Ladies and gentlemen, thank you for standing by, and welcome to the Charles River Laboratories First Quarter Earnings Conference Call. At this time, all participants are in a listen-only mode. Later, we will conduct a question-and-answer session. As a reminder, this conference is being recorded. I would now like to turn the conference over to our host, Todd Spencer, Vice President of Investor Relations. Please go ahead.

Thank you, Lisa. Good morning, and welcome to Charles River Laboratories first quarter 2022 earnings conference call and webcast. This morning, I'm joined by Jim Foster, Chairman, President and Chief Executive Officer; David Smith, Executive Vice President and Chief Financial Officer; and Flavia Pease, Executive Vice President and incoming Chief Financial Officer. They will comment on our results for the first quarter of 2022. Following the presentation, they will respond to questions. There is a slide presentation associated with today's remarks, which is posted on the Investor Relations section of our website at ir.criver.com. A webcast replay of this call will be available beginning approximately two hours after the call today and can be accessed on our Investor Relations website. The replay will be available through next quarter's conference call. I'd like to remind you of our Safe Harbor. All remarks that we make about future expectations, plans and prospects for the company constitute forward-looking statements under the Private Securities Litigation Reform Act of 1995. Actual results may differ materially from those indicated. During this call, we will primarily discuss non-GAAP financial measures, which we believe help investors gain a meaningful understanding of our core operating results and guidance. The non-GAAP financial measures are not meant to be considered superior to or a substitute for results from operations prepared in accordance with GAAP. In accordance with Regulation G, you can find the comparable GAAP measures and reconciliations on the Investor Relations section of our website. I will now turn the call over to Jim Foster.

Thank you, Todd. Good morning. We're pleased to report solid financial results for the first quarter that were precisely in line with our expectations. Organic revenue growth was slightly below the 10% level. Operating margin improved by 70 basis points year-over-year, and earnings per share growth was in the high single-digits. Revenue growth rate is expected to increase from the first quarter level, positioning us well to achieve our robust outlook for the year. There are several factors that we believe support our outlook, including the continued strength of the biopharmaceutical market environment. First, we continue to benefit from strong sustained business trends, particularly in our largest business, Safety Assessment, which represents approximately half of our total revenue. We are booking work well into 2023 and have over $1 billion of backlog already for next year. We continue to get price and anticipate continued share gains. Our scale, scientific expertise and geographic reach continues to resonate with our clients. We have added a significant number of staff in the second half of last year and continued hiring in the first quarter. Coupled with our growing backlog, we are poised to meet the escalating demand, which will result in a DSA organic revenue growth rate approaching 20% in the second half of this year. Another factor that supports our 2022 outlook is our well-funded client base, both large and small. Based on daily conversations with our clients and our key performance indicators, clients are continuing to spend at the rate that we anticipated and moved the nonclinical development programs forward. Given our early-stage focus, we are a canary in the coal mine, should funding become a concern. This is not surprising as we believe biotech clients are resilient and continue to have an average of about three years of cash on…

Thank you, Jim. I'm excited to join the Charles River family and become Chief Financial Officer. Charles River presents a compelling opportunity to join a life sciences industry leader, work with a deep and talented finance team and collaborate with experienced senior leaders. I intend to leverage my experience as a trusted business partner to help the company achieve its financial goals, supported significant growth potential and create value for shareholders. I look forward to meeting many of you in the investment community in the coming weeks and months. I would also like to thank David for his support and guidance over the past few weeks, and I will continue to work closely with him to ensure a smooth and seamless transition. Now, I'll turn the call over to David.

