Good morning. My name is Darla and I will be your conference operator today. At this time, I would like to welcome everyone to Merck's Q1 2017 Sales and Earnings Conference Call. All lines have been placed on mute to prevent any background noise. After the speakers' remarks, there will be a question-and-answer session. Thank you. I would now like to turn the call over to Teri Loxam. Please go ahead. Teri Loxam - Merck & Co., Inc.: Thank you, Darla, and good morning. Welcome to Merck's first quarter 2017 conference call. Today I'm joined by Ken Frazier, our Chairman and Chief Executive Officer; Rob Davis, our Chief Financial Officer; Adam Schechter, President of Global Human Health; and Dr. Roger Perlmutter, President of Merck Research Laboratories. Before I turn the call over to Ken, I'd like to point out a few items. You will see that we have items in our GAAP results such as acquisition-related charges and restructuring costs and certain other items. You should note that we have excluded these from our non-GAAP results and provide a reconciliation of these in our press release. We have also provided a table in our press release to help you understand the sales in the quarter for the business units and products. I would like to remind you that some of the statements that we make during today's call may be considered forward-looking statements within the meaning of the Safe Harbor Provision of the U.S. Private Securities Litigation Reform Act of 1995. Such statements are made based on the current beliefs of Merck's management and are subject to significant risks and uncertainties. If our underlying assumptions prove inaccurate or uncertainties materialize, actual results may differ materially from those set forth in the forward-looking statements. Our SEC filings, including items 1-A in…

Thank you. Your first question is from Geoff Meacham with Barclays.

Hey, guys. Thanks for the question and congrats on the quarter. One for Adam, one for Roger. So for Adam, can you talk a little bit about what you anticipate with respect to pent-up demand or expected use going forward for chemo combos with KEYTRUDA just ahead of the PDUFA date? And then for Roger, I realize that we'll see data at ASCO, but what was the tipping point in moving forward with the six additional trials of epacadostat? Was it more data driven or was it reflecting the competition? Thank you. Adam H. Schechter - Merck & Co., Inc.: Hi, Geoff. This is Adam. So let me start by saying we're pleased with the progress that we have with KEYTRUDA across indications including lung. And if you look at what we've done with our proved indication, the vast majority of patients within our indication are already being prescribed KEYTRUDA for first-line lung, and KEYTRUDA's now the most prescribed drug for first-line lung in the marketplace. As we start to think about KEYNOTE-021G, first of all, it obviously expands the market opportunity in nonsquamous patients and it also includes patients with low or no PD-L1 expression, so basically, it opens up the rest of the market. But with that said, there's a couple other things to consider. First of all, we believe that physicians will look at individual patients and decide whether or not combination therapy is right to start those patients. So if you have a younger patient that's relatively healthy, they might think about treating that patient with combo differently than if they have an older patient that's more complicated. In addition to that, we believe that, since we've studied the drug with ALIMTA, that early adoption will probably be used where physicians would use ALIMTA. Over time…

It's from Seamus Fernandez with Leerink.

Oh, thanks very much for the questions. Just two questions. Roger, can you help us understand a little bit of the dynamics? You guys just brought a STING, or are bringing a STING agonist into the clinic. Can you talk a little bit about your enthusiasm for that mechanism, and where you really see a mechanism like that potentially playing an important role in the treatment paradigm? And then the second question is, as we look at the competitive landscape in all of the different treatments in I/O and the various combinations, one that continues to come up, and where we will see some data at an investor presentation, is the combination of KEYTRUDA with niraparib, the PARP inhibitor. Can you just help us understand your enthusiasm for PARP combinations with PD-1 agents? And also, just the PARP mechanism in general would be really helpful. Thanks so much. Roger M. Perlmutter - Merck & Co., Inc.: Yeah, Seamus. First of all, with respect to the STING agonist, you're right, we've brought a STING agonist forward, and we're interested in it in the same way that we're interested in a variety of other agents, some of which I mentioned a moment ago, that, when given intratumorally, create both a more inflamed environment that should stimulate the – further stimulate immune cells that have had the brakes released, if you will, by KEYTRUDA administration, and also provide an opportunity for an abscopal effect. We see that sort of thing in our preclinical studies very well, but of course, it's not clear that those preclinical results will translate to real patients. Time will tell, and we're interested in it, we're enthusiastic about it. I'm not sure that there will be a winner among the various different choices, the oncolytic viruses, the toll-like receptors,…

