Good afternoon, everyone. Thank you for standing by and welcome to the CytomX Therapeutics Second Quarter 2024 Financial Results Call. Please be advised that today's call is being recorded. I will now hand the call over to your host for today, Chris Ogden, CytomX's Chief Financial Officer. Please go ahead.

Thank you. Good afternoon and thank you for joining us. Before we begin, I'd like to remind everyone that during this call, we will be making forward-looking statements. Because forward-looking statements relate to the future, they are subject to inherent uncertainties and risks that are difficult to predict, and many of which are outside of our control. Important risks and uncertainties are set forth in our most recent public filings with the SEC at sec.gov. We undertake no obligations to update any forward-looking statements whether as a result of new information, future developments, or otherwise. Earlier this afternoon, we issued a press release that includes a summary of our second quarter 2024 financial results and highlights recent progress at CytomX. We encourage everyone to read today's press release and the associated materials which have been filed with the SEC. Additionally, the press release, recording of this call, and our SEC filings can be found under the Investors and News section of our website. With me on the call today is Dr. Sean McCarthy, CytomX's Chief Executive Officer and Chairman. Sean will provide an update on the company's progress and pipeline before I cover the financials for the quarter and we open up the call for Q&A. With that, I'll turn the call over to Sean.

Thanks, Chris, and good afternoon, everyone. We're delighted today to provide an update on our recent progress which includes the continued development of CX-904 and Phase I dose escalation and clinical study initiation for our newest wholly-owned programs, CX-2051 and CX-801. CytomX's PROBODY Therapeutic Platform encompasses more than a decade of innovation in antibody masking and conditional activation and it's designed to enable the clinical development of anti-cancer modalities directed against targets that would otherwise be undruggable or significantly limited by therapeutic window. CytomX currently has 15 active programs across our internal and partnered research and development activities, including three clinical-stage PROBODY therapeutics designed to address large patient populations. Based on our continued strong execution, CytomX is currently very well positioned to build value and make a meaningful difference for cancer patients. Let me dive right in and start with CX-904, our masked PROBODY T-cell Engager targeting EGFR. Last quarter, we announced positive initial Phase 1a clinical data for CX-904, which was an important first step in the clinical development of this program. EGFR is a very attractive target, given its broad expression across multiple tumor types and also its high level of clinical and commercial validation with multiple approved small molecule and antibody therapies. CX-904 constitutes a novel therapeutic strategy that leverages EGFR as an address to direct T-cell mediated killing to tumor cells via CD3 binding. EGFR-CD3 has previously been considered an attractive, but undruggable target combination because of the widespread expression of EGFR in normal tissues. In the absence of masking, we would expect an EGFR-CD3 bispecific to be severely toxic and undevelopable, likely with high rates of severe skin rash and cytokine release syndrome. By using the CytomX PROBODY platform to mask both EGFR and CD3 binding domains, however, we are opening a therapeutic window for…

Thank you, Sean. It is a privilege to be part of the CytomX team and I look forward to helping lead the company towards multiple new treatment options for our patients over the long term. Now, turning to the second quarter results, I am pleased to be able to share an update on our financials with everyone today. CytomX finished the second quarter of 2024 with $137 million in cash, cash equivalents and investments versus $150 million in cash at the end of the first quarter of 2024. We expect our cash balance will fund the operations of the company to the end of 2025. Also, as a reminder, this cash guidance does not assume any additional milestones from existing collaborations or any new business development. Operationally, we continue to be focused on controlling cost and discipline capital allocation, investing behind the clinical progression of our lead pipeline programs. Now, moving on to revenue and operating expenses for the quarter. For the second quarter of 2024, revenue was $25.1 million compared to $24.7 million in the second quarter of 2023. Operating expenses for the second quarter were $33.6 million. R&D expenses were $25.2 million in the second quarter of 2024, an increase of $4.5 million versus Q2 2023, driven by investments in our clinical pipeline. G&A expenses increased by $1 million during the three months ended June 30th, 2024 to $8.4 million compared to $7.4 million for the corresponding period in 2023. Overall, our prudent financial management of the company and focused capital allocation has resulted in continued balance sheet strength and positions us to deliver meaningful value through our pipeline over the next 12 to 18 months and in the long-term. Now, I'll turn the call back to Sean for closing remarks.

Thanks, Chris, and thanks everyone for joining us today. CytomX has continued to make excellent progress throughout 2024, but we believe the company outlook is very compelling as we drive forward with our multi-modality PROBODY therapeutic pipeline. Our current pipeline reflects broad investments over time and deep learning as a leading innovator in the field of antibody masking and conditional activation. Our progress with CX-904 positions CytomX at the forefront of the exciting field of T-cell engages for solid tumors, and we, like many others, see this area as being on the cusp of breakthroughs for patients. CytomX continues to prosecute a multi-modality strategy with each of CX-904, CX-2051, and CX-801 being well-positioned for new clinical data sets over the next 18 months. Moreover, masking strategies, as exemplified by the PROBODY therapeutic platform, are growing strategic interest in the biopharma R&D area, and CytomX remains a recognized leader having created this field. In conclusion here at CytomX, we remain highly committed and focused on creating innovative treatments for people living with cancer, and we believe our PROBODY pipeline has the potential to deliver safer, more effective therapies. I want to sincerely thank the patients who join our studies, their families, and our team for helping to drive our mission forward, and with that, Operator, let's go ahead and open up the call for Q&A.

Thank you. [Operator Instructions]. Our first question will come from the line of Etzer Darout from BMO Capital Markets. Your line is open.