Thank you, Jim, Flavia, and good morning. Before I begin, may I remind you that I'll be speaking primarily to non-GAAP results, which exclude amortization and other acquisition-related charges, costs related primarily to our global efficiency initiatives, our venture capital and other strategic investment performance and certain other items. Many of my comments will also refer to organic revenue growth, which excludes the impact of acquisition, divestitures, foreign currency translation and the 53rd week in 2022. We are pleased with our first quarter performance, which included revenue and earnings per share growth in line with the outlook we provided in February. Organic revenue growth of 9.4% and operating margin expansion of 70 basis points were partially offset by a higher-than-expected tax rate resulting in an earnings per share increase of 8.7% to $2.75. As Jim mentioned, we have reaffirmed our organic revenue growth and non-GAAP earnings per share gains for the full year. Our earnings per share guidance of $11.50 to $11.75 was effectively absorbed a higher-than-expected tax rate and interest expense compared to our initial outlook. I will discuss both of these items in more detail shortly. Our organic revenue outlook for the full year is unchanged at 12.5% to 14.5% growth. With the addition of Explora BioLabs, we've increased reported revenue growth guidance to a range of 13.5% to 15.5%. This includes a larger 1.5% headwind on foreign exchange due to the strengthening of the US dollar. Given the robust top line performance, we remain well positioned to moderately expand the operating margin in 2022. As I mentioned, our tax rate and interest expense outlook have increased since the beginning of the year. We expect a slightly higher tax rate in 2022, because the lower stock price during the first quarter resulted in a lower excess tax benefit…

That concludes our comments. Operator, we will now take questions.

Thank you. Our first question will come from the line of Eric Coldwell with Baird. Please go ahead.

My question -- two questions on DSA segment. First one, DSA growth expected to approach 20% in the second half. I'm curious if there's any additional color available on the split between 3Q and 4Q; i.e., would both be at a similar rate? Or would the ramp continue through the year finishing out at or above that range in the fourth quarter? And then my second question, I believe I heard you say there was a take-or-pay deal in DSA done this quarter. Juggling a few calls today, so I missed that section. But I'm curious if you can provide any more detail on that and what you think the client appetite for further take-or-pay deals might be at this time? Thanks very much.

Sure. So we do anticipate the ramp will continue through the back half of the year. Each quarter will be progressive -- should be progressively strong and will end well. The back half of the year will be at 20%. That's a combination of significant price, share gain, overall volume and mix, great capacity utilization, utilization of staff, which has been hired but being trained and sort of not contributing to the top or the bottom line in Q1 and just the strength of our competitive position from a scale point of view, geographic proximity point of view and the constituent scientific parts of our business. So we've never had backlog like this. It continues to elongate. It's $1 billion of backlog already for next year. It's -- the volumes are up substantially over the prior year and over the last quarter. So we're quite confident in our numbers and the progression. Take-or-pay thing, Eric, is really interesting. I don't know if I said it to you about it that’s sort of been saying at least to ourselves that we were surprised. We weren't hearing more of this. So capacity is kind of appropriately tight. Clients are really busy. Clients are well finance. Lots of new modalities. People are booking pretty far out. The booking pretty far out is a combination of lots of work and making sure they get a slot. And so I've often said if I was running a drug company or the Head of R&D, I certainly would try to lock up some space. So I had some flexibility and could slot things in perhaps -- slot priority things and perhaps earlier than we were giving them slot. So we signed the first one. It's nothing special about the client, except it's a big one and it's multiyear. We feel pretty strongly that others will follow. It's just too much of an appropriate tool for them to use as the demand continues to increase. And that's kind of a safety valve, which I think takes a lot of the pressure off of them. We spent a lot of time with our clients over the last six to 12 months about -- tell us what your real priorities are. Don't tell us every drug is important to start a study next month or it's going to have the same revenue contribution because, of course, that's not true. Help us prioritize and will, a, help slot those in earlier. And b, if you want to really be sure of belts and suspenders and lock up some space on a take-or-pay basis. So not surprised, pleased to see it. I think that's going to make the kind of scheduling more rational, more comfortable for everybody. And we can't project it because it hasn't happened yet, but we would be surprised if we don't see additional large companies do similar things by the end of the year.

Jim, thanks very much for the details. I'll jump back in queue, if I have anything else. Congrats on the outlook.

Thanks, Eric.

Thank you. Our next question comes from the line of Jacob Johnson with Stephens. Please go ahead.

