Good morning. Welcome to the Lantheus First Quarter 2024 Conference Call. This call is being recorded, and a replay will be available in the Investors section of the company's website approximately 2 hours after the completion of the call and will be archived for at least 30 days. I will now turn the call over to Mark Kinarney, Vice President of Investor Relations. Mark?

Thank you. Good morning, and welcome to today's call. With me today are Brian Markison, our CEO; Paul Blanchfield, our President; and Bob Marshall, our CFO. We will begin the call with prepared remarks and then open the call for Q&A. This morning, we issued a press release, which was furnished to the Securities and Exchange Commission under Form 8-K, reporting our first quarter 2024 results. The release and today's slide presentation are in the Investors section of our website at lantheus.com. Any comments made during our call could include forward-looking statements. Actual results may differ materially from these statements due to a variety of risks and uncertainties, which are detailed in our SEC filings. Please refer to our SEC filings for a detailed discussion of these risks and uncertainties. Discussions during this call will also include certain non-GAAP financial measures. Reconciliation of these measures to the most directly comparable GAAP financial measures is also included in the Investors section of our website. It is my pleasure to now turn the call over to our CEO, Brian.

Thank you, Mark, and good morning. This marks my first earnings call as CEO of Lantheus, and I am delighted to be here to lead this incredible team. I began my career as a pharmaceutical sales rep and have more than 40 years of experience. Throughout my career, I have successfully led commercial efforts in numerous therapeutic categories, including oncology and immunology, across major global markets. Having served most recently as the Chair of the Board and a member of the Board since 2012, I have a deep understanding of Lantheus and the radiopharmaceutical industry and I'm committed to partnering with our exceptional leadership team to enhance the vision, strategy and execution necessary to remain the leading radiopharmaceutical-focused company. The outstanding start to 2024 underscores this operational excellence and innovation as we once again delivered strong performance and made strategic investments to advance and expand our pipeline. I'm particularly proud that our products were used to impact the lives of more than 1.6 million patients and their families in the quarter. As we look to the future, Lantheus will continue to be the leading radiopharmaceutical-focused company through operational excellence and sustained innovation in diagnostics and therapeutics enhanced by AI while delivering better patient outcomes and value to stakeholders. To realize this, we will maximize the value of our existing portfolio, expand our pipeline and expertise through business development and M&A, and sustain an attractive financial profile. With that, I'll now turn the call over to Paul to speak about our existing commercial portfolio. I'll then come back and discuss our pipeline.

Thank you, Brian. I'm excited to share details on another successful quarter. PYLARIFY generated net sales of $259 million, up over 32% from the prior year. Growth was driven by an expanding PSMA PET imaging market and increasing utilization of PSMA PET with PYLARIFY at existing customer sites. We continue to focus on delivering over $1 billion of net sales for PYLARIFY in 2024, making PYLARIFY the first-ever PET imaging agent blockbuster and ensuring PYLARIFY is available for patients, continues to grow and remains a clear market leader. As the clear market leader, we helped to drive growth of the overall PSMA PET imaging market through continued education on the benefits of PSMA PET with PYLARIFY to the prostate cancer community. We recently launched our new marketing campaign, Let's Be Clear, which highlights our differentiating clinical and commercial value proposition, as well as our market leadership as the #1 utilized PSMA PET imaging agent. Last year, we expanded our PYLARIFY sales force to educate nuclear medicine departments and freestanding imaging centers as well as referring urologists and oncologists, and we are beginning to see the impact of these efforts. This new campaign and sales force expansion, combined with our strategic partnerships, enables us to continue to grow the overall market and sustain PYLARIFY brand leadership. Behind all of these efforts is our relentless focus on operational excellence, including reliability, scale and out-the-door time flexibility. PYLARIFY is the only PSMA PET imaging agent that is widely available through a diverse F 18 distributor network, ensuring convenient and reliable supply. We serve patients in all 48 contiguous states as well as Washington, D.C. and Puerto Rico, and in Europe through our partner, Curium, supplying a large and growing market. We continue to expand our network with multiple sites activated in the quarter…