It's from David Risinger, Morgan Stanley. David R. Risinger - Morgan Stanley & Co. LLC: Thanks very much. So, I guess I'd like to start with Roger. Roger, could you talk about your level of conviction on approval of the KEYTRUDA-ALIMTA combo on May 10? And I just wanted to ask about the upcoming KEYNOTE-189 trial. So it would make sense to me to provide access to the FDA to take a private look at that data, to give them comfort approving on just Phase 2 data and eliminate any risk that they end up with egg on their face by approving on a small Phase 2, and then having the Phase 3 disappoint in the fall, even though that seems extremely unlikely, and there would obviously be no statistical penalty for Merck to allow FDA to have access to 189. So I'd love to get your thoughts on that. And then for Rob, if the FDA doesn't approve the chemo combo on May 10, should we assume that 2017 guidance needs to be lowered? I know that the guidance assumes that approval. Thanks very much. Roger M. Perlmutter - Merck & Co., Inc.: Yeah, David. First, with respect to 021G, we've been working closely with the agency. There's been good dialogue on the results and analysis. I will not predict what FDA will do on the PDUFA date. They need to make their own decisions, but I would say that we have a very strong dataset that stands on its own. There's every reason to expect that, based on our discussions with them, that they'll be able to see their way clear for that, and frankly, it doesn't make a lot of sense to start opening up additional clinical trials at this point. Although the 189 trial is underway,…

It's from Tim Anderson with Bernstein Timothy Minton Anderson - Sanford C. Bernstein & Co. LLC: Thank you. Going back to 021G, you guys have made it clear in the past you need to submit additional data from that trial and I'm wondering if that data has been submitted, and if so, any color to add in terms of what it showed? And one of the key elements, of course, would be if there was any separation of the OS curves which we did not see in the ESMO data, so a separate question is, is the separation of any OS curves required for FDA approval in your opinion? Another question on KEYNOTE-189, have you done any interim looks at that trial thus far? And then last question, KEYTRUDA plus YERVOY, should we still continue to expect that you'll advance a program into Phase 3 in lung? Roger M. Perlmutter - Merck & Co., Inc.: Right. Okay. So first of all, with respect to 021G, we did submit additional data to the FDA shortly after our filing which provided – it's fairly standard, actually, in these kinds of settings to provide an update on the results from the original report. And there will be data that provides that kind of update that will be presented at ASCO next month, so you'll have a chance to see some of the data related to that and have a chance to look at PFS and OS and curves in those data. So that will be of some interest. We have not internally reviewed any data from 189. The study is continuing as before. And with respect to CTLA-4, again, CTLA-4 is the CTLA-4 antagonist, clearly an active agent. Ipilimumab is an active agent, and there is reason to hope that a combination of those two will provide improved efficacy and should do so in lung cancer and we have our own internal data from that. We have worked hard to try and get dose and schedule right as I've mentioned to you before with respect to a CTLA-4 combination, and we are looking still further at the recently reported data from AACR from our colleagues at Bristol-Myers with respect to melanoma where again, the evidence that there's activity in terms of overall survival versus monotherapy with nivolumab was less profound than perhaps one might have thought. So we're looking at all of that, but there's no doubt about the activity of a CTLA-4 antagonist. Teri Loxam - Merck & Co., Inc.: Thanks, Roger. Next question, please, Darla.

