Greg Smith
Management
Good morning, ladies and gentlemen, and welcome to the IP Group plc half-year results investor presentation. Questions are encouraged. They can be submitted at any time via the Q&A tab that is just situated on the right-hand corner of your screen. Please just simply type in your questions and press send. The company may not be in a position to answer every question it receives during the meeting itself. However, the company can review all questions submitted today and will publish our responses where it is appropriate to do so. Before we begin, as usual, we would just like to submit the following poll, and if you would give that your kind attention, I am sure the company would be most grateful. I would now like to hand you over to CEO Greg Smith. Greg, good morning, sir. Good morning, Jake. Thank you very much, and welcome everyone to IP Group's 2026 half-year results presentation. Thanks very much to all the Investor Meet Company team and Mark for hosting today's session. Much appreciated as always. For those who do not know me, I am Greg Smith. I am the Chief Executive of IP Group. With me today is David Baynes, our Chief Financial and Operating Officer. We deliberately tried to keep today's presentation a bit shorter and more focused. It is the half-year after all. I will cover the half-year highlights and progress across the portfolio and our strategic priorities. I will get DB to take you through the financials before I return to summarize, and then, of course, there will be time for questions. I would say the headline for today's results is that we have carried the momentum that we had from 2025 into 2026 with further NAV per share growth, strong cash realizations, and as I hope we will demonstrate, broad-based portfolio progress. As usual, the disclaimer is here. Please note these sort of important disclaimers, particularly the bit about forward-looking statements. This presentation will be up on the investor relations section of our website for review post the call. In terms of what we will cover today, four short sections. The half-year overview, portfolio progress, I think particularly the future value opportunity within that, then financial results, and then a brief summary. Please post questions through the platform as we go, as Jake said. We will then group them by theme, and answer as many as we can, and we will do that clearly and directly. Turning first to what we delivered for shareholders in the first half. Before we do that, I just wanted to note that this year marks IP Group's 25th anniversary. Over that period, we have invested over GBP 1.5 billion. We have helped to form and support more than 600 companies, and those companies have created more than 15,000 jobs. That track record matters because science investing, in our view, rewards experience, specialist judgment, and also long-term relationships. From a shareholder point of view, it also gives us a large and increasingly mature portfolio from which future value and cash realizations can emerge. Today is principally about the delivery in the first half and the little period afterwards. Let us move straight into the first half results. The group made disciplined and tangible progress in the first half. NAV per share increased by about 3% to GBP 1.14, taking net asset value above GBP 1 billion. Since the period end, NAV per share has actually increased further to approximately GBP 1.17 a share as at 11th of September, last Friday. We generated GBP 69 million of cash proceeds in the six months, which was slightly more actually than the whole of full year 2025. A further GBP 17 million since June takes our year-to-date proceeds to the mid-GBP 80 millions. Portfolio companies raised over half a billion of third-party capital, and we contributed about 5% of this. This is strong external evidence that other investors are prepared to commit substantial capital to companies as they progress. The largest fair value driver in the period was the further de-risking of Pfizer's obesity programs. That increased the value of our royalty interest by GBP 27 million to just over GBP 150 million, and we ended the period with a healthy cash balance of GBP 239 million gross. The message is not that one asset performed well. NAV growth, cash realizations, external funding, and operational milestones all generally moved forward together. Before going into the detail behind that in the portfolio, I just want to briefly acknowledge the possible offer process during the summer. I would say, as we put in our RNS release, the board sought to engage constructively with Railpen and its partners, and we remain very grateful for their effort and the constructive engagement of all of the shareholders who we spoke to during that period. As you will have seen, the process did not result in an acceptable proposal, and so our focus as a management team and a board is firmly on delivering the substantial value that we see in the group. On that note, let's turn to Pfizer. At the full year, I spent a bit of time explaining why that Pfizer obesity royalty interest had become such a significant asset for IP Group and our shareholders. The first half has added further evidence to that and also reduced development risk. During the period, Pfizer released positive clinical data for the lead program, berobenatide, showing competitive weight loss efficacy