Good morning and thank you for joining the GlycoMimetics Corporate Update Conference Call. [Operator Instructions] I would now like to turn the call over to Ms. Shari Annes of Investor Relations Group of GlycoMimetics. Please go ahead.

Good morning. Today, we will review our accomplishments and financial results for the first quarter of 2020. The press release we issued this morning is available on the company’s website at www.glycomimetics.com under the Investors tab. This call is being recorded. A dial-in phone replay will be available for 24 hours after the close of the call. The webcast replay will also be available in the Investor Relations section of the company’s website for 30 days. Joining me on the call today from GlycoMimetics are Rachel King, Chief Executive Officer; Brian Hahn, Senior VP and Chief Financial Officer; and Dr. Helen Thackray, our Senior VP of Development and Chief Medical Officer. We will start today’s call with comments from Rachel and Helen, and after that, Brian will provide an overview of the company’s financial position. We will then open the call for Q&A. I would like to remind you that today’s call will include forward-looking statements based on current expectations. Forward-looking statements contained on this call include, but are not limited to, statements about the company’s product candidates, uproleselan, GMI-1359 and rivipansel as well as our other pipeline programs and the potential impact of the ongoing global COVID-19 pandemic on the company’s clinic programs operations as well as cash burn. Such statements represent management’s judgment and intention as of today and involve assumptions, risks and uncertainties. GlycoMimetics undertakes no obligation to update or revise any forward-looking statement. For information concerning the risk factors that could affect the company, please refer to GlycoMimetic’s filings with the SEC, which are available from the SEC or on the GlycoMimetics website. I would now like to turn the call over to Rachel.

Thank you, Shari and thank you all for joining our call. Before beginning on behalf of the entire team, I would like to say we hope that you and your families remain healthy while the world adjusts to the challenges in the COVID-19 pandemic. Today on this call, we are all working from our homes as has been our practice now for well over a month in compliance with CDC in Maryland state guidelines. We are diligently coordinating our activities to maintain ongoing business operations. We do look forward to going back to onsite operations as soon as we can but not doing so compromises to health and safety of our employees collaborators for their families. In addition to providing an overview of the quarter, we are opting to use this call to address the questions that you may have about our current programs in future activities. In so doing, I have asked Helen and Brian to provide updates on our clinical activities and financial resource utilization. In our year end call, we commented on several of the first quarter’s highlights, continued enrollment in our Phase 3 registrational trial and relapsed-refractory AML, progress in our collaborative multi-center registration trial with the NCI and newly diagnosed elderly AML patients who are fit for intensive chemotherapy, execution of a license agreement with Apollomics for uproleselan and GMI-1687 in Greater China. Startup of the GMI-1359 trial in advanced breast cancer at the Duke Cancer Center and return to GlycoMimetics from Pfizer of development and commercial rights to rivipansel, our investigational drug candidate for the treatment of vaso-occlusive crisis, or VOC in sickle cell disease. We will comment on each of these achievements in a moment. For quite a long time now, our operational focus has been on uproleselan, the most advanced investigational drug candidate in our pipeline. I have asked Helen to begin with comments on our clinical development activities for uproleselan, including both our company-sponsored Phase 3 trial and the NCI trial. The comments will then also touch briefly on GMI-1359. Brian will comment on our financial planning efforts and then provide the financial results for the quarter. After they finished, I will make a few concluding remarks and then we will open to Q&A. Helen, please go ahead.

Good morning and thank you, Rachel. In February, in our year end call, we noted enthusiasm for the Phase 3 registration trial evaluating uproleselan in relapsed-refractory acute myeloid leukemia or AML was high among clinicians. This reduced the novelty of this approach and the potential benefits of uproleselan observed in clinical data we presented in several prestigious medical meetings. As you know our clinical trials of uproleselan has illustrated the drug’s potential to improve chemotherapy outcome and in addition to ameliorate some of the serious adverse effects of intensive cytotoxic chemotherapy. Furthermore, we have elucidated the role we believe uproleselan plays in the pathology of AML in the tenacity of tumor cells in the bone marrow microenvironment and their survival. New data on this mechanism was just published in Nature Communications this week and there is a very strong scientific case for the potential role of uproleselan in breaking chemo resistance of AML to improve patient survival. In the first quarter of 2020, we continue to see our global Phase 3 trial gain momentum with new sites opening and the brisk enrollment pace. However enrollment slowed in April, not surprisingly because of the pandemic, as well as recommendations both here and abroad to shelter in place and to conserve hospital resources for treatment of patients with COVID-19. However, we are seeing the hospitals continue to screen and enroll patients both in regions with lesser impact of the pandemic and in regions with some of the highest density of infection. At this point, it’s difficult to predict how quickly the affected regions and sites will return to usual clinical trial operation. For those regions and sites experiencing an impact on enrollment, our study team is well positioned to support quickly returning again to full trial activities once that becomes possible. We…

Thank you, Helen. And now I would like to turn to Brian to review the quarter’s financial results, and to provide his perspective on our financial situation, Brian?

