Good afternoon ladies and gentlemen and welcome to the Analyst Call on the GSK First Quarter 2019 Results. I will now hand you over to Sarah Elton-Farr, Head of Investor Relations who will introduce today's session.

Thank you. Good morning and good afternoon. Thank you for joining us for our Q1 2019 results which were issued earlier today. You should have received our press release and can view the presentation on GSK's website. For those not able to view the webcast slides that accompany today's call are located on the Investors section of the GSK website. Before we begin, please refer to slide 2 of our presentation for our cautionary statements. Our speakers today are Chief Executive Officer, Emma Walmsley; Iain Mackay, Chief Financial Officer; Luke Miels, President, Global Pharmaceuticals; and David Redfern, Chief Strategy Officer and Chairman of ViiV. We have a broader team available for Q&A. We request that you ask only a maximum of two questions, so that everyone has a chance to participate. And with that, I will hand the call over to Emma.

Thanks Seth and hello everyone. 2019 is an important year of execution for GSK and I am pleased we've made good progress this quarter with growth in sales and constant exchange rates across the group and an improved group margin. Group sales growth of 5% in CER terms reflected an increase in sales in all three of our global businesses with a particularly strong performance in vaccines. The pharma business continues to shift its portfolio shape well with strong growth from new launches. And although consumer had a slow quarter, we remain confident and excited about the outlook for this business. Group adjusted operating margin this quarter was up one percentage point on a CER basis. On a total basis, earnings per share were up 42% to 16.8 pence and adjusted earnings per share increased 18% to 30.1 pence. Included within operating margin and EPS, there are a number of matters of note that benefited the quarter and Iain will address these in just a moment. Nonetheless, it's a strong start to the year and we reaffirm our full year guidance. Our free cash flow this quarter was in line with our expectations with £165 million impacted as you know by the launch of generic Advair, the phasing of rebates, and higher restructuring charges, all as anticipated. Two years ago this summer, I laid out my long-term priorities for the whole company, innovation, performance, and trust, all to be powered by a necessary culture change. And we've made a strong start to the focus areas for 2019. We've continued to execute on our new product launches and have demonstrated strong growth with Nucala and Trelegy in respiratory and most notably in vaccines with Shingrix. Strengthening our pipeline is critical to our long-term success and we've made good progress here too.…

Thanks, Emma and it's a pleasure for me to be speaking to you in my first quarter as CFO of GSK. All the comments I'll make today will be on a constant currency basis except where I specify otherwise and I will cover both total and adjusted results. On slide 8 you will see a summary of the group's results for Q1, which was a strong quarter with 5% revenue growth driven by all three businesses. Group total operating profit is up 10% with total earnings per share up 42%. And on an adjusted basis operating profit was up 9% and adjusted earnings per share up 18%. There are a number of factors benefiting the first quarter operating profit. Notably, strong growth from Shingrix and introduction of authorized generics, favorable inventory adjustments in Vaccines and phasing of our R&D investments. I'll go through these in more detail in a moment. We delivered £165 million of free cash flow in the quarter in line with expectations. And please bear in mind that cash flow generation is expected to be weighted towards the second half of the year. Net debt at the end of Q1 was £27.1 billion. The increase from the end of the year was primarily driven by the £4 billion acquisition of TESARO along with the adjustment arising from implementation of IFRS 16 of £1.3 billion. On currency a weaker sterling particularly against the U.S. dollar and Japanese yen results in a tailwind of 1% in sales and 4% to adjusted EPS. Slide 9 summarizes the reconciliation of our total to adjusted results. The main adjusting items in the quarter were charges relating to intangibles resulting from the TESARO acquisition, major restructuring focus on the supply chain representing non-cash charges relating to ramp up of the program we announced…

