Welcome to Fate Therapeutics’ Third Quarter 2014 Financial Results Conference Call. At this time, all participants are in a listen-only mode. This call is being webcast live on the Investors and Media section of Fate’s website at fatetherapeutics.com. This call is a property of Fate Therapeutics and recordings, reproduction or transmission of this call without the expressed written consent of Fate is strictly prohibited. As a reminder, today’s call is being recorded. I would now like to introduce Scott Wolchko, Chief Financial and Operating Officer of Fate Therapeutics.

Thank you. Good afternoon. And thanks everyone for joining us for the Fate Therapeutics third quarter 2014 earnings call. At 4:00 PM Eastern Time today, we issued a press release with our third quarter financial results, which can be found on the Investors and Media section of our website under press releases. In addition, our third quarter 2014 10-Q will be filed with the SEC tomorrow and will thereafter be available on the Investors and Media section of our website under Financial Information. Before we begin, I would like to remind everyone that except for statements of historical facts, the statements made by management and responses to questions on this conference call are forward-looking statements under the Safe Harbor provisions of the Private Securities Litigation Reform Act of 1995. These statements involve risks and uncertainties that can cause actual results to differ materially from those in such forward-looking statements. Please see the forward-looking statement disclaimer on the company’s earnings press release issued after the close of market today, as well as the risk factors in the company’s SEC filings, included in our Form 10-Q for the quarter ended September 30, 2014 that will be filed with the SEC tomorrow. Undue reliance should not be placed on forward-looking statements, which speak only as of the date they are made, as the facts and circumstances underlying these forward-looking statements may change. Except it is required by law, Fate Therapeutics disclaims any obligation to update these forward-looking statements to reflect future information, events or circumstances. Joining me on the call today are Dr. Christian Weyer, President and Chief Executive Officer, Dr. Pratik Multani, Chief Medical Officer and Dr. Peter Flynn, Senior Vice President of Early Program Development. I will begin the call by reviewing our financial results for the third quarter of 2014.…

Thank you Scott and good afternoon everyone. In the third quarter of 2014, we continued to make strong progress in support of our mission to pioneer novel stem cell therapeutics to improve outcomes in patients with rare life-threatening diseases. We achieved several key milestones in the execution of our multi-pronged clinical development strategy for PROHEMA, which is aimed at demonstrating its therapeutic potential in patients across a wide range of ages and a broad spectrum of life-threatening malignant and rare genetic disorders. Our Phase 2 PUMA study of PROHEMA, a randomize controlled open-label clinical trial in adult patients undergoing double cord blood transplant for the treatment of hematologic malignancies underwent the first data safety review by an independent data monitoring committee in August 2014. A total of 10 patients including 7 patients that receive PROHEMA, were included in the review and the iDMC supported continuation of the PUMA study. Additionally, we successfully expanded our clinical investigation of PROHEMA to include pediatric patients. We’re actively screening patients for our Phase 1b PROMPT study, which is intended to evaluate PROHEMA in pediatric patients on undergoing single cord blood transplantation for the treatment of hematologic malignancies. And in July 2014, our Phase 1b PROVIDE study which is our first clinical investigation of PROHEMA in pediatric patients undergoing single cord blood transplantation for the treatment of rare genetic disorders was cleared for conduct by the FDA. During the fourth quarter of 2014, we expect to achieve several key additional milestones in connection with our clinical development of PROHEMA. We have now enrolled 12 patients in the PROHEMA arm for our Phase 2 PUMA Study and are targeting the second data safety review by the trials iDMC by the end of the fourth quarter 2014. We anticipate the iDMC will review clinical data from the…

Thank you. As Christian mentioned during the third quarter of 2014, the independent data monitoring committee for the PUMA study conducted its first of two scheduled interim data safety reviews of this 60-patient randomized controlled Phase 2 clinical trial of PROHEMA in adult patients undergoing double umbilical cord blood transplants for the treatment of hematologic malignancies. Total of 10 patients including 7 patients who received PROHEMA were included in this review. As part of its review, the iDMC examined a broad spectrum of patient data, including safety, time to engraftment, rates of graft failure, early mortality, infection and graft versus host disease. Based on its review of the data available on these first 10 patients, the iDMC did not identify any safety signals and supported continuation of the study. Enrollment in the PUMA study is continuing at 11 major transplant centers across the United States and based on investigator interest, we are currently in discussions to add an additional two centers. As Christian mentioned, we anticipate that a planned second data safety review which would include 12 patients that received PROHEMA will occur during the fourth quarter of 2014. Turning now to our expansion of the PROHEMA franchise to pediatric patients, our Phase 1b PROMPT study in pediatric patients undergoing single umbilical cord blood transplantation for the treatment of hematologic malignancies is designed to enroll up to 18 patients between the ages of 1 and 18 years in three age cohorts of patients, 1 to 4, 4 to 12 and 12 to 18 years old. I am pleased to share that the clinical trial is now open for enrollment and we’re actively screening pediatric patients at one major transplant center and we expect to add two additional centers to the study. Our Phase 1b PROVIDE study in pediatric patients undergoing…

