Hello, my name is Stephanie and I’ll be your conference operator today. At this time, I would like to welcome everyone to the Penumbra, Inc. First Quarter 2022 Earnings Conference Call. All lines have been placed on mute to prevent any background noise. After the speakers’ remarks, there will be a question-and-answer session. [Operator Instructions] Thank you. Jee Hamlyn-Harris, Investor Relations for Penumbra. You may begin your conference.

Thank you, operator. And thank you all for joining us on today's call to discuss Penumbra’s earning release for the first quarter of 2022. A copy of the press release and financial tables, which includes a GAAP to non-GAAP reconciliation, can be viewed under the Investors tab on our company website at www.penumbrainc.com. During the course of this conference call, the company will make forward-looking statements pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995, including statements regarding our financial performance, commercialization, clinical trials, regulatory status, quality compliance and business trends. Actual results could differ materially from those stated or implied by our forward-looking statements due to certain risks and uncertainties, including those referenced in our 10-K for the year ended December 31, 2021, filed with the SEC. As a result, we caution you against placing undue reliance on these forward-looking statements, and we encourage you to review our periodic filings with the SEC, including the 10-K previously mentioned, for a more complete discussion of these factors and other risks that may affect our future results or the market price of our stock, including, but not limited to the impact of the COVID-19 pandemic on our business, results of operations and financial conditions. Penumbra disclaims any duty to update or revise our forward-looking statements as a result of new information, future events, developments or otherwise. On this call, certain financial measures are presented on a non-GAAP basis. The corresponding GAAP measures and a reconciliation of GAAP to non-GAAP financial measures are provided in our posted press release. We anticipate the prepared comments on today's call will run approximately 25 minutes. Adam Elsesser, Penumbra's Chairman and CEO, will provide a business update. Maggie Yuen, our Chief Financial Officer, will then discuss our financial results for the first quarter. And Jason Mills, our Executive Vice President of Strategy, will discuss our 2022 guidance. With that, I would like to turn over the call to Adam Elsesser.

Thank you, Jee. Good afternoon, everybody. Thank you for joining Penumbra's first quarter 2022 conference call. Our total revenues for the first quarter were $203.9 million, a year-over-year increase of 20.5% has reported and 21.8% in constant currency. Our gross margin increased 100 basis points sequentially to 62.5%. And I expect important investments we have made in our people, products and production over the past two years will continue to translate into both strong growth and gross margin expansion going forward. Let me touch briefly on progress within our vascular, neuro and immersive healthcare business during the first quarter. Then I will offer some general observations about our business, details about our new product roadmap and growth opportunities that we see ahead. In our vascular business, we reported growth of 37.7% year-over-year to $122.8 million in the first quarter. We grew our vascular thrombectomy revenue 43.2% year-over-year and our vascular embolization revenue 28.8% year-over-year. Our vascular thrombectomy growth was driven by continued robust adoption of our Lightning products in the United States. We saw sequential growth across all segments of our U.S. thrombectomy business, DVT PE arterial and coronary. We delivered strong growth of 30% year-over-year in our U.S. vascular thrombectomy business. We also expanded into China with our partner Genesis. This expanded partnership, which includes our older Indigo vascular thrombectomy products, but not Lightning 7 or 12 yet, occurred a quarter earlier than expected in contributed incremental $5 million to our first quarter revenue. In China overall, notwithstanding recent lockdowns, we have good visibility into our business and we expect solid growth in China in 2022. We are excited to announce the launch of our computer aided mechanical aspiration technology into the European market. We recently secured the CE Mark for both Lightning 7 and Lightning 12. And the…

