Ladies and gentlemen, thank you for standing by. Welcome to the Charles River Fourth Quarter 2017 Earnings Conference Call. At this time, all participants are in a listen-only mode. Later, we will conduct the question-and-answer session. Instructions will be given at that time. [Operator Instructions] As a reminder, this conference is being recorded. I would now like to turn the conference over to Susan Hardy, Corporate Vice President of Investor Relations. Please go ahead.

Thank you. Good morning and welcome to Charles River Laboratories' fourth quarter 2017 earnings and 2018 guidance conference call and webcast. This morning, Jim Foster, Chairman and Chief Executive Officer and David Smith, Executive Vice President and Chief Financial Officer, will comment on our results for the fourth quarter of 2017 and our guidance for 2018. Following the presentation, they will respond to questions. There is a slide presentation associated with today's remarks, which is posted on the Investor Relations section of our website at ir.criver.com. A replay of this call will be available beginning at noon today and can be accessed by calling 800-475-6701. The international access number is 320-365-3844. The access code in either case is 443328. The replay will be available through February 27 and you may also access an archived version of the webcast on our Investor Relations website. I'd like to remind you of our Safe Harbor. Any remarks that we may make about future expectations, plans and prospects for the company constitute forward-looking statements for purposes of the Safe Harbor provisions under the Private Securities Litigation Reform Act of 1995. Actual results may differ materially from those indicated by any forward-looking statements as a result of various important factors, including but not limited to those discussed in our Annual Report on Form 10-K, which was filed on February 14, 2017, as well as other filings we make with the Securities and Exchange Commission. During this call, we will be primarily discussing results from continuing operations and non-GAAP financial measures. We believe that these non-GAAP financial measures help investors to gain a meaningful understanding of our core operating results and future prospects, consistent with the manner in which management measures and forecasts the company's performance. The non-GAAP financial measures are not meant to be considered superior to or a substitute for results of operations prepared in accordance with GAAP. In accordance with Regulation G, you can find the comparable GAAP measures and reconciliations to those GAAP measures on the Investor Relations section of our website through the financial information link. Now, I’m pleased to turn the call over to Jim Foster.

Good morning. I’m very pleased to speak with you today about the conclusion of another strong year for Charles River, our expectations for 2018 and beyond and some important developments that will contribute to our long-term growth. Let me begin with an overview of our industry and factors driving our performance. We are operating in a robust business environment that gives us excellent growth potential. Our total addressable market is in the range of $15 billion, growing at mid-single digit rate. At revenue approaching 2 billion, that gives us a long runway. Biotech funding remains strong, in fact, 2017 was the second strongest year ever, with funding rising 37% from 2016 levels. The FDA approved 46 drugs last year, more than twice the number of drugs as in 2016 and because of our unique early stage portfolio and extensive scientific expertise, we worked on 74% of the approved drugs. We have demonstrated the value we can provide to clients and fully intend to continue to enhance our value proposition, both through internal initiatives and strategic acquisitions. With the strength of the market opportunities and our premier reputation with clients, Charles River is on a path to nearly double its size over the next five years. We are maintaining our long-term target for consolidated revenue growth at high single digits over the five year life of our strategic plan and low double digits, including acquisitions. Our long-term target for the consolidated non-GAAP operating margin remains greater than 20%, even including acquisitions because profitable revenue growth is key to our long term goals. Further to that point, we continue to target at least low double digit non-GAAP EPS growth, exceeding organic revenue growth by at least 200 basis points. Before discussing our fourth quarter results, I'm pleased to share two important events…