Thank you, Paul. Within our existing pipeline, we have a number of opportunities that have the potential to significantly impact the lives of patients and our future growth, including PNT2002, PNT2003 at MK-6240. Each of these assets was acquired or licensed based on our in-depth knowledge of the radiopharmaceutical market and our focused business development and M&A efforts. PNT2002 is our investigational PSMA-targeted radioligand therapy, or RLT, for the treatment of patients with metastatic castration-resistant prostate cancer. In December 2023, we reported that SPLASH, the Phase III registrational study, achieved its primary end point with a statistically significant 29% reduction in the risk of radiographic progression or death. As we have previously shared, we are awaiting more mature overall survival results as only 46% of protocol-specified target events were reached at the first interim analysis. We will analyze the overall survival data when it has matured to 75% of the protocol-specified events, which our models indicate should occur in the third quarter of this year. PNT2003, a product candidate for the treatment of neuroendocrine tumors, is currently under FDA review. If approved and pending positive resolution of the Hatch-Waxman litigation, PNT2003 could launch in 2026, making it the first radio-equivalent to lutetium-177 DOTATATE. This is already a sizable and growing market, and PNT2003 would be an additional option for patients and their health care providers for the treatment of neuroendocrine tumors. We continue to progress MK-6240, our F 18-based PET tracer, under development for the detection of tau tangles, which has the potential to be a best-in-class agent for staging and monitoring progression of Alzheimer's disease and leverages our expertise in radiopharmaceutical diagnostics and specifically F 18-based PET products. Clinical evidence accumulated over the past 5 years has shown the value of tau as a prognostic marker for cognition, which…

Thank you, Brian, and good morning, everyone. I will provide highlights of the first quarter 2024 financials, focusing on adjusted results with comparisons to the prior year quarter, unless otherwise noted. Turning now to the details. Consolidated net revenue for the first quarter was $370 million, an increase of 23%. Radiopharmaceutical oncology contributed $259.3 million of sales in the quarter, up 32.1%, attributable to the continued strength of PYLARIFY with sales of $258.9 million, up 32.4% year-over-year, and in line with seasonal trends we've noted over the last year. Precision diagnostic revenue of $104.2 million was 9% higher. Highlights include sales of DEFINITY at $76.6 million, 11.2% higher, along with TechneLite revenue of $21.7 million, up 3.5%. Lastly, strategic partnership and other revenue was $6.5 million, down 27.5%, due largely to the prior year comparable having $6.2 million of RELISTOR-related royalties not repeated this year. Gross profit margin for the first quarter was 68.8%, an increase of 14 basis points despite an approximate 70 basis point headwind due to the previously noted RELISTOR royalty sale mid last year. The increase is attributable to favorable product mix led by robust volumes of PYLARIFY and DEFINITY, along with a streamlined manufacturing footprint, offset in part by higher contracted material and overhead costs and additional PMF network investments. Operating expenses at 26.8% of net revenue were 538 basis points higher than the prior year rate but in line with previously guided spending levels. As noted earlier this year, increases in operating expense reflect investments made to support several growth and efficiency initiatives. Notably, we successfully went line with our new ERP system on January 1, which we supplemented with external health to ensure a smooth transition and continuity of our business. Operating profit for the quarter was $155.3 million or an increase of…

Thank you. In summary, our outstanding first quarter performance is a testament to the dedication of the Lantheus employees. We are actively implementing our strategy to drive both near- and long-term growth, prioritizing the advancement and expansion of our radiopharmaceutical pipeline while maintaining robust performance. With ample capital and strategic positioning, we're positioned to keep creating value supported by market-leading products, including PYLARIFY, which has the potential to be the first PET imaging agent to reach blockbuster status. Throughout '24, we will continue to harness our team's potential to identify, develop and invest in innovative solutions and leverage our proven operational excellence to serve health care professionals and patients. Having been with the company for a number of years before taking over as CEO approximately 2 months ago, I am more excited than ever about the future at Lantheus. We have a tremendous opportunity to build on our heritage and unrivaled radiopharmaceutical leadership. I want to thank everyone in the Lantheus organization for their ongoing unwavering commitment to our purpose to find, fight and follow disease to deliver better patient outcomes. And with that, we are now ready to take your questions. Operator, please proceed.

[Operator Instructions] Our first question comes from the line of Anthony Petrone from Mizuho Financial Group.

Congrats on the strong quarter here out of the gate for 2024. And again, Brian, welcome and congratulations on taking the CEO role. Maybe to start with PYLARIFY, here also from a 3-month perspective in March but also the guidance, so well beyond our expectations in 1Q. And Bob, you mentioned here plus 20% on a much higher base year, looking out for the remainder of 2024. So just a little bit on the dynamics in the underlying marketplace, are you seeing more utilization mostly in the core indications of high risk and metastatic cancer populations? Or you're actually seeing some usage off-label in earlier indications? And then maybe a little bit on utilization as therapy starts to get going, is that also a driver? And I'll have a couple of follow-up questions.