alongside favorable tolerability and supporting the potential for a monthly maintenance regimen. The berobenatide and amylin combination also advanced into phase IIb, and that was the primary driver of the GBP 27 million uplift that I mentioned. This is an increasingly competitive market, so differentiation matters. I think the potential combination of competitive efficacy, favorable tolerability, and this sort of monthly maintenance profile remains one of the main reasons that Pfizer believes this program can be highly differentiated in that increasingly competitive market. Also to reiterate, Pfizer's committed substantial resource to this. It is progressing 10 phase III studies this year, and launch is targeted in 2028. As we have said in previous notes, there remains clinical, regulatory, and commercial risk. As a result, our valuation is based around a probability-weighted method and is discounted. But the progress in the half strengthens both the quality and the breadth of our exposure to a market that is externally forecast at around sort of GBP 100 billion-GBP 150 billion, or thereabouts, annually by 2030. To hopefully give you a little bit more color, this slide shows the route to market across the programs where we have economic exposure. As I mentioned, the most advanced of the assets at the top there is berobenatide. Two phase III studies are expected to reach primary completion in October 2027, and that supports a potential first approval in 2028. There is also a monthly dosing study and seven further phase III studies that could provide potential to broaden the label and therefore the commercial opportunity. Worth noting that just yesterday at a conference, Pfizer also indicated that recruitment across essentially all of the berobenatide phase III studies is now close to completion. From our point of view, from your point of view as shareholders, that is very encouraging because patient recruitment is often the biggest factor in determining when studies read out and complete, so it supports good confidence in the current program timetable. As I mentioned, the berobenatide and amylin combination is now in phase IIb, so you can see that there. That has got primary completion currently expected in April 2027. We also have exposure to an amylin monotherapy and some earlier oral and next gen programs. There are a couple, as David Baynes will come on to explain, a couple of phase I assets that are not currently attributed value in our model. I think the important takeaway from this for shareholders is that this is not exposure to a single binary program. It extends across the lead program, which is an injectable, some combination therapies, the potential for less frequent dosing, and a number of these earlier stage programs. That gives us several possible routes to value as Pfizer develops the franchise. I think this point on the carrying value, I think the GBP 150 million we have it in at, this definitely does not reflect Pfizer's commercial ambition, and it is based on these risk-adjusted probabilities. DB will take you through those assumptions in a little bit more detail later today. In terms of our investment thesis, our default is to hold the asset and receive the royalties, and they are anticipated to begin in 2028 if the development and launch proceed to the plan that is set out here. This is highly consistent with the venture model. A small number of exceptional outcomes can drive a very disproportionate share of returns. This asset, we believe, gives shareholders direct exposure to that potential. That being said, having a default path definitely does not mean that we stop exploring ways to accelerate value creation for shareholders. As the program matures and de-risks over this period, we would expect the range of strategic options available to us to broaden out, and we will continue to assess these carefully through the lens of long-term shareholder value. Of course, we remain open to exceptional opportunities should they arise. On Oxford Nanopore, they made, I would say, encouraging progress in the half and has performed strongly since the period end from a share price point of view. As you can see from the slide, and many of you will have tracked this directly, revenue was at GBP 117 million, which is about a 12% growth at constant currency. A big thing for us was the fact that gross margin increased by 400 basis points to 62%. I think even more important, and I think this was the bit that came out particularly in the half-year results more than the trading statement, was the adjusted EBITDA loss more than halving to just over GBP 22 million. I think one of the key developments has been the strengthening of the leadership team. Francis joined as CEO in March, and the company has also added a number of senior hires in areas of key capabilities as it prepares for its next phase of commercial growth. Under that leadership team, it feels to us that there is a more focused customer-led growth strategy. The company has spoken about narrowing down the 47 areas in which its technology could compete to the 18 that it considers most attractive. Interestingly, management's own analysis indicates that around 40%-45% of revenue generated over the last three years already comes from those priority markets. The existing revenues therefore provide something of a strong foundation for that strategy and give