Thank you, Rachel. Strategically, Biotech CFOs contribute to the organization’s long-term planning efforts by identifying a range of possible future scenarios and de-capping their likelihood and preparing accordingly to ensure that resources are available to deliver on our goals. Given our companywide focus in the critically important goal of delivering top line Phase 3 data that demonstrates the full value uproleselan in AML, I want to reiterate that our R&D portfolio has always been prioritized in focused, our cash is always been prudently managed and our fixed burn rate is low to allow us to weather potential delays in the normal course of business in R&D. I’d like to elaborate on several of these points in greater detail. First, we have always managed our company with fiscal conservatism and we will continue to do so, we have just under 60 full-time employees, and our fixed burn is low given we are managing two programs in the clinic, one of which is a registrational trial and we are collaborating on two additional pivotal trials in AML. Secondly, our portfolio is already prioritized for success with a focus in the pivotal program for uproleselan where needed and to advance our programs we have relied on collaborations, such as the one with the NCI to maximize the potential commercial value of uproleselan in a cost-efficient way. In other cases, we have backed away from commitments at no longer made sense from a financial perspective, as was the case with HOVON collaboration late last year. Because of this long standing, fiscally responsible financial approach, we importantly sit here today with two years of cash in the bank. Our focus is a late-stage product portfolio, backed by our robust R&D engine. We have and will continue to manage our cash prudently. With that I’d like…

Thank you, Brian. Before I turn to rivipansel, I’d like to hire one more accomplishment with uproleselan in this quarter. In January, we announced our collaboration and license agreement with Apollomics, a Chinese company committed to the discovery and development of oncology combination therapies and their goal to conduct a registration program with uproleselan in AML in Greater China. Just executing the deal Apollomics has made significant progress finding their own development strategy and engaging with KOLs in their territory, their near-term priorities for the regulatory interactions required for program start-up. We are excited by the speed at which they’re operating and as they proceed with executing on their development strategy we will provide some top line guidance on timing of their activities in Greater China. Moving now to rivipansel, we shared with you in our year-end call Pfizer’s decision to return to GlycoMimetics its rights to rivipansel, our investigational drug for vaso occlusive crisis or VOC in sickle cell disease. The transfer of these rights and licenses and the IND for clinical development program together with the entire dataset to the Phase 3 reset trial back to GlycoMimetics is now essentially complete. We are now reviewing the data and we look forward to completing our analysis of the program. We’re committed to a full assessment of what if any next steps to take. Our focus will be determining if there is a potential path forward for this asset in sickle cell disease. We had many KOLs in the sickle cell community continue to believe that the role of the selectins VOC has been clinically validated. As such with the asset back in our hands we intend to evaluate and share the efficacy, safety PK and biomarker data from the Phase 3 reset trial. Furthermore, we can now evaluate opportunities in sickle cell disease for our more potent and more selective new selecting inhibitor, which has been shown in animal studies to be bio-available through subcutaneous dosing. I’d like to close by reiterating our confidence in our clinical pipeline and of course in our specialized glycomimetic chemistry platform. Our chemistry insights have fueled several innovation that we believe will improve the standard of care in AML and potentially in other diseases as well. Notwithstanding the challenges we are facing and working remotely I can share with you the dedication of our team and their commitment to making it through the new normal of the pandemic and forward to improve outcomes for patients where there are also serious unmet medical needs. Operator, please open the call for questions.

[Operator Instructions] Your first question comes from the line of Ed White with HC Wainwright.

Good morning, everyone. Thanks for taking my questions. So just to start with, you just mentioned rivipansel, how long do you think it’s going to be reached before we see what’s the full dataset world? And then also because a sickle cell disease trial would be rather large, is this something that you would bring forward on your own or do you think once you go over the data you would start to look for partner if you think you can move forward.