Thanks, Iain. Good morning and good afternoon. In Pharma and Vaccines our focus on improved commercial execution continues. We've got a good start to the year. And overall, our growth this year will clearly be impacted by the launch of generic Advair. We are seeing our new products perform strongly. Respiratory sales were up 25%, at constant exchange rates. Pleasingly Benlysta continues to grow at double-digit rates. And Bexsero achieved sales of £156 million up 14% at constant exchange rates. I'll now go into more detail on some of our newer products. Starting in Respiratory, Trelegy continues to do well with sales of £87 million in Q1. Globally launches have had a good start. And we now have the only once-daily triple therapy for COPD in 30 countries around the world. 2019 will be an important year for Trelegy, as we are executing our launch strategy in Japan. And expect to have approval and launch in China later in the year. We're also looking forward to data from the CAPTAIN study which is successful, could enable us to reach patients with asthma that struggle to breathe. In asthma biologics, Nucala remains the market leader in total sales, and continues to grow quarter-over-quarter. On past results calls, we signaled that we needed to improve our commercial execution with Nucala. There's more work to do but we are seeing some encouraging signs. As you can see from this chart, it looks at an estimated new patient starts across both retail and non-retail segments. And we now have closed the gap with Fasenra in new patients, and are now back to a 1:1 position versus our closest competitor. We track several measures, but new patient starts remain a key target. Because the IL-5 class as a whole can grow a lot more. We…

Thanks, Luke. Good afternoon and good morning, everyone. During Q1, HIV grew 4% CER to £1.1 billion, which comprised of dolutegravir portfolio of Triumeq, Tivicay and Juluca growing at 7% CER, offset by the anticipated continued decline of the material portfolio. This was slightly slower growth than in previous quarters due to the significantly larger base of the overall business and the more competitive environment. In the U.S. we remain encouraged by the performance of Juluca, which is continuing to gain share with growth in 2,200 scripts per week and over 1,800 physicians now prescribing, giving sales of £70 million in the quarter. We have seen a pickup in Juluca since the publication of the 96 weeks SWORD data in October of last year and this is now being further endorsed by the positive 148-week data. Around 65% of the Juluca business continues to be sourced from non-dolutegravir combinations. We believe this is a good indicator of growing prescriber confidence in two-drug regimens, which will now be further reinforced by the launch in the U.S. of Dovato. The U.S. business grew 3% CER with the dolutegravir portfolio growing by 4%, offset by the decline in the material portfolio. In a continuation of a trend we have previously flagged we have seen some switching at the margin of the Triumeq business in particular to both Juluca and competitor STRs, and the overall market share of dolutegravir-based regimens in the STR and core agent market has declined slightly and is now around 26.5%. Tivicay/Descovy remains a popular and broadly stable business and through the second half of the quarter we have seen Tivicay MBRX improve. Future growth in the U.S. will come from our two-drug regimens Juluca and now Dovato in 2019 with cabotegravir, rilpivirine long-acting providing further momentum subject to FDA…

Thanks very much, David. So as a reminder, we've seen good progress this quarter on our priorities of innovation, performance and trust and we are firmly on track with our key areas of focus. It's important that we now build on this momentum for the year. So we're driving improvements in our operating performance. We are progressing our pipeline with a number of major readouts to come. And we're working towards a successful integration with Pfizer once the consumer JV has completed. Successfully delivering these priorities over the coming years will provide a clear pathway to the creation of two great businesses, one focused on Pharma and Vaccines, the other on consumer health. So we are now joined for our Q&A with Hal on the line and also Brian and Roger. And so with that operator, the team is now ready to take questions. Q – Keyur Parekh: Good afternoon. It's Keyur Parekh from Goldman Sachs. Two questions please. One for Hal and one for Iain. Hal, I noticed there's a slight delay on the time lines for the BCMA study in the second-line multiple myeloma setting. Just wondering, if you could give us some color around that. What's causing this data to go from first half to the second half? And then secondly for Iain. Iain, as I look at Q1 and I look at what's implied for your guidance for the rest of the year, it seems like you're implying margin degradation of somewhere in the region of 250 to 300 basis points across the company. I realized there are several kind of factors that are going to drag margin down. But just help us think about kind of is there upside to that margin number? Where could there be potential for you to take guidance up as…

Thanks very much. Next question please.

Next question is from the line of Jo Walton of Credit Suisse. You line is open. Please go ahead.

Thank you. My questions are along the same lines. I wonder as a new CFO coming in from another industry, whether you could give us your initial thoughts on particularly the cost structures that you see. You have highlighted tight cost control going forward. It's always interesting to hear another person's views of cost in this industry. And the second question going back to generic Advair, if we look at the prescription numbers it does look as if there maybe some capacity constraints with the generic because the generic isn't appearing to gain any more share and the share is stabilizing with yourself and your authorized generic. I wonder, if you could just tell us what you think is happening in the market because maybe you've got a better sense of that than we have?