Thank you, Adam. Good afternoon, everyone. Today I will discuss the financial results for the first quarter of 2022. Financial results on this call for revenue and growth margin are on a GAAP basis, while operating expenses and operating loss income are on a non-GAAP basis. The corresponding GAAP measures and our reconciliation of GAAP to non-GAAP financial measures are provided in a posted press release. For the first quarter end March 31, 2022 our total revenues were $203.9 million an increase of 20.5% reported and 21.8% in constant currency compared to the first quarter of 2021. Our geographic mix of sales in the quarter were 70.8% U.S. and 29.2% international. U.S. and international reported growth of 20.2% and 21.3% respectively compared to the same period in 2021. Moving to revenue by franchise. Revenue from our vascular business grew to $122.8 million in the first quarter of 2022, an increase of 37.7% reported and 38.8% in constant currency compared to the same period last year. Compared to the prior quarter revenue from our vascular business grew by 8.1%, which was driven by our strong performance in peripheral thrombectomy in the U.S. and expanded partnership in China as Adam described earlier. Revenue from our neuro business was $81.1 million in the first quarter of 2022, an increase of 1.3% reported and 2.9% in constant currency compared to the same period a year ago. Compared to the first quarter of 2021, we saw double digit growth in U.S. neuro thrombectomy, partially offset by product mix shift from neuro to vascular in China during the quarter. Moving to gross margin and operating expenses. Gross margin in the first quarter was 62.5% compared to 65.8% in the same quarter last year, but increased sequentially from 61.5% last quarter. While we have seen some gross…

Thank you, Maggie and good afternoon everyone. We reiterate our 2022 revenue guidance range of $860 million to $875 million representing 15% to 17% growth over 2021 revenue of $747.6 million. After a slow start to 2022 caused in part by staffing shortages that affected hospital customers across our industry, our team produced accelerating growth through the first quarter, namely in the United States. We also benefited from an earlier than expected expansion of our business in China, pulling into Q1 slightly over $5 million that we had originally expected to land in the second quarter. Looking ahead, we also face the most robust year-over-year comparison of the year this quarter owing to the successful launches of two major products during the second quarter a year ago, Lightning 7 and RED 62. In sum, we expect a modest sequential increase to our second quarter revenue translating into a year-over-your growth rate in the low teens in Q2. We expect our growth to accelerate in both the third and fourth quarters with Q4 growth expected to be at or slightly above the top end of our annual growth guidance range of 15% to 17%. Looking further out, while we are not giving formal guidance here for 2023, we are optimistic, we could accelerate our revenue growth rate in 2023 compared to 2022 from our interventional business alone based on our expectations for new products and geographic growth opportunities. The potential for material contribution from Immersive Healthcare is incremental to this expectation. Finally, we expect additional gross margin expansion and operating profitability gains through the rest of 2022 and 2023. All while we continue to make meaningful investments in our business to drive long term growth. I will now turn the call back to Adam for closing remarks.

Thank you, Jason, Maggie and Jee. I want to end our prepared remarks today by clearly stating that Penumbra is built to create and innovate the best technology to help patients in many different areas. We do this work in a thoughtful and disciplined manner, but with great urgency. Now in our 18th year, Penumbra has proven we can do this work and succeed in any environment. Thank you. Operator, please open the call for questions.

[Operator Instructions] Your first question comes from Larry Biegelsen with Wells Fargo.

Good afternoon. Thanks for taking the question. Hi, Adam. Hey, Maggie. Hey, Jason. Just one clarification question. Hi guys. One clarification question, one product question. Just Adam, maybe just help us understand what happened in China this quarter and how to think about that $5 million? Is it one-time stocking benefit? And why did it go into vascular as opposed to neuro if I understood correctly. Just maybe just a little clarification around that and I have one follow-up.

Sure. So as you know, we have our deal with China, as we’ve said, many times include a series of different things, both distribution licensing and royalties. This was new. The China deal in the past included only a number – a small number of our old – five of our old stroke neuro products, if you will. I think one of those was an access tool. This was the first time we added the vascular side to it and we had expected to do this in the second quarter and we were able to complete it earlier and do it in the first quarter. So that’s why it came in because of those revenue streams based on that coming in the quarter.

Just one follow-up on that, Adam. Why would that have negatively impacted neuro this quarter? And then let me just ask my second question. You talked about significant iterations for DVT and PE. I guess the question is, what kind of color can you provide us today? What are the unmet needs you’re trying to address and Lightning Bolt, obviously, you would expect me to ask about that. Just kind of any color on that. And can we see any of these new product launches in 2022? On the last call you said there would be some new vascular launches this year. So thanks for taking the question and if you need me to repeat anything, let me know, sorry for that.

