Hello, everybody and welcome to the Guardant Health Q1 2025 Earnings Call. My name is Elliot, and I will be your coordinator today. [Operator Instructions] I would now like to hand over to, Zarak Khurshid, Vice President of Investor Relations. Please go ahead.

Thank you. Earlier today, Guardant Health released financial results for the quarter ended March 31, 2025. Joining me today from Guardant are Helmy Eltoukhy, Co-CEO; AmirAli Talasaz, Co-CEO; and Mike Bell, Chief Financial Officer. Before we begin, I'd like to remind you that during this call, management will make forward-looking statements within the meaning of federal securities laws. These statements involve material risks and uncertainties that could cause actual results or events to materially differ from those anticipated. This call will also include a discussion of non-GAAP financial measures, which are adjusted to exclude certain specified items. Additional information regarding material risks and uncertainties, as well as the non-GAAP financial reconciliation to most directly comparable GAAP financial measures are available in the press release Guardant issued today, as well as in our 10-K and other filings with the SEC. Guardant disclaims any intention or obligation to update or revise financial projections and forward-looking statements whether because of new information, future events or otherwise except as required by law. The information in this conference call is accurate only as of the live broadcast. With that, I would like to turn the call over to Helmy.

Thanks, Zarak. Good afternoon, and thank you for joining our first quarter 2025 earnings call. Starting on Slide 3. We started the year with strong momentum across our portfolio, fueled by ground-breaking product upgrades introduced in 2024, which leverage our smart liquid biopsy platform as well as the launch of Shield. We continue to successfully execute on our long-term vision to support patients throughout their entire cancer journey from early detection, monitoring of recurrence to treatment selection. By delivering critical insights at every stage of cancer care, we empower clinicians to deliver timely, actionable insights that make a meaningful difference in the lives of patients and their families around the world. As we do each quarter, I would like to start our call today by sharing a powerful story that captures the real world impact of our Guardant Reveal test and the difference it can make in the lives of those we serve. In September of 2022, a 55-year old woman was diagnosed with breast cancer and later identified as having a pathogenic BRCA1 variant. She was prescribed neoadjuvant chemotherapy to help shrink the tumor prior to surgery, and a few months later, the cancer was removed successfully. In order to monitor for potential recurrence, her oncologist ordered an initial Reveal test shortly after surgery and six subsequent Reveal tests have been performed over the last two years at three to six months intervals. All six Reveal tests have returned negative results and today the patient is enjoying life with a peace of mind that she remains cancer free. Turning to topline performance on Slide 4. We had an excellent start to the year with Q1 revenue growing 21% year-over-year to $203 million. As we discussed last quarter, we are now reporting revenue in a way that more closely aligns…

Thanks, Helmy. Moving on to Slide 13. We are pleased to see continued strong traction for Shield in the second full quarter of commercial launch. We delivered $5.7 million of Shield testing revenue in Q1, driven by approximately 9,000 tests and exited the quarter with positive momentum. We continue to experience outstanding reception from physicians and patients. The depth of ordering per account continues to be strong reaffirming the market opportunity, the product market fit and the differentiated physician and patient experience compared to existing modalities. We are particularly encouraged by our sales force productivity ramp. Turning to Slide 14. We were very pleased last month with Shield receiving ADLT status, which catalyzed the increase in Medicare price from $920 to $1,495 effective April 1. ADLT status reinforces the value that Shield brings to patients as a more pleasant and convenient option for CRC screening that can help increase the overall screening rate and improve CRC survival outcomes. This more favorable Medicare rate allows us to accelerate the commercial infrastructure build out to bring Shield to a wider audience. Turning now to Slide 15 to take a closer look at our screening highlights for the first quarter 2025. I am excited to share that we achieved positive gross margin for Shield in the first quarter, much sooner than we had originally anticipated. This was driven by COGS improvement and a high mix of reimbursable test volume. We received coverage from the VA Community Care Network, which brings Shield access to over 9 million VA beneficiaries with no copay. Importantly, the VA will cover Shield for all eligible individuals between 45 and 84 years old, which marks Shield’s first coverage of patients below the Medicare age. And last week, the American Gastroenterological Association or AGA, the leading professional organization representing top…