the company a credible base from which to expand. The opportunity available, which is clearly set out within their materials, gives very substantial room for expansion. I think we see this as very much a refinement of focus rather than a wholesale change of direction, and that gives us confidence in the team's ability to execute. That point on profitability or the progress towards profitability, that has been absolutely central to our investment thesis, and I think the results were ahead of where the market appeared to be. The company remains on track for that EBIT break-even in full-year 2027 and positive free cash flow in 2028. The other point of note is the cross-licensing agreement with a global diagnostics company that brings $35 million of committed revenue over the next couple of years, but importantly, ongoing royalties, which we believe could be substantial. They are not currently included in the medium-term guidance, so any early adoption, which we might see as soon as this year actually, could increase recognition of that strategic value to the platform. There's been a bit of an increase in the value of our holdings since the half year of about GBP 26 million, but we remain very focused on that sort of operating thesis and the route to sustainable profitability. Delivery against that should also create more attractive monetization options for us over time without prejudging the timing of those. On the wider portfolio, don't worry, I'm not going to go into all of these in detail, but I think the central message from this slide is breadth and the fact that the progress was not confined to Pfizer or Oxford Nanopore. Quantum Motion, Quantum Circuits, Oxa completed major funding rounds. First Light Fusion and Mantle8 raised capital. Hysata secured its first commercial electrolyzer order. Centessa was acquired by Eli Lilly. So there's been good progress across the portfolio. I would just say Oxa is worth a brief comment in there. Following its strategic rate reset last year and this sharper focus on what we term industrial mobile autonomy, it has formed a new joint venture with the Dubai Future Foundation called Shift, and the venture is designed to put autonomous vehicles to work in ports and airports in an integrated product that combines Oxa's self-driving software, its fleet management platform, and its autonomy hardware. This is really targeting practical gains in things like productivity, efficiency, safety, and operational resilience within these environments. The first scalable commercial deployment is planned before the end of 2027. From Dubai's point of view, of course, it is trying to support the stated ambition to double its foreign trade by 2033. Of course, given the current regional uncertainty, the near-term emphasis from the company is correctly on disciplined execution and securing those early deployments. Management definitely deserves the principal credit for delivering that partnership, but it is worth saying IP Group supported the company in bringing it about. This is hopefully a useful example of how our network and our international network can help portfolio companies across these strategic international partners to accelerate into large markets. Still delivery ahead, but pretty encouraging process from one of the companies that was affected by a significant valuation reduction last year. Overall, the breadth of the financing, the clinical progress, and the commercial partnerships provides evidence of greater maturity across the portfolio with a couple of negative movements as a reminder that execution risk always remains in the portfolio. Cash generation was one of the clearest positives from our first half. We realized GBP 69 million, which compared with about GBP 30 million in the first half of last year. As I mentioned, it is actually now more than the whole of 2025. The principal contributors are set out on the slide, Monolith, Centessa, and Hinge Health. I think they both provide sort of some good illustrations of our model. Hinge Health, following their 2025 IPO, we have now generated a total of GBP 46 million of total proceeds. That was a 50x multiple of invested capital and almost a 50% IRR. Monolith is a bit different. That provides an example of where we have had a strategic acquisition of an important deep tech capability, and that was an acquisition by CoreWeave. Since then, we have generated around GBP 23 million of proceeds this year with, again, greater than 50% overall IRR. I think they show that we can create and realize value from different parts of the portfolio, whether that is a public market success or a strategic acquisition. It is exactly the sort of profile that we would expect from a diversified science and technology portfolio. Including post-period end receipts, we have now delivered GBP 154 million, just over GBP 150 million since the beginning of 2025. We are well over halfway towards our GBP 250 million target by the end of 2027. Looking forward, we continue to see a healthy pipeline of maturing assets and potential realization opportunities over the next 12-18 months. Fair to say that timing is never entirely within our control, but the breadth of the portfolio gives us a number of different paths to achieving that target. As a reminder of the way the components of IP Group work together, Parkwalk provides differentiated access at pre-seed, seed, and