Good afternoon. My name is Grace and I will your conference operator today. At this time, I would like to welcome everyone to Avantor’s Fourth Quarter and Full-Year 2020 Earnings Results Conference Call. At this time, all participants are in a listen-only mode. After the speakers' presentation, there we will a question-and-answer session. [Operator Instructions] I will now turn the call over to Tommy Thomas, Vice President of Investor Relations. Mr. Thomas, you may begin the conference.

Thank you, operator, and good afternoon everyone. Thank you for joining us on today's call. Our speakers today are Michael Stubblefield, President and Chief Executive Officer; and Tom Szlosek, Executive Vice President and Chief Financial Officer. The press release and a presentation accompanying this call are available on our investor website at ir.avantorsciences.com. A replay of this webcast will be made available on our website following this call. Following our prepared remarks, we will open the line for questions. I would like to note that we will be making forward-looking statements within the meaning of the federal securities laws, including statements regarding events or developments that we believe or anticipate may occur in the future. These forward-looking statements are subject to a number of risks and uncertainties, including those set forth in our SEC filing. Actual results might differ materially from any forward-looking statements that we make today. These forward-looking statements speak only as of the date that they are made, and we do not assume any obligation to update these forward-looking statements, whether a result of new information, future events, and developments or otherwise. This call will include a discussion of non-GAAP measures. A reconciliation of these non-GAAP measures can be found in the appendix to the presentation. With that, I will now turn the call over to Michael. Michael?

Thanks, Tommy and good afternoon everyone. I appreciate you joining us today and hope the new year is off to a good start for you. I also hope that you and your families are staying healthy. Reflecting on 2020, the value of the significant transformation we have undergone since acquiring VWR in 2017 is clear. Organic growth has doubled, margins and overall business profitability have increased substantially, and our leverage has now reached our target range of two times to four times EBITDA. This transformation has positioned Avantor as a global life sciences leader and there has never been a more exciting time to serve this space. As shown here on Slide 3, Avantor is deeply embedded in virtually every stage of the most important research, scale up, and production activities in industries we serve. Our model is grounded in supporting our customers early phase discovery activities, and we serve as a one-stop shop in providing scientists all that they need to conduct their research. Our customer centric innovation model enables us to provide solutions for some of the most demanding applications. And we leverage our access to the early stage work to see content and solutions that ultimately become specified into our customers approved production platforms. Our fully integrated business model enables us to support our customer’s journey every step of the way. Resiliency is an element of Avantor’s business model that was demonstrated throughout 2020. Slide 4 provides an overview of our revenue across several dimensions. Our resiliency stems from the consumables driven nature of our portfolio, and our highly recurring revenue base. Approximately half of our revenue comes from proprietary branded products and services. These proprietary products are supplemented by innovative third party offerings from our critical supplier partners, enabling us to provide comprehensive workflow driven solutions…

Thank you, Michael and good afternoon everyone. Slide 4 shows our organic revenue growth by end-market and product group for the quarter. Biopharma representing approximately 50% of our revenue experienced organic revenue growth of over 20% in the quarter, and double-digit growth for the full-year. Strengthening trends in R&D workflows drove growth in our lab products business. In addition, our bioproduction platform experienced very strong growth in production materials, and single used assemblies to support both our base business and COVID-related areas. Healthcare, which represents approximately 10% of our revenue also increased revenues over 20% organically in the fourth quarter, and attain mid-single-digit growth for the full-year. Strength was once again driven by continued COVID testing momentum offset by ongoing elective procedure weakness, which adversely impacted our medical implants business. Education and government, representing approximately 15% of our revenue experienced double-digit organic revenue growth in the fourth quarter, and declined mid-single-digits in the full-year. Fourth quarter growth was driven by government customer purchases offset by ongoing education declines centered in the America. Advanced technologies & applied materials industries representing approximately 25% of our revenue, experienced low-single-digit organic revenue growth in the fourth quarter, and declined low-single-digits for the full-year. The core industrials portion of this end market, including oil and gas, petrochemicals and mining has driven the sequential improvement. By product group, proprietary materials and consumables experienced approximately 20% revenue growth, with strong growth in the Americas. Third party materials and consumables also experienced very strong high teens organic growth. Services and specialty procurement increased high-single-digits driven by ongoing clinical services strength and continuing equipment services as sites continued to reopen. Equipment and instrumentation experienced a sequential recovery to low-single-digit growth, reflecting a modest improvement in CapEx investment. Let me move to Slide 8. Looking at growth from a regional…

