Earnings Labs

Adaptive Biotechnologies Corporation (ADPT)

Q2 2020 Earnings Call· Tue, Aug 11, 2020

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Transcript

Operator

Operator

Ladies and gentlemen, thank you for standing by and welcome to the Adaptive Biotechnologies Second Quarter Financial Results Conference Call. At this time all participants are in a listen-only mode. After the speakers presentation, there will be a question-and-answer session. [Operator Instructions]. Thank you. I would now like to hand the conference over to your speaker today, Ms. Karina Calzadilla. Please go ahead.

Karina Calzadilla

Analyst

Thank you, Tino. And good afternoon, everyone. I would like to welcome you to Adaptive Biotechnologies second quarter 2020 earnings conference call. Earlier today, we issued a press release reporting Adaptive financial results for the second quarter of 2020. The press release is available on our corporate website at www.adaptivebiotech.com. We are conducting a live webcast of this call, a replay of which will be available on our website after its conclusion. I would also like to remind you that during the call, management will make projections and other forward-looking statements within the meaning of federal securities laws regarding future events and the future financial performance of the company. It is important to note that these statements reflect management's current perspective of the business as of today's date. Actual results may differ materially from current expectations and projections, depending on a number of factors which are set forth in our public filings with the Securities and Exchange Commission, including the Form 10-Q to be filed today. Adaptive disclaims any intent or obligation to update these forward-looking statements, except as expressly required by law. In addition, non-GAAP financial measures will be discussed during the call. Our GAAP financial metrics and reconciliation from non-GAAP to GAAP metrics can be found in our earnings release issued earlier. Joining the call today are Chad Robins, our CEO and Co-Founder; Julie Rubinstein, our President; and Chad Cohen, our Chief Financial Officer. In addition, Harlan Robins, Adaptive's Chief Scientific Officer and Co-Founder, will be available for Q&A. With that, I will turn the call over to Chad Robins. Chad?

Chad Robins

Analyst

Thanks, Karina. Good afternoon, everybody. And thank you for joining us on our second quarter 2020 earnings Call. I hope that you and your loved ones are staying safe and healthy as we continue to navigate through these difficult times. I want to start off by saying I'm truly honored to be part of the Adaptive team and want to congratulate my colleagues on our first year anniversary from our IPO. The past months have been challenging for everyone and our entire company has shown unwavering dedication and flexibility. Thank you to all our Adaptive employees. As you all know, the current coronavirus pandemic is highlighting the critical importance of understanding immune response to disease broadly, making Adaptive's technology more relevant than ever. At Adaptive, we're focused on translating the genetics of the adaptive immune system into clinical products to detect and treat disease. And we are committed to leveraging our immune medicine platform to support the efforts to combat COVID-19 pandemic. COVID-19 brought the role of the immune system to the forefront of society, and has created the opportunity for Adaptive to be positioned as the go-to company to rapidly and reproducibly assess the T cell response to any pathogen, including future pandemics. The breadth of advances we have made recently in each of our business areas is remarkable, particularly given the impact of COVID on all of us. Among the main highlights, we reported revenues of $21 million, above our pre-announced revenue range associated with our follow-on offering. In our research business, we launched a new product immunoSEQ T-MAP COVID to elucidate the T cell response to vaccine in development for COVID-19. In our clonoSEQ business, we achieved an important milestone with a label expansion into CLL, our first FDA approval for blood based testing. For immunoSEQ Dx,…