It's from Steve Scala with Cowen. Steve Scala - Cowen & Co. LLC: Thank you. I have a couple questions. First, KEYTRUDA fell a bit short of consensus in Q1. Do you attribute that to not gaining as much share in second-line lung as anticipated, that expectations were simply too high, or was there some sort of stocking issue in the quarter? And the second question is for Dr. Perlmutter. Letermovir in CMV prophylaxis, you noted that the data was presented from the first Phase 3 trial. I think Merck is only running one trial. Does this mean you have to run another trial to file the drug? Thank you. Adam H. Schechter - Merck & Co., Inc.: Yeah, so this is Adam. First of all, we're pleased with the progress of KEYTRUDA and the $584 million in sales. If you look at the U.S. which is the first market where we're really launching lung because we're still working on reimbursement outside the U.S., and we saw a 170% increase versus the same quarter prior-year. And if you look at quarter-over-quarter growth and you adjust it for the $40 million that we told you about last quarter, you had over 30% quarter-over-quarter growth in the United States. And if you look at the data from simply (33:18) other areas, you would've gotten to about the number that we achieved. In addition to that, to provide additional context, if you look at the sales in the United States, right now about 40% of it is coming from lung. So you've seen a very significant increase in the amount of sales coming from the lung indication and in fact the first quarter of this year is the first quarter in which lung is the largest percent of our total sales. So we remain optimistic about the progress with KEYTRUDA. We think that there are opportunities to continue to grow with all the indications that we have and we'll look forward to seeing what happens with 021G. Roger M. Perlmutter - Merck & Co., Inc.: And thanks very much for listening so closely to my comments on letermovir. Yes, there's a single study in hem [hematopoietic] transplant for letermovir in terms of suppressing CMV reactivation. It has always been the plan which is well formulated to do the second Phase 3 study in solid tumors where there's also a meaningful need to suppress CMV reactivation and frankly, we're in a three-point stance to begin that Phase 3 study in solid tumors, eager to move forward with that and that's the study I was referring to. Teri Loxam - Merck & Co., Inc.: Thanks. Next question, please, Darla.

It's from Umer Raffat with Evercore ISI.

Hi. Thanks so much for taking my question. I have two for Roger if I may. Roger, first, perhaps on KEYNOTE-189 trial design, so one of the things your competitors are doing in first-line trials is they're "not enabling PD-1 as part of the trial." Are you allowing pembro as part of the trial for crossover on the chemo arm, number one? And secondly on 021G, was the PSS data in the subgroup of PD-L1 positives 1% to 49%, was the PSS beating the I/O chemo versus chemo for that specific cord (35:12)? I know that wasn't presented at ESMO, but you may have that in-house. Thank you. Roger M. Perlmutter - Merck & Co., Inc.: Right. So first for the second one, we're not breaking out the 021G data. We showed at ESMO the sets of patients with respect to PD-L1 expression and there's a similar trend overall, but frankly, it's such a small number of patients, I wouldn't try and draw any conclusions with respect to PD-L1 expression. The totality of the data was pretty much the same across the entire set. And with respect to KEYNOTE-189, crossover is permitted and that obviously will have an effect. And more and more, as we've said, in all studies, there will be a meaningful effect of crossover, both the same PD-1, PD-L1 directed agent and to other PD-1, PD-L1 directed agents. We see that and that will make overall survival harder to see, although so much depends on the timing of the crossover.

Thank you. Teri Loxam - Merck & Co., Inc.: Next question, please, Darla.

It's from Jeff (sic) [Gregg] (36:24) Gilbert with Deutsche Bank.

I've never been called Jeff before but thanks. First for Rob, can you comment on the growth margin outlook for the rest of the year given the very strong growth we saw in gross margin in Q1 versus last year? And not sure if I missed you quantifying the customer purchase timing for the JANUVIA franchise. And then for Roger, I'm sure you've studied MYSTIC and all that's known about it. Can you frame the importance of that event for Merck? Is this simply about CTLA-4 and its relevance in lung, or are there other key questions that you know are likely to be answered here? Thanks. Robert M. Davis - Merck & Co., Inc.: Yeah, so with regards to the gross margin, as we look at the full-year gross margin, we continue to expect that we will see a moderate increase over 2016 and obviously while we had a very strong first quarter gross margin as we mentioned, driven largely by FX and discards in the quarter, our gross margin fluctuates quarter by quarter so we are not changing our outlook for the full-year gross margin guidance. And then on your second question around the JANUVIA stocking, it's about $70 million. So if you look at the decline in JANUVIA in the United States, it's virtually all due to the stocking. Roger M. Perlmutter - Merck & Co., Inc.: And Gregg, it's Roger. With respect to MYSTIC of course, probably a question better addressed to our colleagues at AstraZeneca, but I would say that as with all of the agents now, there are five PD-1, PD-L1 directed agents, the details of response across tumors and across populations are pretty important. It's nice to know what the level of activity is. MYSTIC will provide a large data set and shows the activity of durvalumab in combination with c and we don't have a lot of data on those two agents, certainly not data in large studies. And so I think that will be important to see. Again, the goal for everyone is to try and improve treatment for cancer patients. That's what we're trying to get to, so every additional piece of information that we get helps us to understand how better to sequence these agents in treating patients with a variety of malignancy. Teri Loxam - Merck & Co., Inc.: Next question, please, Darla.