Hi, Jo, so just firstly on the Advair generic and then I will come back to Iain to speak for his first impressions. But it is early days. I don't think it's for us to comment on the supply of Mylan. But at the moment, we think we are completely where we would expect and there's no change to the outlook that we've previously shared in terms of our expectations for Advair overall in 2020. Iain, would you like to comment on –

Comment on costs. Yeah.

First impressions.

First impressions, as you quite rightly point out Jo, there are both dissimilarities and similarities across the two sectors believe it or not. I think initial observations there are a number of important I shouldn't call them restructurings, but refocusing of energy within the pharma that, I'm seeing the early indications of and that is to the work that Luke and the team is doing across pharma commercial in terms of really orientating the commercial organization to the key priorities around product launch and building revenues. And through that process seeing some reorganization from that a very effective cost control in that regard. Equally, as we've talked about before, the work that Hal is doing in the R&D organization about, which we talked about in some detail at the midpoint last year also is focused on improving the overall effectiveness but also the efficiency of the R&D organization. So what I see initially is a strong focus in cost management across the organization whether it's in the SG&A areas, whether it's specifically within R&D, whether it's within the supply chain across Vaccines Pharma, and very notably within the Consumer Healthcare space as well. So, there – I think my first impression is there's a very strong focus on improving the overall efficiency and effectiveness and margins of the organization, with a broad range of activities across really every line and cost category across the P&L. So, in summary favorable.

Thanks, Iain. Next question please.

Next question is from the line of Graham Parry of Bank of America ML. Your line is open. Please go ahead.

Great. Thanks for taking the question. So, first question is on HIV. So, we started to see some formulation which is the Express Scripts national formulary start to add HIV to its exclusion list this year. GSK drugs are still on formulary. But can you run through whether GSK is set to offer any increased rebates to keep the portfolio there and if you expect that to increase price pressure over time? And then secondly, on the Vaccines margin the 40% I think you'd talked about what the 2Q should look like. But it would be helpful if you could just quantify and strip out both the rebate benefit to Shingrix and the phasing benefits across the portfolio so we can understand what the right underlying and ongoing level for both Shingrix and the rest of the portfolio would be as we are trying to calculate the rest of the year? Thank you.

Thanks very much, Graham. So, first to David, knowing that we've never given detailed updates on our commercial relationships. But first to David then Iain perhaps on the Vaccine margin.

Yes. Thanks, Graham. So, as you say, we do have very strong formulary access for Tivicay, Triumeq and Juluca very strong coverage. And as I've said, it's pretty stable. And we're in the discussions over with Dovato having been recently approved with the payers in the U.S. And the initial feedback we've had is in the WACC price which is the lowest integrase STR in the market has been favorably received and those discussions are going very well. So, no real significant change in the dynamic. I mean, I think the one thing that is going on with the payers is there -- some of them at least are trying to much more actively manage their formularies to line up with the guidelines and HIV is very guideline driven. The guidelines are updated regularly. So, you see some formularies like ESI and others, excluding some of the older tenofovir-based regimens. So that is going on. But overall, very stable. And we have very strong coverage and we're very optimistic about the coverage we're going to get for Dovato.

Thanks David. Iain?

Yeah. Graham, on the Vaccines margin front, taking broadly the influence of both rebating and inventory adjustments across that portfolio for the quarter, it contributed positively about five points to the margin in the quarter together. And in total, in sterling terms, represented about 70 million in total. So when you think about the guidance we provided previously looking out to 2020 that gives you a margin broadly consistent with where we'd expect the Vaccines business to be in 2020. That is not to say that we would expect necessarily the Vaccines business to be at that level for the remainder of this year. But that is the impact and that rebating was specific to Shingrix and then inventory adjustments were across a broader range of products within the portfolio.

Thank you. Next question, please.

Next question is from the line of Tim Anderson of Wolfe Research. Your line is open.

Thank you. I have a question on consensus modeling for Tivicay and Triumeq. According to the data that you guys collect, consensus really has those two franchises is pretty much flat over a five-year window on a global basis. But if I look at script trends at least in the U.S., it shows some pretty stiff competition from Gilead. So, I'm hoping you can give us some perspective on whether you think consensus modeling again for Tivicay and Triumeq over something like a five-year window is right. Second question is just if you could disclose emerging market performance in the quarter, including China performance. Thank you.