Julie Rubinstein

Analyst

Thanks, Chad. And thanks to all of you for joining us today. I really hope you and your families are safe and healthy. I want to echo Chad's thanks to our incredible employees. It has been a busy and successful quarter during an uncertain time. Starting with our clinical diagnostic product, clonoSEQ. As Chad mentioned, we recently got FDA clearance for our first clonoSEQ label expansion in CLL in blood as well as bone marrow. This marks an inflection point within our clonoSEQ as it is our first approval in blood and doubles the size of our addressable population under our FDA label. Importantly, it will also support our expansion into the community oncology setting where most patients with CLL are treated. In addition, we launched a service offering which will enable clonoSEQ patients to safely obtain blood draws outside of their doctor's offices, given the risks that COVID-19 poses for cancer patients. Now, patients can access minimal-contact blood collection services at any of the nearly 2000 LabCorp patient service centers in the United States. Or they can have a blood draw performed in the comfort of their own homes through Adaptive's collaboration with Phlebotek Solutions, a nationwide provider of mobile phlebotomy services. Following our launch of CLL in blood, we will continue to expand into blood testing in ALL and multiple myeloma, which enables an increase in the number of tests run per patient. Ultimately, we plan to expand the use of clonoSEQ into NHL. These efforts, coupled with increased payer coverage and patient engagement, set the stage for clonoSEQ's growth trajectory. ClonoSEQ sequencing volumes grew 31% to 3,136 tests versus prior year. These volumes speak to the value of clonoSEQ MRD testing and to our ability to maintain customer engagement even though clinical care is significantly restricted for…

Chad Cohen

Analyst

Thanks, Julie. Turning to our financial results, total revenue in the second quarter was $21 million, representing a decrease of 5% from $22.1 million in the same period last year. Our revenue mix for the second quarter consisted of 38% of our revenues coming from our sequencing category and 62% coming from our development category. Sequencing revenue in the second quarter was $8 million and decreased 33% from the same period in 2019. This decrease was primarily driven by a $4.8 million decrease in revenue generated from our biopharma and academic customers, partially offset by an increase in revenue generated by our clinical customers. Research sequencing volume, which includes sequences reported to both our biopharma and academic customers, decreased by 54% to 4,185 sequences from 9,084 sequences in the second quarter 2019. On the other hand, clinical sequencing volume increased 31% in the second quarter 2020 to 3,136. clinical tests from 2,388 clinical tests from the second quarter of 2019. Clinical sequencing volume did recover sequentially from April through June, returning back to our exiting Q1 volumes, although the initial impact of the COVID lockdown did slow our overall testing volumes on a sequential basis quarter after quarter. Development revenue grew to $13 million in the second quarter, up 27% from the same period last year. The increase was largely due to growth in revenue generated from our Genentech collaboration, which continued to accelerate in the quarter and led to higher development revenues than originally contemplated. Shifting now from our revenue to our operating costs. Total operating expenses for the second quarter of 2020 were $57.9 million, representing a 52% increase from $38.2 million in the same quarter last year. Working down our operating expenses, cost of revenue was $4.9 million during the second quarter 2020 compared to $5.7 million…

Chad Robins

Analyst

Thank you, Chad. As you can see, our platform continues to be an open ended growth story. We were executing on multiple fronts and, importantly, we're delivering on our promises. The world is now on notice that the immune system is key to understanding disease. And our immune medicine platform has removed the technological hurdle to include the T cell response to disease at scale. We believe this will fundamentally change immunology. Our future is bright and I can't be more enthusiastic about what we can accomplish. With that, I'd like to turn the call back to the operator and open it up for questions.

Operator

Operator

[Operator Instructions]. For the first question, we do have Derik de Bruin from Bank of America.

Derik de Bruin

Analyst

A couple of questions, if I may. I guess the first question is, can you talk a little bit about how you're thinking about pricing on both the vaccine side and sort of the opportunity there for drug development? And then also, on the commercial serology test, if you look at some of the other commercial serology tests out there, they're fairly inexpensive and reimbursement for standard tests is around $42, I believe. And, obviously, your test is not going to be in those ranges, given everything that's involved with it. So, can you talk a little bit about the reimbursement opportunities, how you're looking at this just so we can get a better sense with it? And the question is, any initial conversations about how payers are looking to – have you had any conversation with payers at this point? Thanks.

Chad Robins

Analyst

Julie, do you want to take immunoSEQ T-MAP COVID?

