver on a very exciting future for our liquid biopsy franchise. So that mean that the focus that we have in M&A is clearly along the growth drivers and bioinformatics was a big focus over the last 18 months, will continue to be, and we are, however, also looking at other areas and I think the news flow will then further validate that.

Operator

Operator

The next question is from Dan Arias of Citigroup. Please go ahead. Daniel Arias – Citigroup: Afternoon. Thanks for the question. Just wanted to ask about the early days of the C. diffs as they uptake. How are you finding that market to be just given the landscape? And as a related question, if I could, it seems like CMV and MC, they both sort of need to have assays for hospital labs. So I’d be curious just to hear how much bundling, if any, you’re doing there with those tests?

Peer M. Schatz

Management

Absolutely. I think there are two – you’re actually right that hospitals, it’s a cornerstone for hospital and the QIAsymphony provides an excellent testing platform for these medium-sized hospitals at it allows broad array of different tests including LDTs be on it. The same is true for cytomegalovirus. That should be closer to patients as it is a monitoring assay. We are seeing a very significant interest in C. diff. We already converted first accounts. We have a very strong franchise already in CMV. We’re at CMV franchise since almost 10 years. We were under an exception from FDA to continue selling the ASR prior to the approval of the CMV assay this year, which basically allows us now to convert the existing uses over into the PMA approved product. So CMV is not a new area for us. It’s one in transplantation testing where we have an incredibly strong franchise and I think one that we’ll be able to talk more about and also going forward. There’s a lot of exciting things happening in this area. And healthcare-acquired infection, this is simply and add-on to – at QIAGEN, need to provide value to the hospitals that are thinking about putting in some patient in that assay, also gives a certain amount of base volume that allows (indiscernible) fab.

Operator

Operator

The next question is from Zarak Khurshid of Wedbush Securities. Please go ahead. Zarak Khurshid – Wedbush Securities: Hi, there. Good afternoon. A couple of question on cash flow for Roland. How did the working capital improvement play into cash flow? And then how sustainable might that be? And generally how much does HPV contribute to cash flow? Thanks, guys.

Roland Sackers

Management

Working capital improvement is a smaller part of it. It is clearly one part, but at the same time we see the majority coming from operational efficiency really about the project we started earlier in 2013 and finally I would say coming all the time and giving us quite significant impact here. So I think there is clearly something where we believe also going forward we see even larger contribution coming from as we again typically towards these efficiency programs by starting and rolling it out on a limited area and then you take it over a region on to a global base, so that (indiscernible) controlled set up. At the same time of course you’re creating larger impact on longer time period. The other thing what we of course to your second question around it’s re-contributions. As (indiscernible) clearly still is a business with a good gross margin, at the same time you have to have in mind that still its part of our business which has two sales forces, as you know we have a clinical and laboratory sales force. So in terms of actually in EBIT contribution, I would say it’s below company average and I think it is also something to have in mind and it’s also the reason why we are able actually to absorb quite nicely the impacts we are seeing here from the revenue side. And at the same time with bioinformatics, of course we have a huge opportunity going forward, because bioinformatics to a large part has even a higher gross margin than we have seen and used to from those previous slides. I would say the product mix is also quite helpful for us.

Operator

Operator

The next question is from Vijay Kumar of ISI Group. Please go ahead. Vijay Kumar – ISI Group LLC: Hi, guys, thanks for taking my question. Peer, I had a big picture question for you and I guess when you look at the (indiscernible), obviously you had a challenging time with some of the challenges in U.S. on HPV side. I guess the question is after 2015 right in resuming the HPV stabilizing. I think the core part of your business has been doing high singles, right. And I think if you look at what the key growth drivers out there, it should have basely been QuantiFERON-TB and profiling within the molecular diagnostics. I guess given some of your comments on QTB were reasonable. That market is expanding and 20% growth rate in QTB is a reasonable assumption but in the medium term I guess, what’s going to drive that strong double digits within profiling or other parts of your diagnostic business right? And to that extent how key is gene expert to the thesis? Thank you.