So good morning, Ed and thanks for the questions. As far as when we see the data, it’s hard to predict specifically when that would be, because we are in the process of reviewing the data and looking at the overall program. I would say within the coming months we would be able to say something about that data. And as far as what we would do next again, that would follow from the review of the data as well as from our assessment and potentially discussions with regulatory authorities around what a follow on trial might look like if that is where – if that does seem to be the appropriate next step. So at the moment it’s premature to say anything specifically about what those next steps might potentially be. But in the coming months we’ll be reviewing the data more fully, hopefully getting more of that data out and in the context of that assessing what if any next steps we will be taking with that program. And as part of that, we would also be assessing whether those are steps that we would take alone or with the partners. So I would say that whole process of evaluating the data and the opportunity is going to be undertaken now in earnest once the data – now that the asset has been returned to us.

Okay. Thanks, Rachel. And then, I understand, it’s tough to comment on any of the timeline for upro and it seems that 1359 has completely stopped now, but just on 1687, I’m curious as to, since this is preclinical data, when do you think you can reach the clinic or at least have the IND filed and be ready to go with that product?

Yes, that is the product that we’re excited about and the preclinical data has been very compelling in a number of indications. We think it’s an interesting potential follow-on to uproleselan. We have not given forecast as to IND readiness for that asset. So at this point I am not prepared to say when we would take that to the clinic, other than to say we are looking at opportunities with 1687 and we do believe it represents a potential important follow on asset to uproleselan.

Okay. Thanks, Rachel. And then maybe a question for Brian, just with the COVID-19 and working from home and everything I’m curious as to impact on SG&A and R&D. If you are going to see any impact has there been any lay-offs or expense cuts that will be material to R&D or SG&A expenses going forward?

No, as we have discussed in the past, we have just under 60 employees. So we’ve been very capital efficient over the years with a very low fixed burn rates. So we did evaluate the impact of that – some reduction in travel expenses and some other overhead expenses with working from home, but no anticipation of any layoffs is done. And as we get through this, again, once we get through this we will be able to give an updated cash guidance.

Okay. Thanks, Brian. And when you say you have cash through 2 years is that instead of firm through 1Q into 2Q 2022?

I’d say 2 years right now into Q2 of 2022 and again, as we get through this, we start to see the rent pick back up of the Phase 3 trial, we’ll be able to give a better cash guidance on that.

Okay. Thanks, Brian and thanks for taking my questions. I hope everybody remains healthy.

Thank you. You too, Ed.

Your next question comes from the line of Boris Peaker with Cowen.

Good morning. I’d like to focus on the upro. I am just curious how frequently do patients need to show up to the hospital in the trial, how long do they have to spend their during each visit and how does that compare to their alternative options?

So I’m going to turn that question over to Helen. So, Helen could you take that?

Yes, good morning. The uproleselan trial is in the setting of intensive induction chemotherapy and so the patients are being admitted to the hospital for usually multiple weeks and perhaps longer than a month for their treatment of the relapsed or refractory acute leukemia. And so that need for hospitalization for intensive chemotherapy is presence for the underlying condition that leukemia and it is in the context of our existing admission to the hospital that you know then enrolling on the trial. There are follow up visits, once they have recovered from the initial reduction in leukemia when they recover their accounts or proceeding to treatment at home. They will come into the clinic for their usual scheduled visits for their medical care through the follow-up period, and it is during those scheduled visits that subsequent evaluation take place. I would emphasize that the great majority of data that is relevant to this trial to assessing the safety and efficacy for uproleselan in the treatment of patients with AML patient is being collected during that hospital stay, which is part of their routine care and during the follow up visits, which are again part of routine care. So there is access to patients for the data that needed for assessment of the drug and others in the setting of either the hospital stay or follow up visits happened and those potentially could include virtual visits.

And then just wanted to understand how does that compare to their alternative options like, how much extra burden or is there any extra hospital stay burden being on the trial or so not being on a trial?

So they, this trial is designed quite specifically to be assessing during those routine medical interactions and so there is – there are – there is no additional hospital stay that would be trial specific, it’s just during the routine treatment. So for example, the hospital stay is driven by their medical care, not by their study participation and their visits to the clinic or purchase – follow up afterwards driven by the medical care rather than the trial itself. Does that answer the question?

Yes, it does. That’s great. Thank you very much for taking the question.

Thank you.

Your next question comes from the line of Stephen Willey with Stifel.

Hey, good morning. Thanks for taking my questions.

Good morning, Steve.