Julie Rubinstein

Analyst

Sure. Absolutely. Hi, Derek. So, the way we're thinking about pricing for immunoSEQ T-MAP COVID, it's really an extension of our existing fee for service offering for immunoSEQ where we're really keeping it in line with the way that we currently work with our pharma partners. And that pricing is broken into two components. One is a per sample sequencing fee. And the other is what we call a technology access fee for the data analysis. We're actually keeping the per sample sequencing price the same because it's the same – your blood sample that we typically run and we're increasing the technology access fee to enable annotations from the antigen map. So, we see this as, hopefully, a nice seamless way to continue the work that we already do with most of these companies and really treating it as an extension of our existing sort of bread and butter immunoSEQ offering.

Chad Robins

Analyst

And with respect to immunoSEQ Dx COVID, we're currently in discussions with payers. We're discussing pricing across the board. Right now, we recognize that a sequencing test by nature is going to be a more expensive test than an antibody serology test. However, we also do believe, as was mentioned during the script, that this is just the first kind of data and we believe that our results are going to improve over time as a determinant of past infection. So, we're waiting with our clinical data, submission to the FDA and determining how much better it is. We're also assessing kind of the pricing, but we're not there yet.

Derik de Bruin

Analyst

Julie, any idea on just sort of the size of the opportunity for vaccine developers? I have no idea how to size that market?

Julie Rubinstein

Analyst

Sure. So, the way that we're breaking it down, we're looking into three main variables. One is all of the programs by phase, of course, which are – I think we all probably are following a similar list of about 150 or so trials that are out there by phase. We look at the number of patients that are needed for each of those trials and each of those phases, and then we have an estimate for the number of tests per patient that we think would be run on these trials. And that varies, of course, by the phase of the study. And that's kind of – of course, you'll assign a penetration estimate to that calculation of volume.

Derik de Bruin

Analyst

So, you've alluded to this in your prepared remarks, could you expand a little bit on it. Given what you've learned from your ImmuneCODE initiative, how do you feel about the development of a vaccine targeting the spike protein? Is targeting to spike protein going to elicit enough of an immune response? Or do vaccines need to be targeting other areas of virus as well?

Harlan Robins

Analyst

So, we hope so. But certainly, in a natural infection, in terms of cellular immune response, it's a relatively small part of the overall immune response. There's obviously the possibility that if you only put the spike protein in as your antigen, as in a vaccine, you could elicit a much greater response because the immune system doesn't have the opportunity to hit the entire virus, just that one gene. But, probably, I should just say, we hope for the best, but we'll measure it and be able to directly evaluate the difference.

Derik de Bruin

Analyst

Got it. And I guess on – just an unrelated question. So, can you talk a little bit about your Lyme disease pricing strategy?

Julie Rubinstein

Analyst

So, the pricing opportunity for Lyme or the way we're thinking about it, as we've talked about in the past, we're currently focused on patients in the acute setting and then we'll be expanding into patients who've been previously treated and then on to the chronic population over time. We've done a first round of pricing research to date. And the price range we're still focused on is in the sort of $600 to $800 price range per test. And that's due to a lot of feedback we get in their research that Lyme patients are actually quite expensive to this system. We are going to be launching another round of pricing research as we hone in on the data we're generating from our CV study. And we'll continue to report out as we learn more from that ongoing research.

Derik de Bruin

Analyst

And I guess, Julie, how much better does your test need to perform in order to get sort of that sort of premium pricing relative to the other serology tests that are on market, acknowledging that they're pretty crappy. But what's sort of the differential that you think you need to show in the trials to command the premium for that nature?

Julie Rubinstein

Analyst

So, the data we're seeing so far is that we're basically about – at least twice as good as the current test. And I think that's really a big difference in what we're also hearing from just the patient advocacy work we're doing and what happens to the patients who are on these sort of diagnostic Odysseys that everybody here from are familiar with. That's I think why we believe we will be able to command a higher price. There are also LDCs out there that patients go to all the time that are even more expensive than that because I just think there's a lot of frustration with the current testing paradigm and the resulting frustration that these – I'll use the same word we're hearing now in the news, these sort of long haulers feel and the payers are quite aware of it.