It's from Jami Rubin with Goldman Sachs. Jami Rubin - Goldman Sachs & Co.: Thank you. I have a few. Rob, first for you. Can you quantify where the guidance raise is coming from? It seems that it's all FX but I just wanted verification from you. Secondly for you Roger, just on what we should expect in terms of labeling for KEYNOTE-021. Obviously this was a small study with just ALIMTA. Should we expect that the label will be restricted to just ALIMTA use? And then Adam, what is ALIMTA's share in the frontline nonsquamous market? Thanks very much Robert M. Davis - Merck & Co., Inc.: Good morning, Jami. This is Rob. So, if you look at the top line guidance that we provided, the midpoint of the range increased by about $350 million. If you look about roughly a half a point of FX against that is about $200 million. So actually on the sales line, we did have obviously the benefit of FX, but we also had an increase due to strength of sales of about $150 million, so it's both. On the bottom line, we increased the midpoint about $0.02 and that is largely FX. As we now continue to look at the full year and with the great opportunities we see with 021G and with continuing to support KEYTRUDA in general, we want to make sure we're also making the right investments behind our clinical spend and our promotional spend in advance of the opportunities we hope to see. So, as a result of that, largely the bottom line is FX. Roger M. Perlmutter - Merck & Co., Inc.: And Jami, it's Roger. With respect to 021G labeling language, again, can't speculate on precisely how FDA would choose to label 021G except to say that as you know in general, you tend to get what you study. There's little reason for the agency to reach outside of that. Adam H. Schechter - Merck & Co., Inc.: And, Jami, if you look at the share, it's about 25% in non-small lung cancer. And as I said in my remarks, I think that it'll start off with physicians using it within whatever the indication is. So if it's with ALIMTA, they'll use it with ALIMTA. We'll obviously continue to promote based upon the label that we have. I do believe that over time, physicians will begin to use it with other chemotherapy, irrespective of label. But again, that's nothing that we would promote. Teri Loxam - Merck & Co., Inc.: Next question, please, Darla.

It's from Tony Butler with Guggenheim Securities.

Yes, thanks very much. Roger, briefly on REVEAL, which you stated would be revealed in the middle of the year, would that simply be a press release? Would the European heart meeting be too soon for any data readout, or would it need to be at the cardiology meetings later in the fall? And then briefly, Adam, the GARDASIL franchise obviously being strong on government purchases, but it was stated that price did have an effect. To what degree did price have an effect in the quarter? Thanks very much. Roger M. Perlmutter - Merck & Co., Inc.: Yeah, Tony, on REVEAL, the study data are being managed by Oxford, so at some point when they've pulled the early results memo together, I expect that I'll get a call. I can't specify exactly when that's going to be, but our expectation is mid-year. The data set is very large, of course; 30,000 patients, many years of study. So it will take a while to pull that together into a presentable form. Given the importance of the data, we'll likely provide top line information. But it will take until the fall until, I think, we'd probably have a good presentation pulled together. It all depends on what we get to see and when we get to see it. Adam H. Schechter - Merck & Co., Inc.: And then if you look at GARDASIL, we had $530 million of sales. The two things I'd point out is one, there's about $45 million of CDC purchases in the quarter, that was due to timing; the second thing is, there's about $50 million of sales from Europe because we dissolved the joint venture with Sanofi. Outside of those two things, I would say demand remains strong, and we continue to see increased penetration rates, not just in males, but even in females as well. And right now, Tony, our market share is greater than 90% globally, almost 100% in the United States. So we remain optimistic about demand. To me, the key thing is, is what happens with the two-dose regimen. So we're seeing increased demand right now, a lot of people getting their first doses. The question will be, do they come back for their second dose in six months? Or will it be next year, a year later? And we still have to wait to see how the two doses plays out Teri Loxam - Merck & Co., Inc.: Thanks, Adam. Next question, please, Darla.

It's from Chris Schott with JPMorgan.