No, I think I got them. Let me start on the last question. Yes. Our hope and expectation is you will see the two vascular products that you alluded to or that we talked about in the very end of 2022 that certainly very likely and possible. That being said, let me walk through as best I can without going to the point of, as you know, we have lots and lots of competitors here, and we have to be a little cognizant of sharing all the product detail. Even though with these products, there’s some really good patent production. And we’re pretty excited about that. As you know have not had that all the time. But even with that I think you would agree and most investors would agree that there’s certain things we need to keep more confidential until the product launches. But go back to what I said earlier in the script, what are – how do you get clot out? What are the things that are important? And I went through a very clear list of things that are important so that you can get clot out safely without taking too much blood and without damaging the vessel. As we move to the next phase, we are at a point and we want to continue to expand on that where you don’t have to make those trade-offs anymore. And you know, because you’ve followed us for a long time. There’s always been those trade-offs being made between how do you get clot out. And we’re now at a point where we don’t think with this new technology that you will need to make any trade-offs. And that is really important because if we’re going to get to the point, where this is being done all over – it’s a democratized procedure and no longer do you have to think about other means of dealing with blood clot in the body. You can’t be doing it with trade-offs. So those are – that’s where we’re headed. And the reason we lay that out that clearly is we have a lot of confidence that we’re almost there now. But we’ll be there without any question very soon. And when I say we’re almost there now is on a comparative basis, our products really do that right now, pretty darn well. We just want to get it to the point where it’s even easier and easier. And we’re pretty excited about that.

The Lightning Bolt and the $5 million, why did it – Adam, sorry, why did the $5 million kind of come from neurovascular? I didn’t understand. I can understand stocking for vascular, but I don’t understand why it came from. It sounded like it came at a neurovascular. So thanks for hope. Thanks for taking the questions.

Yes. Jason can give you that specific.

Yes. It didn’t come at the expense of neuro. We had been expecting solid growth in China with just the previous partnership with those five products. What we got was a quarter early adding vascular to that mix. And so overall our China business, it’s a combination of multiple revenue streams as Adam mentioned. And it will fluctuate quarter-to-quarter Larry between neuro and vascular. Overall, we expect a solid growth out of China this year and for years to come. But it didn’t come at the expense of neuro, it added to the overall Chinese business, which ended up being that $5 million more than we had anticipated for the first quarter.

I got it.

Still under obviously 10 – well under 10% of our total revenue or else we would’ve broken it out.

Thanks so much.

Yes. Thank you, Larry.

Your next question comes from Robbie Marcus with JPMorgan. Your line is open.

Great. Thanks for taking the question and congrats on a good quarter.

Thank you.

Maybe I can ask about the guidance. And maybe Maggie, walk me through just the thought process here on the beat. Even if you back out the $5 million from China, it was still a $4 million beat in the quarter reiterating guidance. So just walk me through the puts and takes there? And why you decided to hold guidance.

Yes. Robbie, I can take a shot at first and then others can chime in if that’s okay. It’s a great question. So if you look at sort of the first half of the year relative to where consensus was and where folks were heading into the quarter, I think we’re tracking ahead of that. The first quarter was above our expectations and obviously significantly above consensus expectations in part, because we had a stronger quarter overall and in part that $5 million that we had expected to land in the second quarter. But I think the important point is that the first half is tracking maybe a little bit better than what we’d anticipated when we originally gave that guidance. And then the second piece of that to your question about reiterating the guidance as opposed to doing something else. We just wanted to take account at this early point in the year of the moving parts both from a macro perspective and also wanting to get just more clarity on timing of our own product launches that we talked about on this call, as well as product launches we talked about internationally and just the pace of those. So we thought it prudent at this point in the year to maintain that guidance, which we were obviously very happy about when we gave it a quarter ago.

Okay. So just chalk it up to conservatism earlier in the year and nothing that we should read into beyond that.

I think you got it.