Thanks for the congrats. This is Brian. I'll kick it off and then turn it over to Paul. But I think the short answer on PYLARIFY is we are seeing the use of the brand expand. And most importantly, it's within our existing locations and customer accounts. So I think more referring physicians are getting on the bandwagon. Our commercial team is really expanding the knowledge base that's out there. And we are also seeing through a lot of clinical trial use that people are beginning to look at much earlier settings for PYLARIFY, much like the MIRROR study. But Paul, do you want to add to that?

Thanks, Brian, and thanks, Anthony. If we look at drivers of PYLARIFY in the first quarter, and then Bob can touch a little bit more on the guidance, I would say it's driven by three overall factors. The first is the growth in the overall market. The continued expansion of PSMA PET, particularly among existing prescribers, has been stronger than we anticipated and market research suggests an increasing scan utilization for BCR patients as well as for patient selection and monitoring, which is really leading to a larger current addressable market than we initially anticipated at the beginning of the year. As Brian alluded to, the biggest driver of the PYLARIFY growth is really the increasing utilization at existing customers where we are seeing existing prescribers continue to support and see the brand preference that we see in PYLARIFY. We think this really validates the marketing initiatives, including our new campaign, our 2023 sales force expansion, our strategic partnerships with customers, as well as our continued enhancement of our PMF network, which is now up to about 58 sites, including [ call ] times, available days and new sites. And then lastly, we did take a price increase at the beginning of the year. That had a far lesser impact, but we did take a 6% WAC price increase at the beginning of this year. Would reiterate what Brian mentioned around the label. As we've always said, the label for PYLARIFY is incredibly broad. And indeed, some of the life cycle management, as noted the MIRROR study, is really about addressing guidelines given the breadth of the label for risk of metastases prior to definitive therapy or a rising PSA, there really is a broad population for Lantheus to continue to educate physicians on and we see those paying rewards from all the investment and hardware. Maybe on a future-looking guidance basis, I'll let Bob provide some commentary.

Anthony, I can't really expand much more on that. I mean I guess what I would tell you is that, each quarter, we evaluate or reevaluate to confirm or dismiss our assumptions. And as I said in my prepared remarks, and I think we heard Paul sort of detail that in his as well, is that we see clear signals of market expansion, brand awareness and market leadership. And so from that perspective, we learned from these historic data, and we make adjustments to our view of the world. So based on that, we have confidence that we can deliver more than $1 billion in PYLARIFY sales for the year.

Our next question comes from the line of Roanna Ruiz from Leerink.

Another one for PYLARIFY. I was curious if your strategic partnerships are already gaining traction. Is that driving your guidance raise? And since you just mentioned net price a little bit, I was curious if that's going to be sustained through the year.

So I'll take that one. So I guess, from a strategic partnership, while Europe is a large market, the launch there is just getting underway. So from that perspective, the contribution is de minimis and that the guide is really predicated on the U.S. market and in our efforts here in the U.S. In terms of the contribution of strategic partnerships using PYL, if you will, within other clinical studies, again, that number, is not that significant in the grand scheme of things.

The other piece to just think through is the strategic partnerships with our key customers in the U.S. As part of the broader remarks, we did note we haven't continued to enter into those strategic partnerships with key customers. We began that in 2023. We continue to see traction in 2024. That's naturally been but one of the drivers. But I would still say, overall, the overall market growth continues to grow. And as the market leader, strategic partnerships are really around solidifying our position and ensuring that PYLARIFY remains the #1 PSMA PET imaging agent going forward. I think we are very pleased with our progress overall, but it is one of multiple strategies to ensure that PYLARIFY continues to grow and we feel comfortable with its competitive position, its clinical and commercial value proposition, and noting that the TPT piece, which drives some of the strategic partnerships, impacts 95% of the approved market currently. And so these products are not interchangeable. Each of them have differentiated clinical and commercial attributes, and we really deeply understand our customer base, including their site of care mix, whether that's hospital outpatient or otherwise, their payer mix, specifically the Medicare fee-for-service. And as such, we are able to work with them to mitigate the potential impact of any financial exposure. Given the competitive nature of the business, I'm sure they'll be more questions, but we don't want to elaborate further at this point.

Our next question comes from the line of Richard Newitter from Truist Securities.