Thank you, Jim and good morning. Before I begin, may I remind you that I’ll be speaking primarily to non-GAAP results from continuing operations, which exclude amortization and other acquisition related charges, costs related primarily to our global efficiency initiatives, the divestiture of the CDMO business in 2017 and certain other items. Many of my comments will also refer to organic revenue growth, which excludes the impact of acquisitions, the CDMO divestiture, the impact of foreign currency translation and the 53rd week in 2016. I will focus my discussion on our 2018 financial guidance. This guidance does not include the impact of MPI Research since the acquisition has yet to close. In 2018, we believe that we are well positioned to deliver earnings per share between $5.42 and $5.57. The 2018’s earnings growth rate appears compressed by the year-over-year comparison of venture capital investment gains and the excess tax benefit associated with stock compensation, which creates a combined headwind of $0.24 per share. Adjusting for these headwinds, the year-over-year earnings per share growth is expected to be approximately 8% to 11%, primarily driven by higher revenue and modest operating margin improvement. This year, we have forecast venture capital investment gains of $0.14 per share compared to a gain of $0.29 per share in 2017. Because of these strong historical returns, we increased our estimate for VC gains to $0.14 a share from a level of $0.04 in prior years. We believe the higher estimate for 2018 more closely aligned with historical performance because in each of the last five years, we have outperformed our initial $0.04 outlook with gains ranging from $0.05 in 2015 to $0.29 last year. Given the inherent difficulty of forecasting VC gains or potential losses, we will evaluate eliminating these gains from our guidance beginning in…

That concludes our comments. The operator will take your questions now.

[Operator Instructions] And we’ll go to Eric Coldwell with Baird.

Questions on MPI. First off, I'm sorry if I missed any of this. Facility utilization, can you talk about where they are with their capacity utilization and also any additional commentary on overlap you might have with their client base or perhaps lack of overlap in terms of ability to crosssell or upsell into MPI’s specific accounts?

So Eric, we have a similar client base. So, I’d say that highly complementary, their client base is largely small and medium size biotech clients and obviously that's been the major driver of our growth. As we said in our remarks, it's a very large facility, 1 million square feet, conservatively larger than the ones that we have. Facility has some capacity available, which we think is extremely opportune, both in terms of its geographic footprint and the scale and diversity of what they do at that site. It will allow us to expand smoothly into new space as we need it, probably in lieu of building it out somewhere else. So we think this will be a highly strategic facility addition to our portfolio and one that expands our capabilities in a few new areas, but also expands some of the areas that we are currently participating in a more robust way.

Jim, can you share with us whether they were using Charles River’s animal model business or in part or in whole or were they using other providers?

I don't think we have a lot of details on that yet. So I'm going to modify my answer by saying that I suspect that they are meaningful client of ours. And we'll have to get back to you on the extent of that. Most of the large CROs are meaningful clients of us. So I suspect at least in part, Eric, this will add to our assertion that our largest client of the RMS business is indeed our DSA business as well. And additionally, regardless of what percentage of their research models came from us, we would hope to have an opportunity to supply more to them and there is just great operational elegance and symmetry in that, as we've seen in France in particular and as we've seen in other parts of our business across the world. The supply of the animal models is obviously critically important from both a timing point of view and the diversity of models point of view.

And our next question will go to the line of Dave Windley from Jefferies.

Jim, I know you -- sounds like you want to kind of sunset comments around pricing in DSA. I wanted to explore margin improvement trajectory there. I guess I'm thinking about 2017 as being a year where the WIL acquisition achieved kind of its 20% target. I think you said on more of a sustainable basis. So margin contribution from WIL would have been positive, but you highlighted that year-over-year margins were under pressure a little bit for, I think you said, labor costs and some other things. So just wanted to understand the moving parts in margin in BSA and how you believe that can continue to improve over time?