Hey. Good morning. Thanks for taking the question. Jim, I wanted to follow up on something you alluded to in your comments in terms of the cell and gene therapy clients you have in biologics and kind of your ability to I don't know if we want to call it pull-through or cross-sell them into CDMO work. Can you just talk about the initial reception there and what your experience has been?

Yes. It was -- I'd say the major strategic rationale for us to pivot back into the CDMO space, having exited several years ago, we find ourselves with this escalating, high growth, improving margin Biologics business on a worldwide basis. So we're testing the drug before it goes into the clinic. We're testing the drug if it's approved after it goes into the clinic, perhaps indefinitely. And we began to have requests from clients to why can't you manufacture the drug. So there's a correlation. So if we -- if someone else manufactures that we could still test it or vice versa, but I think there's a lack of elegance to that for the clients, I think it's less efficient for them and slows things down. So we have competitors who do both -- sorry, who do either but don't do both. So we think this is a strategic benefit for us. Also the same -- the connection to Safety and Discovery is also quite significant. So it's a little bit early to comment on the success except to say that we have a sales force that talks about all of it. We have clients that definitely are resonating to it both ways. So former Biologics clients that are now beginning to talk to us about or use us for CDMO manufacturing or buying gene therapy products or vice versa. So we're quite confident that, that's the ultimate value proposition that we've invested in here. That's sort of the way we get one plus one equals three.

Got it. And then just maybe following up on that. Just on HemaCare and Cellero, can you just talk about the latest trends in cell supply of kind of the COVID headwinds there abated? Are you seeing a rebound in those businesses?

So HemaCare and Cellero has new management, has new capacity and has much more sophisticated ways to access and hopefully retain donors. So the slope of that business is positive as we move through the back of the year.

Got it. Thanks for taking the questions.

Thank you. We do have a question from Elizabeth Anderson. Please go ahead.

Hi, guys. Thanks so much for the question. And welcome, Flavia. It's nice to speak with you. I was wondering if you could talk to me a little bit more about sort of the OpEx spend in the quarter that came in a little bit under what we were suspecting especially given the inflationary environment. Just any additional puts and takes you can sort of talk about on that so we can sort of think about the run rate for the rest of the year. Thank you.

I’m sorry. I'm not sure I heard the whole question. Speaking a little quickly. Yes.

Operating expenses in the current kind of inflationary environment.

Yes. We -- I don't think anybody has a crystal ball, but we feel that we accommodated well for inflationary pressures when we put our operating plan together, and it's embedded in our guidance. And when I say that, I'm obviously talking about supply chain costs. I'm talking principally about numbers of people and salaried levels, hourly rates, whatever, compensation levels and what we anticipate that we have already done and may have to do additionally. There's no question that in the first quarter -- tried to allude to this in my answer to the last question. We had a fair number of people that were hired, for instance, in the Safety Assessment business. So more people, higher salary levels, very much tied up in training and not really contributing to either revenue or profitability. So you'll see that sort of, ameliorate through the back half of the year. You'll see pricing for a lot of studies that we book later in the year to come through. So what we've said -- and I'll state this again carefully is that the modest anticipated operating margin accretion that we believe that we'll get for this year will be principally as a result of the Safety Assessment business, and we think that those costs are embedded in that analysis.

Got it. That’s very helpful. Thank you.

We have a question from Elizabeth with William Blair. Please go ahead.

Hi. My name is Christine. Thanks for the question. I was hoping you could give me an update on your plasma DNA business, if this is an area of investment for Charles River. And how does it fit into your end-to-end offering for cell therapy innovators in that strategy? Thanks.

Yes. So working hard to enhance the management of all of these businesses that we bought to, sort of, refine the strategy for both our plasma DNA and viral vector businesses, which are going to be, sort of, geographically-based sort of moving away from some of the work that one of those businesses was doing. That was very much COVID-related both before we bought it and right after we bought it and now that we have capacity available for our plasma DNA. So we -- we're positioned really well for this gene therapy product offering, which is going to allow us to be opportunistic in the marketplace where there appears to be insufficient supply to meet the demand. So -- and we feel really good about our ability to provide those essential products to our clients in this space.

And does that answer your question?

Yes, great. Thank you.