Congrats on a great quarter. If PYLARIFY is not blockbuster status yet, I can only imagine what that threshold looks like. But maybe just to start off, on the contracting question that Roanna just asked, can you give us any sense as to what percentage of the market that would be impacted by transitional pass-through? Do you think you can get under some sort of contract or dealt with in your negotiations by the time transitional pass-through expires? And any sense as to kind of where you are today relative to that goal percentage? And then I have one follow-up.

Yes. So Richard, we have a very strong sense of what the future looks like for PYLARIFY. And I'm going to let Paul elaborate, but our strategic agreements with our customers are multiyear in duration. They've all been in the works for quite some time, and the preparation for this has been, like I said, well underway for a while. But I'll call blockbuster at $1 billion this year. So I'll help you out with that one. Paul, go ahead.

Thanks, Rich, and I appreciate the congrats. So as we've shared in the past, TPT impacts the intersection of site of care and payer mix, and I alluded to this in responding to Roanna. That is really the hospital outpatient setting and the Medicare fee-for-service. And when you look at that intersection, it really only affects about 20% of PYLARIFY revenues. It is concentrated in the hospital space. And so we've understood this since the launch of PYLARIFY and the receipt of TPT. We began entering into long term, as Brian mentioned, strategic partnerships last year. We are pleased with our progress, and I think we see continued growth in the market. But we really bring a high-touch interaction with our customers. There is significant overlap as we look with DEFINITY, which has been on the market for 20 years, many of which we have long-term relationships. And so the amount of interactions that we're having with our customers to understand the impact, to understand their exposure and their sensitivity, we continue to make progress there. We're pleased with the progress. We're obviously not going to share any specifics about where we are in being able to wrap that up given the competitive nature of the business. But suffice it to say, we continue to be incredibly confident with PYLARIFY's leadership position, even amidst the potential expiry of pass-through at the end of this year.

Our next question comes from the line of Larry Solow from CJS Securities.

I'll echo the congratulations and a formal welcome to you, Brian, as well. I guess just sticking with the PYLARIFY theme and the transitional pass-through, any comments on just the cadence of the year in terms of sales? And as we get into the latter part of the year, do you see some impact, right? As some of these centers start preparing, it's hard to switch over a patient during treatment, but do you see some impact from the pass-through ahead of that actual expiration, maybe even modest but some kind of impact? Just thoughts on cadence of sales for PYLARIFY for the year based on that.

So Larry, I'll pick up the sort of the cadence of sales expectation. I keep referring to the sort of the sequential seasonal trends that we've seen over the last year plus where we really do see sort of if you think in terms of quarterly splits, we would expect to see Q1 as the highest sequential improvement than Q4, than Q2, than Q3, in sort of highest to lowest sort of cadence, if you will. But beyond that, I'll let Paul take it from there.

Yes. Thanks, Larry. I think as Bob mentioned, we continue that there are natural seasonal impacts. When we look at the summer months, physicians and imaging center staff do need to go on vacations, so we do expect some of that. I think overall, for the year, the company guided to mid-20% PYLARIFY growth range, with the vast majority of that being volume and a somewhat minor net price impact. Naturally, in the first quarter, we took a 6% price increase at the beginning of this year. We're going to see a little bit more contribution of that now. But as those strategic partnerships further expand, we will see volume be the larger driver. But otherwise, I would stick with Bob's overall commentary on the sequential components.

Our next question comes from the line of Yuan Zhi from B. Riley.

Congrats on another great quarter. We heard you and your partners are expanding the availability of PYLARIFY in New York and the Midwest. I'm curious, is it based on your demand forecast or just building actual capacity there to accommodate the customers' request?

Thanks, Yuan. So yes, we did expand our PMF network in the first quarter. We now have 58 active PMFs, and we did add 4 in the quarter in New York, California, Ohio and in Florida. In some cases, it is about additional capacity. In many cases, it is really around the right out-the-door times. Given the overall growth of the PSMA PET imaging market that has been substantial, we are seeing demand go earlier in the day as well as later in the day. And while F 18 has the longest half-life of an approved PSMA PET imaging agent of 110 minutes, we still need to be able to make product multiple times in the day to continue to serve that increasing demand. And so in building out our PMF network, some of it is redundancy and some of it is really around the capacity to fuel growth at existing sites. We want to make sure that we have the right time slot. F 18 is a fantastic isotope given the size of the PSMA market with FDG doing approximately 2 million doses, and we can tap into that. There's naturally a role for other agents with shorter half-lifes that can be made on a generator, specifically at the margins. But we continue to expand our F 18 capacity to be able to drive that. And we are seeing the majority of growth from those new activated sites be new physicians and new time slots rather than necessarily cannibalizing existing sites where we're bringing in product elsewhere.