So, it's multi-factorial as we've discussed previously. It's the mix of work principally between specialty and general tox, which we tend to have more specialty than most. There will be some price. There will be continued enhanced capacity utilization. I think some of the aggressive hiring that we have been undertaking should moderate because we're close to being caught up. We continue to drive efficiency, as David said in his remarks, we saved 65 million -- we drove 65 million of efficiency savings in ’17. It's going to be 60 to 65 again. A lot of that is in safety and some of that is in discovery. And while WIL’s margins got to where we wanted them to be north of 20%, they're still lower than legacy Charles River. So we have margin accretion there. We’re happy that we’re starting with MPI, with margins higher than WIL’s where when we acquired them, but also lower than legacy Charles River. So we feel that there is improvement there. And then, the last piece with regard to the DSA segment is margin improvement in discovery as a whole. So when you roll that up, maybe, you want to talk about just safety or just DSA, we should have improving margins and we believe commensurate with the long term goals that we just upgraded.

And Jim, the promotions that you announced today, congratulations to those two. I think natural progressions of two folks that have been with the organization for a long time. Could you talk about how your focus may evolve and perhaps what your horizon is?

So. We're very pleased, as you say, to have two significant contributors to the company, take on large responsibilities, particularly as the company gets larger, I mean, just the advent of MPI makes us a larger more complex business. So we have to continue to parcel out the work to additional shoulders and of course there's a whole range of people who will be working with that for the two of them, who have new and different and somewhat enhanced jobs. As I said in my remarks, I look forward to continuing to work closely with them. We flagged the five year horizon for two reasons. One is that we look at the world that's in five year chunks, commensurate with our strategic plan and we really do think we can double the size of the business. I did not say explicitly in my remarks, but I will say explicitly in response to this question that I have just signed a five year contract with the company. So I intend to stay here and participate significantly, principally in my current role and more and more strategic focus I would say going forward.

We'll go to the line of Jack Meehan with Barclays. Please go ahead.

Hi, thanks. I wanted to ask about the synergies. So the $13 million to $16 million you outlined, is that all in the cost side, and what are you targeting? And then what would the underlying MPI EBITDA growth be in 2018?

So, the $13 million to $16 million is all to do with cost synergies, same as we did with WIL. We didn't feel at this stage we should be factoring in any revenue synergies. So our valuation model is based on the $13 million to $16 million in cost and slight subtlety with WIL. WIL, we said $17 million to $20 million over two years. With MPI, we're talking $13 million to $16 million by the end of '19, so slight difference in timeline there. As we've mentioned, we have called out that the LOI, the operating margin for MPI is slightly above 20%. And we do intend to be able to walk that up as we've been walking up on WIL to the sort of legacy safety assessment margins that we have.

Great. And then could you just give us a sense for the recent growth of MPI over the last few years. I know you gave us 2017 and 2019 range. But maybe just a little bit of a view on what the trailing has been, and then what gets us to the step up in 2019?

MPI has been performing extremely well, at least at the same growth rates we have enjoyed. The diversity of their capabilities I think has made them an important partner for lots of companies, particularly small and large high-growth biotech clients. And we're confident because of their scientific footprint, and capability, and client interface, that they will be able to continue at similar growth rates going forward. We didn't justify this deal from a valuation model point of view on sales synergies. There are some cost synergies, so we called out. We of course have had some sales synergies with WIL. We'll really work hard to have clients have a positive experience with Charles River generally, and specifically with our MPI capabilities. So we would be disappointed if we didn't have some sales synergies, but premature to call those out specifically.

And we'll go to the line of John Kreger with William Blair. Please go ahead.

Hi, thanks very much. Hey, Jim, can you just talk a little bit more about the strategic review that you did? What's the sort of underlying macro view of your broader markets baked into that sort of updated five-year targets? And the organic revenue growth goals that you gave across the three segments, what do you think the underlying market growth is there versus some share gains that you think you can deliver over the next five years? Thanks.