Thank you. Our next question comes from Dave Windley with Jefferies. Please go ahead.

Hi. Good morning. Thanks for taking my questions. David, congrats on your great career and best wishes in retirement. I wish I was following you. The question I have -- I wanted to focus -- Jim, appreciate your data on your client mix. Venture funding has actually, I think, held up even a little bit better than the public market. I wondered if, in addition, you had any sense of what the mix is of your -- probably your precommercial that are venture versus public. Any sense of that?

I don't think we size this yet. I mean, we said less than 10% for the small pre-revenue businesses. I think a lot of those are public. I think that -- as you said in your question, we have a lot of formal and informal relationships with pretty much all of the major healthcare venture capital firms, as I think you know. They're raising funds much more quickly than they used to. So the five to seven-year raises are now two to three-year raises. It seems like those companies are two things, which are good for us, extremely well-financed and have no desire, ability, capability or interest in developing any of their own internal capacity to frankly do any of the things that we do. So they're the, in some ways, the best clients. They're always in least get to proof of concept. They're less price-sensitive. They're well financed, and they're 100% outsourced at least -- yes, almost all of them are. So we feel that -- just to give you a broader answer to the -- maybe the broader question that was going to be a follow-up that we feel that the clients have three years of cash generally. We feel that those that may have less than two years of cash -- I think three things. I think that pharmaceutical industry will bank a lot of those companies and a lot of those technologies and/or the VCs. I think any new potential drug to deal with unmet medical needs that really is promising, I just don't think that the pharmaceutical industry is going to let that language and not support it. So I think it's highly unlikely that these companies does somehow flourish, does somehow get funding and does somehow continue to work with us. Having said all of that, based upon the numbers that we just gave you in our prepared remarks, we see elongating backlogs. We see enhanced pricing. We see increased demand. We see our first client do a deal on a take-or-pay basis. So, it seems like our client base is strong that has full product portfolio and is not concerned about their ability to fund those going forward. .

Thank you. Yes. That segues into my follow-up, which was take-or-pay. Eric asked this a little bit. It's been a while -- you've talked about it recently, but it's been a while since we've seen one. I guess, practically speaking, I'm wondering -- you did give us a backlog number this quarter that you don't usually do. How is that take-or-pay contract reflected in backlog, if at all? I guess for the locking in the space, given demand, should we assume that you got kind of spot rate pricing on that take-or-pay contract? Or does the client ask them for that much, get a little bit of discount?

I mean we're pleased with the pricing on this contract. It's part of our -- it's a client that has -- it's part of our backlog. I mean it's only a single client. So we don't want to overstate it. We wanted to call it out because, as I said earlier, we've been anticipating it. I'm surprised nobody has done this sooner. I do think lots of others will follow. And I do think this is probably a template, not that we got to share with anyone else, template for others to have the confidence that for the highest priority studies, they can spot things in earlier. And also that we get on the same side of the table with them and have a much better strategic dialogue about what's coming out of the type to them, when they'll need the space. Just gives us great visibility. It enhances our plans for how much incremental space we're building. It enhances our plans for how much incremental staff we'll continue to add, just provides a much more rational working relationship. So we're thrilled with it. It's not like we weren't looking for it, but it came up in the conversation. And our job is to listen carefully to what clients want to provide them with flexible solutions. They don't all want the same solution, but I do think that some of the larger companies with larger portfolios whose so can afford this, I mean, the whole sort of pricing conversation so we actually be, pharmaceutical companies with billions -- like tens of billions dollars on the balance sheet. They can afford it whatever they want. So as I said before and probably to, you, specifically, Dave, so many of these drug companies have given up their internal capacity or reduced it somewhat. It's a very, very smart thing for them to do and was pretty much foreseeable and predictable.

Got it. Thank you.

Thank you. Our next question comes from Casey Woodring with JPMorgan. Please go ahead.

Hi, guys. Thanks for taking my question and congratulations, David. I guess, so on DSA, you talked a lot about Safety Assessment, but can you elaborate on what you saw in Discovery? You noted the growth rate was below the recent double-digit trend there. So wondering how much of that is related to the tough comp versus maybe some shift in customer spend or pipeline rationalization from customers?