Okay. Thanks very much, Tim. So I'll come to David in just a moment to comment a bit on shares and outlook in HIV knowing that we never comment on the specifics of consensus. And in terms of emerging markets, we're up six. We don't explicitly disclose on China, though we're happy and I'm sure Luke will be happy to give some comments later if anyone wants to ask on what our plans are in our China business. But David, do you want to just comment on the outlook there?

Yeah. Thanks, Tim. So we're not going to comment specifically, as Emma says, on consensus. But I'll just make a few remarks. I mean, firstly, obviously, HIV is a competitive marketplace, but overall actually I think we try to bring Q1 very much in line with our expectations. There has been some switching at the margin, as I said in my remarks, particularly on Triumeq. But overall, we're running at certainly through the quarter at about 32,000 to 33,000 scripts so relatively stable. What is true is that going forward in the U.S., we see the vast majority of the growth coming now from our two-drug regimens so Juluca4 initially, but hopefully now also Dovato and then for next year subject to approval cabotegravir. So that is where the growth will come from. And to some degree, there will be some cannibalization of Tivicay and Triumeq in the U.S., particularly probably Triumeq into the two-drug regimes and that will be fine. So that is where the growth will come from. Outside the U.S., it will be more broadly based, including Tivicay and Triumeq.

Thanks, David. Next question, please.

Next question is from the line of Peter Welford of Jefferies. Your line is open. Please go ahead.

Thanks. I've got my customary two questions. So, firstly, on Nucala. I wonder if you can just comment there in regards to the trends, I guess, you're seeing now starting to evolve perhaps in the marketplace. Obviously, a new competitor entering and also perhaps a new at-home administration reaching the market before yours. And so how you should think -- we should think about that product for the remainder of the year, given I think some prior sort of more cautious commentary you've given perhaps ahead of this quarter? And then secondly, just on BCMA for Hal. Just with regards to the multiple myeloma combo trial with the Keytruda that you've initiated. Just would love to hear the thinking behind that trial given obviously there's been a number of setbacks with the PD-1s in this indication and also whether or not you're confident manufacturing for that is ready to be able to file by year-end when you get the data from the fourth line trial? Thank you.

Okay. Luke and then over to Hal.

Yes. Thank you for the question. So I mean I think with Nucala it's very much back-to-basics with us. We've worked very hard to establish a clear positioning in the market. We've focused on productivity of the sales force, the medical teams. And I think you're starting to see the benefits of that flowing through. In terms of the broader dynamics, I mean again we -- I think we're holding our own. Dupilumab seems to be taking the bulk of its business from Xolair, not from the IL-5 class and I think that -- there's no signs of that shifting at this point. In terms of -- and also our expansion beyond the U.S., I think we're doing quite well. I think we have a better understanding of the patient profile and the true size of the patient pool in countries, in Europe. And we're doing very well with around 70% market share in Japan. In terms of the auto-injector, I mean it's very, very interesting. If you look at perception mapping around Nucala historically, there we were able to work on the efficacy profile. We're able to work on the mechanism all of these components. But obviously one of the challenges that we had, it was difficult to move with what we have available today is this perception around dosing frequency. So the opportunity for the auto-injector provides another option for patients and physicians. So really they have the choice whether they want to dose every four weeks in the office or write a script and enable those patients to subsequently dose at home. So it's an attractive option for us. We're very much focused on the launch. We expect approval in the second half of the year in the U.S. and Europe.

Thanks, Luke. Hal?

Yes. Thank you for the question, Peter. First of all, yes we will have the data to review by end of year and there won't be any concerns really from a manufacturing perspective in terms of filing the fourth line data. And the second part of your question. In terms of the PD-1 combination trial it's important to point out actually that the BCMA ADC really has multiple mechanisms. It only inhibits the BCMA signaling which is important for plasma cell survival and the obviously the toxin conjugate the ADC component gives it an enormous potential for destroying the plasma cells as well. But the antibody is afucosylated which also gives an immune component to a very enhanced ADCC. And lastly, what we observed preclinically is that there's a significant immune component to this therapy that may be due to the ADC or maybe even to the ADCC, but we see preclinical a very interesting immune response that we think will be synergistic with PD-1. You're right to point out that previous trials with pembro haven't been successful in fact, I think taught us a lesson about how to think about PD-1 inhibition in diseases in particular myeloma. And we're going to leverage that finding where there sometimes is an early hazard that one needs to progress past in order to see the full benefit as you can see now with the longer-term follow-up. So we think based on the mechanism and based on some preclinical data we think that the -- it's a smart risk to take and we'll see what the data shows.