into Series A through our dedicated EIS funds and relationships with leading universities. The permanent balance sheet, which shareholders are exposed to, supports selective companies as they mature, while our private funds can add science and technology scale-up capital alongside the balance sheet. That additional capital matters in three ways. It can accelerate our strongest businesses across a broader opportunity set. It can generate management fees to help reduce our net overheads over time, and strong investment performance in those funds can generate performance fees for shareholders. The model gives us proprietary sourcing, long-term ownership, and the potential to increase the capital available to portfolio companies without relying solely on our balance sheet. On the subject of third-party capital, we made progress in expanding that platform during the period. Although I'd say the focus is now firmly on delivery of the two new mandates that we announced during the first half. Our strategic relationship with Aberdeen is moving quickly towards its first investment, and we expect the initial portfolio to be up and running by the end of the year. This is definitely an early example of a dedicated defined contribution mandate, providing access to scaling science and technology businesses. We believe there is good potential for it to provide a route for further long-term capital savings coming into this sector. In Australia, just after our full year results, we also launched the GBP 50 million IP Group Climate Catalyst Fund. That was with the Clean Energy Finance Corporation in Australia, which is the sort of equivalent of the Australian Green Bank. Similarly for that fund, the next milestone is to begin investing that capital by the end of the year into Australian companies that are addressing hard-to-abate industries. Together with Parkwalk and Hostplus and those funds, we manage around GBP 550 million of third-party capital. We have further opportunities in the pipeline where we aim to demonstrate material progress over the next 6-12 months. This remains, at the moment, a smaller part of today's shareholder value story, but over time, it should help us support more companies, reduce our overheads, and create this performance fee potential if we can deliver strong returns. I'll now turn to the first half outcomes in the portfolio, but also the future value opportunities that we see within them. At 30th of June, the total portfolio was valued at about GBP 900 million, and that's equivalent to about GBP 1.00 per share, GBP 1.03 per share. The top five assets account for about GBP 0.50 per share. You can see them set out on the slide. Probably just worth recognizing, each of these has different value drivers. So royalty income and clinical de-risking for our license, listed market performance and path to profitability at Oxford Nanopore, clinical milestones at Istesso and Mission, and industrial scale-up at Hysata. As I mentioned, Hysata secured its first binding megawatt scale order during the first half, and delivery is expected in the first half of 2027. I should also note that Mission Therapeutics, their acute kidney injury program, was acquired by Dimerix for potential consideration of up to nearly $300 million. That upfront extends the, obviously not all that was upfront, but the upfront they received will extend Mission's runway for its core Parkinson's program. I think the broader point here to make is the top five assets do provide distinct routes to value, but the other GBP 0.53 per share gives us and shareholders exposure to a much wider group of businesses and a good level of optionality within those. I am just going to highlight a few of those over the course of the next few slides. Before I do that, it would be worth just pointing out our successful exit in Centessa. This is another example of realized value, not paper value. Our involvement in this company began through a University of Cambridge spin-out that we backed back in 2017. ApcinteX became part of a roll-up, Centessa, which then listed on NASDAQ in 2021. Then earlier this year, it was acquired by Eli Lilly for about $6 billion upfront, with a further $1.5 billion in potential milestones. For us, we sold during the course of the development of that company during its NASDAQ life, and the remaining balance we sold at the point of completion this year. That has given us a realized IRR of about 24%, and there is a bit of potential CVR payments that could be another GBP 3 million, GBP 4 million potentially. I think really this is just to illustrate the validation of the model. So breakthrough university science, supported through several stages, and has exited to a global pharmaceutical buyer. We believe that there are a number of assets that look today like ApcinteX did back then at the early part of its journey. In terms of the rest of the therapeutics portfolio, I think there are just a few things to highlight, three milestones, particularly from the half standout. Two of these were catalysts that we flagged at the full year that have now delivered. So Enterprise Therapeutics met its primary endpoint in a phase II cystic fibrosis trial, and that showed improved lung function over 28 days compared with placebo. Microbiotica delivered a second positive phase I-B this time data set, and that was in melanoma. I think that is building