Sure. So, obviously we're in multiple markets that are somewhat disparate. I suspect your question is about DSA or maybe just SA. If it isn't let me know. So just to talk about that, our sense is that biotech is the principal driver, even though pharma is aggressively dismantling space and outsourcing a lot of work, we have some really interesting conversations going on right now with some big pharma companies to do more for them, both individually and collectively. But biotech has an enormous infusion of capital from the capital markets and directly from VC investments in big pharma. And so we think between being extremely well financed, having multiple breakthrough technologies, and the fact that, while not an enormous number, more drugs were approved last year than the year before. That the market dynamics are as good as we have ever seen them. And the breadth of our portfolio and our client interface, as evidenced by the fact that we work on 74% of the drugs that were approved last year, and we think that's a number that could increase, sort of puts us -- the epicenter might be an overstatement, but we're sort of in the middle of demand and needs that both pharma and biotech have to do work for them, and instead of them doing it internally, and in some cases to work -- to provide the interface between clients. We would say that the safety assessment market as a whole is growing at about 5%. So we have been growing in excess of the market. Obviously the denominator is getting bigger. We're pleased with the growth rate, we're pleased to be growing ahead of the market, we're pleased with an opportunity to continue to improve the margins. We're pleased with the scale and diversity of our clients, and our ability to play a greater role. And one of the raison d'êtres of the organizational change with Davide and Birgit and others who are working with them besides their own talent, is the opportunity and necessity for us to have greater pull-through from Discovery into Safety, and some working backwards with clients -- current Safety clients who want to do Discovery work with us. And so managing those businesses as one without any demarcation from an operating point of view or a sales and marketing point of view, we believe we'll be very meaningful in terms of supporting the growth rates going forward.

And we'll go to the line of Tim Evans with Wells Fargo Securities. Please go ahead.

Hey, Jim. The big picture question here for me is basically trying to square up your 2018 revenue guidance with your long-term targets. Long-term, you're looking for high single digits organic. 2018, your consolidated organic growth rate looks to be about 6%, which I would think is maybe just more like mid-single digits. And it looks like maybe you're expecting the DSA piece to be the thing that accelerates more in the longer term. And I guess the thing that I'm struggling with is it's hard to imagine living in a better environment than we're living in right now for DSA given where biotech hunting has been. What gives you -- number one, am I reading that correctly, is it really the DSA segment that bridges the gap between 2018 and the long-term target? And then secondly, what is it that creates that acceleration?

So, there's multiple pieces that should contributed to the high single-digit growth rate. RMS delivering at low double digits, which it was very low -- sorry, low single digits. It was very low single-digit in '17. So we think as China grows and the services businesses grow, we should be able to do that. That's still a large business for it, albeit one that isn't growing as quickly as it was historically, although the China growth rates are significant. And as we indicated in our prepared remarks, it was capacity constrained in the back-half of the year, so going forward, as we build more sites that should be significant. Discovery has also been a drag. And so we feel confident going forward that we should get an uplift there. We feel we should get continual uplift in safety as we provide more solutions to clients. And I guess most importantly, as we really get to execute and derive the benefit of having both Discovery and Safety and using them more in a comprehensive way, I think we've been a bit too siloed in the way we've thought about it, and sold it, and the way the clients have heard about it. Plus, Discovery still is feeling like a new business to a lot of clients. And so I think managing and selling in a more holistic basis should be extremely powerful. And then we would expect manufacturing to continue to deliver low double-digit organic growth rates. The Avian business has been a bit of a drag lately. We should be freed up from that as well. The whole notion for us, I think our principal and distinct competitive advantage is the breadth and diversity of the portfolio. And I think every year we're telling that story better, and every year we're having more of a pull-through, we're having more clients buy more from us than less, because it's a better value proposition, and it's better for them to manage that. I think as we continue to invest aggressively in our current businesses and add to that portfolio through M&A, and perhaps add some additional capabilities through M&A that that should also fuel the organic growth going forward.

And we'll move to the line of Ricky Goldwasser with Morgan Stanley. Please go ahead.

Yes, good morning. So, Jim, when you talk about doubling the revenue over the next five-year period, obviously that includes the combination of organic growth and acquisition. So obviously you've just announced a very large acquisition, so -- but I guess never too early to talk about what's next. So, personally, what do you expect the leverage to be following the close of the acquisition? And when you think about kind of like your strategic plan in the next five-year, what do you think you need to kind of continue and augment growth?