Thanks, AmirAli. Turning to Slide 19. I’ll now discuss some select financial highlights for the quarter ended March 31, 2025. I’ll refer to year-over-year growth rates unless otherwise noted. As previously mentioned, going forward, we’ll present new revenue categories. To help with modeling and analysis, we’ve included supplemental information on our Investor Relations website that breaks our historical 2024 quarterly revenue into the new categories. First quarter total revenue grew 21% to $203.5 million and was largely driven by oncology revenue, which grew 20% to $150.6 million. Oncology volume grew 25% to approximately 59,000 tests in Q1, with the majority of unit growth driven by Guardant360, closely followed by strong contribution from Reveal. Year-over-year Guardant360 growth accelerated again in Q1, marking the third consecutive quarter of accelerated growth. Reveal continued to represent our fastest growing product on a year-over-year basis. Guardant360 ASP was in the range of $3,000 to $3,100 in the first quarter of 2025 compared to approximately $3,000 in Q4 2024. This increased Guardant360 ASP was a function of continued improved reimbursement for Medicare advantage and commercial payers. First quarter Oncology revenue also benefited from an asset period upside of approximately $5 million above our normal expected level. This compares to an $8 million out of period upside that we recognized in Q1 2024. Our Biopharma & Data business performed incredibly well again in the first quarter with revenue totaling $45.4 million, an increase of 21%. Our biopharma pipeline continues to shape up solidly, driven by Guardant’s Infinity on our smart liquid biopsy platform and the recently announced multi-year strategic collaboration with Pfizer further adds to our confidence in both the short-term and long-term business. Screening revenue totaled $5.7 million in Q1 2025, generated from the 9,000 Shield tests that we reported in the quarter. And finally, licensing…

Thank you. [Operator Instructions] Our first question comes from Mark Massaro with BTIG. Your line is open. Please go ahead.

Hey, guys. Congrats on the quarter. Thanks for taking the questions. Maybe the first one for you, Helmy. You’ve had Guardant360 in the market now for I think this is year number 11. And yet you are raising the oncology volume to accelerate to over 25% growth. As this is accelerating, I was wondering if you could help us perhaps rank order what these opportunities are. To what extent is this epic? To what extent is this potentially competitive takeaways? And then to what extent could this be some boost from attachment to the Guardant360 Tissue?

Yes. Thanks for the question, Mark. We are very pleased in terms of the progress that we are making. And I was looking at where we were with the 360 over the last couple of years. And with the recent smart liquid biopsy upgrade, we are actually seeing some of the strongest growth we’ve seen in a number of years. This is the third quarter of sequential sort of accelerating growth for that product. And so we really know we’ve achieved product market fit with respect to the sort of liquid biopsy marketing therapy selection. So that’s going to continue to be a really nice growth driver. Obviously, Reveal is growing nicely. We are seeing accelerating growth there for the last two quarters as well, and we are going to really lean into that now that we are gross margin positive on that product. And then last but not least, this massive upgrade we’ve done on tissue where we are really taking everything that has worked so well and liquid for us, especially last few quarters, and essentially putting all of that into the tissue product. And then everything else you mentioned that increases depth, that like simplifies the ordering experience in terms of EMR and digital and so on is sort of gravy on top of all of that. So it’s a really nice setup in 2025 for us, and we are really excited for this next chapter.

Okay. Great. And then maybe a two-parter on the screening business. Nice to see the raise guide. Can you walk us through the components of that? Obviously, you signed VA in Abu Dhabi. I’m curious what you are seeing on the business development side as well. Any other potential similar type systems that you are engaged with? And then as we think about the ASP assumptions of the raise guide, it’s somewhere in the $770 range per test. Why is that the right number when your ADLT price is $1,495 and you are focusing on the Medicare population? And just curious what that Medicare mix was in Q1?