Yes. I mean the Discovery business continues to be a strong business. It was – includes more slowly than it has previously. The comps were really, really tough. As we said, we had a bunch of COVID-related work, which we were happy to have and proud to have, but not sustainable. And we had some one-time events that are repeatable. So if you take that out, we feel good about the growth rate of that business going forward. Again, that's a service -- a series of services that so many of our clients need, large or small, and an important service in terms of selling into the Safety Assessment business. So we like to look at DSA in whole, which is why we haven't peeled the deck any further than that, but we did give a little bit of color that quarter was a bit slower but we anticipate the strong finish for DSA sequentially and a very strong back half of the year for that whole segment.

Got it. And then I'm just wondering how much of the RMS demand you saw in North America is catch-up work from canceled or delayed projects from COVID. And can you also quantify what the China lockdown impact was to RMS in 1Q? What's implied there in 2Q and for the full year? And any other color around China? Thank you.

So all we can tell you about China is kind of a tale of two cities. The demand is -- continues to be considerable. So we have a growth rate in China that totally outstrips growth rate in other parts of the world, had a nice first quarter, tiny impact from the lockdowns. We don't anticipate, as we said in our prepared remarks, that it will have a meaningful impact in the second quarter, but it's a little bit impossible to predict. Our overall feeling is that the RMS segment is so strong that unless the impact is greater than we anticipate, we'll be able to offset it. So we'll see. But right now, we feel quite good about it. We were particularly pleased with North America. I would say that's not a rebound from anything in particular COVID-related. I would say that it's about the spending by our North American clients. It's about our strength versus the competition. It's about our continued investment in that business and the sophistication of the product line. It's about significant pricing, some mix and share gains. So I can't tell you how delighted we are. So you didn't ask this, but I'm going to say it anyway. I mean I do think that we are living in the renaissance in the RMS business, which between China, legacy businesses, the service businesses, particularly IS, now enhanced by this Explora acquisition that we've done, that we're going to see that business squarely in the high-single-digits as we move forward with hopefully strong operating margin. So we're really thrilled actually with pretty much all of the constituent parts and pieces of that business, which it's been a while coming. So we feel really good about that. We'll obviously continue to give you updates on the China situation vis-à-vis RMS, we think, will be fine.

Thank you.

Thank you. Our next question is from Justin Bowers with JPMorgan -- I'm sorry, Deutsche Bank. Sorry about that.

Hi. Good morning, everyone. Just was hoping to get a little more context around the backlog growth in DSA. I think you said that you have $1 billion booked out to -- for 2023 at this point. And versus my model, that's probably 40% of forecasting revenue, plus or minus. And you really don't have to go too far back to where your total backlog for the year was $1 billion. So I was just hoping to kind of understand how far out you're willing to go and also provide some historical context maybe around like how much you would have booked at this point for the following year, a few years back, for example.

I mean it's unprecedented. The best years we had were six, seven and eight. This is way better. But it's a totally different industry. Competitive scenario has totally changed. Strength of Charles River has totally changed. The numbers of clients have total changed, and biotech as a driver has changed at all. So, we have most of the revenue book -- we have a backlog this year that will accommodate our guidance in Safety. I'm not going to validate your number, but you can do the math as to how big you think our Safety Assessment business is, what will grow next year and how much is in backlog. It's much higher than we would see at this point in the year. And I would anticipate that will continue to grow. So, hopefully, we'll have a similar situation when we get into next year, which is most of it is already in backlog. And that's enhanced by the highest pricing that we've been able to achieve, which is appropriate. It's commensurate with the fact that the studies are more complex than they've ever been. Capacity is appropriately tight. The clients have more drugs to work on than ever. And the availability of competitive capacity is somewhat limited. So, it's obviously a very nice demand curve for us, and our job is to try to do all of it, to try to build enough space now to the end of 2023 and 2024 to accommodate incremental demand to hire people slightly ahead of when they need them, to drive our digital portfolio such that we are more efficient and are more responsive to our clients, to kind of price appropriately and rationally to continue to have more clients have these take-or-pay relationships if that's what they want and also to continue to always save enough space for both shorter-term and longer-term studies. It just simply absolutely have to start earlier for clients. And we're having -- as I've said now for several quarters, we're getting together with all of our clients and say, just tell us what's what your priorities are in our portfolio, and we'll try to accommodate it. So, it's a very attractive business model. We're spending all of our time trying to execute against that demand, but we've never seen a demand like this. So we're not going to take it for granted. We're going to respond really well. Our execution is going to be as well as possible. And we're going to have both people and physical capacity in place ahead of what we needed.