Peer M. Schatz

Management

Sure. If you look at the portfolio, the diagnostics portfolio overall you saw very high double digit growth again in the third quarter excluding the HPV headwinds and these are significant degree of pricing headwind. So we still maintain very large number of accounts. Now this product is down to 5% or lesser sales going forward. So I think we’re seeing stabilization probably happened over the course of 2015, which means at the rest of the growth, it seems to shine through and while clearly we’re fully aware this is an impact that we are moving through. And therefore, it also demands a certain amount. Attention, if you look at the diagnostics portfolio, you have several hundred millions of dollars of profiling test and franchise that where you have the QIAsymphony now being the hardware for – or the carrier for all that and we are moving forward quite aggressively in an early stage of that product life cycle. So we talked about four approvals in the state, but we have about 23 assays in Europe running on this and we just launched the whole hospital acquired infections portfolio in Europe and whole suite of STB products as well. And are really charging ahead in the 60% of the world which is not the United States and in the United States we’re seeing very good uptake following the FDA approval. That’s several hundred millions of dollars of opportunity that we basically have there and personalized healthcare, we talked about – I couldn’t imagine something more fascinating, we’re seeing the assay technologies, the platforms, even the software elements not come together. We’re signing up record agreements that couldn’t image anybody having even – even though the number of partnerships that we have in molecular field and which will be proven to…

Operator

Operator

Next question is from Dan Leonard of Leerink. Please go ahead. Daniel L. Leonard – Leerink Swann LLC: Thank you. Another one on HPV, so for U.S. HPV to be a three point headwind in 2015 that seems to imply another decline of about 40% year-over-year. So my question is one is that, is that math right? And then two as you look now your budget for 2014 and U.S. HPV is coming in, I think was there any plant, is there a primary – you have a number of growth drivers, but is there a primary offset you’d put on the pedestal to say that this offset the decline in HPV.

Peer M. Schatz

Management

We expect the declines to be pretty similar to what it was this year, so we had a decline this year plus or minus 30%. And the decline was to a significant degree pricing. If you assume that that would continue for a certain period of time if these pricing levels have been set at a certain level, we’re not seeing dramatic declines anymore that was kind of like a step change, in particular, one competitor and then another following. That is kind of like floor at a level which is really not far away from commenting another test which kind of gives you a sense that this is – may be a level where you wouldn’t see a similar step change, at least certainly not in terms of dollars. So from that perspective we’re actually fully in line with our targets for this year, came in pretty much as what we had predicted for the year, also in terms of overall headwind. But offset set is, if you look at the third quarter, you see almost 20% growth in the molecular diagnostics franchise, ex-HPV you see a very, very strong underlying growth which kind of like sometimes is not in the limelight, because we see QuantiFERON is a very strong $100 million growth driver and we see HPV as a negative impact. But just personalized healthcare and the profiling portfolio primarily symphony are very strong growth drivers.

Operator

Operator

Next question is from Jeff Elliott of Robert W. Baird. Please go ahead. Jeffrey Elliott – Robert W. Baird & Co.: Yes, thanks for letting me in here. First one on the instrument growth, as you mentioned really strong growth there, as far as that we seen it sometime. It was some of the pull out from the fourth quarter, I guess what’s behind the growth and how stable is that?

Peer M. Schatz

Management

Excuse me the audio was not – didn’t work could you repeat the question? I’m sorry. Jeffrey Elliott – Robert W. Baird & Co.: Yes, the question is on the instrument growth in the third quarter, like you said as strong as we’ve seen in sometime with some of this pullback we had from the fourth quarter, or what’s behind the growth you saw in the third quarter?

Peer M. Schatz

Management

No, I think you sensed from the call in the second quarter that we were that’s a good cash. We were quite satisfied with the instrument performance moving into the second half of the year, we made some changes in the way we managed the funnel and also in the way the instruments are packaged to our customers. So we’ve started to see a reemergence in growth in terms of the assay portfolio and new assays coming online that are reinvigorating growth of instrumentation sales. So, I’d say that is more an execution issue. The teams have been doing a very good job since a few months managing that tunnel.

Operator

Operator

Next question is from Gunnar Romer of Deutsche Bank. Please go ahead. Gunnar Romer – Deutsche Bank: Hi, good evening, guys. Thanks for taking my question. First one would be to Roland on the likely FX impact on your top line next year. I think this question was already asked earlier, but I probably missed the answer. So what would be your best guess given current spot rates? What the impact on your top line would be next year? And then, if I may have a second question on the companion diagnostics pipeline, how should we be thinking about that pipeline evolving into next year and potentially translating into, say, when you would be expecting the first significant contributions here?

