Tom Hook
Analyst · KeyBanc
Thanks, Michael. I'd now like to do a quick review of each of our product lines. Turning to the Advanced Surgical and Orthopedics product line, which includes Portable Medical. Operationally, we closed out 2016 on a strong note. Customer relationships are advancing, and we have made improvements in quality performance and inventory management practices, which have positively contributed to total company cash flows. Last quarter, we talked about the significant progress we have made advancing the wireless power initiative. During the fourth quarter, we shipped the first wireless prototype. Additionally, we are making good progress advancing a second customer relationship while continuing conversations with a broad group of potential wireless customers.
The Advanced Surgical and Orthopedics product line revenues remain a solid contributor to overall results. Product line revenues declined when compared to the fourth quarter of 2015. However, in the prior year, several customers increased demand at the end of the year in advance of product line transfers to our facility in Tijuana. As these product lines are fully qualified, we expect that revenue will return to normalized levels. Additionally, the Advanced Surgical and Orthopedics product line is driven by customer product launches, and 2016 has been a slower launch year when compared to 2015.
Operational performance remained steady, and we continued to see improving relationships at high levels of collaboration with our top customers. Multiple continuous improvement initiatives advancing across our operations are driving incremental cost savings. Additionally, operational and quality programs are in progress to standardize and harmonize our systems and processes across the product line.
In 2017, we expect incremental revenue growth opportunities driven by new product launches and acceleration in targeted areas. We believe there are multiple opportunities for Integer to successfully partner with customers to help them streamline and mitigate cost pressures by providing industry-leading solutions. I look forward to sharing more details on future calls.
Revenues in the Cardio & Vascular product line ended the year strong, increasing 7% year-over-year on a quarterly basis, driven by strong demand for precious metal machining components and our OEM product lines. The outlook for 2017 is positive. We continue to see strong demand for several key products, have successfully launched the significant co-development product and had a number of new opportunities well positioned in the sales process. Customer relationships remain strong with greater penetration and increased opportunity with mid-sized OEM customers. Accelerated interest and opportunity in co-development and OEM product offerings and a near execution of several significant medium- and long-term supply agreements will build momentum across the product line throughout 2017.
The cardiac rhythm management and neuromodulation product line delivered positive quarterly momentum following the challenges experienced during the first half of 2016. Revenues improved supported by deeper customer engagement and the completion of several new agreements during the quarter. By leveraging integrated product technology and manufacturing capabilities, customers are providing even more visibility into future opportunities. We expect these will translate into revenue growth in the future.
We believe that there are many growth opportunities within the neuromodulation market and also the CRM market, even though the overall market is flat to declining. OEM partners and customers are seeking more comprehensive, value-added solutions and supply-chain efficiencies, which Integer is well positioned to provide. We believe that the recent CMS approval for leadless pacing will accelerate adoption and further technological innovation in the CRM market.
Additionally, the neuromodulation market is rapidly growing. Our leading position to design and manufacture full active implantable systems increases the total value we provide and ultimately capture as future revenue streams. We are focused on long-term business development to sustain and grow this product line into the future. We also continued to accelerate short- and mid-term revenue opportunities.
In addition to recently awarded new product development and manufacturing programs, we have a solid pipeline of future opportunities in various stages of development that provide us confidence as we head into 2017. The recent FDA approval of an MRI safe pacemaker offered by a leading OEM provides incremental revenue growth opportunities. We are currently working closely with our customer partners to remain synchronized with their demand requirements and the longer-term opportunity for Integer. We look forward to sharing more information in future quarters as we progress in these areas.
Turning to Non-Medical sales. The Electrochem product line faced a challenging year throughout 2016 with a continued downturn in the oil and gas market. However, during the fourth quarter, we saw the price of oil begin to stabilize. This has started to bring energy customer activity back online, particularly in North America, which has helped to improve Electrochem revenue, a positive sign as we head into 2017. As the energy market worked through these challenges, we have remained focused on maintaining and growing our market share within this space. Additionally, we have worked hard to engage with customers across all of the market segments we serve and have made good progress on multiple new business opportunities with existing and new customers. As we navigated the Electrochem product line through this challenging period, we took steps to protect our market share in parallel with adjusting our cost structure and reducing inventory levels to improve our return on invested capital. We expect to return to growth in 2017 based on the oil and gas industry market recovery and new business wins.
Last quarter, we shared Integer's high-level strategic objectives: First, we will invest to drive growth with customers across the full range of the products and services continuum; second, we will deliver shareholder returns through growth in profitability and cash generation to drive accelerated repayment of debt obligations; and third, we will continue to cultivate an ethical value-driven culture that optimizes the commitment and contribution of our exceptional associate team. We remain laser focused on achieving these objectives to realize our vision to enhance the lives of patients worldwide by being our customers' partner of choice for innovative medical technologies and services.
Integration efforts remain on track and we expect to be largely completed by the middle of 2017. We closed out 2016 exceeding our original synergies target of $25 million and at the top end of the range we provided last quarter with cumulative synergies of $34 million. Productivity initiatives to reduce direct and indirect spend, primarily through supplier negotiations and vendor consolidation, continue to advance and are generating the desired results. We expect to achieve $50 million of cumulative synergies by the end of 2017 and $60 million in 2018.
We recently completed several major integration milestones: first, the comprehensive integration of associate compensation and benefit plans; second, the consolidation of finance and IT systems; and third, the process optimization within our sales and operating planning processes. Remaining activities are on schedule to further support our ability to successfully complete the formal integration of our company in 2017.
We are advancing plans to leverage our manufacturing footprint, increase scale and product capabilities to support the needs of our customers. These efforts include continuous improvement programs, productivity initiatives, direct material and indirect expense savings opportunities and the establishment of global centers of excellence. Facility transfers and closures previously announced and in progress, including the closure and transfer of our Clarence, New York facility, the completion of the Plymouth relocation and the full qualification of our Tijuana facility are advancing towards completion. At this time, we do not have any additional plans to commence new projects to consolidate or close any manufacturing facilities. We are evaluating the plans and policies of the new U.S. administration in parallel with assessing our operational infrastructure to meet customer needs and future growth.
Integer is well positioned within the medical technology and medical device outsource manufacturing markets. We believe there is a robust funnel of opportunities to pursue. It is contingent upon us to capitalize our needs. We have expanded our medical device capabilities and are excited about opportunities to partner with customers to drive innovation. We have the scale and global presence supported by world-class manufacturing and quality capabilities. We are confident in our abilities as one of the largest medical device outsourced manufacturers with a long history of successfully integrating companies, driving down cost and growing revenues over the long run. We continue to drive shareholder value by enhancing the lives of patients worldwide by being our customers' partner of choice for innovative medical technologies and services.
Before we open the call up for questions, let's discuss our Chief Financial Officer transition plan. Today, we announced the appointment of Gary Haire as the Executive Vice President and Chief Financial Officer. Gary has an extensive background in finance and operations with significant experience in manufacturing and distribution industries. We look forward to welcoming Gary aboard in early May.
As previously announced, our current Chief Financial Officer, Mike Dinkins is retiring in early March. I'd like to thank Michael for his dedicated service to Integer over the past 8 years as a board member and as a key member of the executive leadership team. Tom Mazza, Corporate Controller and Treasurer, will serve as interim Chief Financial Officer until Gary joins the company.
Operator, we will now turn to the question-and-answer portion of the call.