Thank you, Hal. Next question, please.

Next question is from the line of Steve Scala of Cowen. Your line is open. Please go ahead.

Thank you. In 2015 the company provided six or seven pieces of 2015 to 2020 guidance. Iain I'm just wondering if you have embraced all seven or if you are revising any. And just briefly if you will allow me, Pharma was low single digit ex Vaccines. Vaccines was mid- to high single digit, but that now looks light. Respiratory at 2015 levels that looks light. Consumer low to mid-single digit that looks aggressive. Total company low to mid-single digit, EPS mid-single digit. Tax rate increased 2 to 3 percentage points over the next three to five years. And if I missed any please reflect on those as well? Thank you.

Iain?

Steve that was a fairly kick-ass question. Thank you. Look I think from where I sit somebody that started my job 30 days ago, what I am particularly focused on is how we close out the remainder of 2019 and build on the progress that we made in the first quarter. I think at the fourth quarter we talked about the 2019 guidance and how that took us through to 2020. And in that regard the guidance that we updated then and that we've reaffirmed today, I think is hopefully suitable guidance for you to think about what -- how the firm as a whole progresses through 2019 and then sets up for 2020. Clearly, the composition of the business is changing somewhat. We're going into a JV subject to approvals with consumer health later this year, which will have an impact obviously in terms of how Brian and the team perform in that regard. And obviously, we've done the transaction in TESARO, which clearly changes the shape somewhat of pharma. And obviously, there's a couple of disposals going on as well. So I think the shape of the organization is changing. So if I would dare to suggest a way of thinking about the guidance is how we've updated at the end of last year, how we've updated today or rather reaffirm around that with a strong focus on execution in 2019 and setting ourselves up for 2020.

Right. And next question, please.

Next question is from the line of Laura Sutcliffe of UBS. Your line is open. Please go ahead.

Hello. Thanks for taking my questions. Obviously, Shingrix is doing very well. I noticed you have killed your universal flu vaccine project though. And so could you maybe just talk a little bit about what you are excited about in the Vaccines pipeline what there might be coming up after Shingrix. And secondly, I'm going to ask the question that Emma mentioned about your ambitions in China. Could you maybe speak a little bit about that too outside of consumer health? Thank you.

Of course. So we'll come to Luke in a moment on China. But since we have Roger Connor also in the room, who's been working not only on the improvements in our supply in Shingrix, but also responsible for the R&D organization there. So do you want to comment on the pipeline perhaps?

Yes, will do. Listen, thank you very much for the question. You'll notice that there were two assets in our Vaccine pipeline that we have removed this quarter. First of all, not a concern. These are not priority assets. Just maybe to walk through the assets in particular. One was as you mentioned, the universal flu asset, which is a partnered asset in Phase I and II that we have stopped following an interim data analysis. Just to emphasize, we're still very much committed to flu development, and we are looking at the early stages of our pipeline looking at alternative approaches in the universal flu space. Just for your information, the other asset that we stopped was a next-generation option for prevention of pneumococcal disease. We are looking at new technologies there, again, not viable to go forward. Again, these are not priority assets for us and really allow us to stay focused on our priority assets in our pipeline. And maybe I'll just mention two very quickly. One is our RSV portfolio. I'm very excited about this. We have in respiratory syncytial virus three different vaccines in development. As you'll know, I'm sure RSV is the single biggest cause of hospitalization in infants under one. And we have three vaccines in development. One for pediatric, one for maternal, and one for older adult. And we look at that portfolio where actually we think there is a real potential for first and best-in-class vaccines within that portfolio. And you may have seen already that our older adult and maternal vaccine in RSV, they both have received a prioritized Fast Track designation from the FDA. So, lots going on in RSV for us and an exciting area. On our older adult, I should just emphasize as well, that vaccine will use the same adjuvant system as our Shingrix vaccine has proved very effective there. And just on another asset in the pipeline that we are looking at very closely and prioritizing is COPD, chronic obstructive pulmonary disease. Again, this vaccine will use our adjuvant system. Again, it'll be a therapeutic vaccine. And we're looking to see how do we exploit the adjuvant technology to go into this therapeutics space. And on COPD in particular, it's the first vaccine against COPD, which is looking to really address exacerbation with and disease progression. Exacerbations are caused by our associated vest, I’d say, bacterial presence. And we feel that a vaccine addressing those bacteria could have a big impact. So exciting times in the pipeline, but those are just two of the priority assets we have.