Yes. Sure. So maybe I start on the commercial side. I asked Mike to maybe comment on the ASP front. So you are very excited and pleased with what we are seeing in terms of the productivity of the reps in the field. And this improved productivity is giving us more confidence that maybe we can achieve more than what we originally anticipated. On the, Abu Dhabi side, Q1 for them was really to get to the setup of the program. So we have to see really how quickly that program is going to set up. We have limited visibility at this time. As a result, we continue to just assume a fraction of that 10,000 samples that we are contracted for this year would be part of our guide. So really the guide changed that, no impact by the upside that potentially we are going to have from Abu Dhabi. We are very excited about this VA. Like, there are millions of people at age 45 and 64 who are going to also get access to this test. We kind of fine tune some of our targeting to even have kind of more presence in some of the areas that they have more concentration of these VA families and VA members to really extend the offering to them. And I asked Mike to talk about the ASP.

Yes. On the on the ASP, of course, we received the ADLT status in Q1, and that goes effective, or went effective April 1. So the Medicare rate went from $920 to $1,495. And so, yes, that’s going to have a nice positive impact on our ASP. For Q1, it was just north of $600. And we expect for the remainder of the year, Q2 to Q4, the ASP to be around $800. So we’ll get an uplift from the ADLT. You asked Mark around the proportion that’s Medicare. There are basically three elements to the ASP. There’s obviously the Medicare fee-for-service portion. There’s Medicare advantage, and we’re starting to get paid by Medicare advantage payers. But the way that we’re sort of recognizing the revenue and the ASP that we’re using for that is, I’d say, it’s conservative at the moment, and there’s room for that to improve over time as we see the collections come through. And then, there is a portion. It’s a relatively small portion, but there is a portion of commercial pays in that. And, of course, at the moment, we’re getting paid zero. So you put them all together, we expect ASP, again, for the remainder of the year to be about $800. And overall, getting this ADLT status from the April 1, that’s roughly a $10 million increase from our original guidance at the start of the year, and that’s part of the $30 million of lifting guidance that we’ve just announced today.

Great. Thank you.

We now turn to Tycho Peterson with Jefferies. Your line is open. Please go ahead.

Hey, thanks. Maybe just sticking with the guidance theme, there still seems like a lot that’s – you’re not fully baking in here. But can you give us a sense, G360 ASPs, you guided flat previously, what you’re baking in for G360 tissue next? And then Reveal adoption in the surveillance setting, where do you ultimately think you end the year on test per patient?

Yes. Tycho, I mean, I can answer the ASP. On Guardant360, at the start of the year, we were guiding to $3,000. We saw a nice uplift in Q1, mainly coming again from Medicare advantage and commercial reimbursement being stronger than expected, and we’re in this new range now of $3,000 to $3,100. So we expect that to continue for the remainder of the year. And so that helps us raise our guide again. And for TissueNext, current ASP is around $1,700, $1,800. And so we’re effectively assuming a similar rate for the remainder of the year. And we got a nice uplift at the start of the year for tissue with the Medicare rate going from $3,140 to $3,500.

Yes. I know, I mean, obviously, that’s something we’re very focused on in terms of increasing the number of tests per patient that you saw from the patient story. There’s huge potential there in terms of increasing that. And it’s a metric that’s been improving across our portfolio in terms of number of Guardant tests per patient, quarter-over-quarter. And there’s a lot of, I would say, work being done by the teams to make that as simple as possible in terms of the compliance and adherence with each additional test. And so we expect that to see that grow considerably throughout the year.

Okay. And then follow-up on [MCD]. Obviously, it was a big topic at AACR. Good to see the data from you guys. I guess maybe talk a little bit about roadmap from here, what you need to do to get ready for payer discussions? What are you able to do to kind of get them comfortable historically? Obviously, they bought that multi-cancer. So talk about some of the steps you need to take going forward?

