Anastasios Konidaris
Analyst
So, I think you're right. So it's kind of rewind a little bit so we can see how the profitability profile of the company has changed. So when we go back to 2020, the adjusted EBITDA to revenues was about 22%. In 2021, we were at 24% and as you know, that was an incredibly profitable year for us last year, a number of very strong new product launches. And this year, you just said it's 23%. So I think this is the right jumping point for us. And also, when we think about, let's pick the midpoint of the guidance, $510 million, that's 23%, as you mentioned. And that includes kind of solid top line growth and that includes about $40 million worth of incremental investments which is about 2 points of profitability that we're making in support of biosimilars, in support of new product launches and pre-commercialization work around IPX-203. So, I think 23% is the right point. And I think as we think about next year, we'll see how things play out but our expectation is over the course of time, as the injectables which is a more profitable piece, as more of the more complex ANDAs coming to be which are more profitable and less exposure to price erosion and the specialty with IPX-203 in future years, K127 and so forth. So we'll expect that 23% to grow over the course of time. Let me just kind of hit your second question. Your second question was, is $15 million the R&D right now? We think so. But at the same time, we're going to be opportunistic. So over the last few years, we've invested a tremendous amount in our R&D. So we spent about $180 million in R&D. And I think we're going to be opportunistic. To the extent that we see right technologies, that we can in-license, we’ll execute on those. But I think the right level, the way we think about our history, last year, it was $26 million, this year, it’s $15 million. So I think that’s probably the right level we are thinking about it but at the same time, it can go up and down just always depending on what’s available in terms of technologies and interesting new products.