Reflecting on 2020, we executed extremely well on a challenging environment. And our top line performance, strong EBITDA, and adjusted earnings per share and outstanding cash generation reflect the resiliency of our business model. The value of our highly recurring revenue base, broad mission critical product portfolio, and exposure to attractive end markets like biopharma position us well for continued growth as we head into 2021. While the uncertainty associated with the current pandemic continues, our business remains strong, and we have embraced our critical role in providing solutions and services to support COVID-19 testing workflows, head to toe personal protective equipment, and customized materials needed to produce vaccines and therapies. Reflecting our relevance in this critical endeavor, our bioproduction order book continues to experience strong growth and we are actively investing to capture this opportunity. There has never been a more exciting time to serve the life sciences space. The COVID-19 pandemic has underscored the importance of science to our society, and Avantor has the scale and resources to capitalize on the opportunities in this driving industry. We remain steadfast in our focus on executing our long-term growth strategy, and are optimistic about our future. I want to thank you for your interest and investment in Avantor and for your ongoing support. I will now turn it over to the operator to begin the question and answer portion of our call.

Thank you. [Operator Instructions] Your first question comes from the line of Tycho Peterson from JPMorgan. Your line is open.

Hey, thanks. Michael, when you laid out the guidance for the year, you noted a number of variables based [indiscernible] utilization, COVID vaccine trends and non-COVID healthcare demand, I'm wondering as you think about the 4% to 7% organic outlook, you know if you could just talk to where you see conservatism and the numbers, you know would it be additional vaccine approvals or maybe more durability of COVID tailwinds, just curious what could get you to the high-end or maybe above?

Yeah. Thanks Tycho. Thanks for joining the call. Appreciate the question. As we look at how we have kind of constructed the guidance, there's obviously two key components. So, you have our perspective on how the base business will perform and then obviously trying to take a view on how the COVID-19-related revenues will flow throughout the year. So, let me try to unpack each of those for you in some detail here. For the base business, as Tom mentioned in his remarks, we grew in 2020 roughly 1% to 2% and we're estimating somewhere in the mid-single-digit levels for full-year 2021. So, we're definitely assuming some sequential improvement year-over-year. And if we look at where we finished Q4, obviously, we've seen continued momentum in all of our key end markets. But we still do have some headwinds that we're facing. Our education business is still flattish to modestly down. Our medical and science business still have some headwinds to it. And our industrial business is still somewhat below pre-COVID levels. And for most of those end markets, I think we're going to need to see the effects of the pandemic subside before we would anticipate those things growing. So, that's I think one important assumption. Obviously, continued strong momentum in our biopharma platform, particularly in the R&D environment is going to be key here. And then from a vaccine perspective, we obviously generated significant tailwinds in 2020 and we're out of the gates here anticipating somewhere around the same level, although the mix would be different. And with more focus or more weight on the vaccine opportunities compared to 2020 now that we have a number of candidates that are in full scale production. We do have an assumption baked in here that testing while strong here in the…

Thanks. And then a follow-up for Tom, If I think about the margins, the 50 basis points, I think you had said 50 basis points to 100 basis points at our conference in January. So, can you just clarify why the outlook is a little bit more muted than what you talked about at the beginning of the year? And then, secondly, there was a $38 million non-cash charge in the cash flow statement for inventory, was that PPE or something else? Thanks.

Okay. Just on the 50 basis points to 100 basis points, long-term guidance that's what we're quite confident in. Like going into 2020, we guided I think 45 basis points to 75 basis points ended up at 80 basis points. I think, you have considered the 50 basis points to be a somewhat of a minimum. We didn't range the top-end given the variables that Michael talked about, because they can have quite an impact on the margin rate. In terms of non-cash items, we continue to have ongoing strength in cash flow as we [pick that] up in our cash flow statement. But you will as you’re integrating our acquisitions with VWR and Avantor continuing to complete that. You will see some – your non-operating items come through. But it's provisioning for bad debt, provisioning for inventories is a normal course of business, kind of thing overall. And we do see some improvement opportunities, but overall, not that big of a factor for us.