Great. And maybe if I turn to the neuro business. The growth rates are impacted, we don’t know how much of the $5 million move from one to the other. So, part a, wondering if you could give us adjusted growth rates, excluding the China contract? And b, this is a market the growth rates have slowed down. There’s a lot of competitors, others are talking about increased competition in neuro. So maybe you could just give us a quick state of the union, what you’re seeing in terms of underlying growth, geographic growth, if it’s different and any impacts from competitors. Thanks.

Yes. So when you look at international business, particularly this quarter, it obviously gets a little harder to look country by country and compare. I think what you have to look at is, if you look at our U.S. stroke business, we still grew in the mid teens, which was pretty good on a year-over-year basis. And we were pretty happy with that. That being said, there is no question. And I think I was pretty direct in my prepared remarks to talk about the state of the stroke market. We’ve done an amazing job, not only our company, but the other industry partners, as well as the physicians, particularly over the past seven years growing this market from when the first – the stroke trials were first announced. It’s extraordinary. And we’ve gotten to about 25% of those patients being treated. And my comments around this the next wave or the next era, I think we need to reinvigorate this field. We have to have the kind of paradigm shift that brought us this far. And I think Thunderbolt is bringing that attention. As we have started to sign up folks for the trial and demonstrated the product it’s clear from their reaction that this is a different thing. And that it will have the kind of impact that we’re hoping on patient care and probably provide the energy that’s needed to do the really, really hard work to keep growing this market. So I think that’s the state of the universe or of the field, if you will. It is a competitive market. There’s a ton of companies with catheters of all kinds of shapes and sizes at this point. But that’s not going to be what drives it. That’s not how the story ends. And that’s why we’re particularly excited about it, why we outline the size and timing of the trial, so clearly as best we can given that the ID is not issued. And I think you can hear we’re leaning in pretty heavily, because we think this is going to help not only treat patients better, but drive a growth on top of the growth rate that we’ve seen over the past bunch of years.

Yes. And Robbie, this is Jason. Just you had a question in there about the vascular business ex-China. We included in our prepared remarks the comment to we anticipated that would be a question that we grew over 30% in our vascular thrombectomy business in the United States. So hopefully that helps sort of give you a sense for the strength of our vascular business outside or with excluding that Chinese piece.

Do you have the global numbers that you’re able to share since we don’t get the segment geographic breakdown?

Global numbers for what, I’m sorry.

Excluding the mix shift in revenue.

Yes. So you could do it very easily, just if you want to have to exclude that $5 million from our vascular business you saw the growth in our vascular business at large was over 40%. So it wouldn’t be too far off from that.

Great. Thanks a lot.

Thank you, Robbie.

Next question comes from Margaret Kaczor with William Blair. Your line is open.

Hi everyone. This is Brandon on for Margaret. Thanks for taking the question. I wanted to focus on the vascular side. Hey guys. You’ve had several years of really impressive growth here. And as we move typically with the medical devices, as you move further along the adoption curve, maybe your growth is coming from different segments, different channels, or maybe just different functions, maybe new versus existing accounts, things like that. So I was curious if you guys could talk a little bit about where growth is coming from today, where that’s going to come from in 2022? And contrast that a little bit to what you’ve seen in the earlier parts of the adoption curve. And maybe what’s the green space left out there for you guys, because you’re still pretty early within the adoption of the broad market.

Yes. It’s a great question, Brandon. And in my prepared remarks, I was very clear that we continue to see, and I said, we saw sequential growth across all four, focusing on the U.S. where the lightning products are available, all four of those markets. So DVT, PE, coronary and arterial all four of those we saw continued growth. And we expect that it obviously is not going to be even quarter-by-quarter, as our team out in the field is focused on individual accounts and their caseloads and what the specialty of those doctors are. But all of those are seeing growth and really some serious – real success with the products. And they really comes back down to the point that I made in the prepared remarks that that as people use these products, as people talk to each other about these products, they’re realizing that really for the first time, they don’t have to make trade-offs. They’re using appropriate size catheters with smart technology, lightning that deals with blood loss and also where you are in the vascular surgery, vis-à-vis the clot. And they’re having great success with it. And it’s proving to be the type of thing that they can see using on a regular basis. And that’s how we’re going to see growth. So we have a lot of optimism that where we are today with these products will continue. I didn’t mention CAT RX on the coronary side in this answer. But obviously we’re seeing that as well continue to succeed on the back of the CHEETAH study and then the [indiscernible] study that followed up. So all of them are pretty healthy and I think going forward we’ll see growth in all of them.