Operator

Operator

Next one on the line is by Tycho Peterson from J.P. Morgan.

Tycho Peterson

Analyst

Maybe just a follow up, Julie, on the T-MAP offering. I know you talked about the pricing structure in 150 or so trials, but can you just give us a sense of the number of projects that you can T-MAP offering now and how material it could be in the back half of the year? We're just trying to kind of get a framework here.

Julie Rubinstein

Analyst

Sure. So, we launched the product last week. It's very new. The great news is that the feedback has been very positive. And we're in advanced discussions with vaccine manufacturers in all phases of development. I think it's probably a little early to tell exactly what to expect over the coming weeks and months, but we're getting very positive feedback. And we believe that immunoSEQ T-MAP is really critical as we all hope for a persistent efficacious vaccine. And this really enables us to be able to study that in conjunction with our pharma partners because it's really the first time you can quantitatively look at T cells. And I think that is definitely resonating.

Tycho Peterson

Analyst

Okay. And then, on the clinical COVID test, besides clinical utility and share versus serology, can you just talk about how you're going to be bringing that to market? Would you potentially partner with somebody? Do you need to build out a channel? What kind of resources do you need to put behind it?

Julie Rubinstein

Analyst

Sure. That's a great question. So, initially, as a T cell based alternative to serology, we're really going to be starting with the self-pay consumer market, employers and we're actually getting some positive feedback from surveillance programs as well. And we believe that we can handle the capacity for that first tranche of testing commercially with the infrastructure that we have in our lab. So, it would be run much like the way clonoSEQ is today. Having said that, as we continue to generate data and really, hopefully, be able to contribute to answering big questions about immunity, like immunity to the virus itself, post infection or immunity from the vaccine, or if we are able to really bring to market a quantitative way of measuring T cells that might confer preexisting immunity, we are planning for extra capacity with a commercial lab or more than one commercial lab to make sure that there would be the ability to run this test more frequently. And we also are looking into the ability to include our existing RUO kit in the EUA discussions that we're having with the FDA. So, we have a variety of paths that we're exploring, but we would be starting with a standout test much like the way we run clonoSEQ today.

Tycho Peterson

Analyst

And then, on clonoSEQ, on the FDA approval for CLL for blood first, I think you had talked last quarter about maybe more volume would shift to blood first anyway in the COVID environment. So, has your thinking kind of evolved here that you would put additional resources behind mobile phlebotomy? You mentioned the LabCorp and the home testing offering, but I'm just curious if you're considering kind of accelerating some of that, given the current pandemic.

Julie Rubinstein

Analyst

So, I guess we feel we've definitely put in place the ability to accelerate that by working out partnerships with LabCorp and Phlebotek. So, now there's a variety of convenient and flexible, safer options for patients to obtain blood draws for clonoSEQ. And these partnerships were announced towards the end of July, but we're already processing our first couple of orders from clinicians and patients who have utilized these offerings. So, I think we're also looking at increasing the size of our sales force to reach more community oncology practices because, as we all know, that's where the majority of CLL patients are treated and to make sure that these available blood draw options are present for patients today. I think it's something that's going to be here to stay. So, right now it's an alternative. But in the future, we do believe it will be a real driver for the clonoSEQ business.

Chad Robins

Analyst

We now also, with the FDA clearance, have the ability to market the blood based testing in CLL. So, we've got a whole launch plan around CLL. And in the fall, you'll see we're going to be marketing towards direct to the consumer to the patient as well, which should potentially drive volumes.

Tycho Peterson

Analyst

And then, last one on ImmuneRACE, when do you think the earliest we could see data from the trials? Thanks.

Harlan Robins

Analyst

A variety of the data we've been making public as we go on our ImmuneCODE study with Microsoft. So, a lot of the data is available. Our clinical data in the – we're planning to run a critical validation study using some of those samples in the fourth quarter this year. So, that's when it would be made available. And separately from that, we just had a publication on some of the ImmuneCODE data last week and we'll probably have another publication coming up as well.