Okay. Thank you.

Thank you. And your next question comes from the line of Derik de Bruin from Bank of America. Your line is open.

Hey, good afternoon. Just a couple of questions. I think on the first one. Can you, I mean, you sort of alluded to it, but can you talk a little bit more about the mix between PPE diagnostics and bioprocess. And I'm also particularly – I'm particularly interested in specifically as mRNA vaccines roll-out, just what essentially – how is the way to sort of think about your revenue contribution specifically from the different vaccine types? I know, you've laid out some stuff in the past, but [indiscernible] be have a little bit more granularity on how we should sort of think about the mix on this and the margin profile on this incremental growth?

Yeah. Derik, thanks for the question. Look at kind of where each of the categories that we participate in related to the COVID pandemic, the relative proportions of contribution remain somewhat steady throughout the year, meaning that roughly half of the tailwinds came from diagnostics and then in kind of equal parts than PPE and vaccines may have the balance. One [dynamic] we did see obviously in the fourth quarter is, as anticipated, given the order book a meaningful step-up in the absolute contribution from vaccines. But you also then saw COVID tailwinds accelerate from kind of the 300 basis points, 400 basis points in the third quarter to 800 basis points, 900 basis points in the fourth quarter. And in addition to the strong contribution from vaccines, diagnostic testing obviously quite a meaningful role in the quarter given the number of tests that were being run. So, the proportions didn't actually change that much in the fourth quarter despite vaccines staffing-up as much as they did. Going forward on a full-year basis, we would anticipate the $250 million to $350 million of cost of revenue coming in 2021. Roughly half of that we would anticipate coming from vaccines. And then, diagnostics and – kind of being the one that's declined and PPE probably being similar in 2021, relative to 2020 is how we would see that playing out. We intentionally kind of put the range of $250 million to $350 million plus to indicate there are obviously scenarios here that could evolve here that would cause us to move the range up. I mentioned earlier in response to Tycho's question that we made an assumption the diagnostic testing falls off in the second half of the year and we'll see how that develops. And then, depending on how the vaccine rolls out, you could theoretically, see some upside there from additional approvals and more aggressive ramp of production throughout the year. As we've said in [lot of their reforms] Derik we're relevant in all these modalities. You mentioned mRNA and we're certainly well-positioned there with the candidates that are in production at the moment. I think, it's also important to point out that the viral-vector vaccine, J&J vaccine, AstraZeneca vaccine, for example, are also pretty significant – have pretty significant requirements for our raw materials and excipients and single-use systems, actually not that far behind what we would supply to mRNA. And so we're excited about the potential of getting those vaccines approved in the market as well. I don't think our view probably hasn't changed in terms of [economic] content that is required for each of these various modalities and just to reiterate how well represented we are throughout the pipeline here.

I think, just – once again, I think that the question I'm getting is like – is on general the bioprocess contribution higher margin in 2020, basically it is higher margin in the diagnostic contribution, I think that sort of the – most of the questions you're getting?

Yeah. So if you look at the three areas, Derik, I’ll just stack it up for you in terms of margin contribution. Nearly everything that we're going to be supplying to those vaccines is going to be proprietary content and carry corresponding events, you know the highest margins of any of the solutions. The diagnostic piece were probably second in line there with the mix of kind of third-party content, but we do have quite some proprietary content there as well, whether it'd be some of the reagents, some of the other consumables or even some of the equipment in the thermal cyclers, for example. And then, PPE, we're probably lagged that a bit with quite a lot of that. A majority of that being third-party in nature.

Great. You did spike [indiscernible] take me on one follow up on that one. You mentioned the lab equipment, I mean that sort of – that grew in the quarter. Could you just sort of characterize through that pick up, I mean, just given – is it pent-up in spending that's been through like pent-up and people are like waiting for as the new labs being build out? I'm just wondering, just given your equipment mix is a little bit different than some your peers, given more sense of like where the laboratory builds are [and they're going on]? Just sort of curious in terms of what's you're seeing in terms of placements of instrumentation equipment?

