Carl Hansen
Analyst · Credit Suisse. Your line is now open. You may ask the question
Thank you, Tryn, and thank you to everyone for joining us today. It's my pleasure to provide an update of the second quarter of 2021 in which we continue to execute on our long-term strategy for growth. First, we closed the quarter with nearly $800 million in cash and over $60 million in accounts receivable and accrued accounts receivable. In addition to our strong liquidity position, we maintained our forward momentum, showing strong growth in our core business across key performance indicators, including 19 new programs under contract bringing our total number of programs to 138; 16 programs starts, bringing the total number of starts to 60; and three new molecules that have entered into the clinic, bringing the total number of molecules in the clinic to four. Two of those molecules are from our COVID-19 program with Eli Lilly, which continues to be both a proof point for our technology capabilities and business model and a source of non-dilutive funding. Unfortunately, and despite vaccine rollout, we are seeing a strong uptick in COVID-19 cases globally with well over 100,000 cases reported daily in the U.S. alone. Our first COVID-19 therapeutic antibody is bamlanivimab. Bamlanivimab administered together with etesevimab was paused in June because at the time, the beta and gamma variants, which are resistant to this combination were prevalent in the U.S. Today, the most prevalent variant, both in the U.S. and globally is the Delta variant. Preclinical data demonstrate that bamlanivimab and etesevimab administered together retain utilization activity against the Delta variant, as well as other variants currently in circulation in many countries. I note that there is an existing supply of bamlanivimab and etesevimab that we believe could be used effectively to help patients today, both in the U.S. and around the world. Our second therapeutic anybody for COVID-19, 1404, which is now known as bebtelovimab, is currently in Phase 2 clinical testing with Eli Lilly. Preclinical results posted to a preprint server in June demonstrate that bebtelovimab is an exceptionally potent antibody that binds to a highly conserved region of the spike protein. The data also show that bebtelovimab is effective against all variants of concern and of interest, including the Alpha, Beta, Gamma, Epsilon, Iota, Kappa and Delta variant. Bebtelovimab is being evaluated alone and in the three-way combination together with bamlanivimab and etesevimab. As indicated in our last quarterly call, we expect top line data from these trials this summer. We look forward to clinical results from Eli Lilly on the use of bebtelovimab and believe it has strong potential to be an effective tool in the long-term fight against COVID-19. As previously noted on earnings calls, our work in COVID-19 represents only one program in our portfolio. In total, we have 138 programs under contract with 33 different partners. These programs span nearly every indication for its therapeutic antibodies and associated modalities are used. Of the 138 programs in our portfolio, we know the therapeutic areas for 95 of them, with the remainder attributable to slots into which targets have yet to be elected. These programs target indications in oncology, pain neurodegeneration, infectious disease, autoimmune disease, allergic inflammation, ophthalmology, women's health, cardiovascular disease and metabolic disorders. Beyond therapeutic areas, our portfolio includes a range of different target types. About 28% of the targets are part of the selected fall into the difficult or challenging area and may well be considered intractable using legacy technologies. These include multipath transmembrane protein targets, high homology targets, peptide MHC complex targets, and others. In pursuing therapies against their targets, our partners are looking to leverage the next generation of antibody modalities. Each of these brings its own specific and demanding requirements, making diversity and data analytics critical. Today, we're working with our partners on programs that cover the full range of target modalities, including IgGs, IgMs and IgAs, bispecific antibodies, leveraging our proprietary OrthoMab technology, single-chain antibodies, CAR-T cell therapies, radioisotope conjugates, and CNS-delivered antibodies. The value our capabilities provide to partners is reflected in our deal structures, which include downstream participation that directly increases with the challenge of finding the right antibody for the target. While the majority of our programs with downstream participation are with partners that are publicly listed companies, mostly in the large-cap and mid-cap bracket, we also work selectively with much earlier-stage ventures. Most of these programs are with companies considered biotech. But for a significant number of programs, you're working with a range of global pharma partners. During this work, we aim to create long-term shareholder value, building a large and diversified portfolio of royalty and other downstream positions in the next generation of antibody-based therapies. And we are seeing that our portfolio capture strong diversification across therapeutic areas, modalities, and partner types. Within the