Operator

Operator

Next question comes from Doug Schenkel from Cowen.

Doug Schenkel

Analyst

I'm just wondering if there's any update on how you are going on with private payers in terms of getting paid on blood based testing for ALL and multiple myeloma. Medicare obviously was a nice addition for you in terms of getting them on board relatively recently. I'm just wondering if that's helped you gain any momentum on the private payer side.

Chad Robins

Analyst

We continue to make progress on the private payer side. As you know, we're more going one by one through the private payers and through the health tech assessment bodies. We do believe that the FDA approval on CLL gives us an opportunity to engage them for coverage on the CLL front as well. Although not required, it's been certainly helpful. But I would say we're making incremental progress on the blood based testing from the private payers. But it's still a pretty small percentage, Dough, in terms of our overall test volumes. It's the larger percentage of CLL, obviously, a smallest percentage of ALL and something that's pretty close to zero in terms of myeloma.

Doug Schenkel

Analyst

One of the things I think you talked about in your prepared remarks was the momentum you had with new accounts and that playing a key role this quarter for clonoSEQ? I know it's, in the grand scheme of things, still small volume and still early days, but it was good relative to what we were looking for. I'm just curious, was this really a function of just you gaining steam in terms of how you go about detailing? Or do you think that this was some of the carryover and really just the reward of some of the strong efforts you put in pre pandemic?

Julie Rubinstein

Analyst

I really think this is kudos to the clonoSEQ commercial team who truly really understand how to build this market and build relationships with clinicians in this market for that sort of growth that we're starting to see now, exactly as you said. And for example, even during this year with COVID, the team signed over 400, new HCPs. And those HCPs are really starting to use the product a lot faster. So, in 2020, the new HCP has contributed to around 15% of the test volume in Q2. And at this time last year, the new HCPs in 2019 contributed about 8% of the total test volume in the same quarter. So, you're beginning to see the fruits of the labor of the team and the way in which they went about penetration and relationship building, which became even more important in the COVID environment. And there's a lot of trust that's been built between the team and the clinicians, and particularly also in response to the things that we're putting in place to make it easier for patients to continue to know their MRD status, even if it's challenging for them to go into inpatient clinic. So, I think it's really been a great effort led by the team where we continue to add new accounts, new HCPs and faster time to order for the HCPs.

Chad Robins

Analyst

I was just going to say, one other data point that I find relevant, we had some of our major historical [Technical Difficulty] because of the pandemic. So, these numbers were put up despite some of the cancer centers being closed that have traditionally contributed significant amount of the order test volume. You had a significant amount of new accounts over the year, particularly in Q2, during a pretty tough time. So, I think a lot of the efforts that the team had put into place have started to pan out.

Doug Schenkel

Analyst

And then, maybe just one last one on product pipeline and future milestones. It's great to hear that the first T cell therapy product from Genentech is expected to be ready for IND filing. I think you said in Q1 of next year, which is great news, especially given some concern more broadly is that timelines could slip just given what's going on in the world. Beyond that, I'm just wondering if there's any development in terms of other T cell therapy products from Genentech? I'm sure there are, but I guess what I'm getting at is could we expect any other announceable milestones if not later this year, maybe in 2021, beyond that first IND? Thank you.

Harlan Robins

Analyst

Hi, Doug. I'll probably pass to Julie for the milestone comment, but I can talk about the science side. Yeah, we're moving ahead quite rapidly in two directions. So, the product that we're that we've been discussing that we're going to go to IND filing and hopefully clinic in first quarter is our first shared product. We're also working diligently on a second shared product. We're actually building a library. But the second one we're hoping to transition to Genentech actually quite soon. And then, separately, the real goal behind all this is our personalized product where we're going to create an individual therapy for each person by pulling out their T cell receptors and then putting them back in with a transplant. And that requires a build out of facilities and both Genentech and Adaptive are building out the required facilities with the goal of having those up and running in sort of early 2021. So, first quarter, as well. And then throughout next year, working on getting that workflow and pipeline down and hopefully moving at the end of next year towards a filing.