All right. We definitely did see some acceleration in the quarter, but even with the sequential improvement that we saw moving from third quarter to fourth quarter still somewhat muted. I think equipment and instrument growth for us in the quarter was low single-digits. So, it's nice to see the category return to growth and certainly the budget flush topic that we encounter this time of year kind of played out, I would say, probably at historical levels, which is to say that nothing particularly unusual. But across the biopharma space, for example, we did see probably the strongest acceleration of the equipment and instrument purchases in the quarter and to support a lot of the new projects and things that are going on here. But still, even in – with the growth we did see, still somewhat muted relative to historical levels, Derik.

Great. Thank you very much.

Thank you. And your next question comes from the line of Vijay Kumar from Evercore ISI. Your line is open.

Hey, guys, congratulations on a good print here. Michael, if I may start on – one on the guidance, the top line here. I guess, if you look at the Q4 number, a 130 million of COVID tailwinds, a sequential step up of [70 million]. I'm assuming most of that was vaccines. You annualize that number and we're getting close to [300-ish]. And if I heard you correctly, I think you said 150 to 175 of vaccine revenues in fiscal 2021, so I'm curious what would cause the vaccine to drop off, is that a mix change? And I think on the base, ex the incremental tailwinds, the guidance assume 3% to 6% on the base, off of a 1% comp, so perhaps talk about the base business as well in the context of easy comps.

Yeah. Happy to address both of those elements, Vijay. Firstly on kind of the Q4 split and contribution, yes, vaccine contribution definitely stepped up, but we also saw a meaningful step up in the quarter for diagnostic platform as well. Testing in the quarter was obviously at its highest point at any point in the year and we participated in that in a meaningful level. So that's probably [important phrase] to account for a meaningful step up on the testing side of things as well as your extrapolating out where things could land in 2021. I do think, you know with the order book that we have in place at the moment and visibility we have, kind of the guidance that we've given around [250, 350] plus with half of that coming from vaccines is still a pretty reasonable estimates and perhaps as more vaccines get approved and new orders come in, we'll see a way to increase, but not a bad jumping off point. Relative to the base business, if you kind of book in 2020 with the Q1 growth of core growth, a little over 4% and the Q4 growth of 6% to 7%, we're going to – we have relatively modest comps still to address in the second and third quarter, but pretty good comps in the other two quarters and we do have still some headwinds in important parts of our business. Our education business is still down, improving, but nevertheless still behind pre-COVID levels. Our biomaterials platform and particularly our medical implants business is still up high single-digits and our industrial complex is still lagging pre-COVID levels as well. So – and if you remember, you know last Q1, for example, was a pretty normal quarter, mostly free from COVID impact. So, we don't anticipate any of those end markets. So, I just described as having headwinds as, you know completely recovering until later in the year. So, I think that's maybe some of the differences you're seeing there, but recovering from 1% to 2% growth into that mid single-digit level would reflect I think kind of momentum that we've got exiting the year, but it does take into account some of the comp dynamics.

Yeah, that's a helpful comment, Michael. And maybe one for Tom. My favorite question and that's the cash flows, impressive fiscal 2020. It looks like there were some timing element guiding to free cash of [800], a step-down for fiscal 2021. I guess if that's normalized level, what if free cash flows grow off of that [800] normalized level? And it looks like you're guiding to tax rate stepping up, any comments on why tax rate will step up?

Yeah, a couple of things, Vijay. On the free cash flow, first of all, we did 868 million in 2020, which was up significantly from the 300 million we did in 2019. So, more than 2x, almost 3x. We were signaling throughout the year that there were some extraordinary items coming through around CARES Act. Just to refresh you, we had some deferrals of employee taxes or employer taxes. We also – on payroll, we also had some interest deductibility improvements or enhancements from the Act. And there were a couple of other things in the tax area. We settled some open audits and got some refunds there. So, when you look at the tax area in particular in the cash taxes, the 2020 number was extraordinarily low. I mean, we had roughly $40 million or so in taxes. To return to a normalized level that we will be north of 120 million given those one timers that I talked about. I think we're signaling these items throughout most of the year. If I look at what our entitlement is on net income – on adjusted net income, we should be around 110%, 115% and because of some of these factors, we ended up converting at around 150% in 2020. One other element that’s, you know when you look at 2021 is there are some investments that we're ready to make. We had some opportunities. We talked about the need to add capacity in some of biopharma production areas. As an example, we've got some projects under way that are [indiscernible], some exciting additional growth. And then, also, in working capital, I mean, to support to an ongoing growth there could be some additional working capital investments there. So, between just the one-time out of the ordinary sort of benefits that we had signaled throughout the course of the year, as well as some modest investments into 2021, we're starting with an $800 million estimate for free cash flow for 2020, sorry, 2021 relative to the $868 million in 2020. Hopefully we will drive it higher, but we think that a prudent starting point at this early point in the year. Your second question, Vijay [indiscernible]?

