Good morning, everyone and welcome to our third quarter call. You can listen to a live webcast with slides or a replay of today's call by going to the Investors and Media section of our website agios.com. With me on the call today with prepared remarks are Dr. David Schenkein, our Chief Executive Officer, who will provide an overview of our corporate strategy, vision and progress to date. Dr. Chris Bowden, our Chief Medical Officer who will review our recent Clinical development updates, and Glenn Goddard, our Senior Vice President of Finance, who will summarize Agios' third quarter 2015 financial results. Before we begin, I would like to remind you that today's discussion will include statements about the Company's future expectations, plans and Prospects that constitute forward-looking statements for the purposes of the Safe Harbor provisions under the Private Securities Litigation Reform Act of 1995. Actual results may differ materially from those indicated by these forward-looking statements as a result of various important factors including those discussed in the risk factors section of our annual report on Form 10-K which is on file with the SEC. In addition, any forward-looking statements represent our views only as of today and should not be relied upon as representing our views as of any subsequent date. While we may elect to update these forward-looking statements at some point in the future, we specifically disclaim any obligation to do so, even if our views change. With that, I will turn the call over to David.

Thank Renee, and good morning everybody and thanks for joining us today. Today's call will be brief given that we've recently spend time together at on R&D day and I encourage those of you who were not able to attend the events to listen to the reply on our website. Will also be meeting with you this coming Sunday after our presentation at the Triple Meeting in Boston. At the beginning of 2015 we laid out an ambitious set of goals which included multiple data read outs and trial initiations across all of our programs in cancer metabolism and rare genetic metabolic disorders, and from where we stand now in November I'm proud to say that we expect to achieve a 100% of those important milestones. Today Agios is a company with five clinical stage investigational medicines two of which are moving rapidly towards regulatory approval. These medicines have the potential to help a large number of patients around the world. Behind these clinical portfolio we have a robust research pipeline in both cancer and RGDs that continues to expand and deliver novel targets. We are an organization with deep science roots that has successfully transitioned into a late stage development company and beginning to build commercial capabilities. On top of that we are very proud of our strong culture which is driven by our passion to help patients and following great science. As we think about what's possible for patients with our IDH inhibitors, we’re deploying a clinical development strategy of speed and breadth to move as quickly as possible with AG-221 and AG-120 in acute myeloid leukemia and then beyond into multiple indications and cancers. Chris will go to the details of our clinical trials in both hematologic malignancies and solid tumors, but I would like to focus…

Thanks, David. David has outlined the role we hope our IDH inhibitors will one day play in the treatment of IDH mutant positive cancers. The clinical development plan we have in place for acute myeloid leukemia combines the strategy of speed and breadth to help us achieve this goal. Speed is represented by our single agent expansion cohorts that are up and running for both AG-221and AG-120 and designed to provide registration quality efficacy and safety data. At R&D Day we announced another significant milestone for this program. The initiation of IDHENTIFY a Phase III international multicenter open label randomized clinical trial sponsored by Celgene. This study represents the first randomized file with global potential for AG-221 in AML. It is designed to compare the efficacy and safety of AG-221 versus conventional care regiments in patients 60 years or older with IDH 2 mutant positive AML that is refractory too or relapsed after second and third lung therapy. The primary end point is overall survival and some key secondary end points include events free survival, duration of response and safety. For AG-120 we have planned to initiate registrations enabling Phase III study in AML patients in the first half of 2015. In addition, I'm excited to talk about two Phase I combination trails with AG-221 and AG-120 in newly diagnosed AML patients. Our goal in front the front line setting is to develop combination data for any newly diagnosed IDH mutant positive AML patients, including those individuals that can handle intensive chemotherapy and those that cannot, based on their morbidities, age and physical status. For newly diagnosed AMP patients eligible for intensive chemotherapy, a Phase IB combination study of our IDH inhibitors with standard induction and consolidation chemotherapy is planned to start by the end of 2015. For newly diagnosed…