Thanks, Pratik. During our second quarter earnings call, we discussed our commitment to researching the therapeutic potential of human induced pluripotent stem cell-derived cellular therapeutics in the areas of hematopoietice and muscle biology. We have been working for over five years to develop proprietary methods for highly efficient iPSC production and expansion combining in center research and development with in-license technology and intellectual property. We have a firm belief that cellular programming will play a major role in the future of cell therapy applications, enabling entirely new classes of autologous, allogeneic and genome additive cellular therapeutics with the disease transforming potential. We are steadily increasing our investment and efforts in this area to ensure we remain at the forefront of this technology and its product opportunities. As part of our satellite stem cell platform, the first iPSC therapeutic program is focused on the generation of the iPSC derived myogenic progenitor cells or iMPCs with the goal of generating a cellular therapy for patients suffering from degenerative disease of skeletal muscle. Myogenic progenies are precursor cells, capable of populating the muscle satellite stem cell niche and thereby contributing to muscle fiber regeneration and repair. We are currently optimizing the generation of iMPCs and assessing their therapeutic potential in preclinical models of degenerative muscle disease. We have also been working diligently to develop a Wnt7a based protein analog to drive muscle regeneration through selective targeting and expansion of the endogenous satellite stem cell population. To-date, we have made considerable progress towards identifying Wnt7a analogs that possess significantly improved product attributes over the naturally occurring Wnt7a protein and that also drive satellite cell biology in role model systems. We saw that two Wnt7a analogs for assessment and manufacturing cell line generation and scale up at an ex general contract manufacturer. This work has now been completed and we have determined that barriers still remain for efficient development and [prioritization] of Wnt7a based protein therapeutic on cGMP. With an increased focus and resource allocation towards advancing and expanding our pipeline of cellular therapeutics including iPSC derived therapeutics, we’ve elected not to advance a lead Wnt7a based protein towards clinical development at this time. We will continue to assess the biology of Wnt proteins specifically of Wnt7a analogs as part of our ongoing research in muscle regeneration. I will now turn the call over to Christian for our concluding comments.

Thank you, Pete. Stepping back from the quarter and looking at the bigger picture. Our work to pioneer novel cellular programming approaches is guided by our goal of bringing innovative disease transforming stem cell therapeutics to patients with the rare life-threatening disorders. And keeping with that goal, our team in collaboration with our partners at the study side is now positioned for the clinical investigation of PROHEMA across three different clinical trials including adult and pediatric patients and addressing hematologic malignancy and rare genetic disorders. We are poised to achieve multiple significant clinical milestones over the next 12 months. Furthermore, as I look towards 2015, additional therapeutic opportunities are emerging from our ex vivo hematopoietic cell programming platform. Lastly, we have strengthened our commitment towards the research and development of iPSC derived cellular therapeutics. We’re running the business with high operational efficiency and our confidential position provides us operating runway into early 2016 allowing us to reach key milestones across these initiatives. And with that, I’d like to turn the call over to the operator for any questions.

Thank you. (Operator Instructions). Our first question comes from Boris Peaker of Cowen. Your line is open.

Good evening gentlemen. Thanks for taking my questions. Just first on the iDMC review, is there a [utility] analyses part of this review or perhaps the next review?

Yes, hi Boris. This is Christian, I’ll ask Pratik to answer that question.

So, the iDMC review is primarily focused around safety and so the analyses is based upon events related to engraftment and early mortality. There is no utility review that is part of the iDMC analyses.

So, and this one and the next one are both the same just safety only, just want to confirm that?

This one and the previous one.

So, my other question is just for your cell programming platform, I mean it’s certainly very (inaudible) platform, curious what are the opportunities for partners, it seems like there are so many projects you need to pursue that you maybe capital eliminate that to maximize the value of the program that partnerships maybe the way go or maybe I am curious how you think about it?