The taxes step-up, is that any one-timers in that 24% and should that [step-up]?

No. On tax rate, if you just kind of recall from where we came from, like if you started in 2019, you would have seen us north of 30%. For 2020, we guided to an improvement, but we didn't guide it to an improvement down the 22.9% that we got to. There certainly was a positive impact from the initiatives that we've talked about in terms of removing some of the inefficiencies in terms of how we're funding our international operations. We also had some one-time benefits in 2020 around just excess benefit around employee stock option exercises and some other minor things. Those probably gave us 50 basis points to 100 basis points of improvement on tax rate. I do expect those to continue on a normal run-rate basis. Haven't factored those into the return, sorry, into the estimate. I do expect that is as we've said to continue to drive our tax rate down on a long-term basis to the lower 20s. So, I wouldn't read into the starting guide for 2021 if any significant change in how we're approaching tax or confidence in being able to drive continued improvement.

[Indiscernible] convinced on.

Thank you. And your next question comes from the line of Doug Schenkel from Cowen. Your line is open.

Hey, good afternoon, everybody. Thank you for taking my questions. I'm going to just ask the two questions I have and then get back in the queue, just because I know I'm heading into a bad reception area. So, my first question is really on M&A capacity. You guys have always been a cash flow generating machine and that was never more evident than it was in 2020. Given where the balance sheet sits today, I was just wondering if you could provide a little more detail on the parameters that we should be thinking of as we think about the types of deals that you would pursue, and what, I guess, if you want to give us some parameters mathematically to assess your capacity that would be appreciated as well. So that's the first thing. The second, on COVID, I'm just curious as you think about the doing well there by doing good, is that also opening opportunities with new accounts that you would expect to essentially be more durable over time? So, I guess, put differently the new account openings because of what you're doing in helping with COVID, are they opening new doors for you to expect to be durable even after the pandemic ends? Thank you.

Okay. Hey, Doug. Thanks for the question. I'll take the M&A piece and Michael will address your second question around COVID. In terms of overall capital deployment, you're right around the cash generation and it has had a direct impact on improving our balance sheet and our leverage has gone from 7 times at the beginning in 2019 to the 4 times that you see at the end of 2020. We think that with the continued cash generation, if you didn't do anything around and then you continue to drive that down between a 0.75 and a full point turn a year such that, you know by the end of 2021 you could be approaching 3 times. Our targeted leverage range is 2 times to 4 times. So, we're inside that quarter now. That in itself is one of the governance here. But to get to capacity, we can stay within that quarter and send all the cash flow that we generate. And if you're going to argue about it, you could say that we could take leverage up a little bit as well. But if you just started with $800 million of free cash flow that we projected for 2021, that would be capacity that that would be available plus whatever incremental leverage you'd be comfortable taking on, as well as the cash that we have on the balance sheet. So there's well over a 1 billion of capacity right now to do something. And our approach has been, first of all, to improve that flexibility and that is materializing. We're active, but certainly not desperate in terms of developing an M&A pipeline. We've got all the businesses engaged. We've been actively pursuing individual deals, but we're going to be disciplined. As not to say, we're not willing to pay a fair price, but we want to engage with opportunities that can bring good growth and enhance our overall growth rate, but also bring cash and be accretive to our margin rates as well. And so we're typically looking for deals that involve proprietary content and that would be in biopharma production space, some of the lab, the research spaces that we've talked about in the past that we find to be interesting including genomics and other things in that lab area. So, it’s okay for us. We've got plenty of things to do on the balance sheet, if we're not scoring on M&A every single month, or every single quarter, because we have plenty of capacity continue to deleverage essentially at no cost. So that flexibility is serving us well and had served us well and we'll continue to be disciplined on that front.