Thanks, Chris. Agios is in a very strong financial position today, is well capitalized as we advance multiple programs in the late stage clinical development and expand our research pipeline. As David noted we are on track to achieve all of our corporate goals and milestones for 2015. With five clinical stage medicines advancing, approximately $408 million in cash and a great partnership with Celgene we believe we are in a solid position to build a sustainable multi product biopharmaceutical company. Now moving on to the financial results for the third quarter. Our cash, cash equivalents and marketable securities as of September 30, 2015 were $408 million compared to $467 million as of December 31, 2014. The decrease was driven by cash expenditures for operating activities of approximately $101 million which was offset by $54.8 million of funding from Celgene. The $54.8 million of funding from Celgene was comprised to the following items. A $20 million extension fee related to the final year of the discovery phase of our 2010 collaboration agreement, $10 million from the signing of our new worldwide development cost and profit share collaboration for AG-881, and finally, $24.8 million relates to IDH development cost reimbursements. Our total revenue was $5.5 million for the third quarter of 2015 compared to $33.9 million in the third quarter of 2014. During the third quarter of 2014 the company reported a significant increase in revenue related to the application of new economy guidance for a July to 2014 amendment to our collaboration agreement with Celgene. With the data of this material amendment the company recognized a total of $25.9 million in revenue. Research and development expenses were $36 million in the third quarter of 2015 compared to $25.5 million in the third quarter of 2014. The increase was largely due to increased investments in our three leads investigational medicines as they advance into late stage clinical development. Along with early development cost for both AG-881 and AG-519. General and administrative expenses were approximately $9.9 million for the third quarter of 2015 compared to $5.2 million for the third quarter of 2014. The increase was largely related to increased income personnel related expenses and other professional expenses to grow our growing operations. Today we are also reiterating our previous guidance that we expect to end 2015 with more than $350 million of cash, cash equivalents and marketable securities. Expect this cash position to give us run rate through a late 2017. Our yearend guidance does not include program specific milestones that we may be eligible to receive under our collaboration with Celgene. As a reminder we are eligible to receive up to a $120 million of milestone payments for both AG-221 and AG-120. With the initial milestone of 25 million per program being triggered by the first patient dosed in the Phase III study. And with that I will turn the call back over to David.

Thanks, Glenn. Our team prides itself on the challenge of making medicines that are truly meaningful. Ones that are capable of rewriting the textbook on the diseases they address. The Agios of 2015 has made rapid and exciting progress towards this goal in the seven years since our inception. Creating five novel investigational medicines that have the potential to impact patients’ lives in a profound way. By keeping patients at the center of what we do and focusing on four simple principles that support that ideal we think it will increase the likelihood that we’ll make important medicines. Vision, science, culture and finally execution. We are here to make medicines patients are waiting for and to do that we need to execute and we need to execute flawlessly. I want to thank you for your time for today and as always we want to thank all the patients, their caregivers, the nurses and doctors who participated in our clinical trials and off course all of our employees and shareholders for their continued support. And with that we can go to questions. Operator?

Thank you. Ladies and gentlemen. [Operator Instructions] Our first question comes from the line of Seamus Fernandez of Leerink Partners. Your line is open.

Good morning. This is actually Mark in for Seamus today. I had two questions for you. Number one, can you give us a sense of where you are with enrollment of your 225 patients Phase I expansion cohorts for AG-221 and AG-120 and how we should think about timing there in terms of completion of enrollment and the potential of submission for accelerated approval based on these data? And second question I had is, at this point, have you seen any issues with enrollment in your AG-120 and AG-881 solid tumor trials in that they might be competing for the same patient pool, I understand that some of the IDH mutant solid tumor indications are actually quite rare and at what point would you consider modifying eligibility criteria to avoid competition for the same patients between these programs there? Thank you.