Yes. It’s a very kind of exciting moment for us. Like, know, we had this vision that Shield would be a multi-cancer screening detection kind of a technology. We build it that way. We went through this route of CRC approval for reimbursability pathway and, like approval pathway. I think over time, we are going to figure out that this Shield platform that can detect not only CRC, but that can have some kind of secondary analysis for other cancer type detection, which had a very strong product market fit. So we are excited with the data that we showed in AACR. Technology works, platform works. We are doing some additional data generation. Like, I’m excited that for about 20,000, 25,000 patients that we tested with Shield, right now, we correlated – actually, we gathered the clinical outcome of those patients in real world. Have they been diagnosed with other cancers or not? And we are in the process of now running this answered algorithm on those patients to see in a cohort of tens of thousands of patient what are we going to see in terms of sensitivity and specificity. Definitely very exciting days for us. I’m looking forward to having more conversation about this throughout the year.

Thank you.

Our next question comes from Bill Bonello with Craig-Hallum. Your line is open. Please go ahead.

Thanks a lot. I wanted to circle back a little bit on tissue test and the commentary about needing 40% less tissue seemed really important. But maybe just if you could elaborate a little bit based on discussions you’re having with existing accounts, sort of how do you expect this to play out over time? I mean presumably we’re talking about taking share maybe with your existing customers for liquid biopsy who are sending tissue to somebody else. But are there particular cancers where you think the advantages of your new product are going to be most distinctive? Do you think it’s more about just the ease of working with one provider rather than sending tests to multiple providers, maybe the ability to reflex to blood, et cetera? Just are you sort of expecting to compete there?

You answered the question in some ways. We’re very excited about this product because we have a lot of customers who love the sort of white glove service that we’re able to provide them. And just in terms of the quality of our sales reps and really the knowledge base we have around our medical affairs team and so on. And many of them have said, if you simply add RNA to your tissue project, we’re going to switch to you. And so we did way more than that with this project. We really built it from the ground up where we can use very limited samples. That continues to be one of the issues that many providers have is, not being able to get sort of actionable results out of the limited tissue biopsy samples. We’ve been able to sort of solve that issue, but it’s well more than that. The fact that we’re going deep into epigenomics, it’s really the first tissue product that has a broad-based methylation backbone to it. And you see, really, kind of the richness what we’ve been able to present at AACR and the fact that all of our products now will work together essentially, with these applications all embedded in them and this continuity of information that we believe will provide a lot more actionability than any other product in the market from a clinical outcomes point of view, from a clinical decision making. And that is our North Star, is can we help provide actionable decisions for every patient more so than other tools in the market. And we believe this product absolutely does that. So we’re very excited by it. We had great reception at AACR in terms of unveiling the specifics around it. And I can tell you our sales team has been chomping little bit to get access to this too, to tell the world about it.

Sure. And ultimately, I mean, is your strategy to try and push for a world in where doctors are ordering both tissue and blood based testing? Or is that just not a realistic scenario anytime in the next several years?

No. I mean, the guidelines are already almost there. We have a growing number of payers who believe in that. When you think about the fact that neither modality is perfect, neither modality has a 100% sensitivity, whether it’s liquid or tissue. And when you think about that decision that could be so imperative and could be the difference between life and death for a patient, Isn’t a patient’s life worth searching both liquid and tissue for a potential life saving outcome? We think so. I think the guidelines believe it to be the case. So we believe eventually it will be the standard-of-care to have both for every patient.

Okay. And then just one final one and I’ll hop off. But I have to ask, is there any risk at all of sort of cannibalization of the higher priced blood based test? Just people saying, hey, if we can get tissue, we want to do tissue. And now we can use 40% less tissue, we’re more likely to be able to get a result in cancers where we might have just jumped right to blood.

No. I mean, the way we look at it is, there are going to be many shots on goal with liquid, whether it’s in screening, MRD, or therapy selection. And then, obviously, we’re the one company that really has a continuum of testing across the board. So if we can also provide what we believe to be a leading modality and product on the tissue side, we think that ultimately just grows the pipe for us.