Hey, Doug. Let me pick up the second question. Probably take the opportunity to expand the question a bit to think about or maybe our longer-term perspective on what we're – what we've learned or what this experience of COVID has may be changed our thinking here. Firstly, I think my personal view here that's evolving is that the COVID vaccine will – is probably going to be more durable than not. And I think given what we're seeing unfold here with the variance limitations that are emerging and the work that's going on by even some of the existing vaccine manufacturers, it's likely going to be necessary to even have some kind of a booster market perhaps in the latter part of the year heading into the winter flu season again, and I think the data is starting to indicate that this is perhaps heading toward being something more pandemic in nature, meaning, we could be facing kind of an annual COVID vaccine. So, it – I would say not definitive at this stage, but certainly the durability of COVID seems to be increasing. The second piece, which may be more responsive to your question. We see a great opportunity here emerging beyond COVID, you know leveraging the technologies that have been accelerating here. Bioengineered vaccines as a category, I think is going to take on a whole new level of importance for us. COVID, you know if something becomes and that will be a part of that, but you already see many of these companies initiating research activities to apply the technology to other areas that would maybe more common vaccine technologies that we're used to that could be potential replaced by this, which would bring in, you know biologic player like ourselves into that realm and that could be exciting. And I think just the acceleration of a modality like mRNA, there was obviously a nice pipeline building for the technology outside the vaccine space that presumably will have been accelerating through this experience. We've all learned a lot in scaling the technology and certainly the benefits of the technology are clear. So, we see some nice tailwinds emerging from this to go even beyond COVID that give us a lot of excitement and we were bullish on the biologic space pre-COVID and certainly as we sit here today, or even be more bullish on that as an end market. And then, relative to new account openings, as we've said all along, our technology is very relevant across all these modalities. Many of the names that have emerged as leading candidates are well-known names that we've had as customers for a long time, but there is obviously a really deep kind of pipeline of activities that includes a number of companies that we probably hadn't done a lot of work with before and that could be another element of this that produces some value to us over the long-term.

That's great. Thank you, guys.

Thank you. Your next question comes from the line of Jack Meehan from Nephron Research. Your line is open.

Thanks. Good afternoon. Wanted to just...

Hey, Jack.

…dig in a little bit more around the assumption behind the guidance for COVID testing. It just seems like an important assumption around the back half, and to frame that, I was wondering if you could provide some color on the fourth quarter step up? Did you have any notable wins in the PCR side and how much did antigen contribute to the step up?

Yeah, all fair questions, Jack. Thanks for calling in tonight. Diagnostics in the fourth quarter was close to half of the tailwinds that we saw in the quarter and that was really – it is a nice pick up on the PCR side of things, where we've been well-positioned throughout the pandemic with and, you know kind of tracking just the daily testing rate there in terms of the volumes that we've been supplying. But we also saw a nice contribution in the quarter from the antigen-based testing, workflow that obviously started to take on prominence late in the third quarter and we kind of got a full quarter's benefit from that. And we did have a number of pretty significant wins. If you dig into the numbers there, you'll see our government business grew at over 50% in the quarter. A lot of that actually is diagnostic-driven and both PCR, but definitely we have a number of pretty significant wins on the antigen side, particularly here in the Americas with some of the state governments and other municipalities that we were able to penetrate in the quarter. So that was – we had anticipated that and I think we signaled that on our last call that we had anticipated seeing some pick-up from that particular workflow and it certainly did materialized in the quarter.

Great, that's helpful color. And then, looking out to 2021, just wondering if you could give some color on the interplay between proprietary and third-party products, it sounds like from all the commentary that should remain favorable, but can you just weigh in and maybe confirm that?