Our next question comes from the line of Justin Walsh from JonesTrading.

It's been great to see your pipeline development continue to expand with the Perspective deal here. Where do you see your pipeline developing over time?

Well, I think we see it developing on two fronts. We're going to be highly selective and maintain our leadership in PET imaging. I think that's very clear. And obviously, radioligand therapy, we're already in the space with the POINT partnership, Perspective partnership. So we are definitively going to be spending a lot more time in BD and M&A in radioligand therapy and building out the pipeline on that front.

Our next question comes from the line of Andy Hsieh from William Blair.

Congratulations on a beat and race quarter. So a question for you, Brian. Just in light of several important developments in the past 24 or 48 hours, right, so we saw Mariana getting acquired by Novartis, a complete response reported by Clarity in prostate cancer, just maybe from the big picture perspective, share your world view on the radiopharmaceutical field and how Lantheus could really play there. And maybe just a quick one related to radiopharma as well, we saw Novartis showing overall survival, hazard ratio down to the less than 1.0 range. So does that impact your confidence level heading into the Q3 update?

Well, with your last comment first, it certainly is encouraging that the passage of time will see a reduction in the point estimate around overall survival. But look, we await the flip of the cards, if you will, and that's why you do the clinical trial, to get the answer. So we're pretty excited about it, but at the same time, the data will tell us what it tells us at the right time. And as far as the recent activity in the industry, I think it certainly validates the Lantheus platform, if you will. And I think we're seeing a lot of things. I think Novartis is clearly among the big pharma players ahead of the pack, right? Their investments are fairly deep, fairly broad and their commitment to radioligand therapy is fairly clear. I think when you look at the other big pharma investments, they seem to be platform acquisitions with one lead asset, and they're hoping that works out, but also a lot of science projects. And I think we're going to be, I think, very selective in what we pick up and what we look at. We have that expertise. We don't need a platform because we are the platform. And I think just stay tuned and you'll see some activity from us in the near future.

Our next question comes from the line of Kemp Dolliver from Brookline Capital Markets.

Back to PYLARIFY, given your comments about growth in your business in imaging centers and some of the other initiatives you've undertaken, has the mix of site administration changed?

That's a great question. I really appreciate the focus there. Generally speaking, the site mix around hospitals, freestanding imaging centers, and government accounts has not changed materially. We generally view kind of the book of business as being relatively stable with about 2/3 hospitals, little bit less than 1/3 freestanding imaging centers and then government facilities, both VA, Walter Reed and others, being in that mid-single-digit range. So overall, we continue to activate new prescribers. But the largest growth is really just increasing demand and prescriptions being sent to those existing sites, all in a relatively comparable portion. Now overall, we do see increasing Medicare Advantage relative to fee-for-service. And that's just not necessarily a PYLARIFY trend, but overall, kind of a national trend as Medicare Advantage continues to become more important. But the overall site mix relatively comparable year-over-year.

Our next question comes from the line of Tara Bancroft from TD Cowen.

This is Greg speaking on behalf of Tara. So you have a substantial cash balance that should continue to grow with increased revenue year-over-year. So can you tell us more about your plans for capital allocation either in terms of R&D, marketing for PYLARIFY or potential plans for business development?

So I'll take that. This is Bob. Yes, you're right. We had a record quarter for free cash flow at $118 million. So it was great. But I think what you also saw us do in the quarter is deploy $98 million of that with the Perspective transaction. So I think from the perspective of what are we going to do with the money, we constantly, between management and the Board, evaluate capital deployment strategies. Clearly, as Brian indicated in his remarks, we are going to be busy on the business development front. But Paul also noted internal development. But we also focus on capital structure optimization. And that can include any number of deployment options. But as we think through the fact that we have this dry powder, it affords us the ability to look at the landscape of business development opportunities to continue to add to the pipeline and be able to strategically advance important projects internally to solidify our portfolio that sets us up for growth for the long term.

Our next question comes from the line of Roanna Ruiz from Leerink.

So I noticed on the call, you also mentioned expanded field force and new marketing and education campaign. I was curious, within that, what are you doing to help educate new physician targets and new customers who might not yet have the deep experience with PYLARIFY yet? And how can you help drive their use through the year?