Thanks for the question. I will take the first and then I ask to Chris Bowden to take that second one on the 120, 881. So with respect to enrollment, I think as you may know from our typical guidance that we don't give out details around the enrollment, what I can tell you is that we're really pleased with enrollment to date, everything remains on track and sites have done just a terrific job across the country and our ex-U.S. sites as well. So, everything there is on track and rolling. We as you know, feel that this is a very important set of patients that we're enrolling both for 221 and 120 and we think that data will be important for patients, for physicians and potentially for regulators, but I want to make it clear, we certainly have not given out any guidance on what the regulatory landscape looks like or whether that will be used to file for accelerated approval. We're excited to generate that data as quickly as possible and then share that with the appropriate audiences. Let me turn it over to Chris for the second question.

Good question about potential competition between AG-120 and AG-881. The trials are enrolling well, we're not seeing problems with that and in fact we put a fair amount of thought into setting the studies up in AG-881, so that would not pose -- reduces the possibility that would be a problem and we'll continue to look at it, but if you thinks specifically about this AG-881 in hematologic malignancies as I stated previously those patients have to have to come on the 881 on the hematologic cohort, the hematologic Phase I, they have to have progressed after an IDH inhibitor.

Thank you. Our next question is from Eric Schmidt with Cowen & Company. Your line is open.

Just a quick housekeeping one for Glenn and I apologized if I missed this, but did you mentioned the size of the milestone payments you might be getting from Celgene for initiation of these different trails?

Yes. So the Phase III milestone will be $25 million for each program.

Okay and are there any other milestones that you're expecting? Say as we look over the next 12 months.

Well, we're not specifically guiding on the timing of milestones, but if you think -- so the first -- you think of the milestones as really in three pieces, the piece is, as we're initiating these later stage clinical trials and then there is -- so that's $25 million per program at under the 2010 agreement. And then there is a second wave of milestone, up to $70 million worth of milestones and those will be upon regulatory and those are really regulatory improve milestones, And then the final milestone in that cascade of $120 million is $25 million milestone based on a commercial -- hitting a commercial number. So, that's kind of the way to think of those, Eric.

Thank you. Your next question is from Terence Flynn of Goldman Sachs. Your line is open.

This is Sameer on for Terence. We had a question on AG-348, we know that enrollments recently began in the Phase II drive PK trails, but is it possible for you to report interim data from this trial next year and if so, what's the trigger? Thanks.

We've not given out any guidance yet on when to expect to see data and as you know our policy is that we wait to see, when there is an aggregate amount of data that makes sense to bring to a medical conference or medical venue and we've not given out any guidance to that yet, but we will give you guidance in advance when that's ready, drive PK is going great, rolling fine, on track and we look forward to be able to share that data at some point in the future.

Thank you. [Operator Instructions] Our next question is from Anupam Rama of J.P. Morgan. Your line is open.

Just a quick one on AG-881, David, I know you’ve quantitatively talked about similar to which you declined in potency to IDH 1 and IDH 2, for 881 relative to 221 and 120. Just wondering when we might get a formal preclinical presentation at a medical meeting or a publication? Just trying to better understand that molecule. Thanks.

Yes, thanks Anupam. So there are two aspects of 881 program where when we think the time is right we’ll bring out to the medical venues conferences. One of them will obviously be the first clinical data and we haven’t given out any guidance. Again as Chris mentioned enrollment is doing really well and is on track for 881, so at some point when there is an aggregate amount of data we’ll bring that out and at some point we’ll bring out some preclinical data as well at the appropriate venue showing event, as we mentioned though, we too are very pleased with the 881 because it is equally potent against both IDH-1 and IDH-2 and as potent as the lead molecules 221 and 120. But it is on the radar screen and will probably get out there as soon as we can.

Great. Thanks so much for taking our questions.

Thank you. And that concludes our Q&A session for today. I would now like to turn the call back over to Mr. David Schenkein for any further remarks.

Thanks. Again I just want to thank everybody for all of your support and those of you who are attending the triple meeting this weekend we hope to see you at our event which as you know is at 12:30 at the Hilton Back Bay and if not it will be on our webcast. So enjoy the rest of the day and thanks for all your support.

Ladies and gentlemen, thank you for participating in today's conference. This does conclude today's program. You may all disconnect. Everyone have a great day.