Okay. Thank you guys very much.

Thank you.

[Operator Instructions] We now turn to Subbu Nambi with Guggenheim Partners. Your line is open. Please go ahead.

Hey, guys. Thank you for taking my questions. AmirAli, what are the potential drivers or catalysts to drive upside or downside to your Shield volume guidance of 52,000 to 58,000?

So in terms of upside, like, if we continue to outperform the productivity of our reps in the field, that could be upside of what we are assuming right now. The other upside could be the inclusion in the ACS guidelines, any kind of guideline inclusion definitely has some kind of impact on the commercial adoption of the test. And although we are very optimistic about the timing for that guideline inclusion for some time this year since we don’t know when, we are not assuming that in our volume guidance. The other potential upside could be on this Abu Dhabi contract. It’s kind of a sizable contract, we’re just assuming there’s small fraction of it in our numbers. And lastly is, as we talked about it in our prepared remarks, there are additional positive gross profit that we are getting because of this sooner than expected ADLT pricing. We are reinvesting it back in building more commercial infrastructure, a lot more kind of reps in the field. We are just going through that process right now. It would help us to have more reps deployed very late this year. It’s mainly a 2026 kind of upside for us, but if we can bring the reps and deploy them to the field sooner than the current plan, maybe there would be some upside there too. Downside, I think, we'll see. So it's hard to say.

Hopefully, there aren’t any downside. Can I quickly squeeze a short question? How much TissueNext is assumed in the guidance?

Well, without specifically breaking out, Subbu. I mean, it’s relatively a small portion of the oncology guidance. The main drivers on oncology in that guide are obviously Guardant360 and Reveal.

Thank you, guys.

Thanks.

We now turn to Puneet Souda with Leerink Partners. Your line is open. Please go ahead.

Yes. Hi, AmirAli, Helmy and the team. Thanks for taking my question, Mike. First one, if I could, on the screening side, Guardant has obviously met all of your products in a unique way they’re working to the top right now. But just wanted to understand from the Shield side, how are you thinking about in this multimodal market, where you’re – I would love to know where you’re getting the most traction, the type of patients, the type of practices. And now with ADLT and better margins, how are you thinking about the size of the sales force? And I have a follow-up for, Helmy.

Okay. Yes. So it’s definitely exciting days for us. When we look at the market, like, we talked about it before, and we are now just experiencing it. Like, there are a lot of unscreened patient population out there, 50 million unscreened. We are seeing very good traction on the PCPs that we onboarded. The depth of ordering continues to be very favorable, which is an endorsement that there are many unscreened patient in the practices that we are going through in general everywhere. So that’s actually pretty good. In our steady state in terms of commercial infrastructure, it continues to be the same. We are planning to get to the 700 rep at some point. This additional gross profit helps us to accelerate to some extent, like, we are probably are going to have in terms of fully trained deployed sales force, probably are going to have about 200 people by end of the year. That’s where we are targeting, and we continue from there.

Got it. And then, on the Reveal side, Helmy, could you talk a little bit about, where you’re getting the best product fit for Reveal? Because you’re coming into this market much later versus some of the tissue inform tests out there. Can you just talk to us in terms of the adoption you’re seeing today in CRC Surveillance, the way the product could grow in breast and then beyond that other indications where tissue might be a little bit challenged. Could you talk to us about that and the sort of the growth expectations potentially for Reveal? Thank you.