Okay. Thanks. And then internationally, you guys have Lightning starting to roll out there. You believe your most impactful product launch that you’ve ever had. I think I was afraid you used to use Adam in the U.S. when it launched and clearly in the results we’re seeing, it definitely has been one of the best products we’ve seen. So I guess, maybe can you talk a little bit about how big is the sales force organization you have internationally right now? Kind of what’s the opportunity that you’re launching into this year? How many countries are you planning to go to? And what other investments are you planning to make internationally as you prepare for that product launch? Thanks.

Yes. So the product launch in Europe is in the earliest, earliest stages. Obviously, we put out a release on that saying, we were doing the early cases. They’ve gone really well. I didn’t make the trip over to Charing Cross, but Sandra Lesenfants, our new President of Interventional did. And this is a field she knows really well met with a number of the key opinion leaders that were at the Charing Cross meeting in London. And I will tell you, the desire, the interest in this product is really high. The things that this product this both Lightning 7 and Lightning 12 do in the respective areas was understood. The only difference in Europe, and this is just a reality, not a caution and meant is a caution is, it’s a bit more of a patchwork quilt of reimbursement country by country and we’re on top of that. And we’ll navigate that. So that’s a little different than the U.S. obviously. But I’m really, really excited about it. Our size of our sales force, we have been selling our peripheral coil over there already, so we had built up a relatively robust sales force. So I don’t think we need to add to that for a while. And it’s really just doing the work like we’ve done in the U.S. to get the product out there and get it used and see the growth. So again, excited about the future with it as well.

Great. Thank you.

Thank you.

Thanks, Brandon.

Your next question comes from Joanne Wuensch [Citi]. Your line is open.

Thank you for taking the question and good evening. Two questions. SG&A was higher than I expected. Could you peel that apart so I can figure out what is sort of, I want to say ongoing, but may only be ongoing for the remainder of the year and what sort of one-time in nature that move that up.

Okay. Yes. Thanks for the question, Joanne. So if you look at the total SG&A expenses compared to last year, there’s probably three major components of increases. One is just naturally a lot of the in-person activities and marketing conferences come back. I think last year, we even mentioned that that we got the 10% reduction of our overall SG&A expense as a result. The second component is related to head count investment across functions. And then the third component is related to some facilities and infrastructure investment. So going forward we talk about in Q1, there are some seasonality like sales meeting and one-time expenses more seasonal in nature about $5 million. And going ahead is probably going to be gradually lower increases quarter-over-quarter.

Yes. I just want to add for those who’ve followed us for a long time. We’re pretty disciplined in our spending and the – we have a lot of control here. This is purposeful spending. We were very clear that particularly now as we sort of enter a slightly different environment, which we’re obviously quite aware of. We are not going to get over our skis. We know how to do that. And that’s the point we were trying to make on that side of the ledger.

Thank you. My follow-up question, which is product related has to do with REAL. It sounds like you’re making progress on it, and the words sound like more to come next year. But I’m sort of a, curious did I hear that correctly? And b, can we finally start talking a little bit about what the ramp might look like and make it a little bit more tangible than less real?