total portfolio, we have started work on 60 programs. Currently, once we delivered candidate and the associated data packages to our partners, they take on the late-stage preclinical development that ultimately lead to an IND application. This process typically takes two to four years depending on the program and depending on the experience and resources of our partners. As previously discussed, we plan to greatly accelerate the timeline to IND application down to one year through forward integration adding CMC and GMP manufacturing capabilities to our tech stack. This quarter, we secured a site for our new 130,000 square foot antibody manufacturing facility. When complete, this facility will allow us to provide our partners with a full and integrated solution that goes from target right through to IND submission. Turning to business development, our pipeline continues to be strong showing strong demand for our partnership business and adding more deals with different types of companies. Of the 35 programs under contract that were added in the first half of this year, all programs include downstream participation, typically achieved through clinical development milestones, commercial development milestones and royalties. Over the past year, the general trend has been increasing royalty positions, reflecting additional technology capabilities and expanded scope of work and are recognized leading position in the market. This also encompasses partnerships with equity or equity like positions as a way for us to capture yet more value. What I'm excited about this quarter is that we announced two new deals, one with Tachyon and one with EQRx, that represent a further amplification of our business model, through which we have the option to invest in the subsequent stages of preclinical, clinical and commercial development for a greater share of the assets. We believe that these deal structures have the potential to create more long-term value for our shareholders, providing the option to deepen our position in select programs and in turn yielding economic similar to an internal pipeline while still staying true to our business model of being a technology enabler for the industry. Today, our approach is to capture downstream value can generally be grouped in three broad categories. First, royalties and milestones or milestone payments are earned at various points of clinical and commercial progress and royalties that are typically but not exclusively in the low to mid single-digit range. Second, discovery partnerships with equity or equity-like participation, which has been a feature within the last year of deals that include Invetx, Abdera and Angios. And third, deals that include an option to invest, as mentioned, which are similar to those we've announced with partners Tachyon and EQRx. Within our portfolio of 138 programs under contract, we have an equity or equity-like position in about two dozen programs and we have almost a dozen programs where we have the option to invest in the molecules we discover. In the future, we may expand our deal types further as we explore new ways to capture the value of our partnership model. To lead our BD efforts and the expansion of our commercial team, we recently welcomed industry veteran Neil Berkley as Chief Business Officer. Neil brings more than 20 years of strategic planning and corporate and business development expertise across a wide range of transactions and therapeutic indications. We are excited to have him join our leadership team. Before handing off to Andrews to discuss the financial results, I'd like to re-emphasize how our efforts today support our long-term vision for making drug discovery faster, more efficient and more cost effective. First, we believe our technology can solve discovery problems and unlock new opportunities for therapeutic antibody development and that this will be a source of continued growth within the industry. Second, our strategy emphasizes technology integration at scale. This is not just a state-of-the-art technology in IP but also the assembly of a world class team of scientists, data systems, facilities equipment, and processes into a high performing whole that is a critical advantage to achieving compounding returns and to creating a long-term competitive advantage. Third, we are leveraging vertical integration as a central theme to accelerate and also to have control over the entire preclinical process. And fourth, we're continuing to invest in technological differentiation to broaden our reach across the industry. Examples of this include our bispecific [indiscernible] technology, as well as internal efforts that we believe in time will unlock high value target spaces that are currently out of reach. In the long run, our goal is to replace the legacy technologies of today and the traditional model of doing business, and to help the industry continue its growth and become more efficient. We believe that we have already established a world leading technology position which we are now bringing to the market at scale, and that we have created a new technology curve that will lead to continual improvement not just now but for decades to come. And with that, I'll turn it over to Andrew Booth, our CFO, to provide an overview of our second quarter 2021 financials.