Yes. We see the product as sort of being adopted in a pretty broad-based way. I mean, I think they’re just – the reality is that the anxiety of waiting three, four, five, six, seven weeks in the adjuvant setting is just too much to bear for many patients. And we believe that our product profile in terms of the performance and so on is, is one that, I think, matches up favorably in that market, in that setting. So yes, we’re seeing a lot of physicians in the admin setting prefer Guardant Reveal. We’re averaging less than seven days in terms of turnaround time for that product. So it’s really exciting to see the operational efficiency the team has kind of built up to. And then, clearly, in the surveillance setting, as the patient is negative for a year or two, there’s a big chance that what comes back may not be the same as what was taken out. And there’s a greater confidence in something that, like Reveal, that can have a much larger catchment in terms of catching a disease that might be slightly different that comes back. And so we’re feeling very confident in terms of trajectory, in terms of the growth that Reveal has ahead of it, especially with surveillance reimbursement and then clearly some of the other indications that we’re building towards. Obviously, breast is a huge, huge opportunity and one where having the kind of profile we have in the surveillance setting, I think, is really going to be nice.

Got it. Okay. Thank you.

We now turn to Dan Leonard with UBS. Your line is open. Please go ahead.

Thank you very much. I’ll ask a two-parter on the tissue launch. For starters, I’m trying to put some context around the launch and wonder how would you frame your market share today in tissue versus what you view as your long-term entitlement in that market? So that’s the first part. And then the second part, and I’ll keep this to one question. Are there any ASP implications of the new tissue product? Is there potentially a different Medicare rate than that $3,500 that might be attainable long-term? Thank you.

Maybe I’ll start with the second one. It’s a product that, I think we’re eventually going to take through FDA-approval, and then we’ll have the opportunity to qualify for ADLP status. And I think there’s the opportunity to have higher price at that point, which we’ve seen for our other products here at the company. I don’t want to get into specifics in terms of market share and where we think we can be, but certainly, we think we can take a much greater share of the market than we have today on the tissue side. We believe our product now that compares favorably in terms of product market fit to a lot of what’s – to a lot of the products that are on the market today. And ultimately, that’s going to do a lot of good for patients. And when you have that kind of profile, I would say there’s no ceiling in terms of where you can reach in the market. So we think there’s no reason why we can’t catch up to where we are in the liquid side over time.

Thanks, Helmy.

Our next question comes from Dan Brennan with TD Cowen. Your line is open. Please go ahead.

Great. Thank you. Thanks for taking the questions. Maybe just starting on Reveal, just a two-parter. Mike, did I hear you say realized price about $600. Sorry, you went through the prepared remarks. So just any color on pricing that you shared there? And then if there is – I know there’s a question asked earlier, but any additional color you can provide about just how the first quarter kind of played out in surveillance and kind of what we should think about for the rest of the year in terms of the accelerant to that business now that you’ve got the approval?

Yes. I mean, I can address that. The ASP, we said in the prepared remarks, and it’s in the deck that we also shared that our Reveal CRC ASP now is over $600. And of course, that puts Reveal now in a gross margin positive position. So it’s allowing us to push on the volumes. And I don’t know, Helmy, if you want to…

Yes. No. As I said, I think maybe in response to one of the other questions. We’ve seen accelerating growth over the last few quarters with the Reveal. And certainly, there’s a lot of opportunity now in terms of pushing the surveillance testing that we’re starting to pursue. So we’ve been very pleased to the start of the year. It’s been really nice. And we believe that it will continue to be our fastest growing product on the oncology side as it was in Q1.

Great. And then maybe, AmirAli, just kind of back to Shields. You took the volumes up 7,000 or so. Obviously, the unscreened opportunity is pretty massive. I think there are 55,000 tests this year. But can you just – I know, back to Puneet’s question, can you spend a little more time on just kind of what you’re seeing in the field? Maybe what’s surprising you on the positive? Anything on the negative? Exact talks about the frequency of doctor visits when they start to see an uptake maybe 6x or 7x visiting the doctor before they see someone do a test. Is the same thing playing out on the blood side? Or just any color you could share in terms of what informs this modest raise and kind of how the launch is going versus expectations?

