I think it’s a great question to have, I think that the bio-manufacturing sector have two hats on, I think one hat is the IP license holder, it’s the product owner, so a Big Pharma. They have systematically asset transferred and outsourced and completed outsource CARG year-over-year between 8% and 10% more, toward a big CTMO model, so we have seen the big CTMOs grow. Mark, mentioned Samsung as a case in point, they off course have grown with the safety net or record tree, wholesale as the standard which we have described. And I think while Joe has an established pathway of a good expression in handling, it isn't cost-effective. I don’t believe that I’m throwing a number although I have in my opinion would be helpful, what I would say is that a number of biopharmaceutical companies have asked us that they would be interested themselves in that number and we are having conversations to give them the support and collaborative partnership, so they can also go head-to-head. They are themselves thinking of cost of goods, they are also thinking of the advance tiers in terms of the cycle time, but most importantly they are looking to try and work with parts of their patient base where they can supply biologics cost-effectively and as Mark describes that’s not going to be mature in the future. What is true is the industry itself has over invested heavily in stainless steel and what you are seeing in the quarterly report that would suggest from big CTMOs is they are now starting to think about how that business base heavily on royalties and based on large overhead, fixed costs overhead is moving now more towards as Mark mentioned, models like GE, PAL, Helmut Fischer have been developing which are the single-use bioreactor bags and all the path maybe that goes around those disposal units. This was an inflection point of the partners, on one side the technologies and the barriers to entry for cheaper bio-manufacturing, lab bench equipment, molecular biology tool kits, all those good things that are in front of us and they are improving all the [indiscernible], what has been missing has been the actual cell host itself, that’s a workhorse. And now we have other platforms which you can research, we don’t believe they are anyway near as developed or as strong as ours, a Big Pharma have a duty of [indiscernible] to look at a number of platforms, but we are pretty confident, we are pretty excited by the announcements we have made, there is more to come.