We can. What we wanted to be very clear about is to lay out the first round of information and metrics that we're going to provide later this year. I think that is the starting point for being able to start to talk about more specifics, the business models, as well as timing in the ramp. I think that will be the right starting point. Otherwise, it becomes a little more theoretical and so far, obviously most people have waited to see the real tangible success. And so those metrics that I've talked about will be the starting point of that success. And, and I want to sort of add a point to this, when we started Penumbra many, many years ago, 18 years ago, there was – the idea of treating stroke patients was really out there, people – the doctors didn't really all want to do the thing. There wasn't reimbursement. There wasn't anything patentable, all kinds of hurdles, but we have built our culture around this company where we know how to go into areas that no one's been and carve out that work. We've done it in the peripheral side as well. And we're now doing it in an immersive healthcare platform. And so it's never been done before. And so you're going to have to give us a little leeway to do the work necessary. What I’m going to tell you. And it's really heartening to see is we've had a lot of conversations with all sides of this, both on the developer side, but almost most importantly, on the user side, and there is a lot of interest, there is a lot of knowledge. There's a lot of understanding about the benefit that immersive computing has on many, many people's healthcare. So and there's a lot of interest that we got the model, right. There's a lot of acknowledgement that they need one source of platform, but they want all of the content that they can have. So we feel really, really good about where we're sitting right now. And the next time, we really go into the details. You'll start to hear some of that success.

And Joanne, just to add a little color to Adam's remarks. Just to go back to one thing that I said in my prepared remarks was that we do have the potential for material contribution for immersive healthcare. And it would be incremental to that expectation next year in 2023 of accelerating growth. So if you're landing somewhere in our guidance range for this year, what we're seeing is we think we can accelerate next year just on our interventional business, but we did make a point to say there's potential for contribution for immersive healthcare. We'd like to get to a point, as Adam mentioned with those three points to start to talk about that more granularly as we get towards the latter end of the year.

Thank you.

Thank you.

Your next question comes from David Rescott with Truist Securities. Your line is open.

Hey guys. Thanks for taking the questions. And hey guys, congrats on the quarter and thanks for taking the questions. I guess first on the vascular business. I think over the past couple years or even prior to that compared to the North American business, you've always talked about there's been multiple entrants in this space and I’m not sure, its known you from 10 to 15, really outside of these larger size competitors that have come in, and attempted to kind of take share in the space, but really hadn't had much of a meaningful impact, I guess, on the company's market share. Again, this is outside some of the larger players. When we think about some of the recent approvals in the vascular space. How do you think about the differentiation with the product, with the portfolio and then kind of juxtapose, I guess the experience on the neurovascular segment, really how do you think about the competitive position here going forward?

Yes, listen, I think it's a really fair question. And I think everyone who follows us knows I'm not going to use this call or something to be specific about any particular company and competitors. I don't think that's appropriate. I do think it is appropriate though, to do what we've already done on this call, which is to be very, very clear about what is necessary to move, to be at the forefront of removing clot and putting something together real quick, trying to get something done and out, the field isn't going to move backwards. It's going to move forwards. And the criteria that I outlined are really critical for patient care and for how this field advances and I think we know that, physicians know that and it's not going to be the same as I can just come up with a catheter and aspiration source. So, something that scrapes the vessel wall, those are no longer valid tools as we move into the next more sophisticated phase. So again, we feel pretty darn comfortable and confident about the work we've done over the last 18 years to perfect this. And I think we'll be in pretty good shape to continue to show that we can make the best products to take clot out.

Okay. That's helpful. I guess my second question on Thunderbolt, so probably, I guess some insight so far is the goal here to really democratize stroke treatment, providing this or broaden at least the use of this type of therapy into a larger number of stroke centers. And so I guess, my question here is, should the data really here bear out when Thunderbolt does evolve into this type of technology that really opens the door toward broader use of thrombectomy in the U.S. I guess, how should we think about technology here being brought to a wider range of designated stroke centers. I mean, is this something that would take kind of a guideline change to expand the therapy, or is there some low hanging fruit maybe or a pathway perhaps toward primary care centers or primary stroke care centers or maybe even acute stroke ready hospital that may not specifically have these designations for stroke, but as we know are already doing these types of procedures.