So, I'm going to let David talk about leverage in a second. But I just want to remind you that we like to hang out below three turns. So that's kind of our goal as we come off of acquisitions. Obviously this is the big one. We have a lot of confidence in our ability to integrate this one well because we did a really good job with WIL, probably our best integration effort and result. They're obviously not the same company, but WIL had multiple sites, and this is a single site, so we feel that we're going to be able to focus on this WIL. And of course we have a guy who was a senior WIL executive who is running a WIL site now and a Charles River site who's going to be full time on the integration. So we have a really strong feeling that the integration will go well. Having said that, we need to close it, and we hope that will be early in the second quarter, and then we need to get to work on the integration. And I think we need to do that before we move on to the next deal. Having said that, we have been active across multiple fronts, obviously in Safety, as you've just heard, definitely in Discovery, and in a few areas that we're not in, in Discovery. We actually have opportunities across most of our businesses, including RMS, including Biologics, including Microbial, and for sure in China. And what the cadence of those deals will be, it would be inappropriate for me to say because we can't really control it. But we have a very clear line of sight on what we would like to buy, what we can afford, and how we will feather those into the portfolio over the next, let's say, three to five years. And the whole purpose is not just scale. The purpose is to have a much better value proposition or much greater service offering for our clients, all of whom want that. So whether you're a second-year startup biotech company or the biggest pharma company, you just want to stop doing this work yourselves. And you don't want to find 15 partners to do it; you'd prefer to have one or two. So, we feel very good about our ability to afford these deal -- find them, afford them, and integrate them, and increasingly to promote them. And I'll let David talk to you about leverage.

Yes, so about two years ago, when we bought WIL, we went to 3.5 turns. As we speak, at the end of 2017, we're actually at 2.2 turns. So it's interesting how it looks like it can be a bit of a repeat performance because the MPI acquisition will also take us back up to 3.5 turns, similar to where we were with WIL. And again, it is our intent to bring that leverage down below 3 turns.

Okay. And then one follow-up, as we talk about the opportunity to grow with biotech customers, can you just remind us of anything about your revenue mix, where is biotech now versus pharma versus academics and government? And how do you think this mix will look like five years out?

So, a little bit tough to slice that cleanly since so much of what's biotech sort of -- grey areas as it becomes pharma, and there's so much money from pharma going directly into biotech. So we don't spend as much time on the demarcation as we would like to. I think the last time we did at pharma was kind of 25% to 30%. And the biotech clients were probably 50% or 60%. I think academic was around 20%, so yeah, biotech -- biotech and other, which includes chemical companies and agricultural companies and CROs, et cetera. So, there's no question that we have a disproportionately fast growth in biotech clients which should continue. And so that demarcation between biotech and pharma to the extent that it's an important one will become even greater. And so we're spending a lot of our time thinking about how we do a better job communicating with and servicing clients who are in a race to get to market, and some of whom have a single compound, but we have organized ourselves to do that well.

And we'll go to Sandy Draper with SunTrust. Please go ahead.

Thanks very much. A lot of my questions have been asked and answered, so I appreciate the commentary, and also add congratulations on the transaction and the promotions. Maybe, Jim, just a little bit on RMS and the outlook there. Obviously there are a couple of positives in terms of around China, some biotech, the negative especially big pharma in the US. When you think about the long-term, how much risk is there? How do you think about the risk of that business actually not doing low single-digits, but actually being in a moderate -- three to five years from now ending up being flat to slightly down. What would happen to drive that type of scenario? Thanks.