Good morning. Just maybe if you guys, I guess, specifically Helen might be able to comment just to the rate of patient screen failures that you might be seeing, as you enroll the trial and I guess just whether or not if there is any variables that are proving to be not necessarily problematic but I guess occurring more frequently on the screen failure side and just whether or not that that rate of screen failure is trending towards your internal assumptions?

Thank you, Steven. Could you just repeat that last few words trending towards?

Towards your internal assumptions that – your model.

Okay, okay, yes. So, good morning and thank you for the question. We are, we are, are seeing risk assessment of patients, risk presentation of patients for screening for the trial. There are some patients who are screened and do not meet the eligibility criteria. As you would expect, we are seeing a great number of patients. I would say, a good proportion of patients who are approached and screened for the trial are in fact eligible and are in fact enrolled on the trial until our screen fail rate is well within what we would have expected it to be as the reasons for not meeting eligibility criteria are also fairly typical and well within the range of what we expected. And I would say that we’re seeing a proportion of patients who were then enrolled on the trial to be very closely aligned with what we would have expected. So there is nothing unusual or different in what we’re seeing on the trial and I find that actually quite reassuring. We’re seeing investigators who are very knowledgeable of the disease, but also knowledgeable about the protocol and they are appropriately offering this trial to their patients and enrolling patients who fit the criteria that we need.

Okay, that’s helpful. And I guess I was just looking at some of the participating sites. The most updated version on controls.gov and I guess it looks like MD Anderson is no longer participating. And I guess I would have perhaps just thought that they would have been a large pool of potentially accessible patients too. Can you maybe just kind of speak to their exclusion there and maybe if that’s just a conflict that they have perhaps another sponsor on the AML side?

So I’ll actually we’ll have to check on that, because as far as I’m aware MD Anderson has been participating in the trial and has been an enthusiastic center in terms of our discussion around the use of the drug in this disease.

Okay. And then just on the pre-clinical publication that came out. I know that we’ve seen a lot of data around e-selective inhibition and, and its utility in AML and its chemo resistance. I guess, I haven’t had a chance to go through the manuscript in detail. But can you maybe just highlight what you think is kind of the most important points there and maybe what’s incremental relative to some of the other presentations that we’ve seen on the preclinical side? Thanks.

Yes. This is with regards to Nature Communications’ manuscript just published?

Yes, correct.

Yes. We’re very excited about that Manuscript and this is definitive preclinical elucidation of the mechanism, it’s assessing the specifics of how the drug is – how AML cells are interacting through isolectin to achieve chemo resistance essentially and be protected from chemotherapy the specifics in this manuscript are further describing how that is achieved and the use of uproleselan to block that on a mechanistic basis. So we’re very excited with the strength of the data here which is illustrating the mechanistic reasons for what we’re seeing in the clinic.

Yes. And I would add that one of the – I think important observations, there was the fact that the greater amount of isolectin ligand on the, on the, on the blast leads to even increased chemo resistance. So again further tying the ligand to the chemo resistance.

Okay. And actually, I just looked at a different view of the clinictrials.gov and then, and it actually does look like the most current version shows on the Anderson recruiting. I was looking at the historical changes on kind of side by side basis and I think the way that they had portrayed it suggested that may be MD Anderson has had dropped. So.

Yes. So thank you clarifying that...Clearly surprised.

So.

No, MD Anderson has been an important – now there of course they are a thought leader in the field they’ve been important collaborators for us and important – they’ve been very helpful in thinking through not only this trial and how the drug in the rivipansel is best used in this relapsed refractory population, but also in thinking through where else the drug may be important to assess in AML and the impact they have been an important collaborative partner with us throughout. So, I was surprised by your comment and I appreciate your clarifying.

Yes. No, of course. I’m going to practice my web browsing skills. I appreciate. I appreciate the color. Thank you.

Thanks, Steve.

Your next question comes from the line of Zegbeh Jallah with ROTH Capital Partners.

Good morning. Thanks for taking my question. First one, I think for Helen had any additional patient has been enrolled in the 1359 study since January?

Good morning. So we have advised on initiation of enrollments for the 1359 study being run at the Duke Cancer Center and that was the early guidance this year that the first patient has been, had been enrolled and we are not commenting on individual patient enrollments and so our guidance today was simply that with this trial being run in the outpatient setting and the elective participation setting enrollment is currently on hold briefly for the, for the pandemic.

Okay. And then can you comment at all on the screening process for this. And then is this something that you could potentially expand to another clinical side as well or no?