Great. Thanks for taking the question. Just a quick one on CX-904. You know if you've had any more insights into sort of the correlation between efficacy and EGFR expression and what could be driving the activity that you're seeing in pancreatic cancer? And maybe just remind us for CX-904, can you discuss sort of the venue if you've kind of given some thoughts into sort of the venue where you'll be presenting this update by year end? Thanks.

Yes, thanks for the questions. So we're considering to look at EGFR and how it relates to activity for 904. As we've mentioned, pancreatic cancer, like many others, expresses EGFR. More than 90% of pancreatic ductal adenocarcinoma expresses EGFR, so that clearly relates to the activity that we're seeing, we were thinking, in that tumor type. As to specific correlations between target level and response, I think that remains to be determined. And I would also say that, of course, for T-cell engagers, if we look at historical data from other programs, from other organizations, these agents are quite different to functional blocking antibodies. In that we wouldn't necessarily expect to require too much antigen to drive responses, but I think this is something we're still learning both for 904 and in the field of T-cell Engagers more broadly. In terms of the next update, so yes, as we mentioned, we're planning on an update by the end of the year. That could take the form of a strategic update in terms of next steps for the program with actual data that underpins that strategic update, which will, of course, include dialogue with Amgen. With that data coming at a future date at a venue to be determined. So no additional color on that at this time.

Great. Thank you.

Thank you. One moment for our next question. And our next question will come from Malcolm Kuno from JPM. Your line is open.

Hi, thank you for taking the question. This is Malcolm on for Anupam Rama. So you've talked about the scope of the 904 update at the end of the year. How should we think about the size of -- maybe the data that we may receive? And then given that you saw a signal earlier this year, how are you thinking about prioritizing indications?

Yes, thanks, Malcolm. So again, with regard to our goal for an update by the end of this year, our overriding focus in the second half of 2024 is to generate additional data to facilitate strategic dialogue with our partner Amgen regarding potential next steps for the program. And the obvious next step, if the data supports it, of course, is to move from Phase 1a to Phase 1b. So, we're currently enrolling, of course, additional patients in pancreatic cancer to continue to more fully explore that promising initial signal. And so I would say that, as we reach the end of 2024, I would hope that we'd have a reasonable number of patients enrolled in pancreatic to have a much better sense of the overall profile of the activity of the drug in that tumor type. We're also prioritizing enrollment in head and neck and also in non-small cell lung. And in those two indications, we've really enrolled very few patients when we gave the update in May. And so, there, we're looking to enroll additional patients to really look for an additional signal in those two tumor types. And that would be our goal by the end of this year as well. So, and again, just to be clear in terms of our overriding objective, generate data, meet with Amgen, have that strategic dialogue, define Phase 1b strategy. Again, should the data support that? And most likely give a strategic update on the program by the end of the year with the data that underpins that update, more likely than not being presented at a venue TBD in 2025.

Great. Thank you so much.

You're very welcome.

Thank you. [Operator Instructions] Our next question comes from Mitchell Kapoor from H.C. Wainwright. Your line is open.

Good afternoon, this is Dan on for Mitch. Thanks for taking our questions and congratulations on the promotion, Chris.

Thank you.

I apologize if my questions are redundant. You're welcome. I hopped from another call. We were wondering, given the context of the positive responses you've demonstrated in pancreatic cancer, what response rate or duration of response would be considered meaningful in future updates?

Yes, so regarding, again, thanks for the question. Regarding pancreatic, I think we're all aware of just how the dearth of therapies available for patients out the front line. And in the second-line setting, you're seeing activity of principally chemo regimens with single digit response rates. So these are patients that are in tough shape, very few options. And quite frankly, we think that bar is quite low, unfortunately, given the current state of treatment of pancreatic cancer. So that's one of the many reasons that we've been really excited about this initial signal in pancreatic that we're in the midst of firming up with additional enrollment as we move into the second half of the year.

Awesome. If I could ask a follow-up, do you expect to see any tolerability differences with 2051 given the variability in IHC EpCAM expression?

I'm sorry, could you repeat the question?

Do you expect to see tolerability differences with 2051 given the variability in IHC EpCAM expression and the difference in EpCAM expression between individuals?

Well, we're obviously very early in our clinical exploration of 2051. We're very pleased to have, in a very short order, already have navigated into the third cohort in the Phase 1 dose escalation. And we're on track for initial data in first half of next year. EpCAM is, to us, a highly attractive target as it for a long time because of just how high its expression is in so many tumor types. And its expression is actually pretty consistent, particularly in colorectal, where we're focusing enrollment in Phase 1. In CRC, EpCAM is expressed at IC3 plus in the majority of patients. And that's actually allowing us to not need to select patients for enrollment in the Phase 1 study. So in terms of the expression in normal tissues, there's a fair amount of EpCAM in normal tissues, particularly also in the GI tract. It can be heterogeneous, but I think we'll have to see how that plays out in the clinic. But so far so good as we're into our third cohort.

Awesome, thank you so much.

You're welcome.

Thank you. I'm not showing any further questions in the queue. I would now like to turn it back over to Dr. Sean McCarthy, Chairman and CEO for closure remarks.

Thanks very much, and thanks everyone for tuning in today. We're really excited about the progress we've made so far this year at CytomX and looking forward to a busy second half and to reporting on additional progress as the year goes on. So have a great rest of the day.

Thank you for your participation in today's conference. This does conclude the program. You may now disconnect. Everyone have a great day.