Roland Sackers

Management

It’s Roland. Good question. Gunnar, of course if I take Deutsche’s expectations and we have still a significant drop to expect, but putting that aside if you would use current rate, I actually don’t think it will be too much of them over all topic for us. We probably have it in a – impact that you will see on the warning side, not necessary in terms of changing our overall growth rate, which is also reason why we look at constant exchange rate go for it on the revenue side, which makes it then very transparent in terms of what is overall growth rate going forward on the revenue side. On the profitability side, I would say probably it’s helpful of course on the modern side. It’s the question on the absolute dollar side. It would stay as it is right now. It is probably also something, which is more on the warming, might be $0.01, might be $0.02 on a full year basis. So this year if you see so far for the nine months period it small as nothing and we expect now up to $0.01 for the remaining quarter. Again, I’m not too pessimistic on the currency side. Our natural hedge on the profitability side is actually working quite nice, duplicate it only by this event if you see one specific country see on Brazil, see on Turkey as Australia. And so those significant development in a typical key areas, but typically that’s also brought out on a global basis as some other countries who are in a different direction. So again we have to mention it and we do so, but at the same time I think it very well manageable from our perspective Gunnar Romer – Deutsche Bank: Yes, I think it’s a very…

Operator

Operator

The next question is from Tim Evans of Wells Fargo. Please go ahead. Tim Evans – Wells Fargo Securities: Hi, thank you. I was hoping that might ask a little bit more about the strength in the instruments, particularly in the pharma customer base. Can you talk about a little bit more about the dynamics there and maybe also by geographic region.

Peer M. Schatz

Management

Sure. If we talk about pharma, it’s predominantly U.S. into certain degree of the Europe, but in particular if we look at instrumentation in the third quarter of this year and hopefully this will secure into future period, instruments as always a little bit more a lumpy business spending on the instrument the capital cycles and the budget cycles. But effectively taking the portfolio that we have and it’s a very, very good portfolio across sample and assay technologies. We simply improved the final management in this area and focused more on the instrumentation side versus in the first half of the year where we’re more focused on some of the reagent and the new assays that were coming in the next-gen sequencing portfolio, and others that are actually doing very well. And so with additional resources on the instrument funnel, starting in the second quarter of this year moving into the third you start, you hopefully see the first times here in the third quarter and you look forward to further success in that area.

Operator

Operator

The next question is from Paul Knight of Janney Capital Markets. Please go ahead. Paul Knight – Janney Capital Markets: Good evening. What are the other target growth rate on the personalized medicine business or what should we really think for on a multi-year period, is it contract-by-contract or should we assume 20% type growth, what’s your thought on the business plan?

Peer M. Schatz

Management

If you look at the overall revenue in that area, it can be anywhere between 20% to 30%, is related to development mile stones. And we don’t expect this to grow at very high growth rates and we’re scaling like crazy in the Manchester side that we have, where we already have a couple of 100 assay developers. And for those of you who know the industry, this is probably one of the largest assay development sites in the world. And we’re scaling with quite aggressively that capability there. But that won’t grow at the same growth rate as scalability of a kit sale and an instrument or reagent sales to pathology labs. So be the real-time PCR, or be the next generation sequencing panels, or be it the related equipment and consumable for that, we see a very strong growth opportunity for this and we’re in the early days of personalized medicine. We’re not playing it for 2015 and 2016, these are growth rates that we assume are well in the double digits, but we’re planning it for, also here this is a very long term high growth driver for us, just like QuantiFERON, just like QIAsymphony, just like Bioinformatics and just like NGS. So we’re lining up multiple growth cylinders that have multi-year perspective and funnel them and fueling them aggressively.

John Gilardi

Management

So, thank you very much Peer and with that I would like to close this conference call, and thank all of you for your participation. If you have any questions or comments, please do not hesitate to give us a call. Thank you very much.

Operator

Operator

Ladies and gentlemen, this concludes the QIAGEN’s Conference Call. Thank you for joining, and have a pleasant day.