Great. Thanks very much for the questions. First, can you just elaborate a little bit more on your expectations in the HCV market from here, as we think about your launch, how that's ramping, as well as additional competition coming in the space? And my second question is coming back to chemo combo, and just how that fits in the I/O landscape. To the extent your chemo combo is approved based on 021G, with potentially other chemo combos coming to market in 2018, how do you think about IDO and other I/O-I/O combo agents factoring in the market relative to chemo combo, given the time-to-market kind of dynamics playing out here? I was thinking about both the lung cancer setting and other indications. Thanks so much. Adam H. Schechter - Merck & Co., Inc.: Yep. So for HCV, we continue to see good progress with ZEPATIER and we saw it, not just in the U.S., but we've seen good progress in Europe, but also in Japan. As you look at the HCV market, there's no doubt that it's a large market and it's a large opportunity, but it's going to play out over many years. And as we look at the market, we see a reduction in number of patients being treated this year versus last year, and we think that that's going to continue to be difficult, as it's harder to get new patients into the market. Many of the tough-to-treat patients or those that were already previously diagnosed have been treated. Although there's still a lot of patients, we have to work harder to get those patients into the buying process. That's particularly true in the United States, but it's also true in country like Japan, where there's less patients each and every year, and there's not a…

It's from Vamil Divan with Credit Suisse. Vamil K. Divan - Credit Suisse Securities (USA) LLC: Great. Thanks so much for taking my questions. So first one, more on the – a commercial question on KEYTRUDA. Can you just give a sense of the adoption you're seeing in academic centers versus community-based centers? Just given community docs may be more general oncologists as opposed to being subspecialists, may have an incentive to see patients more frequently. Just wondering if the difference in terms of the breadth of indications, or the dosing frequency for KEYTRUDA versus the other drugs, is making any difference in how different doctors are using the product. And then second one, maybe if I could bring Ken into the Q&A here around business development, it's something if I look back at your prior earnings releases, something you've mentioned as a top priority. We haven't seen Merck pull any real significant sized deals. Just if you give an update on what's maybe the limiting factor in pulling the trigger in terms of is it the availability of assets? Is it the price for the assets, or is there any of the unknowns around drug pricing or tax reform and some of those things that might be making Merck wait a little bit? Thanks so much. Adam H. Schechter - Merck & Co., Inc.: Yeah. Let me give you some additional context on KEYTRUDA. So first of all, we're seeing pretty broad adoption. As I mentioned, the vast majority of patients within our approved indication for lung cancer are being treated. So that tells you it has to be both an academic but also outside of academic centers. So for our first line share to be what it is, you would have to see pretty broad utilization. And if…

It's from Alex Arfaei, BMO Capital Markets.

Good morning, folks. Thank you for taking the questions. Adam, I think you mentioned 40% of KEYTRUDA sales in the U.S. were in lung. How should we think about the breakdown of that in first- and second-line setting? And what is the rate of PD-L1 screening that you're seeing out there? And a follow-up for Roger, if I may. When can we expect data from your own IDO inhibitor, which I think you acquired early in 2016? How should we think about the potential of that, given the breadth of your activity with Incyte? Thank you. Adam H. Schechter - Merck & Co., Inc.: Yeah, so Alex, as you look at the utilization of KEYTRUDA in the U.S, and this is, again, a rough estimate with the data that we have, about 40% is lung, 30% melanoma, 15% head and neck and then 15% is all other utilization of the product. And if you look at PD-L1 testing, the vast majority of patients are being tested somewhere between 75% to 80% in the United States. If you look at our share in first-line lung, our share is about – if you look at early data, one in four patients or so are being treated for first-line setting. And then if you look at second-line lung patients, we have a share of about 15% which has been pretty stable over time. Outside the U.S, PD-L1 testing is increasing significantly. In Japan, it's remarkable how fast they've begun to adopt PD-L1 testing and frankly, even in Europe, about two thirds of physicians are already testing PD-L1 including about 80% in Germany and 60% or so in the U.K. So we're seeing PD-L1 testing pick up around the world, frankly. Roger M. Perlmutter - Merck & Co., Inc.: And Alex, it's Roger. Yes, our program with epacadostat is quite broad. But we felt in light of what we were seeing, that there were potentially opportunities both in the IDO1 inhibitor space and the TDO1 inhibitor space and maybe actually dual inhibitors to create agents that could be superior. We actually have a whole family of such compounds which have different properties. They're just beginning to come out of the preclinical space, soon into the clinic. So fairly soon we'll have an opportunity to see how those actually behave. Teri Loxam - Merck & Co., Inc.: We'll move on to the next question please, Darla.

It's from Andrew Baum with Citi.