Yes. I mean, as I mentioned, like, we continue to hear a lot of positive feedback from the market on PCP side. Like, we are a blood drop modality, so we are going, like, in terms of integration of blood workflows into the practice and stuff. It takes some more energy from us probably than just dropping up. It’s still [indiscernible] accounts in terms of activating accounts, but the depth of ordering we are hearing and seeing are very positive. I cannot point to any specific thing that we are hearing that we did not expect it and consider it negative. Maybe if I want to highlight something, but we knew it, we expected it is the reality of the importance of quality scores. Like, that’s very important. Once we get into [indiscernible] score, it’s going to be a huge catalyst for us. But there is a lot of business for us to mind that we are focused on it, and we are growing off the place so far. And we’re excited of, like, the rest of this year. Still very, very, very early innings of this. So I don’t want to get ahead of our skis, but so far, better than what we thought. We’ll see how it goes.

Great. Thanks.

We now turn to Rachel Vatnsdal with JPMorgan. Your line is open. Please go ahead.

Great. Good afternoon, and thanks so much for taking the questions. So I wanted to ask another follow-up just on Shield and some of the volumes that you’re seeing. You increased volumes by 2,600 sequentially roughly. So if we apply that same sequential increase for the rest of the year, that really gets us near that low end of the guidance range for Shield volumes. So I wanted to dig into a few questions around that. First, as we look specifically to the second quarter, should we see a sequential step up above that 2,600 sequential in volume increase? Or could it kind of be the same level that you guys saw this quarter? And then if we were to get towards that high end of the Shield volume range, at what point in the year would you expect a larger step up in the sequential given what you’re seeing in this field so far?

Yes. I think, maybe I reiterate what we mentioned in the prepared remarks. We continue to expect it to be second half loaded, and the reason for it is there are a bunch of new reps that we have the productivity ramp of those people need to reconsider when you’re modeling sequential Q-over-Q growth. And we are continuing to hire, so we are going to end the year with more reps than the year that the number of reps that, for instance, we deployed in the field in Q1. So when you consider all this, I think, you need to consider that as a result, it should be biased towards second half growth.

Guys, maybe just digging deeper on that, though, specifically on 2Q. Should we be modeling a step up sequentially relative to this 2,600 you did in the first quarter? Or at this point, given the reps are still kind of getting deeper ingrained into their territories, should we assume a similar step up to what you had?

Yes. I think maybe what I can comment is, like, we exited Q1 with just marginally a little bit more reps than the number of reps that we started with Q1. I don’t want to get into, like, a lot more details of the exact number of reps than what we are seeing, but I think you should consider that. And the reality of diagnostics, it takes 12 to 18 months to get to the full productivity when you add the reps within the first three months. You shouldn’t expect anything really. Six months, maybe some material contribution. So I think if you consider all this, you’re going to get to some reasonable numbers.

Fair enough. That’s it for me. Thanks, guys.

We now turn to Luke Sergott with Barclays. Your line is open. Please go ahead.

Hey, thanks for the questions guys. I just wanted to ask about the SERENA-6 trial with Astra and kind of how that’s ramping and how we can think about those volumes as it goes through and as that trial keeps progressing?

Obviously, hasn’t gotten approved yet. It’s still not something that…

Trials, right?

Yes. So we’re waiting for – the trial is done in terms of enrollment and so on. I believe some of that data maybe presented later this year that’s up to our pharma partner in terms of their timelines. We’re not going to comment on that. But it’s something we’re very excited about in terms of the paradigm that it means, in terms of being able to test patients, look for essentially molecular changes in a patient’s genotype. We think this is really the way of the future in terms of where many drugs will start being developed, really the first sign of molecular progression being able to switch therapies. And so it’s something that we’re coordinating, I think, very closely on, and we’re very excited for in terms of the potential that it means for uptake in terms of liquid biopsy volume, Guardant360 volume in the future. And so, yes, I would just say maybe stay tuned over the remainder of the year. But, yes, certainly, we think it could present some nice upside for testing – for liquid biopsy testing and Guardant360 testing in the future.

Operator, I think we’re out of time.

Ladies and gentlemen, that concludes our Q&A and today's conference call. We thus thank you for your participation. You may now disconnect your lines.