Appreciate the color there. I’ll hop back in queue.

Thank you. We have a question from Tejas Savant with Morgan Stanley. Please go ahead.

Hey, guys. Good morning. And Dave, congrats on your tenure and best of luck in retirement. And Flavia, looking forward to working with you. Jim, maybe to start things off, did you disclose what organic constant currency growth look like when adjusting for the COVID impact last year? Any color you could share on that at the segment level perhaps would be helpful.

Yes. I'll take that, Jim. So yes, we did call out the COVID impact by segment when we gave -- went through 2001. And actually, at the end of the year, we gave that color. So we had 980 basis points in RMS. We had 80 basis points in DSA and 210 basis points in Manufacturing. So hopefully, that gives you the numbers you're looking for.

Got it. That's helpful. And then, Jim, as we think about sort of operating margin expansion here, you did talk about continuing to expect modest expansion year-over-year. Can you just walk us through the impact from Explora, sounds like, it's going to be a little bit of a headwind on RMS? And then to Dave's point earlier and your commentary around expecting a lot more of these take-or-pay contracts, how confident are you that the magnitude of the pricing increases that you foresee working their way through the backlog here can help offset any take-or-pay sort of headwinds in addition to staffing costs and wage inflation?

Yes. So we don't look at the take-or-pay deals as headwinds. We'll -- clients are very much in need of that sort of accommodation structure for us. They're going to pay us well for that -- for those combinations and to have that space available. So I think those -- that would be just part of the portfolio. It's impossible to predict how big it will be, but I think some of the larger clients will want to do the same thing. So I don't see that as a headwind. I mean Explora is a really nice strategic deal. It's going to double the size of our CRADL life business. It's going to be a slight headwind to margins in that business. We have had very high margins in the Charles River businesses, and the scale at which they are opening up new facilities and just their overall structure has slightly lower margins, which should improve over time. So that's already baked into our guidance. So again, we feel confident that we'll deliver this modest improvement that we talked about that's going to come principally from Safety. I hope it comes from other places, but that's not what we're guiding to right now. But we do feel that the demand pretty much across the board is quite significant or a strong competitive position. We don't really see any external disruptors to that overall demand.

Got it. That's helpful, Jim. And one final one on Biologics Safety Testing. You spoke about, sort of, vaccine lot-release work you're settling into steady state for the COVID component heading into back half of this year in 2023. Can you just help share some more color on what your assumptions are in terms of that steady state demand? And if there were to be a relatively sharp drop-off, should we be thinking of a slight moderation here versus that, sort of, 20% growth target you've spoken about for BST?

No, I would anticipate softening demand. And I think we said last year that -- and I think we had a 30% growth quarter. And I think we said if you take all the COVID workout, it's still growing at 20%. So it's a really strong growth business. It's all driven by large molecules. There's a multiplicity of different ways large molecules are utilized. Cell and gene therapy is definitely a big driver of our growth, so as our geographic scale. So we're going to do some vaccine work, COVID and not COVID. It's part of the portfolio, but we won't be whip-sided by any fundamental change in COVID vaccine revenue or testing.

Very helpful. Thank you.

Thank you. We have no further questions in queue. I will turn the conference back to Todd Spencer for any closing remarks.

Great. Thank you for joining the conference call this morning. We look forward to seeing you at upcoming investor conferences. This concludes the call.

Thank you. That does conclude our conference for today. Thank you for your participation and for using AT&T Executive Teleconference. You may now disconnect.