Julie Rubinstein

Analyst

In terms of milestone payments, we expect milestone payments upon IND acceptance and upon first in humans for each product. We haven't disclosed the amounts of those milestones, but they are – the first in human follows shortly from acceptance. And obviously, Genentech certainly controls the timing for the IND filings.

Operator

Operator

Next one on the queue is Salveen Richter from Goldman Sachs.

Salveen Richter

Analyst

So, just two for me. One, with regard to the head to head study with your T cell based diagnostic test, could you go further here into the data and how confident you were in this and with the comparative arm with regard to the serology tests? And then secondly, with regard to the TCR program with Genentech, when will you disclose the first target here?

Harlan Robins

Analyst

This is Harlan. I'll start with the first question, which is on our T cell based tests that would be a comparator to the serology test. We actually feel quite good about the data and we did a real world study. And we focused on patients where they were in the spot where the serology test is valid, meaning after – these were convalescent patients at least 14 days past diagnosis. And the majority of the subset, I think six or seven of the patients of the Adaptive test showed negative. It was showing negative by serology. So, we had a massive overlap between the two and the big delta between them was a set of patients that Adaptive was able to find as positive and serology was not. So, I think we feel quite good about the data. Obviously, it's not a massive study yet and our clinical validation study will be – that we're going to go for EUA will be bigger. This was a test to just make sure that we really, in a fair way, understood the data and understood our expected results. And the great part is that that we're also – our test continues to get better over time. That's where we're at right now. And so, that's why we felt good about presenting it where we are. We don't think it's going to get worse relatively speaking because there's a very large number of T cell receptors in the entire population that are specific for SARS-CoV-2 and we've only uncovered a set of a few thousand so far. And every one we uncover makes our test better. So, we're moving in a very good direction.

Chad Robins

Analyst

Your second question was about when we would know the target. And the first target will be disclosed at the time of the IND filing by Genentech, which is expected again in the first quarter. We have disclosures against the solid tumor target.

Operator

Operator

Next one on the queue is Brian Weinstein from William Blair.

Brian Weinstein

Analyst

Curious if all the work in COVID-19 is helping advance discussions with partners or potential partners on anything beyond COVID-19 if you guys are really able to showcase your capabilities, which obviously would be more important to longer term. So, anything on that?

Harlan Robins

Analyst

That's a great question, Brian. And the answer is absolutely. We've been in discussions about kind of mapping T cell receptors versus antigen for multiple disease states. And I think the fact that we could do this quickly when COVID came up, release the data in a publicly available database and show our capabilities has catalyzed some additional discussions that we've been – actually ongoing with several partners.

Julie Rubinstein

Analyst

I'm just going to add something interesting. As you know, the initial proof of concepts for our ability to map receptors to antigens was in CMV. But now that we've actually offered T-MAP, some of our academic groups that we work with have actually started to ask – they're like, 'oh, now, I really understand it, can you give me the information for CMV also?' So, it's interesting that it's actually helped to sort of clarify what is possible from our platform disease by disease. And I think it's actually putting into context some of what we've sort of explained in past and it's coming back up for other disease states we've done and new disease states that we can do.

Brian Weinstein

Analyst

And then, as it relates to the work with Amgen, you guys give a little bit of an update there, but can you just talk about your confidence of your ability to kind of find, as you referred to, called the MJ of neutralizing antibodies here and then Amgen's willingness to commercialize. How you're seeing that market sort of play out?

Harlan Robins

Analyst

I think we're feeling pretty confident. We've been going at this quite broadly and moving through a very large number of potential antibodies and screening from hundreds of people now. And the data is looking quite promising. There's some other groups that are ahead of us and seem to be doing quite well, the Regenerons of the world, for example. But we're going after quite different targets, they're all pretty focused on the spike protein. And so, if we need more broad targets than the initial group is finding, which we expect that the efficacy is going to be hopefully reasonable from some of these first movers, but probably, as you can imagine, no one's perfect the first time. So, we think we would have a lot to add. As for Amgen, we're going to present them our best case and they have a lot of factors to consider. But they're pretty open to and excited about the concept. And so, hopefully, the timing's right, we're on schedule as far as our initial plans with them, and so all things are moving well. A lot of effort going on in our various labs. So, we'll update you as we move forward both our own progress as well as discussions with Amgen.