Thank you. A couple of questions for Roger, please, relating to the combination of KEYTRUDA with chemo. As you further experience the use of chemo together with pembrolizumab, do you have any further insights into what we're seeing is addition rather than synergy through some kind of immunopotentiation? The reason I asked is there's been another data set published recently from human ovarian showing that you get an increase in TIL, but there looked like there may be an (53:43) suggesting that you're seeing an additive effect, and obviously, I'm thinking about the implications of that long-term in terms of the science that tells us other approaches. And then second, in relation to your ongoing IDO expansion trials, could you talk to patient selection? Are you selecting patients with a certain (54:04) for PD-L1 expression? Or do you believe there's a role for IDO to actually increase T-cell infiltrate and cull the tumors? Thank you. Roger M. Perlmutter - Merck & Co., Inc.: All right. Okay. Andrew, with respect to the chemo combination and the mechanism of action, it does appear, and here I'm getting a little bit beyond the data, but just sort of the sense of it, that more or less anything that kills tumor cells in a meaningful way introduces more antigen into the system, and through cross-priming effects, we believe that enables more stimulation of immune responses. With respect to whether or not one has an effect on the representation of TILs and whether those tumor-infiltrating lymphocytes are energic, as you know, it's very difficult to characterize those cell populations, and that's one of the reasons why we wandered in the wilderness for such a long time trying to understand what the meaning was of lymphocytes that were present in tumors; were they good, were they bad, those kinds of things. So, at this point, we believe that there is an effect on the immune component, and we're not just seeing a certain amount of tumor killing that comes from chemotherapy and then add onto it the immunologic response, but more work is needed to characterize that. And then, with respect to patient selection, we have a broad range of tumor types that we're looking at. Some of those tumor types, of course, PD-L1 expression is very important as in melanoma, where our first Phase 3 data will become available with epacadostat. In other tumor types, it's much less important. So the entry criteria for those patients are different in the different settings, and we have, in some cases, already described the nature of the study, and we will, in publications, describe what those studies look like. Teri Loxam - Merck & Co., Inc.: Thanks, Roger. Next question, please.

It's from John Boris with SunTrust.

...questions. Just on the MSI-High PDUFA date of June 9 that you referred to earlier, Roger, can you possibly just discuss the opportunity there? Number of tumors that you filed for, or centers actually diagnosing for the MSI-High mutation, and what is the incremental commercial opportunity across those tumors? And then, the second question, at AACR, we saw you initiated a KEYTRUDA plus YERVOY study in melanoma. Just your thoughts around initiating one with YERVOY in lung cancer. Are you waiting for MYSTIC and CheckMate-227 to read out before you consider that? What's the gating factor in initiating that trial? Roger M. Perlmutter - Merck & Co., Inc.: Right, John. First, for the MSI-High, what we've tried to do with MSI-High is to say that we believe, based on the studies that were done at Johns Hopkins and our own studies, that the observation that there is microsatellite instability, which can be demonstrated using standard available tests, by itself, predicts responsiveness in a broad range of solid tumors to KEYTRUDA. And what we're trying to do is something different from what has been done before, and that is to get away from the question of what is the primary histology of the tumor, and say from a molecular point of view, if you've got a DNA repair defect, there's a higher likelihood of response. So we're looking at a broad indication there. Now, microsatellite instability is not present at a very high frequency in many tumors. We're talking about 5% to 10% typically in a variety of different tumor types, so it's not a gigantic opportunity, but the tests are available. They're used to characterize tumors, or can be ordered by physicians, and hence, the drug can be used in those settings. I don't think we can characterize the commercial opportunity in much detail, but knowing that a small percentage, typically 5% to 10% of tumors, might have such things, and there would be some penetration. I think you can probably do the calculation. And then with respect to, as I'd said a little bit earlier, with respect to ipilimumab CTLA-4 directed therapy, there's no question that ipilimumab is active. We are interested in the question of how best to use ipilimumab in combination with KEYTRUDA. We have been doing some studies, previously in melanoma and also in lung, which are helping us to understand what dose and schedule would be. We've been a little bit slower getting those started than perhaps others, in part because we're seeing so many other signals in combination studies with a variety of other agents, particularly intratumoral injections which have less associated toxicity. So we've got a lot of irons in the fire there, but we are intending to do those studies. Teri Loxam - Merck & Co., Inc.: Thanks, Roger. Darla, unfortunately we're out of time so we're going to have to end the call here.

Thank you, ladies and gentlemen. This concludes Merck's Q1 2017 sales and earnings conference call. You may now disconnect.