Yes. Thank you for the question. That’s an interesting question. I will say we have had interest both from investigators and researchers in the field, but investigators who are seeing patients with breast cancer and metastatic breast cancer. We have also had interest from patients and we signed the molecule one that is exciting and has greatly interested in the potential for treating this population. The study is running at the Duke Cancer Center and the investigators there have been important collaborators pre-clinically as well as clinically with this molecule as we learn more about the pharmacokinetics and pharmacodynamics and early first in human experience in patients with, I think we will be considering how best to advance this drug to either other sites or other trials.

Okay, thank you. And then I did see the publication for upro in AML. I thought the data looked really good. I’m showing the potential for you to prevent chemo resistance in AML. So I just had two questions. I think, one of which was, do you expect that this could also be the case for other hematologic malignancies? And then the second question is at ASH, there were some data from Aptus that shows that e-selective inhibition. I think with your molecule could actually prevent a BTK resistance, so wanted to know what your plans were to pursue more preclinical development looking at BTK inhibition as well?

Sure, I’ll take the first cut at that. As far as the potential application to other hematologic malignancies, I think that is a very interesting question. And we have, we have in the past presented preclinical data, which you may, you may be familiar with, and if not, it’s on our website where we have looked at and in fact demonstrated the potential of using e-selective inhibition as a strategy in other hematologic malignancies. So I think that is something that, that is worth exploring that we have explored pre-clinically and that is certainly on our radar screen. As far as the second question on BTK resistance I actually, I don’t know the answer to that. I’m not sure if Helen does. And if we can’t answer that on the call we would be happy to follow up with you more directly with our Chief Scientific Officer. But Helen, do you have a comment on that second question?

Only that we think that that is a very interesting area, we have had some initial discussions about where that may be useful to further explore the utility of the drug in diseases where that’s more of an issue and I think we have no immediate plans for development. No immediate confused plans, but it’s certainly in our range and we are interested to continuing to discuss.

Yeah, that would. I think you’re referring to do that was presented at ASH out of MD Anderson in the laboratory Michael and I believe we presented that data at ASH this year. So yes, I think there is clinical data that’s supportive.

Awesome. Thank you. I think it’s great in terms of looking for and how, in addition to 1687 being used for lifecycle management for upro but applicability for other indications that upro may be useful as well?

Yes, 1687 is interesting molecule that is as you, as you know in our preclinical models is bio-available subcutaneously, so it does offer the potential as a follow on compound that could potentially be used in an outpatient setting. So we do think it does offer longer term potential good lifecycle management opportunities within the e-select and ligand or e-seleci and dosing space today.

Thanks Rachel.

Sure.

[Operator Instructions] Your next question comes from the line of Biren Amin with Jefferies.

Hey, hi guys. Thanks for taking my questions.

Sure. Good morning.

Hope you guys are well just fund I think Brian commented earlier on the cash runway extending out to Q2 or mid 2022 type time frame and if you look at your prior guidance on completion of enrollment in second half of 2021 and given COVID situation slowing your enrollment in the Phase 3, do you still expect that you would be able to meet timelines in terms of Phase 3 data before the cash runway runs out?

So in terms of the guidance that we’ve given, we’ve not yet changed our guidance on completion of enrollment, we want to wait and see we’ve had the one month of effects of RF COVID. So we think it’s too early to assess the specific impact on completion of enrollment. I will say we do feel that two years is a long time, is a long cash runway to have in the bank and we’re certainly glad that we have the financing in the bank for that period of time. As Brian said, we’re continuing to manage the cash very carefully. And we think we may have opportunities – potentially to add to the balance sheet as we did with the Apollomics deal. So we’re going to continue to manage with the objective of both completing enrollment and getting to top-line data with the cash that we have.

Okay. And then, is there a possibility to add additional sites. So for example, with the Apollomics deal, Greater China is available. Have you discussed with them the potential to extend the Phase 3 protocol into China possibly?

Sure we’re currently contemplating that as a separate study and we’re not contemplating adding those sites to the sites as part of the main Phase 3 study, that’s the current plan.

Okay, great. Thank you.

Sure.

And at this time there are no further questions. I would like to turn the call back over to Ms. Rachel King.

Great. Thank you operator and thank you everyone for your questions and for taking the time to listen to our call. And we hope you all stay well.

Ladies and gentlemen, thank you for participating in today’s conference. This concludes today’s program. You may all disconnect. Everyone, have a great day.