Yes, we obviously don't think that's where we're headed, or we would have said that. We are confident that we will continue to get price. We always have, and always do. We get appropriate levels of price. And this is not a business -- this is not an activity that clients engage in. So animals are procured externally, and they're critical to getting your work done, so we will get price. We have a unique, and exquisite, and large geographic footprint even through we're trimming it with the Maryland facility, and have trimmed it previously. And if we had to, we hopefully don't, but if we had to we would trim it further if the demand wasn't there. We think we have growth opportunities principally in US, and secondarily in Europe to grow our share in the academic market, where I would say while we have significant dollar revenue we could have more. We have a huge pharma footprint and a huge biotech footprint, and a growing academic one. So I think that's in the offering. We will continue to have more specialty models that are higher value, and potentially higher margins. And the service businesses are performing well. They're not high-growth businesses, but they're low to approaching kind of mid-single-digit growers. They look good geographically. We have strong capabilities. So those should continue. Those aren't services that clients want to engage in internally. And of course, China is the big growth area, and it is a very nascent market, with competitors that I think we are doing well against, and continue to do well against. And it's really all about building out capacity -- sufficient capacity in advance of the demand. And it has the potential to be large enough to really stabilize the growth rate for this business. And we believe ensure that low single-digit growth that we were talking about.

And we'll go to Derik de Bruin with Bank of America. Please go ahead.

Hi, this is [indiscernible] for Derik. Our question is on the tax rate. You provided tax rate guidance of 25% to 26% for 2018, and excluding MPI. What can you tell us at this time about your anticipated tax rate in the out years, including MPI beyond 2019?

So, while I'm not really going to comment beyond 2019, but I am certainly happy to comment about MPI; MPI being based entirely in the US actually fits quite nicely into the 2018 guidance that we've given on 25% to 26%. So we actually don't think that the acquisition of MPI is going to distort the effective tax rate for '18.

Thank you. And then regarding your recent acquisitions in the DSA segment, Brains On-Line and KWS Test; at what run rate of an M&A revenue contribution do you expect out of these two businesses?

If you’re talking about exact dollar amounts, we haven't given those. I would describe those businesses as quite small, but highly strategic from a scientific point of view. So, Brains On-Line enhances our CNS franchise, KWS enhances our oncology franchise, but they're not moving the needle very much in terms of top-line contribution.

And we'll go to Tycho Peterson with JPMorgan. Please go ahead.

Hey guys, this is Tejas on for Tycho. Jim, just one big picture question here on MPI for you, you know, preserving the high-touch responsive feel of the service offering is probably very important to their customer's skew towards the mid-cap segment, how exactly post-integration do you expect to continue to preserve that within sort of the broader Charles River structure, particularly as you seek to drive some of those cost efficiencies that you talked about earlier on the call?

We had a similar opportunity; let's put it that way, with WIL. We had a lot more small clients who had great expectations on personalized service, because we try to give personalized service to all of our clients. And so, I think we've done a very thoughtful professional job in making those clients feel good, keeping them close to us, and to the extent that they wanted to continue to work at a WIL site with the same study director; nothing really has changed. So we're going to be very cognizant and sensitive about the same need and desire from MPI clients and change as little as possible, except to probably have more consistency across SOPs and allow them the opportunity to work with other Charles River sites to get to no other Charles River sites and get to work with them if they want to. And if they are delighted with where they're at, which I suspect most of them will be, then we will preserve those opportunities for them. So we are buying this company because we think it's a very good company, with happy clients, they had a nice growth rate, they're profitable, they do very good science. And our responsibility is to embrace that and to extent that we can enhance the science and some of the capabilities, we will do that. To the extent that we can't enhance them, then we won't, we will herald what they're capable of doing. In terms of cost synergies, we've been working really hard for approaching a decade on driving efficiency. It's something that we've done progressively better from year-to-year. It's hard work. And we believe we can provide them with the same capabilities while enhancing their work. So that's an opportunity that we are excited about.

