Hey. Thank you, Chris for the questions. And again, I'll start out but Rick will take it to you. So I think the way that we're thinking about the U.S. launch is, again, just to remind folks, we know these medicines inside and out. We know the labels inside and out. We have hired an incredibly experienced field sales team. Just again, as a reminder, on average our territory managers have about a dozen years of sales experience, cardiovascular sales experience. So they know their territory, they know their healthcare providers in their territories. And again, similarly on the marketing side, we have a very experienced innovative team as well. And so, we feel extraordinarily confident Chris, in the ability of our team to execute on our business plan, our commercial business plan in particular. And this is -- I know there's been history obviously including as Mark referenced with the PCSK9s of August in terms of throwing a lot of resources or bodies. And I think as we saw with the PCSK9 step, that was -- that proved to be inefficient, it proved to be ineffective. And I think as Mark said, in his prepared remarks, we had this amazing Managed Care coverage. We have signed contracts that are being implemented, as we speak and we will continue to be implemented over the balance of the year. So we think as that coverage continues to rollout that we will continue to see ever greater momentum, not just with the increased field force engagement with HCPs, but also with this ever-increasing momentum on the Managed Care side. So I think, again, we remain very confident in the launch -- very confident in the launch metrics, as I think Mark said, Rick said, let's all keep an eye on the weekly scripts. And that will continue to be a guide for us, as we track the growth of our medicines. So with that I'll tip it to Rick, to add anything else on that point. But then also talk about the expense side.