Yeah. That's an important question, Jack, because as you know, that’s a strong driver for margin expansion. And historically, our proprietary product category has outgrown our third-party category by anywhere from 2x to 3x and in large part driven by just the dynamics of how our production platform grows out relative to maybe R&D space. That trend didn't exactly hold up exactly like that in 2020 and if you take a look at the fourth quarter, we had phenomenal proprietary growth 20% or so in the quarter. But we also had very, very strong third-party growth as well. It only lagged by a few percent. And that really is a reflection of some of the uptick that we saw in the diagnostic space and particularly on the antigen side where a lot of that has – comes from our third-party partners that we work with. Obviously, we feel comfortable showing at least 50 basis points of expansion moving into the new year and this is our expectation that this proprietary product category will outgrow the third-party category. The question is, by how much? And I think that gets into some of our reluctance to kind of put a specific range on the guidance for the year given how important mix is to us and depending on how testing workflows hold up for the year, will be one of the stronger determinants of mix for the year. Well, there's also a couple of other areas that probably were lagging a bit in 2020, mainly our third-party procurement platform, as well as the equipment and instrument category that lagged for most of the year. How far back those come to normal will also be an influencer on mix and margin for the year, Jack.

Great. Thank you.

Thank you. Your next question comes from the line of Dan Brennan from UBS. Your line is open.

Great, thanks. Thanks for taking the questions. Michael, you mentioned a few times earlier on in the discussion about the start to the year, I think, was good in January. You also talked about the vaccine order book being solid. Could you just give us some visibility or color about the order book itself? Any details about it and kind of how far out the deliveries run through for the order book?

Yeah, absolutely. And maybe to just use the same kind of context as we've quoted in previous quarters, our production order book ending the year was approximately 3 times the level that it was out heading into last year, and that compares to being up roughly 2 times at the end of the third quarter to give you a flavor for how fast the book is accelerating. And I don't have a specific number to share with you for January, but needless to say, it has continued to accelerate into the early weeks here of the new year. And so, we're – a fair bit of good momentum there that we're excited about. That order book in the fourth quarter obviously stepped up in a meaningful way. A lot of that came from the vaccines, but I would highlight the base business continues to be very robust. And similar to the third quarter where I think we said roughly three quarters, if not a bit more, was from our core business and the balance coming from the vaccine space. The order book for the core business continues to be strong. The mix is shifting, no doubt, toward vaccines and the proportion of vaccine in that order book probably moved up another 10%, 15%, 20% something in that range in the fourth quarter and it continues to evolve here in the early weeks of the new year here. So, a very strong order book and it's a mix of very good momentum in the base, and obviously, a growing vaccine order book as we support these production orders. I would say, we've got stronger visibility than we've had historically. The core, we probably have some visibility for orders that go out even into the middle of the year and the vaccine is probably similar – or probably similar kind of visibility on at least the platforms that are approved for now.

Got it. And then as a follow up, I wanted to ask, just kind of within bioproduction, obviously, you've got – you've given a lot of information over the last three to six months about the areas you plan, but could you highlight within median resins and buffers excipients and single-use and you've got more listed on some of the charts you've laid out? Where would you characterize your real strength? Like what are the two or three products maybe that you really dialed in that are critical across whether the vaccines that are rolling out or just more volume bioproduction? Just wondering how you would highlight the real strength for Avantor's offering in that space? Thank you.

Yeah. Referred to the vaccines, clearly very, very strong growth and pull from our single-use portfolio and that's going to be across all the relevant modalities here; very, very strong demand for those technologies. For the mRNA vaccines, while the full breadth of our portfolio is going to be applicable there, probably the piece there was unique. It's going to be some of the cholesterols and lipids that are used in the delivery technology of that platform. Some of the buffers and other process ingredients are key there as well, but that's probably something that's a bit unique to mRNA that you might not see in other platforms.

Great. Thank you.

Thank you. That is all the questions that we have today. I will turn the call over back to Mr. Michael Stubblefield for any closing remarks.

Great. Thank you, operator, and thank you all for participating in our call today. As we close, I would remiss if I didn't express mine sincere gratitude for the tireless efforts of our global associates around the world who are living our values every day and working to fulfill our mission of setting [science and mission] to create a better world as they are giving everything they've got to support our customers during this unprecedented time. And I'm certainly inspired by their passion and dedication to our mission that in fact has certainly never mattered more. As I mentioned earlier, I'm super excited about what lies ahead for our business and for Avantor and look forward to updating you when we meet again soon. Until then, take care and be well everyone.

Ladies and gentlemen, this concludes today's conference call. Thank you all for joining. You may now all disconnect.