Thanks Roger. So Luke, China?

Sure. Thanks, Laura. I mean, we remain very positive about China. I think in contrast to a number of peers we have a very concentrated portfolio there. And so when we look at the opportunities, I think in the immediate products that we have today the first is Seretide. I think it's probably well-known to everyone that COPD is significantly under-treated even when it is diagnosed in China. So we see that as a major opportunity to expand the usage of their product there. Cervarix, we're still in the early days of the introduction there. We have around one-third of the patients who are taking HPV or were vaccinated with HPV. And then linked to that is the opportunity to broaden the Vaccines portfolio within China. And then underlying all of these is really just working very hard in our commercial and medical execution in country and then ultimately working hard in partnership with Hal and his team to accelerate the introduction of pipeline assets such as BCMA and hep B into China.

Thanks, Luke. I mean in the end, obviously we are starting for the reasons you're all familiar with from a lower base. That gives us opportunity for growth in arguably one of the most exciting markets at the moment not least because of the deregulation that's going on around innovation as Luke has alluded to. And we are set on slightly less exposure arguably in terms of the pricing around branded generics. So more to come there and we'll see where the Shingrix approval goes in due course. Okay, next question please.

Next question is from the line of Richard Parkes of Deutsche Bank. Your line is open. Please go ahead.

Hi. Thank you very much for taking my questions. First one for Iain on free cash flow and the balance sheet. You called out and you have done previously a step-down in free cash flow generation this year due to generic Advair. But just wondered if you could give us some kind of steer on where that might fall out in terms of dividend cover this year. And how you're feeling about what flexibility there is still in the balance sheet to do business development and maybe talk about what passes to deleveraging the balance sheet and maybe get more aggressive there in terms of business development. That's the first question. Then secondly on the HIV franchise. Obviously, European sales are declining. I think you flagged the price reductions. I'm just wondering how you expect that to play out for the full year. Can HIV in Europe still grow this year? And are you seeing any impact from cabotegravir launches in that number? Thank you.

So David, why don't we go to you first just comment on HIV and then we'll come back to Iain? No we don't guide on cash flow in the year. But I will come back to you Iain on your other broader finance questions.

Yes. Thanks Richard. HIV in Europe the volume actually grew very strongly with dolutegravir volume up 8% with some very good performances in France, Spain and Italy and actually particularly pleased about how Juluca has started in France. But as I said, there were some government-mandated price cuts in a few markets. So for example, in France the fifth anniversary from your launch you often have to take a price cut and that was the case with Tivicay. So these won't happen every year, but it's normal part of life in Europe, which impacted the quarter and will obviously have an impact across the year. And then there was some comparative, there was a one-off comparative in Italy. So the impact would dissipate during the year, but it won't totally go. But overall pretty pleased with the performance. And in terms of the competition, it is obviously heating up in Europe particularly in Germany, which is -- the markets were all very different in Europe. Germany is probably the most like the U.S. in the sense, it's a free market for pricing and also the most favorable to STRs and we have seen some switching at the margin there to the competition. But everywhere else we've been growing market share and we're quite pleased.

Thanks, David. So over to Iain. And just in terms of the BD appetite point I will say we are largely focused on digesting exactly the rather significant number of deals we haven't had. So Iain, comment overall.