Yes, Boris. This is Christian speaking, I think you’re absolutely right the platform that we have build over the last five years as I have mentioned in my prepared remarks is broadly applicable to a host of different cellular therapeutics including HSC and T cell therapeutics, as well as transplant sources. I would not comment at this point about the potential for business development opportunities and collaborations to enable this pipeline, but sufficed to say those opportunities with this platform to develop own pipeline, as well as potential business development interactions and collaborations.

And lastly, just a quick question on Wnt7 program. I’m curious what you saw in the early stages of development that changed your mind about this partner?

Yes, Boris. This is Christian speaking again. As we said in our prepared remarks, the decision on the Wnt7a in terms of not advancing it to clinical development at this point is based in part on technical observations that we have made as we are scaling up the program for manufacturing. But also really important in the context of the overall pipeline opportunities that we’re looking at and our increased focus on cellular therapeutic. So, really comes down to a prioritization of resources. And as I said in my prepared remarks, we’re really excited about some of the early emerging opportunities in the hematopoietic space.

Got you. Well, thank you very much for taking my questions.

Of course.

Thank you. And our next question comes from Ryan Benjamin of (inaudible). Your line is open.

Hi, good afternoon guys and thanks for taking the questions. I guess, just my first question is in regards to the second interim analysis and these 12 patients. Since enrollments continuing, is the 20 patients, we won’t receive that data for 20 patients -- we obviously see that data for 20 patients or are we expecting significantly more patients will have already been enrolled in the study or as soon as 20 patients are enrolled, the analysis gets completed? And it’s a long winded way of asking if you are on track for completing the study by mid 2015.

Hi, Ryan, this is Christian again. Let me take the first part of your question. Pratik, do you want to?

Sure. So, there is no halt to accrual while the data monitoring committee does review it. As you know, the data that we presented at the committee is not just enrollment of the patients but 12 PROHEMA patients with engraftment data and then the controlled patients that have also been enrolled. And so during that period, we’ll continue to enroll patients. And so, there is no stop. I think that answers your first question. And to your second question, yes, so that because we’re not stopping, we feel that we still are on target for mid-2015 top line data from the entire study.

Excellent. Okay, that clarifies things. And then just in regards to the PROMPT study, I know it just started but are you seeing or anticipating sort of similar rates, potentially even quicker rates as you’re seeing on the PUMA study.

Rates of enrollment?

Correct, yes.

Okay. I mean I think pediatric transplantation in general is a bit more of -- even more focused than allogeneic transplant. And so we feel we’ve selected some very quality centers. And as I said, we are tracking to have at least three centers participate. And so yes, we anticipate that again we should be able to hit the mid-50 mark for that study. It’s obviously much smaller study than the PUMA trial.

And Ryan, this is Christian, just to add one more point. As we said in our prepared remarks, we are actually actively adding centers when it [cautions] of adding centers to all of three trials including the PUMA study at this point.

Okay. And just one final question, you may have mentioned this; I’ve had to jump back onto this call, gone drop. But the PROVIDE study is scheduled to start in the fourth quarter. When do you think, we might see any sort of results from that study? And inherent within that is obviously it depends on the indication you’re choosing to go after. So could you give us some sort of color as to what indication you think might be the first type of patients that’s enrolled and when we might see any signs of safety or potential benefit; is it something in 2015, 2016 just any color would be great?

Yes. So, again this is Christian, let me take the first step and then may be Pratik you can fill in. And the first off with the PROVIDE study, as we reviewed on a previous call, we are looking as one of the key outcomes of the study in terms of engraftment. And with that respect, we do believe that we will generate data in 2015 as we are with the PROVIDE -- with the PROMPT study and the PUMA study. We also reviewed at a prior call the fact that we intend to follow those patients long-term for radiological as well as newer cognitive development. And that data actually, we expect to somewhat trial in the early neutrophil engraftment data just simply because the long-term trajectory of improvements in these endpoints takes time just as a general feature of this procedure.

And Christian just -- because I have in my notes that you’re going to follow the patients for two years, would we expect since it has been an open label study, kind of periodic updates as to how they’re trending or would you wait for let’s say an analysis at a particular time point?

No, I think the former, as with the other study, the PROVIDE study is open label and we do intend to provide updates as we progress and patients are accrued to the trial.

Excellent. Thank you very much and good luck.

Of course. Thank you.

Thank you. (Operator Instructions). I don’t show any questions in queue. I’d like to turn it back over to management for any closing remarks.

Perfect. Thank you all for your participation in today’s call. And as always, we look very much forward to providing updates to you again in the near future. Thank you.

Ladies and gentlemen, thank you for your participation in today’s conference. This concludes the program. You may now disconnect. Everyone have a great day.