evidence that its precision microbiome platform, its gut microbiome platform, can increase or improve responses in these quite difficult-to-treat indications. Istesso began dosing the new phase II study of leramistat in June. As everyone will know, the previous rheumatoid arthritis study did not meet its primary endpoint, but it showed significant improvements in things like disability, fatigue, and reduction in markers of muscle loss. This trial therefore follows those signals into secondary sarcopenia caused by RA, and we are testing muscle quality, repair, and function in a randomized, double-blind, placebo-controlled study that will read out in the second half of 2027. This is worth noting that this sarcopenia market is very significant. It affects around 110 million people globally, and there are no treatments currently approved to treat it. So a safe oral treatment that improves function would be a very significant unmet need. Istesso remains a significant holding from the group from a valuation point of view, and we will of course review its valuation through the normal year-end processes in light of the evolving clinical evidence and the commercial opportunity. I think for today, the important point is that the company has followed the biology into a more focused trial with a clear unmet need and a very differentiated oral regenerative approach. The common thread across these is large indications, high unmet need, and programs moving into study that provide clearer evidence, and if they are successful, support partnering and value realization. Two of our companies in the quantum space raised significant capital this period. The common thread amongst these is that IP Group and Parkwalk Advisors were early investors, and our balance sheet exposure to quantum companies is probably worth about GBP 0.02 per share at the half year. These rounds bring substantial third-party capital into that sector and validate the sort of strategic importance of that. Quantum remains genuinely exciting. It is a longer duration opportunity, but I think alongside it, we also have significant ownership in businesses tackling quite immediate constraints in AI computing, and I will just turn to some of those now to round up this section. I think one of the themes for us, and I am sure you are all seeing it across your lives, is that AI is rapidly moving from experimentation into large-scale industrial deployment. As models become more embedded in products and services, the constraints are increasingly physical in nature. Things like electricity available to data centers, the heat being produced by conventional processes, and also the energy and time required to move data between the memory bit and the compute bit. GPUs remain absolutely central to the system, but they definitely cannot solve every part of that equation on their own. We have three complementary physics-led approaches: light, memory, and probability. On the first, Lumai, which is valued at about GBP 9 million, about GBP 0.01 per share, where we have a 26% holding, uses three-dimensional optical computing for the matrix multiplication that goes on at the heart of AI inference. During the period, it announced that its first Iris system is now running billion-parameter language models in real-time. That hopefully means something to some of you. I guess in commercial terms, this is designed for high throughput workloads in data centers, and the plan here is to develop that system, and it will work alongside conventional GPUs rather than trying to replace the whole computing stack. If you look at their website, you can see those sort of initial products. Intrinsic on the memory side, again, valued at about a penny a share. We own about 28% of this. This is generating and developing what we call next generation ReRAM. That is memory. It is important because getting faster and non-volatile, i.e., it remembers, and low-power memory can sit much closer to the processor and reduce the energy and a little bit of time moving data between memory and the processing. Relevant applications here can include things like Edge AI, autonomous vehicles, wearables, remote sensing, that sort of thing. The company is well capitalized and is seeing strong commercial interest from important industry participants. Then finally, at about GBP 0.002 or GBP 0.003 of a share is our holding in Quantum Dice, and this is photonics, and it is for probabilistic computing. The aim here is to try and accelerate problems that required repeated sampling under uncertain conditions. There are things like logistics and asset management and asset optimization and financial modeling, particularly relevant here. things that are used in robotics and machine vision. So three very complementary areas of the value chain. So although these three represent about GBP 20 million each of carrying value, we have 17%-28%, as you can see, ownership, so a meaningful proportion of any future upside belongs to the group and our shareholders. Each has milestones ahead that could become the next value events. We expect and hope to be able to report further technical and funding, and hopefully some commercial milestones from these businesses over the next six months or so. With that summary of the main drivers and some of the future value drivers, I will hand over to DB to take you through the financial results. Thanks, DB.