Yes, Richard, thanks for the question. Clearly, strong focus in terms of working capital management cash flow generation across the company without embedding any of these goals and objectives. Just talking about the full-year, we talked obviously last year very good year from a cash flow perspective with £5.7 billion for the full year. What we talked about at the fourth quarter was the expectation of a couple of things. One lower profitability in line with the guidance for the full year. Other things kicking in the full impact of Advair which we would expect to see coming through over the next quarter. So, continuing to step up R&D and the investment behind our priorities in that pipeline an important factor. Another thing building on the announcement around the middle of 2000 in July with respect to restructuring. We'll see a bigger impact of restructuring in 2019. So those factors as we said at the end of the year, we'd expect to see cash generation somewhat lower than was the case in 2018, but nonetheless a very, very strong focus in that area. And guidance today, in the dividend obviously no change, reaffirmed expectations around the 80 pence per share for the full year 2019. And in terms of thinking about capital allocation more broadly, Emma talked about really focusing on implementing -- executing the transactions that we've got in the pipeline now, and realizing value from those transactions. Clearly one of those, the disposition of the nutrition business in India to Unilever will generate a significant cash flow as that deal closes, and we'll go largely to improving overall balance sheet capacity. And when we think about that capacity, it's around supporting the pipeline, returns to shareholders through the dividend, and this continued aspect of looking for business development that contributes to strengthening the long-term future of the firm, subject obviously to pretty strict return criteria and structuring within those transactions. But, it would not be an understatement to say that there is very, very sharp focus across the firm on cash generation.

Yeah. Certainly confirm that. And just in terms of what the pathway is, I'll just remind everybody that in -- we're obviously very excited about getting to the close subject and necessary approvals of the consumer deal. We'll then, going to be focused on the successful integration, which we are confident we can deliver. And then up to three years, after close, we do intend to separate these companies. And that will create the reset of the capital structures for both businesses, which then creates a whole new level of capacity for that pharma and vaccines company focused on the science immunology to technology and genetics to both invest in further growth organically and inorganically and deliver returns to shareholders. Thank you. Next question, please?

Yes. The next question is from the line of Simon Baker of Redburn. Your line is open. Please go ahead.

Thank you for taking my two questions. Firstly, just continuing off of Richard's question on free cash flow, perhaps I could broaden out a little for Iain to get your perspectives of this admittedly early stage on where free cash flow conversion is notwithstanding the one-off effects in the quarter, and where you think you could and should be in the coming years. And then secondly, a question for Hal. There was a report out from the IQVIA Institute last week suggesting the potential impact from various new technologies on R&D productivity. Given that the history of R&D is littered with technologies, which have over-promised and under delivered, very interested to get your perspectives on what you think are the principal technological drivers of increased R&D productivity over the coming years. Thanks a lot.

Fantastic. So, we'll come to Iain first, and then come over to Hal on the phone knowing that again, he will be giving you an update on this including that question I think at Q2. But first of all, Iain, any further comments you want to make on cash flow?

Not a great deal just emphasize the focus around working capital management across the organization as a whole and looking broadly across the balance sheet in a lighter portfolio in terms of opportunity, to create monetization opportunities where returns are presently below hurdle rates that we've set. And that's a piece of work that we do across each of the businesses on an ongoing basis. The focus is there. Really nothing more precise on the guidance in that regard.

Thanks, Iain. So Hal, new technologies for productivity?

Thanks for the question, Simon. I think there's no question that the R&D organizations across pharma could benefit from improvements in productivity. And I would say the focus for us is being driven by the observation that only about one in 10 molecules that enter the clinic actually ends up becoming a medicine and helping patients. And we’re pretty focused on seeing if we can increase that substantially. And the three technologies that we have identified that we believe will improve this dramatically, potentially is human genetics and -- with the reduction in the cost of sequencing as well as a number of people and patients who’ve been signing up for various sequencing opportunities such as 23andMe where we have now millions of patients, who've donated their generic information to help us understand better targets. We think it’s going to be a very important technology. In addition functional genomics, which is essentially taking that genetic data and being able to understand what does it really mean, what are the structural variants telling us about human disease could also enable us to find much, much better targets. And given how massive these data sets can become when you do all these technologies, we really do believe that machine learning and artificial intelligence apply to these highly dimensional data sets can unravel the biology in a pretty profound way. And all three of these are growing in sophistication. And I'll be talking a lot more about this at Q2, but we've already started seeing some interesting targets that were never identified previously. And we think that, because they're driven really by using the human as the model organism if you will using human genetics and functional genomics, we think this could have a significant impact on our probability of success and therefore our productivity. But, more on that in Q2.

Thanks very much, Hal. And with that, I think we've come now to the end of the call. So I'd like to say thank you to everybody for joining. Good to hear your voices. And we look forward to catching up soon. Thanks. Bye.