Let me just start out with the market size and the opportunity, I think, I've mentioned the other night that in 2018, there is a study out that the $1.3 trillion of drugs being used worldwide, which a growing proportion of that our biologics, 10% of the European biologics are now biosimilars, the third world countries have patients with chronic disease, they can't afford these medicines, they need to find better cheaper ways for bringing those medicines to their ageing populations that are growing at an accelerated space as here in America even in the U.S. which is a very wealthy country, we can't afford to pay of the cost of these drugs as we age in the growing population of chronic disease patients grows. So, the opportunity is demand, the question comes on the end, it's picking the right molecules with the right companies and handling a right reason and right business model to capitalize on that and I would just give you a simple example to the company that's publically traded called Phoenix the symbol is PFNX, I think there market cap is around $400 million. They have a bacterial [indiscernible] expression system, our belief is that our C1 technology can hit a broader universe of proteins because we can make glyco and non-glycoproteins, the glycosylated proteins are typically for more valuable which means that our platform could have even far more value to the farmer's local business and that platform has. And so the opportunities are endless, the opportunities are there, we're going to be a little put our focus on them as and you pointed out we've been struggling with capital, we've been struggling with time and I think, there's great opportunity for us and DuPont in this space and together we can probably work and create even more value for each other and there is a lot of other people out there including Sanofi and others that have already seen some of the power of C1 and as you have pointed out in the past, when people have in their hands whether that [indiscernible] or BSF, they see the power of it and then they jump into with both feet so I just leave you with there -- with Sanofi in vaccine, there is a way potential with Sanofi and enzymes, and anybody with biosimilars, it's how fast, how broad, I can tell you because these guys move slowly but with DuPont now involved, they're going to have speed up or they can might left behind.