Brian Weinstein

Analyst

And then, last one for me, if I could sneak one in here, is just to confirm that the pricing and the reimbursement on blood versus bone marrow is really no different for CLL. Could you guys talk about the timing for ALL and multiple myeloma? If you did, I think I missed it. If you wouldn't mind repeating it, I'd appreciate it.

Julie Rubinstein

Analyst

Chad, you want to take the pricing question and then I'll answer the…

Chad Robins

Analyst

The answer to the pricing question is, exactly the same for blood or bone marrow. And actually, to a question earlier, some of the private payers don't want to specify sample type either, but the pricing is the same. The second, ALL and MM and blood. Julie, do you want to cover, ALL and multiple myeloma?

Julie Rubinstein

Analyst

Sure. so, the ALL work, the data has been generated, everything that's required for a filing to the FDA. And we are going to be beginning those conversations now that CLL is winding down. So, that'll start up soon, those discussions with the FDA.

Operator

Operator

Next one on the queue is David Westenberg from Guggenheim Securities.

David Westenberg

Analyst

Hi. Thanks for taking the question. And thanks for all the work you're doing with COVID. So, I guess, my first one is probably for Julie, but it might be for Chad. In terms of clonoSEQ, I would think the temptation is to order it more frequently as more information is obviously better than less information. So, if you can maybe talk about the behavior of the early adopters, the 1% maybe of your customers that order the most frequency, what is the frequency in which they order? And I get that not all patient is the same, but I'm just trying to get a sense of – if you could test all the time, how frequently would you test?

Chad Robins

Analyst

Sure, I'll take that. If you're truly talking about the power users, depending on the indication, but in ALL, in multiple myeloma so far, we have clinicians that are testing new patients on a monthly basis. Again, this is a smaller subset of what we'll call the power users that are continually monitoring a patient's disease burden over time, looking for spikes back up and to provide clinical decision making based on that information.

David Westenberg

Analyst

And then, in terms of – I think Brian might have been asking a similar kind of question, but in terms of Amgen and the timing for them to get a product once you give them the antibody, so I'm not kind of familiar with how long the kind of the – it would take that – so do you have a kind of a good estimate on that.

Chad Robins

Analyst

We're working on a lot to just specify exactly, but I can just tell you it's a pretty short fuse by design and construction that if we have something, it's either take it or move on and allow us the optionality to another partner. I think both parties recognize that the external landscape is moving quickly here. So, we want this kind of flexibility to [Technical Difficulty]. Just in Amgen's, since they would control that timeline, what Amgen – their words are months, not years. So, they would be motivated to move fast. Obviously, there's no – this world is not [ph] moving very fast.

David Westenberg

Analyst

On immunoSEQ Dx, you've talked about you could run so many different studies in parallel. I think you've said six, seven, eight projects at a time. Now, you have a building, you have a lot more – you're building a building, you have a lot more cash. In 2021, do you maybe run more programs than that at once? And kind of help us understand how fast these clinical timelines could go.

Julie Rubinstein

Analyst

Sure. That's a great way of phrasing that question. That's absolutely one of the reasons for the capital raise. We've really honed our R&D funnel into five stages. And we sort of move – we're working on about four to five indications in each of the five stages now, and so we're really, really learning how to do this, how long it takes, what it really requires, how to hone the TCR signatures and move the diseases through that funnel. So, we're really focused on this. And that, as you mentioned, is one of the main reasons for the raise.

Operator

Operator

And there are no further question on the queue. You may continue. Ladies and gentlemen, this concludes today's conference call. You may now disconnect.