Yes. I think it's a really good question. And one that I think has a number of different aspects to it. As hospitals have tried to deal with their own staffing issues, there's been an increased use of locums and so on. So there's a lot of work that is being done, but I think it all comes down to, if you can get the clot out faster and easier and better by definition that will likely reignite the energy in this field that the past couple of years of COVID has been really hard on. And so I think it's a pretty fairly, I guess, easy thing to see as we look at what's needed to sort of reengage – the doctors reengage, the hospitals realize that this is something they like to do and want to do that's the place that I think Thunderbolt brings. And for us, again, to remind people, unlike catheter technology, which really wasn't able to be patented, we have issued patents on this technology. And I think that puts us in a different spot than we have been in the past. So, again, pretty exciting time, but look, we're getting up close to the time where we're going to start treating patients. Let's wait and see how that goes. Again, optimistic about it, but let's see how that goes. And we'll connect after we've treated our first few patients.

Yes. And David, this is Jason, just add to that you ask a question on vascular. You ask a question on neuro, just kind of about the procedures and competition and Adam towards the very end of his second answer mentioned, the technology and the innovation, which with the computer aid innovation is patentable. It's important to just remind you that that's the case with the computer technology. We're bringing to bear on the vascular side as well. And so that technology is not only, one, we can that protect, but it allows us to eliminate trade offs that other technologies might have is they're trying to optimize the core criteria of clot removal. It's a critical component that now exists both on the vascular and neuro side for us and is unique to Penumbra.

All right. Very helpful. Thanks for taking the questions.

Yes. Thank you.

Your next question comes from Ryan Zimmerman with BTIG.

Hey guys. Thanks for taking my questions. Thank you.

Hey, Ryan.

Just going to squeeze three hopefully short questions in, but I'm going to squeeze them in real short. So number one, just on China, I want to follow up on Larry's questions earlier. Value based purchasing is wrapping up with recon devices, then they're going to spine. And then the last component that we at least know of right now is neuro. And I just want to see, is there any impact that you're expecting, because I don't think it's defined yet as to what that is encompassed within the neuro segment. And so is there any impact that we need to consider for a value based purchasing program or impact in China? And then the other two questions I'll just ask them upfront. As you roll out into Japan in RED and you roll it into Europe with some of the products, what impact on margins is that expected to have in those markets, relative to the rest of the business. And with all this emphasis and this is just the third question – with all this emphasis on margins that we heard and the hires that you've made, Adam, can we expect potentially some long-term margin targets to compliment the $1 billion target that you've set out. Thanks for taking the questions, guys.

Those are great questions, Ryan. We'll try to attack them, let me work backwards. And then Jason and Maggie can jump in here. I appreciate the request for a margin target. I don't know the answer to that because we haven't talked about it internally and the idea that I would commit to that sitting in a room here with Maggie looking at me I'm just not going to do that. But it's a fair request. And we'll take it under advisement. I will tell you, our goal has always been to have as high as an appropriate margin as we can, we don't want to – again, we talked about our pricing structure so that we price for long-term sustainability. So that includes an appropriate margin, but we certainly can get back to over time where we were historically before COVID. So that's that Japan and Lightning and Thunderbolt and so on and RED, as we move into the computer aided technology, those have slightly better margins. So I think we'll be fine going forward. And then the final question was on China. I'm going to let Jason tackle that.

Yes. So Ryan, on China, certainly we are studying and keeping ourselves abreast of the economic specifics. You mentioned in China, value-based pricing, et cetera. And I'll just tell you that through the course of our partnership work with Genesis, and now this goes back multiple years, as you know we've discussed that both of us and we've factored that into our discussions as we've developed the framework that is driving our revenue across those multiple channels that we've discussed in China with our partner Genesis. So, certainly we're tracking it, but we purpose – we were purposeful in our words, in our script, which Adam I think said we have very good visibility into our business in China. We also said that we expect I think we said solid growth in China. We expect to grow our Chinese business overall. So hopefully those two things and just the commentary about us, keeping abreast of the macroeconomic issues, answer that question and just to go back to one of your questions that Adam addressed. In general, neuro thrombectomy, the thrombectomy businesses or products specifically tend to carry higher margins globally. So in the United States, as well as around the world so that should give you, I think, a bit of an additional color on that side of it.

Thank you for answering all of my questions.

Yes, thank you. No problem.

Thank you, Ryan.

Your next question comes from Mike Matson with Needham & Company. Your line is open.