Got it. And then one quick follow-up sure, given that a bunch of these clients are presumably at the pre-revenue stage, is there any shift in terms of contracting structures perhaps that you need to put in place, or do you anticipate that your bad debt levels might pick up a little bit, or since it's all sort of upfront payments before the work begins, you don't really anticipate that as a real risk?

We wouldn't anticipate that, does it as client basis significantly different, and the WIL client base, having said that, this deal has just been signed. We really haven't spent a lot of time studying this nor have we had access to lot of those materials. So we will be working our way through that during this interim integration period pre-close. We also have a team that look at client's worthiness in terms of ability to pay, letting down -- we do ask them pay ahead and actually we have had historically a very low bad debt write-off in our industry and in Charles River as well.

And we will go to line of Erin Wright with Credit Suisse. Please go ahead.

Hey, thanks. Can you comment on what you're seeing from the VC partnership? I know you shared some metrics in the past on that front. But can you give us an update on the traction there and how that's helping you to get new customers? Thanks.

Sure. Very, very pleased with our VC relationship. Some of those as you know we are LPs and some we are not. The relationships are slightly different when we are LPs just in terms of the level of activity, amongst and between us, and more strategy with regard to therapeutic area of focus and some M&A. But increasingly the VCs like to work with us and get the benefit of our science and capability and value as if they were one large client, which is kind of the way we work with them to ensure that they have access to us in great response times. None of these little companies will ever, that's probably a fair statement, ever internalize the capabilities that we provide to them now. So, we are providing a significantly important capability for them. And of course you get so many new companies mentored by these VCs every year that access to this sort of work is really critical, we get the drugs filed, and to get them in market. I think the last time we reported on this, collective revenue from our VCs was approaching a 100 million. That should continue obviously to increase both as we have new services and we reach out to more VCs, and they meant more companies. So very, very important part directionally of our client base; most of the new companies are literally virtual, small number of people buying everything externally. All they own is IP, and they’re very much dependent upon us. And so, our job is to communicate effectively with them often, and to help them with regulatory filings and interpretation of data. And they really make us better. They really demand explicit science and fast turnaround time. So, we are enjoying our relationships with them a lot.

And just a quick clarification in terms of MPI growth rate, you said a similar growth profile to yours, is that on an organic basis?

Yes, MPI haven't done any acquisitions.

Thank you. And we have time for one last question, and it will come from George Hill with RBC. Please go ahead.

Hey, good morning guys, and thanks for squeezing me in. I guess, Jim, most of my questions has being answered, I guess the last thing I would come back to is that if we think about like the emerging and development stage biopharma companies, the venture-funded companies, it sounds like given the visibility you guys have assumed that the current growth rate continues, I just want to think about how do we think about the risk to the guidance, should we see some type of funding slowdown should something in that end-market reverse or stagnate?

Yes, it's bit of an imponderable. I mean there is always that risk we suppose. Those companies are exquisitely well-financed currently, there's multiple years of cash in the bank. There is more cash available, we believe if the companies hit the milestones and continue to get drugs on the market that are novel, and are treating or curing diseases, and pharma is very is becoming very much dependent, reliant on these companies as the discovery engines and of course end up buying some of the companies are minimally having a deal with them. So, it's not -- look, at anything's possible. It's not foreseeable at all. This is a fundamentally different market that we're in, and the scourge of 2008, in terms of numbers of biotech companies, in terms of prominence and success in terms of their getting drugs to market and relationships with pharmas and pharma company's independence on us. So, look, we watch those numbers carefully. We watch the sort of demand curve and the ebbs and flows from these clients to see if we have any even early indications of funding slowdowns. And we haven't heard anything from any clients that they have a concern, and I think it's unlikely for the long-term foreseeable future.

Thank you for joining us on the conference call this morning. We look forward to seeing you at the Leerink conference tomorrow or Raymond James or Barclays conferences in March. This concludes the conference call.

Thank you. Ladies and gentlemen, that does conclude the conference for today. Thank you for your participation and for using AT&T Executive Teleconference. You may now disconnect.