Very astute question, Roanna. We did expand the field force, as we noted last year, to be able to call on hospitals, freestanding and imaging centers, as well as referring physicians, namely urologists, which is largely in the staging education, and referring oncologists, medical oncologists and radiation oncologists. We do see the vast majority of growth coming from existing prescribers. We do believe we made significant inroads in continuing to educate physicians on that benefit. But we really do this through an omnichannel approach that would be levering both our medical team and appropriately at medical congresses where they get called on to answer questions. There continue to be significant publications and discussions. If you look at recent medical congresses, the number of posters that are discussing PSMA, both therapeutically and diagnostically, has significantly grown over the years. And so that first starts from a medical perspective to raise awareness appropriately. And then commercially, our sales teams are in there in accounts, both at treating sites and referring physicians, to raise awareness. We continue to gain new data and insights on our prescribing base, which allows us to appropriately target those referring physicians. And then naturally, we do appropriate omnichannel marketing efforts, both in appropriate publications and other awareness, including appropriately within the patient segment. We really are seeing the fruits of that investment play out where we made increasing investments in the middle of last year, to really generate demand in addition to just fulfill it. We believe we appropriately invested ahead of the curve. And we believe, as the clear market leader and largest voice in the marketplace, that we are having a disproportionate impact in driving the overall growth of the PSMA imaging market. And naturally as the market leader, we take a disproportionate benefit of those gains in the growth.

Our next question comes from the line of Richard Newitter from Truist Securities.

I just wanted to ask, you mentioned life cycle management on PYLARIFY, you kind of gave us a stay tuned on future indication sets. I'm just wondering what that means and looks like or if you can elaborate there. And also, I asked this last quarter as well, but a competitor of yours is out there publicly talking about kind of a PSMA PET diagnostic 2.0 version that could potentially restart the transitional pass-through clock for them while you're still off pass-through and potentially they're still on. I'm just curious, do you have any insight on how CMS view that type of effort? And is that something that you had in the works or could potentially replicate as needed?

Yes, Richard, thanks. A lot of good questions wrapped up into that. And I think we are holding our product improvements, life cycle management strategies, fairly close to the vest. Like you, we have listened to what other companies have said about their approach to a 2.0 in pass-through, and we have a particularly good knowledge of what needs to happen in order to make that work. So I'm not sure how much we want to elaborate. But Paul, I think if you want, you can add a little bit there.

Thanks, Rich. We very much understand the pathways that are being discussed out there in the marketplace. We have been aware of them. We believe, just for context setting to be eligible for transitional pass-through, based on current regulatory pathways and CMS requirements, you do need a new NDA. There are multiple paths to get there. Our team consistently monitors, as Brian mentioned, developments in the industry, and we consider multiple options to support our ability to maintain patient access and really maximize the value of the entire portfolio. We don't feel the need to share our internal plans at this point publicly, and we will do so when appropriate. But overall, I think the key message for PYLARIFY right now is that we're focused on delivering over $1 billion in sales for PYLARIFY this year, making it the first ever PET imaging blockbuster, executing strategies, including brand awareness, strategic partnerships with key customers that we've talked about, supporting CMS and congressional actions to mitigate that impact, and really expanding the market through our education efforts as well as life cycle management, and we look forward to delivering on those and sharing more about some of the questions you asked when appropriate.

Our next question comes from the line of Andy Hsieh from William Blair.

So at the risk of sounding like an overly sensitive sell-side analyst, you made a very easy comment on the BD strategy, specifically focusing on radioligand. I just want to clarify, are you signaling a preference over other modalities such as antibodies or various peptide-based contracts as you survey the landscape?

Well, I mean, I think at Lantheus, we would naturally have a bias. But look, RLTs are coming of age. The ability to target the tumors more effectively with less off-target toxicity is really evolving, but it's just another modality. And if you look at the overall market, it's a small piece of the total cancer market. So it's emerging. It's growing. It's exciting. We're seeing lots of valuations jump by big pharma paying a lot of attention to the space. So I guess you could say it's validated from that perspective. But I mean, look, the simple truth is the technology has proved to the point where you can really deliver a smarter bomb to the tumor with less talks to the patient, and they can continue to go on and receive additional lines of therapy. So I think it's exciting, it's evolving, but I can't tell you I have a preference, but I certainly have a bias based on the business I'm in.

Thank you. Ladies and gentlemen, there are no further questions at this time. Thank you for participating in today's conference. This concludes the program. You may disconnect, and have a wonderful day.