Yes. Thanks for putting me in.

Hi Mike.

Hi. I know it's running a little over here, so I'll limit to just one question. I think your vascular sales force in the U.S., I think it's a single sales force, correct me if that's wrong, but at what point would you decide maybe to split that up and have reps dedicated to some of the sub segments there? And I mean, do you think you had disadvantage at all, to some of the other more focused smaller companies out there that are maybe focused only on the venous side, for example?

No, I don't. As you know, there are three subspecialties of doctors. They ultimately all cover the four areas, coronary, arterial, DVT and PE not always in the same rotation. Sometimes they all work together, sometimes they don't. So I think the way we've done it allows us to cover a lot of ground. To remind you, if we're ever at – I don't think it's a disadvantage. I think it's actually an advantage, but the team is busy because in addition to the thrombectomy business, we have the coil business. And so they cover a lot of ground. We do have in addition to our sales team, clinical specialists that are incredibly valuable and a hugely critical part of our team that works directly with the sales reps in various territories. So I think we're in pretty good shape. And to be honest with you, if you indulge me, I want to shout out to what I think is the best vascular team ever put together. I couldn't be prouder of the work they've done and the dedication and integrity in which they sell. It's kind of extraordinary. So I think we're in pretty good shape.

Okay. Got it. Thank you.

Thanks Mike.

The next question comes from Pito Chickering with Deutsche Bank. Your line is open.

Hey, good morning, guys. So two quick product questions, can you give us color on the coronary volumes in the quarter so post-CHEETAH in terms of penetration of new centers and new doctors and how the re-order rates are tracking for those. And then on the neuro side, any color on U.S. market share today with RED versus where you were in recall? And how does the growth rates look at the end of the quarter versus the beginning of the quarter when you had the January COVID comps?

Yes. So I'll start with the last question first, and then we can work backwards. Like everyone else, obviously March was a much stronger month in January. That would be typical in any quarter. I think everyone would agree but it was more so this quarter than not, because obviously January, at least the first part of January was particularly noticeable given everyone being absent and staffing shortages. So I think we're in a pretty good track as we move through the quarter and we were very pleased to see the way we finished obviously. As for breaking out, the each specific thing, we haven't done that. That hasn't been something we've done – we may at some point do that in the future, but I doubt it as we think about the business and we actually talk about it to the sales reps, we're doing all of this at the same time and that is really important. We don't put buckets out there and targets for each thing. Our goal is to continue across all of the patients that can benefit from our products to have it and really defeats the purpose in the way we run the business and talk to our customers to be talking about it in those kind of specific things. So we're not going to do that for now. But I appreciate the question very much.

Yes. Pito, just to add a little bit of color to the other question. In terms of market share, a few general observations there, certainly our market share in U.S. drug thrombectomy has improved markedly since the JET 7 Xtra Flex recall early last year. I think the broader point, we wanting to make are twofold. One, as we start the Thunderbolt trial and move through that and we gave some specific details about not only that trial, but also when we expect approval and obviously what we think will happen after that approval to our neuro business. We did talk about expectations for continued gains through this year as we're launching other RED products. And I guess the second point that I'd like to make is that a point that Adam made earlier, which is to say that the stroke field, the number included in others have brought the stroke field to this far, but we're just treating one out of four patients that need help, that could use help from these systems. And I think the energy around this field will benefit significantly with technology that just does a better job. And it is allowing this procedure to be done more ubiquitously and Thunderbolt is that paradigm. So that's what we're working forward. In the meantime, we think we will do fine with our business with the RED catheters. And then I think you also ask about coronary. Coronary was strong in the quarter. We had strong growth in all four segments of our vascular thrombectomy business. We're not going to break it out separately, but it was strong.

Great. Thanks so much.

Thank you.

There are no further questions at this time. Jee Hamlyn-Harris, I turn the call back over to you.

Thank you, operator. On behalf of our management team, thank you all again for joining us today and for your interest in Penumbra. We look forward to updating you on our second quarter call.

Thank you. This concludes today's conference call. You may now disconnect.